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The map label for this gene is gpsA

Identifier: 20808044

GI number: 20808044

Start: 1570652

End: 1571644

Strand: Reverse

Name: gpsA

Synonym: TTE1617

Alternate gene names: 20808044

Gene position: 1571644-1570652 (Counterclockwise)

Preceding gene: 20808045

Following gene: 20808043

Centisome position: 58.44

GC content: 41.19

Gene sequence:

>993_bases
ATGAAAATAGCGGTACTGGGAGCAGGAAGCTGGGGAACTGCTATAGCTATTCACCTTAATAAATTAAACCATCAGGTAAG
GCTGTGGATGAGAAGTAAGGAGCAATTTGAGGAACTTATTGCAACAAGGCACAATTCGAGATACCTTGACGTGGATCTTC
CTTCAAGCATTTTACTGTACAATGACCTAGATAAAGCAGTAGAAGATTCCGAAGTAGTGGTCATTGCTGTTCCTTCCCAT
GCTGTAAGAGAAGTATCCGAAAAATTAAAAGGGAAAATCTCTAAAAATGCTATTGTTGTCAATCTGGCAAAAGGGATTGA
AACTTCTTCATTGAAGAGAATGTCTGAGGTAATAAAGGAATACCTTTTAAACCCTGTGGTAGTGCTGTCAGGACCAAGTC
ATGCGGAAGAAGTAGTAAGACAGATTCCTACGGCCTGTGTACTTGCTTCAGAGGACGTTAAGGCTTGCGAATTCATACAG
GAGGCTTTTATGAACGAGACTTTCAGGCTGTATGTAAATACCGATGTAATAGGAGTGGAACTAGGAGGAGCTTTAAAAAA
TATAATCGCTTTAGGGGCGGGGATTTCCGACGGGCTTGGCTTTGGGGATAATACAAAAGCTGCTCTCATGACAAGAGGGC
TTGCCGAGATTACAAGGCTGGGAGTGGCTATGGGTTCGGACCCTTTGACTTTCCTGGGATTGGCAGGGGTCGGGGACCTT
ATTGTGACCTGTACAAGTAACTATTCAAGAAATAGAAGAGCGGGGATTTTAATAGGCAAGGGGAAAAGTTTAAAAGAAGC
GTTAAAAGAAATAGGGATGGTAGTGGAAGGCGTAAATACTACCAAATCAGCCTACAGGCTTTCTCAAATATATGGAGTGG
AGATGCCAATTACCAAGGAGATTTATTCTATAATTTTTGAAAATAAAAATCCTTTTGAGGCGGTTTATAATTTGATGACG
AGAGATAAAAAGCACGAGTTACACGGAATTTAA

Upstream 100 bases:

>100_bases
AGTAATATTCCAGCATCGCTCTAATATAAAGAGGTTGATAAACGGGACTGAATCTAAAATAGGGCAGAGAGCTCAAATAA
AATAAGAAAGGGAAAGAGAA

Downstream 100 bases:

>100_bases
TCTCCGGCTTTGCCGGAGATTTTATATTTAATCATATAACTGTGGGGTAAAAGCATATATTAGGAATGAGAATGAGGGAC
ATAGCCAAAAGGAGGGAATA

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKIAVLGAGSWGTAIAIHLNKLNHQVRLWMRSKEQFEELIATRHNSRYLDVDLPSSILLYNDLDKAVEDSEVVVIAVPSH
AVREVSEKLKGKISKNAIVVNLAKGIETSSLKRMSEVIKEYLLNPVVVLSGPSHAEEVVRQIPTACVLASEDVKACEFIQ
EAFMNETFRLYVNTDVIGVELGGALKNIIALGAGISDGLGFGDNTKAALMTRGLAEITRLGVAMGSDPLTFLGLAGVGDL
IVTCTSNYSRNRRAGILIGKGKSLKEALKEIGMVVEGVNTTKSAYRLSQIYGVEMPITKEIYSIIFENKNPFEAVYNLMT
RDKKHELHGI

Sequences:

>Translated_330_residues
MKIAVLGAGSWGTAIAIHLNKLNHQVRLWMRSKEQFEELIATRHNSRYLDVDLPSSILLYNDLDKAVEDSEVVVIAVPSH
AVREVSEKLKGKISKNAIVVNLAKGIETSSLKRMSEVIKEYLLNPVVVLSGPSHAEEVVRQIPTACVLASEDVKACEFIQ
EAFMNETFRLYVNTDVIGVELGGALKNIIALGAGISDGLGFGDNTKAALMTRGLAEITRLGVAMGSDPLTFLGLAGVGDL
IVTCTSNYSRNRRAGILIGKGKSLKEALKEIGMVVEGVNTTKSAYRLSQIYGVEMPITKEIYSIIFENKNPFEAVYNLMT
RDKKHELHGI
>Mature_330_residues
MKIAVLGAGSWGTAIAIHLNKLNHQVRLWMRSKEQFEELIATRHNSRYLDVDLPSSILLYNDLDKAVEDSEVVVIAVPSH
AVREVSEKLKGKISKNAIVVNLAKGIETSSLKRMSEVIKEYLLNPVVVLSGPSHAEEVVRQIPTACVLASEDVKACEFIQ
EAFMNETFRLYVNTDVIGVELGGALKNIIALGAGISDGLGFGDNTKAALMTRGLAEITRLGVAMGSDPLTFLGLAGVGDL
IVTCTSNYSRNRRAGILIGKGKSLKEALKEIGMVVEGVNTTKSAYRLSQIYGVEMPITKEIYSIIFENKNPFEAVYNLMT
RDKKHELHGI

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=343, Percent_Identity=32.6530612244898, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI24307999, Length=353, Percent_Identity=30.5949008498584, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1790037, Length=328, Percent_Identity=44.8170731707317, Blast_Score=289, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI32564399, Length=342, Percent_Identity=34.5029239766082, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI193210136, Length=351, Percent_Identity=33.6182336182336, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI32564403, Length=351, Percent_Identity=33.6182336182336, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17507425, Length=334, Percent_Identity=29.3413173652695, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193210134, Length=338, Percent_Identity=30.1775147928994, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324513, Length=342, Percent_Identity=28.6549707602339, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320181, Length=360, Percent_Identity=29.1666666666667, Blast_Score=129, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17136200, Length=334, Percent_Identity=31.437125748503, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17136202, Length=334, Percent_Identity=31.437125748503, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17136204, Length=334, Percent_Identity=31.437125748503, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI22026922, Length=287, Percent_Identity=29.9651567944251, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45551945, Length=235, Percent_Identity=28.936170212766, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281362270, Length=235, Percent_Identity=28.936170212766, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24648969, Length=188, Percent_Identity=29.7872340425532, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_THETN (Q8R9J3)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623215.1
- ProteinModelPortal:   Q8R9J3
- SMR:   Q8R9J3
- GeneID:   996133
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1617
- NMPDR:   fig|273068.3.peg.1592
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- BioCyc:   TTEN273068:TTE1617-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36042; Mature: 36042

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 186-186 BINDING 104-104 BINDING 104-104 BINDING 135-135 BINDING 250-250 BINDING 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVLGAGSWGTAIAIHLNKLNHQVRLWMRSKEQFEELIATRHNSRYLDVDLPSSILLY
CEEEEEECCCCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
NDLDKAVEDSEVVVIAVPSHAVREVSEKLKGKISKNAIVVNLAKGIETSSLKRMSEVIKE
CCHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
YLLNPVVVLSGPSHAEEVVRQIPTACVLASEDVKACEFIQEAFMNETFRLYVNTDVIGVE
HHCCCEEEEECCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCEEEEEEECCEEEEE
LGGALKNIIALGAGISDGLGFGDNTKAALMTRGLAEITRLGVAMGSDPLTFLGLAGVGDL
CCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCE
IVTCTSNYSRNRRAGILIGKGKSLKEALKEIGMVVEGVNTTKSAYRLSQIYGVEMPITKE
EEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHH
IYSIIFENKNPFEAVYNLMTRDKKHELHGI
HHHHHHCCCCHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MKIAVLGAGSWGTAIAIHLNKLNHQVRLWMRSKEQFEELIATRHNSRYLDVDLPSSILLY
CEEEEEECCCCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
NDLDKAVEDSEVVVIAVPSHAVREVSEKLKGKISKNAIVVNLAKGIETSSLKRMSEVIKE
CCHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
YLLNPVVVLSGPSHAEEVVRQIPTACVLASEDVKACEFIQEAFMNETFRLYVNTDVIGVE
HHCCCEEEEECCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCEEEEEEECCEEEEE
LGGALKNIIALGAGISDGLGFGDNTKAALMTRGLAEITRLGVAMGSDPLTFLGLAGVGDL
CCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCE
IVTCTSNYSRNRRAGILIGKGKSLKEALKEIGMVVEGVNTTKSAYRLSQIYGVEMPITKE
EEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHH
IYSIIFENKNPFEAVYNLMTRDKKHELHGI
HHHHHHCCCCHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336