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The map label for this gene is TrpE [H]

Identifier: 20808012

GI number: 20808012

Start: 1539219

End: 1540649

Strand: Reverse

Name: TrpE [H]

Synonym: TTE1583

Alternate gene names: 20808012

Gene position: 1540649-1539219 (Counterclockwise)

Preceding gene: 20808013

Following gene: 20808011

Centisome position: 57.29

GC content: 35.29

Gene sequence:

>1431_bases
GTGGTAAATATTTCTAAAGAAGATTTTTATGCCTATAAAAAAATGGGATACACTTTCCCAGTATATGAGGAAATAAATGG
TGATGAAATCACGCCAATAAACGTTTTTTATAGTCTTTCTGGTAAACACAAATTTTTATTGGAAAGTGCAAATGGAGGGA
GTCACTGGGGTAGATATTCTTTTATAGGAAAGGACCCTTATTTGTCAGTTTTAAGCTATGGAAGGGATATAAAAATTATC
ACAACAGAAGAAGAATCGAATAAAAGAGGTTTAGCACTGGAAGAGGTAAAAAACTTTCTGCAGATTAATTATAACCCATT
AGGGCTTAACATTCCTTTTACAGGAGGTGCGGTAGGCTATGTATCTTATGATGCGATAAGGCTTTATGAAAAATTGCCAG
AAAAAAATCCTGATGAAATAAATATACCGGATGTATACTTCATGTTTTACAAGAGTTTCATCTGCTATGACCATTTTAAG
CATGAAGTCTACATTGTCTACAATGTATTTGCTAATGAGGATACCGAGTATGAGGAAGTTTTGCAAAAGATTAATGAGCT
TTTAAATGAGATAAAGTCAAATAAAATAGAGTTTCACGACCTTTCGCTTCAAGAAGAAAAAGTGATAACTTACAACTTCA
CAAAAGAAGAGTTTTGTCAAATTGTTGAAAGAGCCAAAAAATACATTGAAAAAGGAGACATATTTCAAGTGGTGTTATCC
CAGAGGCTAAAGGCAAAGACAAATTCAGATCCTTTTGAGATTTACAGGAGGTTGCGTTCAAAGAATCCATCTCCCTATCT
TTTCTATATCGACTTTGGCGATTTTCAGCTTCTGGGTTCTTCTCCTGAAAGTCTTGTGAGAGTCTTTCAAGACAAAGTGA
CCACAAATCCTATAGCAGGCACAAGACGAAGGGGAAAAGATGAAAAAGAGGATTTAAAAAACAAAGAAGAACTTTTGAAG
GATGAAAAAGAAAGGGCAGAGCATGTGATGTTGGTTGACTTAGGGAGAAACGACATAGGAAAGGTCAGTGAATTTGGAAG
TGTTAAAGTGGAGCGCTTTATGGAGGTGGATTTTTACTCTCATGTAATGCACATTGTATCAACTGTTTCTGGAAAATTAA
AAAAAGGATTTACCGCTTTTGATGCCCTTATAGCTTGTCTTCCTGCAGGCACAGTTTCTGGAGCGCCAAAGATAAGAGCG
ATGGAAATAATAGAGGAATTAGAAAATGTAAAAAGGTCCTTTTACGCAGGGGCTGTTGGCTATTTTTCCTATAACGGCAA
TATGGATATGTGCATAGCAATAAGGACTATTCTCATAAAAGAAAATACTGCTTATTTTCAAGCAGGAGCAGGTATTGTGT
ATGACTCAATTCCTGAGATGGAATACTATGAAATTTTAAATAAAGTGATGGTACTTAAGGAGGTTCTTTGA

Upstream 100 bases:

>100_bases
GTGAAATGCTTTTTTTTAAATACAGGACAAATTGGGTGGCACCGCGGTCACTCCGCCCCAATGGGCGGAGTGACTTTTTT
AATTTTCAGGAGGTGATAGA

Downstream 100 bases:

>100_bases
TGGTTTTGATTATAGATAATTACGACTCTTTTACCTATAATCTCTATCAATACGTAGGAGAAATGAAAGAGGAGGTCATG
GTGGTGAGAAATGATGAAAT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MVNISKEDFYAYKKMGYTFPVYEEINGDEITPINVFYSLSGKHKFLLESANGGSHWGRYSFIGKDPYLSVLSYGRDIKII
TTEEESNKRGLALEEVKNFLQINYNPLGLNIPFTGGAVGYVSYDAIRLYEKLPEKNPDEINIPDVYFMFYKSFICYDHFK
HEVYIVYNVFANEDTEYEEVLQKINELLNEIKSNKIEFHDLSLQEEKVITYNFTKEEFCQIVERAKKYIEKGDIFQVVLS
QRLKAKTNSDPFEIYRRLRSKNPSPYLFYIDFGDFQLLGSSPESLVRVFQDKVTTNPIAGTRRRGKDEKEDLKNKEELLK
DEKERAEHVMLVDLGRNDIGKVSEFGSVKVERFMEVDFYSHVMHIVSTVSGKLKKGFTAFDALIACLPAGTVSGAPKIRA
MEIIEELENVKRSFYAGAVGYFSYNGNMDMCIAIRTILIKENTAYFQAGAGIVYDSIPEMEYYEILNKVMVLKEVL

Sequences:

>Translated_476_residues
MVNISKEDFYAYKKMGYTFPVYEEINGDEITPINVFYSLSGKHKFLLESANGGSHWGRYSFIGKDPYLSVLSYGRDIKII
TTEEESNKRGLALEEVKNFLQINYNPLGLNIPFTGGAVGYVSYDAIRLYEKLPEKNPDEINIPDVYFMFYKSFICYDHFK
HEVYIVYNVFANEDTEYEEVLQKINELLNEIKSNKIEFHDLSLQEEKVITYNFTKEEFCQIVERAKKYIEKGDIFQVVLS
QRLKAKTNSDPFEIYRRLRSKNPSPYLFYIDFGDFQLLGSSPESLVRVFQDKVTTNPIAGTRRRGKDEKEDLKNKEELLK
DEKERAEHVMLVDLGRNDIGKVSEFGSVKVERFMEVDFYSHVMHIVSTVSGKLKKGFTAFDALIACLPAGTVSGAPKIRA
MEIIEELENVKRSFYAGAVGYFSYNGNMDMCIAIRTILIKENTAYFQAGAGIVYDSIPEMEYYEILNKVMVLKEVL
>Mature_476_residues
MVNISKEDFYAYKKMGYTFPVYEEINGDEITPINVFYSLSGKHKFLLESANGGSHWGRYSFIGKDPYLSVLSYGRDIKII
TTEEESNKRGLALEEVKNFLQINYNPLGLNIPFTGGAVGYVSYDAIRLYEKLPEKNPDEINIPDVYFMFYKSFICYDHFK
HEVYIVYNVFANEDTEYEEVLQKINELLNEIKSNKIEFHDLSLQEEKVITYNFTKEEFCQIVERAKKYIEKGDIFQVVLS
QRLKAKTNSDPFEIYRRLRSKNPSPYLFYIDFGDFQLLGSSPESLVRVFQDKVTTNPIAGTRRRGKDEKEDLKNKEELLK
DEKERAEHVMLVDLGRNDIGKVSEFGSVKVERFMEVDFYSHVMHIVSTVSGKLKKGFTAFDALIACLPAGTVSGAPKIRA
MEIIEELENVKRSFYAGAVGYFSYNGNMDMCIAIRTILIKENTAYFQAGAGIVYDSIPEMEYYEILNKVMVLKEVL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=496, Percent_Identity=34.0725806451613, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1788114, Length=440, Percent_Identity=32.0454545454545, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1786809, Length=381, Percent_Identity=26.246719160105, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082077, Length=270, Percent_Identity=30.7407407407407, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320935, Length=471, Percent_Identity=41.8259023354565, Blast_Score=325, Evalue=8e-90,
Organism=Saccharomyces cerevisiae, GI6324361, Length=394, Percent_Identity=27.6649746192893, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54930; Mature: 54930

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNISKEDFYAYKKMGYTFPVYEEINGDEITPINVFYSLSGKHKFLLESANGGSHWGRYS
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCEEE
FIGKDPYLSVLSYGRDIKIITTEEESNKRGLALEEVKNFLQINYNPLGLNIPFTGGAVGY
EECCCHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHEECCCEEEEECCCCCCEEEE
VSYDAIRLYEKLPEKNPDEINIPDVYFMFYKSFICYDHFKHEVYIVYNVFANEDTEYEEV
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHH
LQKINELLNEIKSNKIEFHDLSLQEEKVITYNFTKEEFCQIVERAKKYIEKGDIFQVVLS
HHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHH
QRLKAKTNSDPFEIYRRLRSKNPSPYLFYIDFGDFQLLGSSPESLVRVFQDKVTTNPIAG
HHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHCCCCCCC
TRRRGKDEKEDLKNKEELLKDEKERAEHVMLVDLGRNDIGKVSEFGSVKVERFMEVDFYS
CHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHH
HVMHIVSTVSGKLKKGFTAFDALIACLPAGTVSGAPKIRAMEIIEELENVKRSFYAGAVG
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEE
YFSYNGNMDMCIAIRTILIKENTAYFQAGAGIVYDSIPEMEYYEILNKVMVLKEVL
EEEECCCCEEEEEEEEHHEECCCCEEECCCCCEECCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MVNISKEDFYAYKKMGYTFPVYEEINGDEITPINVFYSLSGKHKFLLESANGGSHWGRYS
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCEEE
FIGKDPYLSVLSYGRDIKIITTEEESNKRGLALEEVKNFLQINYNPLGLNIPFTGGAVGY
EECCCHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHEECCCEEEEECCCCCCEEEE
VSYDAIRLYEKLPEKNPDEINIPDVYFMFYKSFICYDHFKHEVYIVYNVFANEDTEYEEV
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHH
LQKINELLNEIKSNKIEFHDLSLQEEKVITYNFTKEEFCQIVERAKKYIEKGDIFQVVLS
HHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHH
QRLKAKTNSDPFEIYRRLRSKNPSPYLFYIDFGDFQLLGSSPESLVRVFQDKVTTNPIAG
HHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHCCCCCCC
TRRRGKDEKEDLKNKEELLKDEKERAEHVMLVDLGRNDIGKVSEFGSVKVERFMEVDFYS
CHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHH
HVMHIVSTVSGKLKKGFTAFDALIACLPAGTVSGAPKIRAMEIIEELENVKRSFYAGAVG
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEE
YFSYNGNMDMCIAIRTILIKENTAYFQAGAGIVYDSIPEMEYYEILNKVMVLKEVL
EEEECCCCEEEEEEEEHHEECCCCEEECCCCCEECCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]