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The map label for this gene is PepP [H]

Identifier: 20807729

GI number: 20807729

Start: 1275728

End: 1276795

Strand: Direct

Name: PepP [H]

Synonym: TTE1280

Alternate gene names: 20807729

Gene position: 1275728-1276795 (Clockwise)

Preceding gene: 20807728

Following gene: 20807730

Centisome position: 47.43

GC content: 38.48

Gene sequence:

>1068_bases
GTGAAGACTAGGCTTAGCAATTTGCGGAAGTTAATGAGAGAAAAAGATATAGAAGCTTTTGTAATTTACAAATTTGTAAA
TGTTACCTACATAACAGGTTTTACTGGGGATGACAGCGTAGCGCTGATAACTGATGATGCCGCTATTTTTATCACTGATG
GGAGGTATACGGAGCAGGCACAAAAGGAAGTCAAAGATTTTGAGATTGTGGAACACAAAACGGGAATAAAGGATGTCTTG
AAAGAATACATTAAGAAATTGGGAATAAAAAGATTGGCTTTTGAAGAAAATGTGACATACGGGCAGTACAGAGAATTAAA
AGAAGCTTTAGAAAGGGTAGAGCTTATACCTCAGGCAGGTTTAGTTGAGAGTTTAAGGATGGTAAAAGATGAAGAAGAGA
TAAATCTCATAAAAAAGGCGCAGAGCATAACTGATAGAGCTTTTGAGCACATTTTGAATTTTATAAAACCTGGCATGACA
GAAAAGGAAGTAGCACTGGAGCTTGAATATTTCATGAAAAAGAATGGAGCAGAGGACCTAGCCTTTGATACTATCGTGGC
TTCCGGTAAAAGGTCTTCTCTCCCCCATGGAAAAGCTTCAGATAAGGTGATTGAAAAAGAGGACTTTGTCACGATCGACT
TTGGATGCAAAGTCTCAGGCTACTGCTCTGACATGACAAGGACTATAGTAGTTGGGAAAGCCAGTGAAAAGCAGAAAGAG
ATATACAATGTGGTGTTAGAAGCACAGCAAAATGCCCTTAAAAATTTAAAGGCAGGAATTACTTCTAAGGAAGCCGATTA
TTTAGCGAGGTCTGTGATAGAAGAAAAAGGCTATGGGCCGTATTTTAGCCATTCCTTGGGGCATGGAGTGGGGCTTGAGG
TACATGAAGGACCGAGCCTGACTTTCAGAAAAGAAGAAATTTTAAAAGAGGGCTCGATTGTCACAGTAGAACCGGGAATA
TACATACCTGATTTCGGTGGCGTAAGAATCGAAGATATGGTATTATTAAAAGAAGATGGTGTTATAAATTTAACCAATTC
ACCTAAACATTTGATTGAAATAAACTAA

Upstream 100 bases:

>100_bases
TCTCGCTGCAAGGGAGTGATTACGGGCTTTGGACCGTATAGCTACATACTGGCTCTTTACGCTGTGAAATTTTTAGAGGA
TTCAATTGGGGGGTAGAATA

Downstream 100 bases:

>100_bases
AGTGATGGAGGGATTTTTTTGATAGCAGCAGGGGATTTCAGAAAAGGAGTAACTATTGAGGTTGACGGCCAGATTTTTAC
AGTTGTGGACTTCATGCACG

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKTRLSNLRKLMREKDIEAFVIYKFVNVTYITGFTGDDSVALITDDAAIFITDGRYTEQAQKEVKDFEIVEHKTGIKDVL
KEYIKKLGIKRLAFEENVTYGQYRELKEALERVELIPQAGLVESLRMVKDEEEINLIKKAQSITDRAFEHILNFIKPGMT
EKEVALELEYFMKKNGAEDLAFDTIVASGKRSSLPHGKASDKVIEKEDFVTIDFGCKVSGYCSDMTRTIVVGKASEKQKE
IYNVVLEAQQNALKNLKAGITSKEADYLARSVIEEKGYGPYFSHSLGHGVGLEVHEGPSLTFRKEEILKEGSIVTVEPGI
YIPDFGGVRIEDMVLLKEDGVINLTNSPKHLIEIN

Sequences:

>Translated_355_residues
MKTRLSNLRKLMREKDIEAFVIYKFVNVTYITGFTGDDSVALITDDAAIFITDGRYTEQAQKEVKDFEIVEHKTGIKDVL
KEYIKKLGIKRLAFEENVTYGQYRELKEALERVELIPQAGLVESLRMVKDEEEINLIKKAQSITDRAFEHILNFIKPGMT
EKEVALELEYFMKKNGAEDLAFDTIVASGKRSSLPHGKASDKVIEKEDFVTIDFGCKVSGYCSDMTRTIVVGKASEKQKE
IYNVVLEAQQNALKNLKAGITSKEADYLARSVIEEKGYGPYFSHSLGHGVGLEVHEGPSLTFRKEEILKEGSIVTVEPGI
YIPDFGGVRIEDMVLLKEDGVINLTNSPKHLIEIN
>Mature_355_residues
MKTRLSNLRKLMREKDIEAFVIYKFVNVTYITGFTGDDSVALITDDAAIFITDGRYTEQAQKEVKDFEIVEHKTGIKDVL
KEYIKKLGIKRLAFEENVTYGQYRELKEALERVELIPQAGLVESLRMVKDEEEINLIKKAQSITDRAFEHILNFIKPGMT
EKEVALELEYFMKKNGAEDLAFDTIVASGKRSSLPHGKASDKVIEKEDFVTIDFGCKVSGYCSDMTRTIVVGKASEKQKE
IYNVVLEAQQNALKNLKAGITSKEADYLARSVIEEKGYGPYFSHSLGHGVGLEVHEGPSLTFRKEEILKEGSIVTVEPGI
YIPDFGGVRIEDMVLLKEDGVINLTNSPKHLIEIN

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=264, Percent_Identity=30.6818181818182, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI149589008, Length=293, Percent_Identity=26.2798634812287, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI260593665, Length=293, Percent_Identity=26.2798634812287, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI264681563, Length=370, Percent_Identity=24.5945945945946, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI260593663, Length=248, Percent_Identity=26.6129032258064, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI264681565, Length=367, Percent_Identity=25.0681198910082, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI93141226, Length=165, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788728, Length=362, Percent_Identity=37.8453038674033, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1789275, Length=265, Percent_Identity=32.0754716981132, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790282, Length=308, Percent_Identity=23.3766233766234, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508215, Length=294, Percent_Identity=29.5918367346939, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71989583, Length=264, Percent_Identity=22.7272727272727, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=363, Percent_Identity=23.6914600550964, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320922, Length=253, Percent_Identity=29.6442687747036, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321118, Length=283, Percent_Identity=26.8551236749117, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322999, Length=169, Percent_Identity=29.585798816568, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19920384, Length=261, Percent_Identity=29.1187739463602, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357079, Length=298, Percent_Identity=28.1879194630872, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 40013; Mature: 40013

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRLSNLRKLMREKDIEAFVIYKFVNVTYITGFTGDDSVALITDDAAIFITDGRYTEQA
CCCHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEECCCCCEEEEECCEEEEEECCCCHHHH
QKEVKDFEIVEHKTGIKDVLKEYIKKLGIKRLAFEENVTYGQYRELKEALERVELIPQAG
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
LVESLRMVKDEEEINLIKKAQSITDRAFEHILNFIKPGMTEKEVALELEYFMKKNGAEDL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHH
AFDTIVASGKRSSLPHGKASDKVIEKEDFVTIDFGCKVSGYCSDMTRTIVVGKASEKQKE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCEEEEEEECCCHHHHH
IYNVVLEAQQNALKNLKAGITSKEADYLARSVIEEKGYGPYFSHSLGHGVGLEVHEGPSL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCCEEEECCCCC
TFRKEEILKEGSIVTVEPGIYIPDFGGVRIEDMVLLKEDGVINLTNSPKHLIEIN
EEEHHHHHHCCCEEEECCCEEECCCCCCEEEEEEEEECCCEEEECCCCCEEEEEC
>Mature Secondary Structure
MKTRLSNLRKLMREKDIEAFVIYKFVNVTYITGFTGDDSVALITDDAAIFITDGRYTEQA
CCCHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEECCCCCEEEEECCEEEEEECCCCHHHH
QKEVKDFEIVEHKTGIKDVLKEYIKKLGIKRLAFEENVTYGQYRELKEALERVELIPQAG
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
LVESLRMVKDEEEINLIKKAQSITDRAFEHILNFIKPGMTEKEVALELEYFMKKNGAEDL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHH
AFDTIVASGKRSSLPHGKASDKVIEKEDFVTIDFGCKVSGYCSDMTRTIVVGKASEKQKE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCEEEEEEECCCHHHHH
IYNVVLEAQQNALKNLKAGITSKEADYLARSVIEEKGYGPYFSHSLGHGVGLEVHEGPSL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCCEEEECCCCC
TFRKEEILKEGSIVTVEPGIYIPDFGGVRIEDMVLLKEDGVINLTNSPKHLIEIN
EEEHHHHHHCCCEEEECCCEEECCCCCCEEEEEEEEECCCEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]