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The map label for this gene is SsnA

Identifier: 20808022

GI number: 20808022

Start: 1549483

End: 1550784

Strand: Reverse

Name: SsnA

Synonym: TTE1593

Alternate gene names: 20808022

Gene position: 1550784-1549483 (Counterclockwise)

Preceding gene: 20808023

Following gene: 20808021

Centisome position: 57.66

GC content: 40.17

Gene sequence:

>1302_bases
GTGAATTTGTTAATTAAAAATGTAAACCTTCTTTCCATGGAGGAAGATAAGGTATTAGAGGGCGTGAATGTGTATGTCGA
GGGAGATACTATAAAGCACATAGGAGAGTTGCTCCCTGATGTTAAAGTAGACGTAGTCATTGAGGGAAAAGATAAGCTTG
CAATGCCAGGTCTCATAAACGCTCATACACATCTAGGGATGTCTTTGTTTAGAAATTATGCAAATGATGTACCTCTTTTT
GACTGGCTTACAAAGTACATATGGCCGCTTGAAGCAAGGCTTACTGCAGAGGATGTTTACTGGGGCTCCCTTCTTAGCAT
GATAGAGATGATTTACTCAGGTACTACTACTTACTGTGATATGTACTTTTTTATGGAGGAAGTAGCAAAAGCTACAGAAG
AAATAGGCATAAGAGGCGTGATTTCCAGGGGAATTATAGAAGAACAGGATGCCAAAGTTAATGAAGAGAAGCTAAAGGAT
ACGGAAAATTTGTATAACGCTTGGAATGGCAAGGCTGAGGGCAGAATCAAAGTGATGGTAGGACCTCACGCACCTTACAC
CTGTGGACCAACTTATTTGAAAGAAATTTTGGACCTTGCCAAGAGATTAGGTACGGGGATTCACATTCATGTGTCAGAGA
CAAAGAGGGAAGTAGAAGAAAGCCTTGAAAAGTACGGTAAAACCCCTGTACAGCATTTAAAGGATTTGGGAATTTTTGAA
GTGCCTACTGTAGCTGCTCACTGTGTACACCTTACAGATGAAGATATTGAGGTATTAAAAGAGATGAAAGTCTCTCCTGT
GTACAATCCCACCAGCAATTTAAAGCTGGCAAGTGGATTTGCTCCTGTAGAGAAAATGTTAAAAAAAGGGATAAATGTTG
CTCTTGGAACTGACGGTCCTGCCAGCAACAACAATTTAAACATGTTTGAAGAGATTCATTTCGCGGCCACCATCAACAAA
GCCTTAAATGAGGATGCTCTGTCTGTACCTGCTTTTGAAGCTTTAAAGATGGCCACAGTGAGTGGAGCAAGAGCGCTTTT
ATGGGAAAGAGAGATAGGCACTATTGAGGTTGGGAAAAAGGCAGATGTAATTCTCATAGACCTTAATAAACCTCATTTAC
ATCCCAAGAACGACTTAATCTCTGCTTTAGCCTATTCTGTTCAGGGTTCAGATGTAGATACAGTTATAGTAAATGGCAAA
GTGATAATGGAAAAAAGGGAGATAAAAACTGTGGACGTAGAGAGGGTTTACTACGAAGTGGAGAAAAGGGCTCAAAATTT
GATAAGAGGAGAAATCAGTTGA

Upstream 100 bases:

>100_bases
CTATCTGTGCAAGATGTGCTTCTCACATTGAGGAGCAGTTAAAGGTATAGAAAGGGGATTCCCCTTTCTATACTTATATT
TTTGATAGGAGGGGAAAGAA

Downstream 100 bases:

>100_bases
CAGCCCCTTTCTCTTGTTATATGATGGATTTAGTGGGAATATTCATACAAAAACGGGGTGAAAAACGTGCTTTTAAAATA
TGAGAGAGAACAAATAGTAG

Product: cytosine deaminase-like protein

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MNLLIKNVNLLSMEEDKVLEGVNVYVEGDTIKHIGELLPDVKVDVVIEGKDKLAMPGLINAHTHLGMSLFRNYANDVPLF
DWLTKYIWPLEARLTAEDVYWGSLLSMIEMIYSGTTTYCDMYFFMEEVAKATEEIGIRGVISRGIIEEQDAKVNEEKLKD
TENLYNAWNGKAEGRIKVMVGPHAPYTCGPTYLKEILDLAKRLGTGIHIHVSETKREVEESLEKYGKTPVQHLKDLGIFE
VPTVAAHCVHLTDEDIEVLKEMKVSPVYNPTSNLKLASGFAPVEKMLKKGINVALGTDGPASNNNLNMFEEIHFAATINK
ALNEDALSVPAFEALKMATVSGARALLWEREIGTIEVGKKADVILIDLNKPHLHPKNDLISALAYSVQGSDVDTVIVNGK
VIMEKREIKTVDVERVYYEVEKRAQNLIRGEIS

Sequences:

>Translated_433_residues
MNLLIKNVNLLSMEEDKVLEGVNVYVEGDTIKHIGELLPDVKVDVVIEGKDKLAMPGLINAHTHLGMSLFRNYANDVPLF
DWLTKYIWPLEARLTAEDVYWGSLLSMIEMIYSGTTTYCDMYFFMEEVAKATEEIGIRGVISRGIIEEQDAKVNEEKLKD
TENLYNAWNGKAEGRIKVMVGPHAPYTCGPTYLKEILDLAKRLGTGIHIHVSETKREVEESLEKYGKTPVQHLKDLGIFE
VPTVAAHCVHLTDEDIEVLKEMKVSPVYNPTSNLKLASGFAPVEKMLKKGINVALGTDGPASNNNLNMFEEIHFAATINK
ALNEDALSVPAFEALKMATVSGARALLWEREIGTIEVGKKADVILIDLNKPHLHPKNDLISALAYSVQGSDVDTVIVNGK
VIMEKREIKTVDVERVYYEVEKRAQNLIRGEIS
>Mature_433_residues
MNLLIKNVNLLSMEEDKVLEGVNVYVEGDTIKHIGELLPDVKVDVVIEGKDKLAMPGLINAHTHLGMSLFRNYANDVPLF
DWLTKYIWPLEARLTAEDVYWGSLLSMIEMIYSGTTTYCDMYFFMEEVAKATEEIGIRGVISRGIIEEQDAKVNEEKLKD
TENLYNAWNGKAEGRIKVMVGPHAPYTCGPTYLKEILDLAKRLGTGIHIHVSETKREVEESLEKYGKTPVQHLKDLGIFE
VPTVAAHCVHLTDEDIEVLKEMKVSPVYNPTSNLKLASGFAPVEKMLKKGINVALGTDGPASNNNLNMFEEIHFAATINK
ALNEDALSVPAFEALKMATVSGARALLWEREIGTIEVGKKADVILIDLNKPHLHPKNDLISALAYSVQGSDVDTVIVNGK
VIMEKREIKTVDVERVYYEVEKRAQNLIRGEIS

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=338, Percent_Identity=31.6568047337278, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI87082177, Length=449, Percent_Identity=27.3942093541203, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789249, Length=397, Percent_Identity=26.9521410579345, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17540282, Length=379, Percent_Identity=24.802110817942, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319963, Length=365, Percent_Identity=26.8493150684932, Blast_Score=119, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24643849, Length=393, Percent_Identity=26.7175572519084, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_THETN (Q8R9L4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623193.1
- ProteinModelPortal:   Q8R9L4
- SMR:   Q8R9L4
- GeneID:   996076
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1593
- NMPDR:   fig|273068.3.peg.1541
- HOGENOM:   HBG668170
- OMA:   KVIDMAT
- ProtClustDB:   CLSK901320
- BioCyc:   TTEN273068:TTE1593-MONOMER
- BRENDA:   3.5.4.28
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 48350; Mature: 48350

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: BINDING 91-91 BINDING 143-143 BINDING 183-183 BINDING 213-213 BINDING 298-298

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIKNVNLLSMEEDKVLEGVNVYVEGDTIKHIGELLPDVKVDVVIEGKDKLAMPGLIN
CCEEEECCEEEECCHHHHHCCCEEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
AHTHLGMSLFRNYANDVPLFDWLTKYIWPLEARLTAEDVYWGSLLSMIEMIYSGTTTYCD
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHHHHCCCCHHHH
MYFFMEEVAKATEEIGIRGVISRGIIEEQDAKVNEEKLKDTENLYNAWNGKAEGRIKVMV
HHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEE
GPHAPYTCGPTYLKEILDLAKRLGTGIHIHVSETKREVEESLEKYGKTPVQHLKDLGIFE
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
VPTVAAHCVHLTDEDIEVLKEMKVSPVYNPTSNLKLASGFAPVEKMLKKGINVALGTDGP
CCHHHHHHEECCCHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHCCCEEEECCCCC
ASNNNLNMFEEIHFAATINKALNEDALSVPAFEALKMATVSGARALLWEREIGTIEVGKK
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHEEEECCCCEEEECCC
ADVILIDLNKPHLHPKNDLISALAYSVQGSDVDTVIVNGKVIMEKREIKTVDVERVYYEV
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCEEEEECCCCCEEHHHHHHHHH
EKRAQNLIRGEIS
HHHHHHHHCCCCC
>Mature Secondary Structure
MNLLIKNVNLLSMEEDKVLEGVNVYVEGDTIKHIGELLPDVKVDVVIEGKDKLAMPGLIN
CCEEEECCEEEECCHHHHHCCCEEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
AHTHLGMSLFRNYANDVPLFDWLTKYIWPLEARLTAEDVYWGSLLSMIEMIYSGTTTYCD
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHHHHCCCCHHHH
MYFFMEEVAKATEEIGIRGVISRGIIEEQDAKVNEEKLKDTENLYNAWNGKAEGRIKVMV
HHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEE
GPHAPYTCGPTYLKEILDLAKRLGTGIHIHVSETKREVEESLEKYGKTPVQHLKDLGIFE
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
VPTVAAHCVHLTDEDIEVLKEMKVSPVYNPTSNLKLASGFAPVEKMLKKGINVALGTDGP
CCHHHHHHEECCCHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHCCCEEEECCCCC
ASNNNLNMFEEIHFAATINKALNEDALSVPAFEALKMATVSGARALLWEREIGTIEVGKK
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHEEEECCCCEEEECCC
ADVILIDLNKPHLHPKNDLISALAYSVQGSDVDTVIVNGKVIMEKREIKTVDVERVYYEV
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCEEEEECCCCCEEHHHHHHHHH
EKRAQNLIRGEIS
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336