Click here to switch to the map view.

The map label for this gene is infB

Identifier: 20807840

GI number: 20807840

Start: 1375444

End: 1377567

Strand: Reverse

Name: infB

Synonym: TTE1393

Alternate gene names: 20807840

Gene position: 1377567-1375444 (Counterclockwise)

Preceding gene: 20807841

Following gene: 20807839

Centisome position: 51.22

GC content: 40.07

Gene sequence:

>2124_bases
ATGGAGGTGAATAATATGTCCAAAACAAGGGTATACGAATTAGCAAAAGAACTTAATATTTCCAGCAAAGATCTTCTCTC
CAAATTGAGTGATTTAGACATAAAAGTAAAAAACCACATGAGCACTTTGGAGGACGAAGAAGTAGAATTAATAAAAGACC
TGCTTGCAGAAAAACCTAAGGAAGAGAAGCAAAAAGATCAAAAAAATCATGAACAGGAGGCACAGGACAAAGAAGAAAAG
GAAATAGAGGAAGACTCTTTTTATGAGGACAGAGAAGAGAAAAGAGCTTACAAAAAGAGTTTTAAAAAGGGCGGCAAAAA
GAACAAGAAGCTGCAGAAAAAATTTGTCTCAGAAGAAAGCGCTAAAGAAGATGAAATTAAAATAATAACAATTCCTGAAT
TTCTCACCGTCAAAGAATTGGCTGAAAAAATGAAAGTAAATCCTACTGAAATAATAAAGAAATTGATAGCACAGGGAATA
ATGGTTACTGTAAACCAGCAAATAGACTTTGAAACAGCTTCAAAAATAGCGGAAGAGTACGGTTTCCTGGTGGATAAGGA
AGAGGTTAAAGATGAACTGGAAGCCATATTTGAGGATACACCTGATAGAGAAGAGGATTTGAAACCTCGTCCTCCTATAG
TTACAGTGATGGGGCACGTAGACCACGGAAAGACTTCTCTGCTTGATGCCATCAGAAAGACAAATGTAACTATGAAAGAG
ATGGGCGGAATTACGCAGCACATAGGAGCTTCTGTGGTGGAGATAAACGACAAAAAGGTAGTATTTCTAGATACTCCTGG
TCACGAGGCTTTTACTGCGATGAGAGCGAGAGGCGCTAGTGTCACTGACATAGTTGTGCTGGTAGTGGCTGCTGACGATG
GAGTGATGCCGCAGACAATTGAAGCCATCAACCACGTAAAAGCAGCAAATGTGCCTCTGATTGTGGCTATAAATAAGATT
GATTTGCCTACAGCCAATCCAGATAGGGTAAAAACAGAGCTCAGTGAACTGGGACTTGTGCCAGAAGAATGGGGAGGAAA
CACAATCTGTGTTCCCGTCTCTGCTAAAAAGAATATAGGAATTGACGACCTTTTAGAGATGATACTGCTGGTAGCAGAAA
TGGAAGACCTAAAAGCAAATCCCAACAAACCAGCCCGTGGAACTGTAATAGAGGCAAAACTGGAAAAAGGGAAAGGGCCA
GTGGCTACAGTAATAGTCCAGAATGGAACACTTCAGGTGGGAGATGCTGTAATTGCAGGAACTACTTATGGAAAAGTAAG
AGCGATGTTTGACGACAAAGGAAGAAAGATTAAAAAAGCTGGTCCTTCTATGCCTGTAGAAATTTTGGGCTTTTCCGAAG
TGCCAGAGGCTGGAGATAAATTTGTAGTGGTGGAAAATGAGAAAAAAGCGAGAGAACTTGCAGAGAAAAGAAGAGAGGTT
CAAAGAGAGTTAGAACTCAAGAAAAAGCAGAAAGTCTCTCTGGAAGACCTCTTCAGACAGATACAGGAAGGTACTGTAAA
GGAGCTTAATGTGATCATAAAAGCTGATGTGCAAGGTTCTGTAGAGGCATTGAGAAAGTCATTGGAGGAACTGAGCAATG
AAGAAGTCAGAATAAGAGTCATACACGGAGCAGTAGGAGCCATCACCGAGACAGATGTAATGCTGGCTTCGGCTTCAAAT
GCAATAATAATAGGATTCAACGTAAGGCCTGAGACAAACGCAAAAGCGCTTGCAGAAAAAGAGAAAGTAGAGATAAAGCT
TTATAGAATAATATACGATGCTATTGAGGATGTAAAAGCAGCAATGAAGGGAATGTTAGAACCCAAGTACAAAGAAGTAG
AGCTGGGAAGAGCTGAAGTAAGAGCTGTATTCAAGATACCTGGTGTGGGAAATGTCGCAGGTTGTTATGTTCTAAATGGT
AAAATAGCAAGAAATGCAGATGTGAGAATAGTAAGAGATGGCATAGTCATATATGAAGGCAAAATAGCTTCTTTAAAGCG
GTTTAAAGACGACGTGAGAGAAGTACAGCAGGGATTTGAATGCGGAATAGGCATTGAGAAGTTCAATGACATAAAAGAGG
GAGATATCATAGAAGCATACACAATGGAAGAAATCCCTCGTTAA

Upstream 100 bases:

>100_bases
GATTTAGGTAGAGCGATAGGAAGAGAAATAGTCGGAATCATAGCTATTACTGATGAAGGATTTATGAAACTACTCAAGGA
GGCGGCAAAGGGGGAAAATT

Downstream 100 bases:

>100_bases
GAAGAAAGGATGAGAAAAATGCAGTACAGAAGCCATAGGTTATCCGAGGAATTGAAAAAAGAGATAAGCAAAATGATATT
GGAAGAAATAAAAGACCCGA

Product: translation initiation factor IF-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 707; Mature: 707

Protein sequence:

>707_residues
MEVNNMSKTRVYELAKELNISSKDLLSKLSDLDIKVKNHMSTLEDEEVELIKDLLAEKPKEEKQKDQKNHEQEAQDKEEK
EIEEDSFYEDREEKRAYKKSFKKGGKKNKKLQKKFVSEESAKEDEIKIITIPEFLTVKELAEKMKVNPTEIIKKLIAQGI
MVTVNQQIDFETASKIAEEYGFLVDKEEVKDELEAIFEDTPDREEDLKPRPPIVTVMGHVDHGKTSLLDAIRKTNVTMKE
MGGITQHIGASVVEINDKKVVFLDTPGHEAFTAMRARGASVTDIVVLVVAADDGVMPQTIEAINHVKAANVPLIVAINKI
DLPTANPDRVKTELSELGLVPEEWGGNTICVPVSAKKNIGIDDLLEMILLVAEMEDLKANPNKPARGTVIEAKLEKGKGP
VATVIVQNGTLQVGDAVIAGTTYGKVRAMFDDKGRKIKKAGPSMPVEILGFSEVPEAGDKFVVVENEKKARELAEKRREV
QRELELKKKQKVSLEDLFRQIQEGTVKELNVIIKADVQGSVEALRKSLEELSNEEVRIRVIHGAVGAITETDVMLASASN
AIIIGFNVRPETNAKALAEKEKVEIKLYRIIYDAIEDVKAAMKGMLEPKYKEVELGRAEVRAVFKIPGVGNVAGCYVLNG
KIARNADVRIVRDGIVIYEGKIASLKRFKDDVREVQQGFECGIGIEKFNDIKEGDIIEAYTMEEIPR

Sequences:

>Translated_707_residues
MEVNNMSKTRVYELAKELNISSKDLLSKLSDLDIKVKNHMSTLEDEEVELIKDLLAEKPKEEKQKDQKNHEQEAQDKEEK
EIEEDSFYEDREEKRAYKKSFKKGGKKNKKLQKKFVSEESAKEDEIKIITIPEFLTVKELAEKMKVNPTEIIKKLIAQGI
MVTVNQQIDFETASKIAEEYGFLVDKEEVKDELEAIFEDTPDREEDLKPRPPIVTVMGHVDHGKTSLLDAIRKTNVTMKE
MGGITQHIGASVVEINDKKVVFLDTPGHEAFTAMRARGASVTDIVVLVVAADDGVMPQTIEAINHVKAANVPLIVAINKI
DLPTANPDRVKTELSELGLVPEEWGGNTICVPVSAKKNIGIDDLLEMILLVAEMEDLKANPNKPARGTVIEAKLEKGKGP
VATVIVQNGTLQVGDAVIAGTTYGKVRAMFDDKGRKIKKAGPSMPVEILGFSEVPEAGDKFVVVENEKKARELAEKRREV
QRELELKKKQKVSLEDLFRQIQEGTVKELNVIIKADVQGSVEALRKSLEELSNEEVRIRVIHGAVGAITETDVMLASASN
AIIIGFNVRPETNAKALAEKEKVEIKLYRIIYDAIEDVKAAMKGMLEPKYKEVELGRAEVRAVFKIPGVGNVAGCYVLNG
KIARNADVRIVRDGIVIYEGKIASLKRFKDDVREVQQGFECGIGIEKFNDIKEGDIIEAYTMEEIPR
>Mature_707_residues
MEVNNMSKTRVYELAKELNISSKDLLSKLSDLDIKVKNHMSTLEDEEVELIKDLLAEKPKEEKQKDQKNHEQEAQDKEEK
EIEEDSFYEDREEKRAYKKSFKKGGKKNKKLQKKFVSEESAKEDEIKIITIPEFLTVKELAEKMKVNPTEIIKKLIAQGI
MVTVNQQIDFETASKIAEEYGFLVDKEEVKDELEAIFEDTPDREEDLKPRPPIVTVMGHVDHGKTSLLDAIRKTNVTMKE
MGGITQHIGASVVEINDKKVVFLDTPGHEAFTAMRARGASVTDIVVLVVAADDGVMPQTIEAINHVKAANVPLIVAINKI
DLPTANPDRVKTELSELGLVPEEWGGNTICVPVSAKKNIGIDDLLEMILLVAEMEDLKANPNKPARGTVIEAKLEKGKGP
VATVIVQNGTLQVGDAVIAGTTYGKVRAMFDDKGRKIKKAGPSMPVEILGFSEVPEAGDKFVVVENEKKARELAEKRREV
QRELELKKKQKVSLEDLFRQIQEGTVKELNVIIKADVQGSVEALRKSLEELSNEEVRIRVIHGAVGAITETDVMLASASN
AIIIGFNVRPETNAKALAEKEKVEIKLYRIIYDAIEDVKAAMKGMLEPKYKEVELGRAEVRAVFKIPGVGNVAGCYVLNG
KIARNADVRIVRDGIVIYEGKIASLKRFKDDVREVQQGFECGIGIEKFNDIKEGDIIEAYTMEEIPR

Specific function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 7

COG id: COG0532

COG function: function code J; Translation initiation factor 2 (IF-2; GTPase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IF-2 family

Homologues:

Organism=Homo sapiens, GI53729339, Length=546, Percent_Identity=41.9413919413919, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI53729337, Length=546, Percent_Identity=41.9413919413919, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI84043963, Length=509, Percent_Identity=29.8624754420432, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI157426893, Length=227, Percent_Identity=26.8722466960352, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1789559, Length=685, Percent_Identity=50.9489051094891, Blast_Score=623, Evalue=1e-179,
Organism=Escherichia coli, GI1788922, Length=238, Percent_Identity=29.8319327731092, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI2367247, Length=251, Percent_Identity=31.8725099601594, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI48994988, Length=140, Percent_Identity=34.2857142857143, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1789737, Length=128, Percent_Identity=37.5, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1790412, Length=128, Percent_Identity=37.5, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994658, Length=552, Percent_Identity=36.5942028985507, Blast_Score=316, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI212656558, Length=552, Percent_Identity=27.3550724637681, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17557151, Length=242, Percent_Identity=28.9256198347107, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17556456, Length=225, Percent_Identity=30.6666666666667, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324550, Length=657, Percent_Identity=37.1385083713851, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319282, Length=554, Percent_Identity=26.5342960288809, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323320, Length=229, Percent_Identity=25.764192139738, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28572034, Length=542, Percent_Identity=42.619926199262, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24656849, Length=505, Percent_Identity=28.7128712871287, Blast_Score=133, Evalue=5e-31,
Organism=Drosophila melanogaster, GI160714833, Length=79, Percent_Identity=65.8227848101266, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI78706572, Length=218, Percent_Identity=27.5229357798165, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: 1150 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): IF2_THETN (Q8RA37)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623011.1
- ProteinModelPortal:   Q8RA37
- SMR:   Q8RA37
- GeneID:   997571
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1393
- NMPDR:   fig|273068.3.peg.1358
- HOGENOM:   HBG635083
- OMA:   FQYGRVR
- ProtClustDB:   PRK05306
- BioCyc:   TTEN273068:TTE1393-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00100_B
- InterPro:   IPR006847
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000178
- InterPro:   IPR015760
- InterPro:   IPR023115
- InterPro:   IPR004161
- InterPro:   IPR009000
- Gene3D:   G3DSA:3.40.50.10050
- PANTHER:   PTHR23115:SF41
- TIGRFAMs:   TIGR00487
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF11987 IF-2; PF04760 IF2_N; SSF52156 TIF_IF2_dom3; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 78858; Mature: 78858

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01176 IF2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVNNMSKTRVYELAKELNISSKDLLSKLSDLDIKVKNHMSTLEDEEVELIKDLLAEKPK
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEHHHHCCCCHHHHHHHHHHHHCCCH
EEKQKDQKNHEQEAQDKEEKEIEEDSFYEDREEKRAYKKSFKKGGKKNKKLQKKFVSEES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
AKEDEIKIITIPEFLTVKELAEKMKVNPTEIIKKLIAQGIMVTVNQQIDFETASKIAEEY
CCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHH
GFLVDKEEVKDELEAIFEDTPDREEDLKPRPPIVTVMGHVDHGKTSLLDAIRKTNVTMKE
CCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHH
MGGITQHIGASVVEINDKKVVFLDTPGHEAFTAMRARGASVTDIVVLVVAADDGVMPQTI
HCCHHHHHCCEEEEECCCEEEEEECCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHH
EAINHVKAANVPLIVAINKIDLPTANPDRVKTELSELGLVPEEWGGNTICVPVSAKKNIG
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCHHCCCCEEEEEECCCCCCC
IDDLLEMILLVAEMEDLKANPNKPARGTVIEAKLEKGKGPVATVIVQNGTLQVGDAVIAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHCCCCCEEEEEEECCCEEECCEEEEC
TTYGKVRAMFDDKGRKIKKAGPSMPVEILGFSEVPEAGDKFVVVENEKKARELAEKRREV
CCCHHEEEEECCCCCEEHHCCCCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHH
QRELELKKKQKVSLEDLFRQIQEGTVKELNVIIKADVQGSVEALRKSLEELSNEEVRIRV
HHHHHHHHHHCCCHHHHHHHHHCCCHHHEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEE
IHGAVGAITETDVMLASASNAIIIGFNVRPETNAKALAEKEKVEIKLYRIIYDAIEDVKA
EECCCCCCCHHHEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKGMLEPKYKEVELGRAEVRAVFKIPGVGNVAGCYVLNGKIARNADVRIVRDGIVIYEG
HHHHCCCCCHHHHHCCHHHEEEEEECCCCCCCCEEEEECCEEECCCCEEEEECCEEEECC
KIASLKRFKDDVREVQQGFECGIGIEKFNDIKEGDIIEAYTMEEIPR
CHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEECHHHCCC
>Mature Secondary Structure
MEVNNMSKTRVYELAKELNISSKDLLSKLSDLDIKVKNHMSTLEDEEVELIKDLLAEKPK
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEHHHHCCCCHHHHHHHHHHHHCCCH
EEKQKDQKNHEQEAQDKEEKEIEEDSFYEDREEKRAYKKSFKKGGKKNKKLQKKFVSEES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
AKEDEIKIITIPEFLTVKELAEKMKVNPTEIIKKLIAQGIMVTVNQQIDFETASKIAEEY
CCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHH
GFLVDKEEVKDELEAIFEDTPDREEDLKPRPPIVTVMGHVDHGKTSLLDAIRKTNVTMKE
CCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHH
MGGITQHIGASVVEINDKKVVFLDTPGHEAFTAMRARGASVTDIVVLVVAADDGVMPQTI
HCCHHHHHCCEEEEECCCEEEEEECCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHH
EAINHVKAANVPLIVAINKIDLPTANPDRVKTELSELGLVPEEWGGNTICVPVSAKKNIG
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCHHCCCCEEEEEECCCCCCC
IDDLLEMILLVAEMEDLKANPNKPARGTVIEAKLEKGKGPVATVIVQNGTLQVGDAVIAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHCCCCCEEEEEEECCCEEECCEEEEC
TTYGKVRAMFDDKGRKIKKAGPSMPVEILGFSEVPEAGDKFVVVENEKKARELAEKRREV
CCCHHEEEEECCCCCEEHHCCCCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHH
QRELELKKKQKVSLEDLFRQIQEGTVKELNVIIKADVQGSVEALRKSLEELSNEEVRIRV
HHHHHHHHHHCCCHHHHHHHHHCCCHHHEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEE
IHGAVGAITETDVMLASASNAIIIGFNVRPETNAKALAEKEKVEIKLYRIIYDAIEDVKA
EECCCCCCCHHHEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKGMLEPKYKEVELGRAEVRAVFKIPGVGNVAGCYVLNGKIARNADVRIVRDGIVIYEG
HHHHCCCCCHHHHHCCHHHEEEEEECCCCCCCCEEEEECCEEECCCCEEEEECCEEEECC
KIASLKRFKDDVREVQQGFECGIGIEKFNDIKEGDIIEAYTMEEIPR
CHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336