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The map label for this gene is IspA [C]

Identifier: 20807745

GI number: 20807745

Start: 1286153

End: 1287037

Strand: Direct

Name: IspA [C]

Synonym: TTE1296

Alternate gene names: 20807745

Gene position: 1286153-1287037 (Clockwise)

Preceding gene: 20807744

Following gene: 20807746

Centisome position: 47.82

GC content: 41.58

Gene sequence:

>885_bases
ATGTTTAAAGAAAAATTCAAAAATTTACAACAGATGGTGGAGGAAGAGCTTCACAGGATACTGGATGTACAGGAGAAGCC
GGAGATAATATACGAGGCGATGAGATACAGCGTTTTTGCAGGGGGGAAAAGATTGAGGCCTGTTTTGTGCCTCTCTGCCT
GTGAACTTTTGGGAGGGGATTTAAAAAAAGCTTTGCCAGTAGCCTGCTCTATTGAACTCATACACACTTATTCTCTTATC
CACGATGACCTTCCTGCTATGGATAATGATGATTTGAGAAGAGGCAAGCCTACAAATCACAAGGTATTTGGAGAGGCCAT
AGCCATTCTTGCCGGGGATGGACTTTTAAACCTGGGATATGAGGTTTTGATAAGGCATGCTCTGGAAAATCCCGAAGATT
ATGAGAAAATTTTAAAAGCTGCGAATGAAATAGCTACTGCTTCAGGTTGTAAGGGAATCATAGGAGGGCAGGTAGAAGAT
ATACTTTCTCAAAACACAGAACTTACCTATGAAGAGCTAAAATACATCCACGAACACAAGACCGCAGCTTTGATAGAGGC
TTCTGTCTGTGCAGGAGCCCATATGGCTGGGGCTAGTGAAAAAGAAGTGGAGCTTTTGAGAGAATACGCTGGGCTAATAG
GGCTGGCATTTCAGATAAAAGACGACATACTGGATGTAATAGGAGATGAAAAAACGCTTGGCAAAAAAGTGGGGAGCGAC
AGGGAAAAAGGCAAGTTTACTTTTGTCAACATATTCGGCGTTGAAAAATCCCAAGAAATGGTAAAGGAGCTTACAGATGA
AGCTATAAAGATTTTGGACACTTTTGGCGAAAGGGCACAGTTTCTTAAAGACCTCTCTAATTATTTGATTGAGAGAGTAA
ACTGA

Upstream 100 bases:

>100_bases
ATATCAAAAAGACTAGAAAAAATGTTAAAAGAAGTGGAAGGAAAGATAACCATGCTGATAAGTGAAGATGAGGAAATTGA
GTTTAAAGAGGAGGAAAATA

Downstream 100 bases:

>100_bases
AGATTGAAAGAGCATTGACAATGTATCAGGATAGAAACTGATTTTTTTGACCTTAAGAGACTGTAGCAGGCTTTTACGGT
TTTAAGCGGTGTTTGATATT

Product: geranylgeranyl pyrophosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MFKEKFKNLQQMVEEELHRILDVQEKPEIIYEAMRYSVFAGGKRLRPVLCLSACELLGGDLKKALPVACSIELIHTYSLI
HDDLPAMDNDDLRRGKPTNHKVFGEAIAILAGDGLLNLGYEVLIRHALENPEDYEKILKAANEIATASGCKGIIGGQVED
ILSQNTELTYEELKYIHEHKTAALIEASVCAGAHMAGASEKEVELLREYAGLIGLAFQIKDDILDVIGDEKTLGKKVGSD
REKGKFTFVNIFGVEKSQEMVKELTDEAIKILDTFGERAQFLKDLSNYLIERVN

Sequences:

>Translated_294_residues
MFKEKFKNLQQMVEEELHRILDVQEKPEIIYEAMRYSVFAGGKRLRPVLCLSACELLGGDLKKALPVACSIELIHTYSLI
HDDLPAMDNDDLRRGKPTNHKVFGEAIAILAGDGLLNLGYEVLIRHALENPEDYEKILKAANEIATASGCKGIIGGQVED
ILSQNTELTYEELKYIHEHKTAALIEASVCAGAHMAGASEKEVELLREYAGLIGLAFQIKDDILDVIGDEKTLGKKVGSD
REKGKFTFVNIFGVEKSQEMVKELTDEAIKILDTFGERAQFLKDLSNYLIERVN
>Mature_294_residues
MFKEKFKNLQQMVEEELHRILDVQEKPEIIYEAMRYSVFAGGKRLRPVLCLSACELLGGDLKKALPVACSIELIHTYSLI
HDDLPAMDNDDLRRGKPTNHKVFGEAIAILAGDGLLNLGYEVLIRHALENPEDYEKILKAANEIATASGCKGIIGGQVED
ILSQNTELTYEELKYIHEHKTAALIEASVCAGAHMAGASEKEVELLREYAGLIGLAFQIKDDILDVIGDEKTLGKKVGSD
REKGKFTFVNIFGVEKSQEMVKELTDEAIKILDTFGERAQFLKDLSNYLIERVN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=298, Percent_Identity=40.6040268456376, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789578, Length=222, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17505681, Length=195, Percent_Identity=30.2564102564103, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508563, Length=235, Percent_Identity=29.7872340425532, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24651612, Length=250, Percent_Identity=28.8, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137582, Length=263, Percent_Identity=26.9961977186312, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32796; Mature: 32796

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKEKFKNLQQMVEEELHRILDVQEKPEIIYEAMRYSVFAGGKRLRPVLCLSACELLGGD
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
LKKALPVACSIELIHTYSLIHDDLPAMDNDDLRRGKPTNHKVFGEAIAILAGDGLLNLGY
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
EVLIRHALENPEDYEKILKAANEIATASGCKGIIGGQVEDILSQNTELTYEELKYIHEHK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHH
TAALIEASVCAGAHMAGASEKEVELLREYAGLIGLAFQIKDDILDVIGDEKTLGKKVGSD
HHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
REKGKFTFVNIFGVEKSQEMVKELTDEAIKILDTFGERAQFLKDLSNYLIERVN
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKEKFKNLQQMVEEELHRILDVQEKPEIIYEAMRYSVFAGGKRLRPVLCLSACELLGGD
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
LKKALPVACSIELIHTYSLIHDDLPAMDNDDLRRGKPTNHKVFGEAIAILAGDGLLNLGY
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
EVLIRHALENPEDYEKILKAANEIATASGCKGIIGGQVEDILSQNTELTYEELKYIHEHK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHH
TAALIEASVCAGAHMAGASEKEVELLREYAGLIGLAFQIKDDILDVIGDEKTLGKKVGSD
HHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
REKGKFTFVNIFGVEKSQEMVKELTDEAIKILDTFGERAQFLKDLSNYLIERVN
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]