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The map label for this gene is MetC2 [H]

Identifier: 20808003

GI number: 20808003

Start: 1531753

End: 1532934

Strand: Direct

Name: MetC2 [H]

Synonym: TTE1574

Alternate gene names: 20808003

Gene position: 1531753-1532934 (Clockwise)

Preceding gene: 20808000

Following gene: 20808038

Centisome position: 56.95

GC content: 38.24

Gene sequence:

>1182_bases
GTGGAACTTCATTTCAAAACAAAAGTAGTTCATATTGGAAATTATGTGGATGAAAAAATTCCTCCAAAACCCAAAACTCT
CCCTATATATCAAACTTCTGTATTTACTTTTGATACTCTTGAAGAAGTTTATGATTACTTAGACGGCAATCCTTCAAGGT
ATATGTACACAAGGCTTGGAAACCCAAACCAAACTGCTGTAGAAGAATTAATTGCAAATTTAGAAGGAGCAGAGGCAGGG
CAAGCCTGTGCTTCAGGGATGGCAGCAATTTCCTCAGCTCTCCTGGCAGAAGTAAATTCAGGCGACCACATAATCGCAGC
AAAAGACATATACGGAGGAACAAACAGCCTTTTTAATTTGGAGTTTAAGAGATTGGGAATTGAAATAAGTTTGGTGGATT
TTTCGGACTTAGAATCTGTAGAAAAGGCTATCAAGCCAAATACAAAAGTCATATACATGGAAATCATGACAAATCCTTTG
ATAAGAGTATTTGACATTGAAGAAGTTGTAAAAATAGCAAAAAGGCACGGATTAAAACTTATAGTAGACAATACTTTTAC
AACTCCTTACCTGATAAGGCCTTTAGAAGTCGGCGCTTATGCTGTAATACATAGCGCCACAAAATACATAAACGGACACA
GTGATGTAATAGGAGGACTTATAGCAGGAAATAAAGAATTTATTTTCCGCACAAGGAGAATAGTCCACAATTTTGGAGGC
TCTATGAGTCCTTTTGACGCATGGCTCACTTTAAGAGGTGCTAAAACACTGTTTTTAAGGATGAGAGAGCACTGCAAAAA
CGCAATGCGATTGGCCGAATTTTTAGAAAGCCATCCAAAAGTGAAAAAGGTCTTCTATCCAGGACTGCCTTCTCACCCTG
ATTACAGCATCGCCAAAAAGCTTTTTAAGGATGAATTTGGAGGCATGTTGAGCTTTGAAATTGACGGTGGTGAACAATCT
GTAAATAGATTCATGCAGGAGCTCAAACTTATAAAATTTGCTCCATCACTGGCAGGAGTTCAAACCATGATAACACATCC
GAAGTCCACTTCCCACAGGGCTTTGAGCAAAGAAGAATTAAAAGCTCTTGGAATTTCAGAAGGACTCATAAGGGTGTCTG
TCGGAATTGAGGAAATAGAAGATGTGATAAGAGACTTTAAACAGGCTCTAGATAAAGTGTAA

Upstream 100 bases:

>100_bases
TAATAGTTTACAACAAAATCCATCACAAAGAAAGGGTTGTTGACTTTTAATTTTTCGCATATTATGATAGAGTTAAAATC
TGAAAATTGAGGGTGATAGC

Downstream 100 bases:

>100_bases
AGAGGGAGCTTTTTACACTCCCTCTTTTATTTCATCAAGCGCTTTTAAAACTTGATCCACATGCCCATCCACTTTTACCT
TTCTAAATATCTTTCTCACA

Product: cystathionine beta-lyase/cystathionine gamma-synthase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MELHFKTKVVHIGNYVDEKIPPKPKTLPIYQTSVFTFDTLEEVYDYLDGNPSRYMYTRLGNPNQTAVEELIANLEGAEAG
QACASGMAAISSALLAEVNSGDHIIAAKDIYGGTNSLFNLEFKRLGIEISLVDFSDLESVEKAIKPNTKVIYMEIMTNPL
IRVFDIEEVVKIAKRHGLKLIVDNTFTTPYLIRPLEVGAYAVIHSATKYINGHSDVIGGLIAGNKEFIFRTRRIVHNFGG
SMSPFDAWLTLRGAKTLFLRMREHCKNAMRLAEFLESHPKVKKVFYPGLPSHPDYSIAKKLFKDEFGGMLSFEIDGGEQS
VNRFMQELKLIKFAPSLAGVQTMITHPKSTSHRALSKEELKALGISEGLIRVSVGIEEIEDVIRDFKQALDKV

Sequences:

>Translated_393_residues
MELHFKTKVVHIGNYVDEKIPPKPKTLPIYQTSVFTFDTLEEVYDYLDGNPSRYMYTRLGNPNQTAVEELIANLEGAEAG
QACASGMAAISSALLAEVNSGDHIIAAKDIYGGTNSLFNLEFKRLGIEISLVDFSDLESVEKAIKPNTKVIYMEIMTNPL
IRVFDIEEVVKIAKRHGLKLIVDNTFTTPYLIRPLEVGAYAVIHSATKYINGHSDVIGGLIAGNKEFIFRTRRIVHNFGG
SMSPFDAWLTLRGAKTLFLRMREHCKNAMRLAEFLESHPKVKKVFYPGLPSHPDYSIAKKLFKDEFGGMLSFEIDGGEQS
VNRFMQELKLIKFAPSLAGVQTMITHPKSTSHRALSKEELKALGISEGLIRVSVGIEEIEDVIRDFKQALDKV
>Mature_393_residues
MELHFKTKVVHIGNYVDEKIPPKPKTLPIYQTSVFTFDTLEEVYDYLDGNPSRYMYTRLGNPNQTAVEELIANLEGAEAG
QACASGMAAISSALLAEVNSGDHIIAAKDIYGGTNSLFNLEFKRLGIEISLVDFSDLESVEKAIKPNTKVIYMEIMTNPL
IRVFDIEEVVKIAKRHGLKLIVDNTFTTPYLIRPLEVGAYAVIHSATKYINGHSDVIGGLIAGNKEFIFRTRRIVHNFGG
SMSPFDAWLTLRGAKTLFLRMREHCKNAMRLAEFLESHPKVKKVFYPGLPSHPDYSIAKKLFKDEFGGMLSFEIDGGEQS
VNRFMQELKLIKFAPSLAGVQTMITHPKSTSHRALSKEELKALGISEGLIRVSVGIEEIEDVIRDFKQALDKV

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=389, Percent_Identity=40.8740359897172, Blast_Score=271, Evalue=6e-73,
Organism=Homo sapiens, GI299473759, Length=389, Percent_Identity=37.5321336760925, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI25453487, Length=388, Percent_Identity=36.0824742268041, Blast_Score=211, Evalue=7e-55,
Organism=Escherichia coli, GI1790375, Length=363, Percent_Identity=37.465564738292, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1789383, Length=370, Percent_Identity=24.5945945945946, Blast_Score=141, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71980708, Length=375, Percent_Identity=41.3333333333333, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17560056, Length=396, Percent_Identity=41.1616161616162, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17538055, Length=396, Percent_Identity=38.6363636363636, Blast_Score=268, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6319307, Length=399, Percent_Identity=38.3458646616541, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6323333, Length=438, Percent_Identity=34.2465753424658, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6321254, Length=412, Percent_Identity=32.7669902912621, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6321170, Length=314, Percent_Identity=30.2547770700637, Blast_Score=145, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=381, Percent_Identity=27.8215223097113, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19922554, Length=397, Percent_Identity=39.7984886649874, Blast_Score=281, Evalue=4e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 43945; Mature: 43945

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELHFKTKVVHIGNYVDEKIPPKPKTLPIYQTSVFTFDTLEEVYDYLDGNPSRYMYTRLG
CCCEEEEEEEEECCHHHCCCCCCCCEEEEEEECEEEHHHHHHHHHHHCCCCCEEEEEECC
NPNQTAVEELIANLEGAEAGQACASGMAAISSALLAEVNSGDHIIAAKDIYGGTNSLFNL
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEE
EFKRLGIEISLVDFSDLESVEKAIKPNTKVIYMEIMTNPLIRVFDIEEVVKIAKRHGLKL
EEEHCCEEEEEECHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECHHHHHHHHHHCCCEE
IVDNTFTTPYLIRPLEVGAYAVIHSATKYINGHSDVIGGLIAGNKEFIFRTRRIVHNFGG
EEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCC
SMSPFDAWLTLRGAKTLFLRMREHCKNAMRLAEFLESHPKVKKVFYPGLPSHPDYSIAKK
CCCCHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHH
LFKDEFGGMLSFEIDGGEQSVNRFMQELKLIKFAPSLAGVQTMITHPKSTSHRALSKEEL
HHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHCHHHH
KALGISEGLIRVSVGIEEIEDVIRDFKQALDKV
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELHFKTKVVHIGNYVDEKIPPKPKTLPIYQTSVFTFDTLEEVYDYLDGNPSRYMYTRLG
CCCEEEEEEEEECCHHHCCCCCCCCEEEEEEECEEEHHHHHHHHHHHCCCCCEEEEEECC
NPNQTAVEELIANLEGAEAGQACASGMAAISSALLAEVNSGDHIIAAKDIYGGTNSLFNL
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEE
EFKRLGIEISLVDFSDLESVEKAIKPNTKVIYMEIMTNPLIRVFDIEEVVKIAKRHGLKL
EEEHCCEEEEEECHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECHHHHHHHHHHCCCEE
IVDNTFTTPYLIRPLEVGAYAVIHSATKYINGHSDVIGGLIAGNKEFIFRTRRIVHNFGG
EEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCC
SMSPFDAWLTLRGAKTLFLRMREHCKNAMRLAEFLESHPKVKKVFYPGLPSHPDYSIAKK
CCCCHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHH
LFKDEFGGMLSFEIDGGEQSVNRFMQELKLIKFAPSLAGVQTMITHPKSTSHRALSKEEL
HHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHCHHHH
KALGISEGLIRVSVGIEEIEDVIRDFKQALDKV
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]