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The map label for this gene is AroE

Identifier: 20807710

GI number: 20807710

Start: 1260895

End: 1261737

Strand: Direct

Name: AroE

Synonym: TTE1261

Alternate gene names: 20807710

Gene position: 1260895-1261737 (Clockwise)

Preceding gene: 20807709

Following gene: 20807711

Centisome position: 46.88

GC content: 37.84

Gene sequence:

>843_bases
ATGAAAATTGACAGCACCACAAAGGTCTTTGGACTTATTGGGCATCCAGTCAAACACAGTCTTTCACCTTTGATACATAA
CTCTTCTTTTGAAAAGCTCAATTTCAATGGAGTGTACGTGGTCTTTGATGTAGCCCCTGAGTTATTAGAAAATGCTGTAA
AAGGACTAAAAGCTTTAGGTATAAAGGGATTTAATGTGACTGTCCCTCATAAAGAGAGCGTAATGAATTATTTGGATTTT
GTCACGGAAGAGGCAGAAAAAATTGGAGCTGTGAATACAGTTGTCAATGAAAATGGGATTTTAAAAGGCTACAATACAGA
CGTACAGGGATTCATAGATTCCTTAAAAGAGTTGAAAGAGGATGTAAGAGGAAGAAAAGCCTTTGTACTGGGGGCAGGAG
GAGCATCAAAAGCTATATGTTTTGCCCTTGCAAGGGAAGGAGTAGAATCAATTGTAATAGCCAATAGGACTTTAAATAAA
GCGAAAGCGCTGGCAGAATACATAAGGGAAGAATTTAAGATGAAATGCGATTACTGCAGTATAGAAGAAGTGGAAAAATT
TAATGAAATTGATATTCTCATAAACACAACTTCTGTGGGGATGCATCCTGAAGTGGGGAACTCTCCAGTTTCTGAGGAGG
TAGTGGCAAAGGCAAATTTTGTGTATGATTTAATATACAATCCTTCTGAGACGCTTTTTTTAAAGTACGCAAGAAAAAAC
GGTGTAAAAAGCGCAAATGGCCTCTCAATGCTTGTGAATCAGGCTAGCTATGCTTTTTACCTCTGGACAGGAGAGTTTTT
TGACAAAGACTTTGTGTATGAGAAAATAAGGGGAGAAATGTAG

Upstream 100 bases:

>100_bases
CTTTATACTATCTTGGTAAAACCTTTGTCTGATGAAGAGCTTGCCTGGACTAAGATTATGAGAAGAGCTGAGAAAATCAT
TTTAAAGAGGATTGAAGGAT

Downstream 100 bases:

>100_bases
AGGGAAGAGGTATTTTTATGGCTAAGAAAAAACTTGGAGAACTTCTTGTGGAAGTGGGACTTATCACGGAAGAACAACTG
AAACATGCCATGGAAGTGCA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKIDSTTKVFGLIGHPVKHSLSPLIHNSSFEKLNFNGVYVVFDVAPELLENAVKGLKALGIKGFNVTVPHKESVMNYLDF
VTEEAEKIGAVNTVVNENGILKGYNTDVQGFIDSLKELKEDVRGRKAFVLGAGGASKAICFALAREGVESIVIANRTLNK
AKALAEYIREEFKMKCDYCSIEEVEKFNEIDILINTTSVGMHPEVGNSPVSEEVVAKANFVYDLIYNPSETLFLKYARKN
GVKSANGLSMLVNQASYAFYLWTGEFFDKDFVYEKIRGEM

Sequences:

>Translated_280_residues
MKIDSTTKVFGLIGHPVKHSLSPLIHNSSFEKLNFNGVYVVFDVAPELLENAVKGLKALGIKGFNVTVPHKESVMNYLDF
VTEEAEKIGAVNTVVNENGILKGYNTDVQGFIDSLKELKEDVRGRKAFVLGAGGASKAICFALAREGVESIVIANRTLNK
AKALAEYIREEFKMKCDYCSIEEVEKFNEIDILINTTSVGMHPEVGNSPVSEEVVAKANFVYDLIYNPSETLFLKYARKN
GVKSANGLSMLVNQASYAFYLWTGEFFDKDFVYEKIRGEM
>Mature_280_residues
MKIDSTTKVFGLIGHPVKHSLSPLIHNSSFEKLNFNGVYVVFDVAPELLENAVKGLKALGIKGFNVTVPHKESVMNYLDF
VTEEAEKIGAVNTVVNENGILKGYNTDVQGFIDSLKELKEDVRGRKAFVLGAGGASKAICFALAREGVESIVIANRTLNK
AKALAEYIREEFKMKCDYCSIEEVEKFNEIDILINTTSVGMHPEVGNSPVSEEVVAKANFVYDLIYNPSETLFLKYARKN
GVKSANGLSMLVNQASYAFYLWTGEFFDKDFVYEKIRGEM

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=282, Percent_Identity=35.8156028368794, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1789675, Length=275, Percent_Identity=33.4545454545455, Blast_Score=140, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6320332, Length=272, Percent_Identity=33.4558823529412, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_THETN (Q8RAG2)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622881.1
- ProteinModelPortal:   Q8RAG2
- SMR:   Q8RAG2
- GeneID:   997564
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1261
- NMPDR:   fig|273068.3.peg.1099
- HOGENOM:   HBG553408
- OMA:   NARYLAF
- ProtClustDB:   CLSK901129
- BioCyc:   TTEN273068:TTE1261-MONOMER
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31107; Mature: 31107

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDSTTKVFGLIGHPVKHSLSPLIHNSSFEKLNFNGVYVVFDVAPELLENAVKGLKALG
CCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCCEEEEEECCHHHHHHHHHHHHHHC
IKGFNVTVPHKESVMNYLDFVTEEAEKIGAVNTVVNENGILKGYNTDVQGFIDSLKELKE
CCCCEEECCCHHHHHHHHHHHHHHHHHHCHHHEEECCCCEEECCCCCHHHHHHHHHHHHH
DVRGRKAFVLGAGGASKAICFALAREGVESIVIANRTLNKAKALAEYIREEFKMKCDYCS
HHCCCEEEEEECCCCHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHHHHHHHCCCCCC
IEEVEKFNEIDILINTTSVGMHPEVGNSPVSEEVVAKANFVYDLIYNPSETLFLKYARKN
HHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCCEEEEEHHHC
GVKSANGLSMLVNQASYAFYLWTGEFFDKDFVYEKIRGEM
CCCCCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MKIDSTTKVFGLIGHPVKHSLSPLIHNSSFEKLNFNGVYVVFDVAPELLENAVKGLKALG
CCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCCEEEEEECCHHHHHHHHHHHHHHC
IKGFNVTVPHKESVMNYLDFVTEEAEKIGAVNTVVNENGILKGYNTDVQGFIDSLKELKE
CCCCEEECCCHHHHHHHHHHHHHHHHHHCHHHEEECCCCEEECCCCCHHHHHHHHHHHHH
DVRGRKAFVLGAGGASKAICFALAREGVESIVIANRTLNKAKALAEYIREEFKMKCDYCS
HHCCCEEEEEECCCCHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHHHHHHHCCCCCC
IEEVEKFNEIDILINTTSVGMHPEVGNSPVSEEVVAKANFVYDLIYNPSETLFLKYARKN
HHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCCEEEEEHHHC
GVKSANGLSMLVNQASYAFYLWTGEFFDKDFVYEKIRGEM
CCCCCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336