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The map label for this gene is pyrC

Identifier: 20807969

GI number: 20807969

Start: 1495774

End: 1497069

Strand: Reverse

Name: pyrC

Synonym: TTE1533

Alternate gene names: 20807969

Gene position: 1497069-1495774 (Counterclockwise)

Preceding gene: 20807970

Following gene: 20807968

Centisome position: 55.66

GC content: 42.52

Gene sequence:

>1296_bases
ATGAGGATCGTGATAAAAAATGGAATTGTGATTGATGGTTTTGGCGGTGAAGAAAAAGCTGACATCCTTATAAATTACGG
CATAATAAAAGGGATTGACAAGAATATCGATGTTTCCGATGCTATAGTGATTGACGCTGAAGGCAAATATGTGCTTCCAG
GTTTTGTAGACATGCACACCCACCTAAGACAGCCGGGTTTTGAGGAAAAGGAGACTATAAGGACAGGAACAGAGTCGGCT
GCAGCAGGGGGTTTTACTACTGTCGCCTGTATGCCTAATACCAATCCTCCTATAGACAGCGAAGTAGTCGTAGAGTATGT
GAAGGCTGTGGCTCAAAGAGAAGGAGTAGTGAAGGTACTGCCTATAGGGGCTATGACAAAGGGGATGAAAGGCGAAGAAA
TAACTGAAATGGCAAAGCTGAAAAAGGCTGGAGTCGTTGCTTTATCTGATGACGGCTTCCCGATAATGAGCGCAGGAATT
ATGAAAAGGGTTATGACTTATGGCAAAATGTATGACCTCCTTATGATAACTCACTGCGAGGACAAGACGTTGAGCGGAGA
AGGAGTTATGAACAGCGGGATAATTGCTACAATGCTGGGGCTTAAAGGAATACCGAGAGAAGCGGAAGAAGTGATGCTTG
CAAGAAATATAATACTGGCAAAGGCGACAGGTGCGAAGCTTCACATTGCCCATGTTTCCACTAAAGGCAGTGTAGAGCTC
ATAAGAAGGGCAAAAGAGGAAGGGGTAAGTATAACAGCAGAAGTTACTCCTCACCATCTTACTCGCACAGATGAGGCAGT
CTACAATTACGATACCAATACAAAAGTTTTCCCGCCCTTGAGGACTAGGGAAGATGTAGAGGCTTTGATAGAAGGGTTGA
AGGACGGCACTATAGATGCGATCGCTACAGACCACGCTCCTCATACTAAAGACGATAAAAAAGTTCCCTATGACATGGCT
CCTTTTGGAATATCAGGTCTTGAAACGGCATTCTCTGTTATAAACACTTTTCTGATACAGACAGGTATAATCACTATGAA
AGCCTTAGTGAATTACATGAGTATGAATCCTGCAAGGATACTGGGAATATCCAATGGAATAAGGGTAGGAGCTACTGCGG
ATATTGTGATTGTTAATCCCCATGAAGAATATACCGTGGATAAAGAAAAATTCAAGTCAAAGGGCAAAAACACCCCTTAT
CACGGGATGAAATTAAAAGGAGTTGTGGAATACACAATAGTGGAAGGGCAAATAAGGTATCAGAAAAACAAGAAATTTGA
AAAGGTCGAGATATGA

Upstream 100 bases:

>100_bases
CTGCAAATGCTAGTTACTCCGTAATAGAGGAGCAGATAACAAACGGGGTGGCTGTGAGGATGGCACTTTTGAAAATTCTG
TGTGAGAGGAGGAATTAGAA

Downstream 100 bases:

>100_bases
CTTTGATGGAAAGAAGGGGAAATATGTTTGTGGACAGGCTGATAGAAAGTGTGAAGGCCAAAAAAACCCCTGTGGTTGTG
GGACTTGACCCGCGAATTGA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRIVIKNGIVIDGFGGEEKADILINYGIIKGIDKNIDVSDAIVIDAEGKYVLPGFVDMHTHLRQPGFEEKETIRTGTESA
AAGGFTTVACMPNTNPPIDSEVVVEYVKAVAQREGVVKVLPIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGI
MKRVMTYGKMYDLLMITHCEDKTLSGEGVMNSGIIATMLGLKGIPREAEEVMLARNIILAKATGAKLHIAHVSTKGSVEL
IRRAKEEGVSITAEVTPHHLTRTDEAVYNYDTNTKVFPPLRTREDVEALIEGLKDGTIDAIATDHAPHTKDDKKVPYDMA
PFGISGLETAFSVINTFLIQTGIITMKALVNYMSMNPARILGISNGIRVGATADIVIVNPHEEYTVDKEKFKSKGKNTPY
HGMKLKGVVEYTIVEGQIRYQKNKKFEKVEI

Sequences:

>Translated_431_residues
MRIVIKNGIVIDGFGGEEKADILINYGIIKGIDKNIDVSDAIVIDAEGKYVLPGFVDMHTHLRQPGFEEKETIRTGTESA
AAGGFTTVACMPNTNPPIDSEVVVEYVKAVAQREGVVKVLPIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGI
MKRVMTYGKMYDLLMITHCEDKTLSGEGVMNSGIIATMLGLKGIPREAEEVMLARNIILAKATGAKLHIAHVSTKGSVEL
IRRAKEEGVSITAEVTPHHLTRTDEAVYNYDTNTKVFPPLRTREDVEALIEGLKDGTIDAIATDHAPHTKDDKKVPYDMA
PFGISGLETAFSVINTFLIQTGIITMKALVNYMSMNPARILGISNGIRVGATADIVIVNPHEEYTVDKEKFKSKGKNTPY
HGMKLKGVVEYTIVEGQIRYQKNKKFEKVEI
>Mature_431_residues
MRIVIKNGIVIDGFGGEEKADILINYGIIKGIDKNIDVSDAIVIDAEGKYVLPGFVDMHTHLRQPGFEEKETIRTGTESA
AAGGFTTVACMPNTNPPIDSEVVVEYVKAVAQREGVVKVLPIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGI
MKRVMTYGKMYDLLMITHCEDKTLSGEGVMNSGIIATMLGLKGIPREAEEVMLARNIILAKATGAKLHIAHVSTKGSVEL
IRRAKEEGVSITAEVTPHHLTRTDEAVYNYDTNTKVFPPLRTREDVEALIEGLKDGTIDAIATDHAPHTKDDKKVPYDMA
PFGISGLETAFSVINTFLIQTGIITMKALVNYMSMNPARILGISNGIRVGATADIVIVNPHEEYTVDKEKFKSKGKNTPY
HGMKLKGVVEYTIVEGQIRYQKNKKFEKVEI

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=375, Percent_Identity=29.3333333333333, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI19923821, Length=457, Percent_Identity=28.0087527352298, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI190194363, Length=459, Percent_Identity=23.9651416122004, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4503051, Length=456, Percent_Identity=22.5877192982456, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI62422571, Length=456, Percent_Identity=22.5877192982456, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1786722, Length=444, Percent_Identity=28.3783783783784, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI87082175, Length=443, Percent_Identity=27.9909706546275, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193204318, Length=368, Percent_Identity=30.9782608695652, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71989490, Length=457, Percent_Identity=27.5711159737418, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17539558, Length=455, Percent_Identity=25.4945054945055, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI86575075, Length=424, Percent_Identity=25.2358490566038, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=399, Percent_Identity=26.0651629072682, Blast_Score=119, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24642586, Length=371, Percent_Identity=30.9973045822102, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI18859883, Length=472, Percent_Identity=26.4830508474576, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17137462, Length=460, Percent_Identity=26.9565217391304, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221377917, Length=464, Percent_Identity=26.2931034482759, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_THETN (Q8R9R6)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623140.1
- ProteinModelPortal:   Q8R9R6
- SMR:   Q8R9R6
- GeneID:   997967
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1533
- NMPDR:   fig|273068.3.peg.1487
- HOGENOM:   HBG724623
- OMA:   PRVAEES
- ProtClustDB:   PRK09357
- BioCyc:   TTEN273068:TTE1533-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 47024; Mature: 47024

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVIKNGIVIDGFGGEEKADILINYGIIKGIDKNIDVSDAIVIDAEGKYVLPGFVDMHT
CEEEEECCEEEECCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEECCCCEECCCHHHHHH
HLRQPGFEEKETIRTGTESAAAGGFTTVACMPNTNPPIDSEVVVEYVKAVAQREGVVKVL
HHCCCCCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
PIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGIMKRVMTYGKMYDLLMITHCE
ECCHHCCCCCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHEEEEEEEECC
DKTLSGEGVMNSGIIATMLGLKGIPREAEEVMLARNIILAKATGAKLHIAHVSTKGSVEL
CCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHEEEEECCCCEEEEEEECCCCHHHH
IRRAKEEGVSITAEVTPHHLTRTDEAVYNYDTNTKVFPPLRTREDVEALIEGLKDGTIDA
HHHHHHCCCEEEEECCCCCCCCCCCCEEECCCCCEECCCCCCHHHHHHHHHHCCCCCEEE
IATDHAPHTKDDKKVPYDMAPFGISGLETAFSVINTFLIQTGIITMKALVNYMSMNPARI
EECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LGISNGIRVGATADIVIVNPHEEYTVDKEKFKSKGKNTPYHGMKLKGVVEYTIVEGQIRY
EECCCCEEECCEEEEEEECCCHHCCCCHHHHHHCCCCCCCCCEEEEEEEEEEEEECEEEE
QKNKKFEKVEI
CCCCCCEECCC
>Mature Secondary Structure
MRIVIKNGIVIDGFGGEEKADILINYGIIKGIDKNIDVSDAIVIDAEGKYVLPGFVDMHT
CEEEEECCEEEECCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEECCCCEECCCHHHHHH
HLRQPGFEEKETIRTGTESAAAGGFTTVACMPNTNPPIDSEVVVEYVKAVAQREGVVKVL
HHCCCCCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
PIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGIMKRVMTYGKMYDLLMITHCE
ECCHHCCCCCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHEEEEEEEECC
DKTLSGEGVMNSGIIATMLGLKGIPREAEEVMLARNIILAKATGAKLHIAHVSTKGSVEL
CCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHEEEEECCCCEEEEEEECCCCHHHH
IRRAKEEGVSITAEVTPHHLTRTDEAVYNYDTNTKVFPPLRTREDVEALIEGLKDGTIDA
HHHHHHCCCEEEEECCCCCCCCCCCCEEECCCCCEECCCCCCHHHHHHHHHHCCCCCEEE
IATDHAPHTKDDKKVPYDMAPFGISGLETAFSVINTFLIQTGIITMKALVNYMSMNPARI
EECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LGISNGIRVGATADIVIVNPHEEYTVDKEKFKSKGKNTPYHGMKLKGVVEYTIVEGQIRY
EECCCCEEECCEEEEEEECCCHHCCCCHHHHHHCCCCCCCCCEEEEEEEEEEEEECEEEE
QKNKKFEKVEI
CCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336