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The map label for this gene is TrpF

Identifier: 20808008

GI number: 20808008

Start: 1536253

End: 1536864

Strand: Reverse

Name: TrpF

Synonym: TTE1579

Alternate gene names: 20808008

Gene position: 1536864-1536253 (Counterclockwise)

Preceding gene: 20808009

Following gene: 20808007

Centisome position: 57.14

GC content: 36.76

Gene sequence:

>612_bases
GTGGTAAAAGTAAAAATTTGCGGTTTAAGAAGGCTTGAAGATATCTATTATGCAAATCAGTTACAGCCAGATTTTATAGG
TTTTGTATTTTCTGAGAGCAAAAGAAGAGTTGATTTGAAAGAGGCATTGGAATTTGTAAAAAGGCTCAAAGAAGGGATTA
AAAAGGTAGGAGTTTTTGTAAATGAACCTGTTGAGAAGGTCATGGAAATAGCTGAAAAATTAAAGCTAGATGTCTTGCAG
TTTCACGGCGATGAGACACAGGAGTATATAGACAATTTTAAAAATTTCACGGTCTGGAAGGCTATAAGAATAAGAAGCAA
ACTTGACTTAAAAAAGACAGGAGAATTTAAAGTGGATGCCTTTTTGTTTGACTCATTCTCCGAGAAAGGATATGGAGGTA
CAGGAGAGGCATTTGATTGGAATATCCTTAAAGCATACAAAAGAGAAATACCGGTTGTTTTGTCAGGAGGGCTTAAGGAG
GAAAATGTTGAAGAGGCGATAAAACTAGTAAGACCTTACGCCGTCGATGTGTCGAGTGGCGTTGAGGTTGGGGGATATAA
GGACTTTAATAAAATGAAGTCATTTATTGAGAAAGTGAGGGGTGTTGTATGA

Upstream 100 bases:

>100_bases
TCTTCCCTTGGGGTTAAGGCGGTTTTGATAGGTGAAAGTTTTATGAAAATGGATGAGGGAAGAATAAAGGAGTTTGTGAA
AAAAGTGAGGGGAGGATAAA

Downstream 100 bases:

>100_bases
AAGGTAGGTTTGGAAGGTTTGGAGGGCAGTATGTGCCGGAGACAGTTATGAATGCTCTTATAGAGTTAGAGAGAGAATTT
GAAGAGGCAAAGAAGGACGA

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MVKVKICGLRRLEDIYYANQLQPDFIGFVFSESKRRVDLKEALEFVKRLKEGIKKVGVFVNEPVEKVMEIAEKLKLDVLQ
FHGDETQEYIDNFKNFTVWKAIRIRSKLDLKKTGEFKVDAFLFDSFSEKGYGGTGEAFDWNILKAYKREIPVVLSGGLKE
ENVEEAIKLVRPYAVDVSSGVEVGGYKDFNKMKSFIEKVRGVV

Sequences:

>Translated_203_residues
MVKVKICGLRRLEDIYYANQLQPDFIGFVFSESKRRVDLKEALEFVKRLKEGIKKVGVFVNEPVEKVMEIAEKLKLDVLQ
FHGDETQEYIDNFKNFTVWKAIRIRSKLDLKKTGEFKVDAFLFDSFSEKGYGGTGEAFDWNILKAYKREIPVVLSGGLKE
ENVEEAIKLVRPYAVDVSSGVEVGGYKDFNKMKSFIEKVRGVV
>Mature_203_residues
MVKVKICGLRRLEDIYYANQLQPDFIGFVFSESKRRVDLKEALEFVKRLKEGIKKVGVFVNEPVEKVMEIAEKLKLDVLQ
FHGDETQEYIDNFKNFTVWKAIRIRSKLDLKKTGEFKVDAFLFDSFSEKGYGGTGEAFDWNILKAYKREIPVVLSGGLKE
ENVEEAIKLVRPYAVDVSSGVEVGGYKDFNKMKSFIEKVRGVV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=205, Percent_Identity=31.7073170731707, Blast_Score=87, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320210, Length=214, Percent_Identity=33.6448598130841, Blast_Score=98, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_THETN (Q8R9M8)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623179.1
- ProteinModelPortal:   Q8R9M8
- SMR:   Q8R9M8
- GeneID:   995998
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1579
- NMPDR:   fig|273068.3.peg.1526
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   CLSK883395
- BioCyc:   TTEN273068:TTE1579-MONOMER
- BRENDA:   5.3.1.24
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23349; Mature: 23349

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVKICGLRRLEDIYYANQLQPDFIGFVFSESKRRVDLKEALEFVKRLKEGIKKVGVFV
CEEEEECCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHH
NEPVEKVMEIAEKLKLDVLQFHGDETQEYIDNFKNFTVWKAIRIRSKLDLKKTGEFKVDA
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEHH
FLFDSFSEKGYGGTGEAFDWNILKAYKREIPVVLSGGLKEENVEEAIKLVRPYAVDVSSG
HHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCHHEECCCC
VEVGGYKDFNKMKSFIEKVRGVV
CCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVKVKICGLRRLEDIYYANQLQPDFIGFVFSESKRRVDLKEALEFVKRLKEGIKKVGVFV
CEEEEECCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHH
NEPVEKVMEIAEKLKLDVLQFHGDETQEYIDNFKNFTVWKAIRIRSKLDLKKTGEFKVDA
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEHH
FLFDSFSEKGYGGTGEAFDWNILKAYKREIPVVLSGGLKEENVEEAIKLVRPYAVDVSSG
HHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCHHEECCCC
VEVGGYKDFNKMKSFIEKVRGVV
CCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336