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The map label for this gene is MutT2 [H]

Identifier: 20807759

GI number: 20807759

Start: 1301252

End: 1301794

Strand: Direct

Name: MutT2 [H]

Synonym: TTE1310

Alternate gene names: 20807759

Gene position: 1301252-1301794 (Clockwise)

Preceding gene: 20807758

Following gene: 20807760

Centisome position: 48.38

GC content: 37.2

Gene sequence:

>543_bases
ATGGAACAAAAAGAGCCTACAGTAAGCACTAGAAAGGTATTTGAAGGGAAGATAATAAACTTAAGAGTTGATGAGGTAAG
GCTTCCAAATGGGAAAATAACTACGAGAGAAATAGTAGAGCACCCTGGCGGTGTCTCAATAGTAGCAGTCACAAATGATG
GGAAAATCCTTTTAGTAAAACAGTACAGAAAACCGGCTGAAGAAGTTTTGCTAGAGATACCTGCAGGAAAGCTGGAAAAA
GGAGAAGACCCTTTGGAGTGTGCCAAAAGAGAGCTTTCAGAAGAGACAGGGTATGAAGCGGGTCACATAGAGCATTTGAT
TACTTTTTACACTACTCCTGGCTTTTCCAATGAAAAGATGTACCTTTATTTTGCAAAGGATTTAAAGAAAAGCAAGGTAC
ATCCTGATGAAGATGAGTTTTTAGAAGTGGGCGAATATTTTCCAGAAGAACTGTGGAAGATGATTTTAGAAAATAAGATA
AAAGATTCCAAAACGATAATAGGCGTTCTGTACTATTTGAAAATGAGGAATGAAAAAATATGA

Upstream 100 bases:

>100_bases
TTTGAAAATTTCCCTGTGTATAAGAGCACAATCATTTTTTTCACCTCATTTCTATAGTATGTATTTGGAGTAAAAATTAT
ACATAGAAAGGAAGGTAAAA

Downstream 100 bases:

>100_bases
TGAAGATTTATGGAGATTTGCACATCCACATAGGTAGAACTGAAAAGGGTATTTCTGTAAAAGTCGCTGCTTCGAAGGAT
TTGACTGTTTTAAACATTTT

Product: NTP pyrophosphohydrolase including oxidative damage repair enzyme

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MEQKEPTVSTRKVFEGKIINLRVDEVRLPNGKITTREIVEHPGGVSIVAVTNDGKILLVKQYRKPAEEVLLEIPAGKLEK
GEDPLECAKRELSEETGYEAGHIEHLITFYTTPGFSNEKMYLYFAKDLKKSKVHPDEDEFLEVGEYFPEELWKMILENKI
KDSKTIIGVLYYLKMRNEKI

Sequences:

>Translated_180_residues
MEQKEPTVSTRKVFEGKIINLRVDEVRLPNGKITTREIVEHPGGVSIVAVTNDGKILLVKQYRKPAEEVLLEIPAGKLEK
GEDPLECAKRELSEETGYEAGHIEHLITFYTTPGFSNEKMYLYFAKDLKKSKVHPDEDEFLEVGEYFPEELWKMILENKI
KDSKTIIGVLYYLKMRNEKI
>Mature_180_residues
MEQKEPTVSTRKVFEGKIINLRVDEVRLPNGKITTREIVEHPGGVSIVAVTNDGKILLVKQYRKPAEEVLLEIPAGKLEK
GEDPLECAKRELSEETGYEAGHIEHLITFYTTPGFSNEKMYLYFAKDLKKSKVHPDEDEFLEVGEYFPEELWKMILENKI
KDSKTIIGVLYYLKMRNEKI

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Homo sapiens, GI37594464, Length=170, Percent_Identity=31.1764705882353, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319587, Length=148, Percent_Identity=34.4594594594595, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 20773; Mature: 20773

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQKEPTVSTRKVFEGKIINLRVDEVRLPNGKITTREIVEHPGGVSIVAVTNDGKILLVK
CCCCCCCCHHHHHHCCEEEEEEEEEEECCCCCCCHHHHHHCCCCEEEEEEECCCCEEEEH
QYRKPAEEVLLEIPAGKLEKGEDPLECAKRELSEETGYEAGHIEHLITFYTTPGFSNEKM
HHCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHEEEEEEECCCCCCCEE
YLYFAKDLKKSKVHPDEDEFLEVGEYFPEELWKMILENKIKDSKTIIGVLYYLKMRNEKI
EEEEECCHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEQKEPTVSTRKVFEGKIINLRVDEVRLPNGKITTREIVEHPGGVSIVAVTNDGKILLVK
CCCCCCCCHHHHHHCCEEEEEEEEEEECCCCCCCHHHHHHCCCCEEEEEEECCCCEEEEH
QYRKPAEEVLLEIPAGKLEKGEDPLECAKRELSEETGYEAGHIEHLITFYTTPGFSNEKM
HHCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHEEEEEEECCCCCCCEE
YLYFAKDLKKSKVHPDEDEFLEVGEYFPEELWKMILENKIKDSKTIIGVLYYLKMRNEKI
EEEEECCHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]