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The map label for this gene is FabH3

Identifier: 20807922

GI number: 20807922

Start: 1446802

End: 1447797

Strand: Reverse

Name: FabH3

Synonym: TTE1475

Alternate gene names: 20807922

Gene position: 1447797-1446802 (Counterclockwise)

Preceding gene: 161760532

Following gene: 20807921

Centisome position: 53.83

GC content: 42.37

Gene sequence:

>996_bases
GTGTGTGAAAAGATTGCAGCAGGAATATTGGGAACTGGCAGCTATCTGCCAGAGAAAATTTTGACAAATTTTGATTTAGA
GAAAATGGTGGACACTTCTGATGAATGGATCACTACTAGAACAGGCATAAAAGAAAGAAGGATAGCAGACCCTTCTCAGG
CTACATCTGATCTGGCTACTGAAGCTTCTAAAAGAGCTTTAGAGGATGCGAATTTGAAACCAGAGGATTTAGATATGATA
ATTGTTGCAACTGTCACACCAGACATGAACTTTCCTTCTACCGCCTGCATAGTTCAGGCAAATCTAGGAGCTTTAAATGC
GGCTGCTTTTGACATTTCTGTAGGATGCTCTGGTTTCATATATGGCCTTGCTATTGCTCAGCAGTTTGTAGAAACTGGCA
TGTACAGGAATGTGCTTGTAATAGGAGCAGAGACTCTTTCAAAAATAATTAATTGGAAGGACAGGAATACTTGTGTCCTC
TTTGGCGACGGTGCGGGAGCAGCAGTAGTTGGAAGAGTTGAGAGCGGGTATGGCATACTTGGGAGCTACTTGGGGGCTGA
TGGGACAGGAGGAAAGTATCTGTACATGCCTGCTGGTGGATCGAGAATGCCAGCAAGCCATGAGACTGTAGAAAAAAATC
TGCACACCATTTTTATGGAAGGGCAGGAAGTGTTTAAATTTGCAGTGAAGGTGATGGACAGCGCCACAATAGAGGTTTTG
GAAAGATGTGGCCTTACGCCAGAAGACATAGACATGTTAATTCCTCACCAGGCAAATACCAGGATAATTGAAGCAGCTAG
GAAGAGACTTAAACTAACGAATGACAAAGTCTATATAAATTTAGACAAATACGGGAACACATCAGCGGCTTCTGTTGCAA
TCGCTCTTGATGAGGCTTATAGAAAAGGTTTGATAAAAAAAGGAGATATAATACTGACAGTGGCCTTTGGGGCTGGTTTG
ACTTGGGCTTCAAGTGTAATAAAATGGAGCAAATGA

Upstream 100 bases:

>100_bases
AAGGCTATTTTTAATGCCATTAAACAGGCTAAAAACCTTGTGGGAAATGACGTATTGCGTCATATAAAAGAAGAAATTGA
GCTTACGGGAGATGAGATAA

Downstream 100 bases:

>100_bases
AGGAGTGAAGATGATGTTCAAGACAAAGATAACTGAAATGCTCAACATAAAATATCCCATATTTCAAGGAGGAATGGCTT
GGGTAGCTACTGCAGAACTG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MCEKIAAGILGTGSYLPEKILTNFDLEKMVDTSDEWITTRTGIKERRIADPSQATSDLATEASKRALEDANLKPEDLDMI
IVATVTPDMNFPSTACIVQANLGALNAAAFDISVGCSGFIYGLAIAQQFVETGMYRNVLVIGAETLSKIINWKDRNTCVL
FGDGAGAAVVGRVESGYGILGSYLGADGTGGKYLYMPAGGSRMPASHETVEKNLHTIFMEGQEVFKFAVKVMDSATIEVL
ERCGLTPEDIDMLIPHQANTRIIEAARKRLKLTNDKVYINLDKYGNTSAASVAIALDEAYRKGLIKKGDIILTVAFGAGL
TWASSVIKWSK

Sequences:

>Translated_331_residues
MCEKIAAGILGTGSYLPEKILTNFDLEKMVDTSDEWITTRTGIKERRIADPSQATSDLATEASKRALEDANLKPEDLDMI
IVATVTPDMNFPSTACIVQANLGALNAAAFDISVGCSGFIYGLAIAQQFVETGMYRNVLVIGAETLSKIINWKDRNTCVL
FGDGAGAAVVGRVESGYGILGSYLGADGTGGKYLYMPAGGSRMPASHETVEKNLHTIFMEGQEVFKFAVKVMDSATIEVL
ERCGLTPEDIDMLIPHQANTRIIEAARKRLKLTNDKVYINLDKYGNTSAASVAIALDEAYRKGLIKKGDIILTVAFGAGL
TWASSVIKWSK
>Mature_331_residues
MCEKIAAGILGTGSYLPEKILTNFDLEKMVDTSDEWITTRTGIKERRIADPSQATSDLATEASKRALEDANLKPEDLDMI
IVATVTPDMNFPSTACIVQANLGALNAAAFDISVGCSGFIYGLAIAQQFVETGMYRNVLVIGAETLSKIINWKDRNTCVL
FGDGAGAAVVGRVESGYGILGSYLGADGTGGKYLYMPAGGSRMPASHETVEKNLHTIFMEGQEVFKFAVKVMDSATIEVL
ERCGLTPEDIDMLIPHQANTRIIEAARKRLKLTNDKVYINLDKYGNTSAASVAIALDEAYRKGLIKKGDIILTVAFGAGL
TWASSVIKWSK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=321, Percent_Identity=46.1059190031153, Blast_Score=291, Evalue=4e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_THETN (Q8R9V7)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623093.1
- ProteinModelPortal:   Q8R9V7
- SMR:   Q8R9V7
- GeneID:   997567
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1475
- NMPDR:   fig|273068.3.peg.1440
- HOGENOM:   HBG649927
- OMA:   HYLNLAY
- ProtClustDB:   PRK09352
- BioCyc:   TTEN273068:TTE1475-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 35679; Mature: 35679

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: ACT_SITE 116-116 ACT_SITE 256-256 ACT_SITE 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCEKIAAGILGTGSYLPEKILTNFDLEKMVDTSDEWITTRTGIKERRIADPSQATSDLAT
CCCHHHHCCCCCCCCCHHHHHCCCCHHHHHCCCCCEEEECCCCCHHCCCCCHHHHHHHHH
EASKRALEDANLKPEDLDMIIVATVTPDMNFPSTACIVQANLGALNAAAFDISVGCSGFI
HHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHH
YGLAIAQQFVETGMYRNVLVIGAETLSKIINWKDRNTCVLFGDGAGAAVVGRVESGYGIL
HHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCHH
GSYLGADGTGGKYLYMPAGGSRMPASHETVEKNLHTIFMEGQEVFKFAVKVMDSATIEVL
HHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHH
ERCGLTPEDIDMLIPHQANTRIIEAARKRLKLTNDKVYINLDKYGNTSAASVAIALDEAY
HHCCCCHHHHHEECCCCCCHHHHHHHHHHHEECCCEEEEEEECCCCCCHHEEEEEEHHHH
RKGLIKKGDIILTVAFGAGLTWASSVIKWSK
HCCCCCCCCEEEEEECCCCHHHHHHHHCCCC
>Mature Secondary Structure
MCEKIAAGILGTGSYLPEKILTNFDLEKMVDTSDEWITTRTGIKERRIADPSQATSDLAT
CCCHHHHCCCCCCCCCHHHHHCCCCHHHHHCCCCCEEEECCCCCHHCCCCCHHHHHHHHH
EASKRALEDANLKPEDLDMIIVATVTPDMNFPSTACIVQANLGALNAAAFDISVGCSGFI
HHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHH
YGLAIAQQFVETGMYRNVLVIGAETLSKIINWKDRNTCVLFGDGAGAAVVGRVESGYGIL
HHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCHH
GSYLGADGTGGKYLYMPAGGSRMPASHETVEKNLHTIFMEGQEVFKFAVKVMDSATIEVL
HHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHH
ERCGLTPEDIDMLIPHQANTRIIEAARKRLKLTNDKVYINLDKYGNTSAASVAIALDEAY
HHCCCCHHHHHEECCCCCCHHHHHHHHHHHEECCCEEEEEEECCCCCCHHEEEEEEHHHH
RKGLIKKGDIILTVAFGAGLTWASSVIKWSK
HCCCCCCCCEEEEEECCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336