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The map label for this gene is Dxr

Identifier: 20807849

GI number: 20807849

Start: 1386706

End: 1387854

Strand: Reverse

Name: Dxr

Synonym: TTE1402

Alternate gene names: 20807849

Gene position: 1387854-1386706 (Counterclockwise)

Preceding gene: 20807850

Following gene: 20807848

Centisome position: 51.6

GC content: 36.64

Gene sequence:

>1149_bases
ATGAAGAAACTCATAATACTAGGTTCTACTGGATCGATTGGTAGACAAACTTTGGACGTAGTGAGAAGTTTAAAAGAAGA
GTTTGAAATTGTAGGGCTTACAGGATATAACAATGTGTCTTTGCTCTCAAAACAGATAAAAGAGTTTAGACCCAAGGTAG
TAGCAGTAAAAGACGAGGAAAAAGCAAGAAAGCTAAGAGAAAATTTAGATGAACCGATAGAGGTTTTGACAGGTAAAGAA
GGGCTCAAAGAGATTGTGAAATACGAGGCTGACATGGTGGTAGTTGCGGTAGAGGGCATTGCAGGCCTTATACCTACAGT
TGAAGCTATAAAATTGGGGAAAAACATAGCTTTAGCAAATAAAGAGGTTTTAGTTACTGCAGGAGAAATAGTAATGGGGC
TTGTCAAAGAAAAGAAAATTGAATTTTTGCCTGTAGACAGTGAACATTCTGCTATTTTGCAGTGCCTTAAAGGAAATAAT
AAGAGAGAAGTTTCAAATCTCATTTTAACTGCTTCTGGAGGACCTTTCAGAGGAAAGAAAAAGAAGGATTTGGTAAATGT
TACAGTAGAAGAGGCTTTGAAACATCCCAACTGGAAGATGGGGAAAAAAATAACAATAGATTCTGCTACCTTGATGAACA
AAGGTTTTGAAGTTATAGAAGCCAGATGGCTCTTTGACATGCCTTTAGATAAGATAAAAGTGGTAATACATCCTCAAAGC
ATAATTCATTCGATGGTGGAATATGTAGATGGAAGTGTCATAGCTCAGCTTTCTGTGCCAGACATGAGGATTGCGATCCA
GTACGCCTTGAATTACCCTGACAGAAAATATGTGGAAGGTGTAAAATTTTTAGATTTCTATGCATTAGGCCAGCTGACAT
TTGAAGAGCCTGATTTTGAAACTTTTAAATGTCTTTCTCTGGCGTATCATGCGGCAGAATGTGGCGGAACGATGACTGCT
GTTTTAAATGCGGCAGATGAAGTAGCAGTGTCTTTATTTTTGCAGAACAAAATAAATTTTTTAGAAATTGCAGAGATTAT
AGAAGAAGCTTTAGAGAATCATAAAAATATACAAAACCCTACTTTGGATGATATAATAAGTGTAGACCTTGAAACGAGAG
AAAGGATAATGAGAAAGTATTTGAGGTGA

Upstream 100 bases:

>100_bases
TCCCGGCCATGGGGGGATTTTAGATAGATTTGATAGCATATTATTCGCTTCGCCCTTCGTATATTTTATTTTCAAGTACT
TTTTGTAAAGAGGGATAAGT

Downstream 100 bases:

>100_bases
TAGGAGTTGACTATAATTTTAAGCATCATAGTCTTGAGTGTTCTAGTGATGTTTCACGAGTTTGGTCACTTTATAGTAGC
AAAACTTTCTGGAGCAAGAG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKKLIILGSTGSIGRQTLDVVRSLKEEFEIVGLTGYNNVSLLSKQIKEFRPKVVAVKDEEKARKLRENLDEPIEVLTGKE
GLKEIVKYEADMVVVAVEGIAGLIPTVEAIKLGKNIALANKEVLVTAGEIVMGLVKEKKIEFLPVDSEHSAILQCLKGNN
KREVSNLILTASGGPFRGKKKKDLVNVTVEEALKHPNWKMGKKITIDSATLMNKGFEVIEARWLFDMPLDKIKVVIHPQS
IIHSMVEYVDGSVIAQLSVPDMRIAIQYALNYPDRKYVEGVKFLDFYALGQLTFEEPDFETFKCLSLAYHAAECGGTMTA
VLNAADEVAVSLFLQNKINFLEIAEIIEEALENHKNIQNPTLDDIISVDLETRERIMRKYLR

Sequences:

>Translated_382_residues
MKKLIILGSTGSIGRQTLDVVRSLKEEFEIVGLTGYNNVSLLSKQIKEFRPKVVAVKDEEKARKLRENLDEPIEVLTGKE
GLKEIVKYEADMVVVAVEGIAGLIPTVEAIKLGKNIALANKEVLVTAGEIVMGLVKEKKIEFLPVDSEHSAILQCLKGNN
KREVSNLILTASGGPFRGKKKKDLVNVTVEEALKHPNWKMGKKITIDSATLMNKGFEVIEARWLFDMPLDKIKVVIHPQS
IIHSMVEYVDGSVIAQLSVPDMRIAIQYALNYPDRKYVEGVKFLDFYALGQLTFEEPDFETFKCLSLAYHAAECGGTMTA
VLNAADEVAVSLFLQNKINFLEIAEIIEEALENHKNIQNPTLDDIISVDLETRERIMRKYLR
>Mature_382_residues
MKKLIILGSTGSIGRQTLDVVRSLKEEFEIVGLTGYNNVSLLSKQIKEFRPKVVAVKDEEKARKLRENLDEPIEVLTGKE
GLKEIVKYEADMVVVAVEGIAGLIPTVEAIKLGKNIALANKEVLVTAGEIVMGLVKEKKIEFLPVDSEHSAILQCLKGNN
KREVSNLILTASGGPFRGKKKKDLVNVTVEEALKHPNWKMGKKITIDSATLMNKGFEVIEARWLFDMPLDKIKVVIHPQS
IIHSMVEYVDGSVIAQLSVPDMRIAIQYALNYPDRKYVEGVKFLDFYALGQLTFEEPDFETFKCLSLAYHAAECGGTMTA
VLNAADEVAVSLFLQNKINFLEIAEIIEEALENHKNIQNPTLDDIISVDLETRERIMRKYLR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=45.7070707070707, Blast_Score=334, Evalue=6e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_THETN (Q8RA28)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623020.1
- ProteinModelPortal:   Q8RA28
- SMR:   Q8RA28
- GeneID:   997869
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1402
- NMPDR:   fig|273068.3.peg.1367
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   TTEN273068:TTE1402-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42769; Mature: 42769

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: BINDING 121-121 BINDING 148-148 BINDING 172-172 BINDING 195-195 BINDING 217-217

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLIILGSTGSIGRQTLDVVRSLKEEFEIVGLTGYNNVSLLSKQIKEFRPKVVAVKDEE
CCEEEEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCHH
KARKLRENLDEPIEVLTGKEGLKEIVKYEADMVVVAVEGIAGLIPTVEAIKLGKNIALAN
HHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCEEEEEECCHHHHHCHHHHHHHCCCEEECC
KEVLVTAGEIVMGLVKEKKIEFLPVDSEHSAILQCLKGNNKREVSNLILTASGGPFRGKK
CEEEEEHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCHHEEEEEEEEECCCCCCCCC
KKDLVNVTVEEALKHPNWKMGKKITIDSATLMNKGFEVIEARWLFDMPLDKIKVVIHPQS
CHHHHHEEHHHHHCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCHH
IIHSMVEYVDGSVIAQLSVPDMRIAIQYALNYPDRKYVEGVKFLDFYALGQLTFEEPDFE
HHHHHHHHHCCCEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCEEECCCCCH
TFKCLSLAYHAAECGGTMTAVLNAADEVAVSLFLQNKINFLEIAEIIEEALENHKNIQNP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
TLDDIISVDLETRERIMRKYLR
CHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKKLIILGSTGSIGRQTLDVVRSLKEEFEIVGLTGYNNVSLLSKQIKEFRPKVVAVKDEE
CCEEEEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCHH
KARKLRENLDEPIEVLTGKEGLKEIVKYEADMVVVAVEGIAGLIPTVEAIKLGKNIALAN
HHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCEEEEEECCHHHHHCHHHHHHHCCCEEECC
KEVLVTAGEIVMGLVKEKKIEFLPVDSEHSAILQCLKGNNKREVSNLILTASGGPFRGKK
CEEEEEHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCHHEEEEEEEEECCCCCCCCC
KKDLVNVTVEEALKHPNWKMGKKITIDSATLMNKGFEVIEARWLFDMPLDKIKVVIHPQS
CHHHHHEEHHHHHCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCHH
IIHSMVEYVDGSVIAQLSVPDMRIAIQYALNYPDRKYVEGVKFLDFYALGQLTFEEPDFE
HHHHHHHHHCCCEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCEEECCCCCH
TFKCLSLAYHAAECGGTMTAVLNAADEVAVSLFLQNKINFLEIAEIIEEALENHKNIQNP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
TLDDIISVDLETRERIMRKYLR
CHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336