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The map label for this gene is GltP [H]

Identifier: 20807669

GI number: 20807669

Start: 1216025

End: 1217314

Strand: Direct

Name: GltP [H]

Synonym: TTE1214

Alternate gene names: 20807669

Gene position: 1216025-1217314 (Clockwise)

Preceding gene: 20807668

Following gene: 20807670

Centisome position: 45.21

GC content: 39.53

Gene sequence:

>1290_bases
ATGAAAGATTATCAAAAATTACTGACAGGTTTTATCTTGGGAATAATCGTAGGCTTGATATGTTACTACACACTGCCAAT
AAAAACATTTCCATTTATGCAATGGGCAGTAGACATAGCTACGCTGATAGGTGCTATCTTTCTGAGGCTAATATTTATGG
CAGTAATTCCTCTCTTAACATCTGCGTTAATTTTGGGCGTTTTTGAGCTAAGTCAGGGTAGAGCTTTAGGAAAAGTAGCA
GTTCAAGCACTAGTCTGGACTATAGTTCTTTCTACAATTGCTGTAGCAATAGGCTTAATAGGAGTTAATGTGGTCAAACC
AGGAGTCGGTACTAATTTTGATATTGCTGCTGCAGAGAAGCAATCCATAATAAGTATAACACAAACAGCGGAGACCCTCA
GAGGATTGCGCTGGTACCAGTATATAGTGAACCTCTTACCCCAGAACCCGATAGAGTCTGCAGCAAAAGCTTTACAAGGG
GAAATAATTGCAGTAATGGTATTTGCTGCCATTTTTGGATGGGCAGTTAGCATAGTAATAAAAGAAGAAAATCATTCATT
CATTCAGGTAATGCAAGCAATCTTTGAAGCATCAATGGGTGTTGTTAAACTTGCCCTTAAAATGGCGCCTTATGCTATTT
TTTGCATAGTGTTTAATACTACTTATAAAATGGGTGCTGGATTCTTGAAGAATCTTGGAGTATATGCTGCGGTAGTTGTT
GTAGGTCTAGCTATTCAGTTGTTTGTTGTTTATCCATTTTTCCTTAAAGTTTTTGCCAAAAAATCTCCGGGCGAGTTCTT
TAGAGGAGCTAAGGAACCCATGCTTTACGCGTTTTCTACTTCTTCTTCAAATGCTACCTTGCCAATATCTCTAAAAGCAG
CAGAAGAAGAACTAAAACTTCCCCCTCACATTGCAAGATTTATTCTGACTATTGGTGCTACTGCGAATCAAAATGGCACG
GCTTTATTTGAAGGAGTCACAATTTTATTTTTAGCTCAGGTATATGGTGTAGATTTATCCCTTTCTACTCAATTGCTTGT
GATGTTTGCAGCGATATTAGCCGGTGTGGGAACAGCAGGAGTGCCAGCGGGTTCTTTGCCAGTGATTGCTGCACTGCTAG
CGCAAGTAGGTGTACCCCCAGAAGGAATTGGATTAATTTTAGGGATAGATAGATTTTTAGATATGTGCAGGACTACTCTG
AATGTCACAGGAGACCTAGTAATTGCTGAACTTGTAACGACTTCTTCTGGAGAAAGAGGTATCCCGACAGTGAGTACTAC
TCAAAGCTAA

Upstream 100 bases:

>100_bases
ATCGTTTACAAAAAAGGAGGGATGAAATTCAGAAAATTCAGTAGAAGGGGATACACTTTTCAAAAGTAAAAACTAATAAA
AGAGAGGGGAAATGGGAAAT

Downstream 100 bases:

>100_bases
CAATAAATTTTCTCCAATCAAGGCTGCCTCCTCTCAGAATCTTTCATGAGGGGAGGCAGCTAATTAAGGTCTTGAAATAA
CCATAAAAAGGAGAGAGCAG

Product: Na+/H+-dicarboxylate symporters

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKDYQKLLTGFILGIIVGLICYYTLPIKTFPFMQWAVDIATLIGAIFLRLIFMAVIPLLTSALILGVFELSQGRALGKVA
VQALVWTIVLSTIAVAIGLIGVNVVKPGVGTNFDIAAAEKQSIISITQTAETLRGLRWYQYIVNLLPQNPIESAAKALQG
EIIAVMVFAAIFGWAVSIVIKEENHSFIQVMQAIFEASMGVVKLALKMAPYAIFCIVFNTTYKMGAGFLKNLGVYAAVVV
VGLAIQLFVVYPFFLKVFAKKSPGEFFRGAKEPMLYAFSTSSSNATLPISLKAAEEELKLPPHIARFILTIGATANQNGT
ALFEGVTILFLAQVYGVDLSLSTQLLVMFAAILAGVGTAGVPAGSLPVIAALLAQVGVPPEGIGLILGIDRFLDMCRTTL
NVTGDLVIAELVTTSSGERGIPTVSTTQS

Sequences:

>Translated_429_residues
MKDYQKLLTGFILGIIVGLICYYTLPIKTFPFMQWAVDIATLIGAIFLRLIFMAVIPLLTSALILGVFELSQGRALGKVA
VQALVWTIVLSTIAVAIGLIGVNVVKPGVGTNFDIAAAEKQSIISITQTAETLRGLRWYQYIVNLLPQNPIESAAKALQG
EIIAVMVFAAIFGWAVSIVIKEENHSFIQVMQAIFEASMGVVKLALKMAPYAIFCIVFNTTYKMGAGFLKNLGVYAAVVV
VGLAIQLFVVYPFFLKVFAKKSPGEFFRGAKEPMLYAFSTSSSNATLPISLKAAEEELKLPPHIARFILTIGATANQNGT
ALFEGVTILFLAQVYGVDLSLSTQLLVMFAAILAGVGTAGVPAGSLPVIAALLAQVGVPPEGIGLILGIDRFLDMCRTTL
NVTGDLVIAELVTTSSGERGIPTVSTTQS
>Mature_429_residues
MKDYQKLLTGFILGIIVGLICYYTLPIKTFPFMQWAVDIATLIGAIFLRLIFMAVIPLLTSALILGVFELSQGRALGKVA
VQALVWTIVLSTIAVAIGLIGVNVVKPGVGTNFDIAAAEKQSIISITQTAETLRGLRWYQYIVNLLPQNPIESAAKALQG
EIIAVMVFAAIFGWAVSIVIKEENHSFIQVMQAIFEASMGVVKLALKMAPYAIFCIVFNTTYKMGAGFLKNLGVYAAVVV
VGLAIQLFVVYPFFLKVFAKKSPGEFFRGAKEPMLYAFSTSSSNATLPISLKAAEEELKLPPHIARFILTIGATANQNGT
ALFEGVTILFLAQVYGVDLSLSTQLLVMFAAILAGVGTAGVPAGSLPVIAALLAQVGVPPEGIGLILGIDRFLDMCRTTL
NVTGDLVIAELVTTSSGERGIPTVSTTQS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=445, Percent_Identity=28.9887640449438, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI66773030, Length=402, Percent_Identity=27.6119402985075, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI194239697, Length=470, Percent_Identity=28.2978723404255, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI223468564, Length=247, Percent_Identity=36.8421052631579, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI223468566, Length=247, Percent_Identity=36.8421052631579, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI5032093, Length=386, Percent_Identity=31.0880829015544, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI21314632, Length=393, Percent_Identity=28.7531806615776, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4827012, Length=281, Percent_Identity=32.0284697508897, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI40254478, Length=487, Percent_Identity=25.6673511293634, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI262359914, Length=380, Percent_Identity=27.3684210526316, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI301601644, Length=164, Percent_Identity=37.8048780487805, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1790514, Length=418, Percent_Identity=28.7081339712919, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1789947, Length=367, Percent_Identity=29.4277929155313, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788024, Length=392, Percent_Identity=25.765306122449, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1789473, Length=301, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71996953, Length=432, Percent_Identity=28.9351851851852, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71983106, Length=404, Percent_Identity=28.960396039604, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71983099, Length=404, Percent_Identity=28.960396039604, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17537407, Length=422, Percent_Identity=26.303317535545, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17541374, Length=401, Percent_Identity=27.1820448877805, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=439, Percent_Identity=25.0569476082005, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=427, Percent_Identity=25.5269320843091, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24583025, Length=422, Percent_Identity=26.0663507109005, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17137668, Length=422, Percent_Identity=26.0663507109005, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24583023, Length=422, Percent_Identity=26.0663507109005, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI281360481, Length=452, Percent_Identity=25.2212389380531, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360483, Length=452, Percent_Identity=25.2212389380531, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137666, Length=452, Percent_Identity=25.2212389380531, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45775; Mature: 45775

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDYQKLLTGFILGIIVGLICYYTLPIKTFPFMQWAVDIATLIGAIFLRLIFMAVIPLLT
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALILGVFELSQGRALGKVAVQALVWTIVLSTIAVAIGLIGVNVVKPGVGTNFDIAAAEK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHCH
QSIISITQTAETLRGLRWYQYIVNLLPQNPIESAAKALQGEIIAVMVFAAIFGWAVSIVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
KEENHSFIQVMQAIFEASMGVVKLALKMAPYAIFCIVFNTTYKMGAGFLKNLGVYAAVVV
ECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEECCHHHHHHHHHHHHHHHHHHHH
VGLAIQLFVVYPFFLKVFAKKSPGEFFRGAKEPMLYAFSTSSSNATLPISLKAAEEELKL
HHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCCCEEEEEEECCHHHCCC
PPHIARFILTIGATANQNGTALFEGVTILFLAQVYGVDLSLSTQLLVMFAAILAGVGTAG
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCC
VPAGSLPVIAALLAQVGVPPEGIGLILGIDRFLDMCRTTLNVTGDLVIAELVTTSSGERG
CCCCCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
IPTVSTTQS
CCCCCCCCC
>Mature Secondary Structure
MKDYQKLLTGFILGIIVGLICYYTLPIKTFPFMQWAVDIATLIGAIFLRLIFMAVIPLLT
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALILGVFELSQGRALGKVAVQALVWTIVLSTIAVAIGLIGVNVVKPGVGTNFDIAAAEK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHCH
QSIISITQTAETLRGLRWYQYIVNLLPQNPIESAAKALQGEIIAVMVFAAIFGWAVSIVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
KEENHSFIQVMQAIFEASMGVVKLALKMAPYAIFCIVFNTTYKMGAGFLKNLGVYAAVVV
ECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEECCHHHHHHHHHHHHHHHHHHHH
VGLAIQLFVVYPFFLKVFAKKSPGEFFRGAKEPMLYAFSTSSSNATLPISLKAAEEELKL
HHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCCCEEEEEEECCHHHCCC
PPHIARFILTIGATANQNGTALFEGVTILFLAQVYGVDLSLSTQLLVMFAAILAGVGTAG
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCC
VPAGSLPVIAALLAQVGVPPEGIGLILGIDRFLDMCRTTLNVTGDLVIAELVTTSSGERG
CCCCCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
IPTVSTTQS
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]