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The map label for this gene is ruvC

Identifier: 20807634

GI number: 20807634

Start: 1177208

End: 1177705

Strand: Direct

Name: ruvC

Synonym: TTE1178

Alternate gene names: 20807634

Gene position: 1177208-1177705 (Clockwise)

Preceding gene: 20807633

Following gene: 20807635

Centisome position: 43.77

GC content: 42.77

Gene sequence:

>498_bases
ATGAGGGTATTGGGAATAGATCCGGGAATTGCCACATTGGGATATGGAGTCGTTGAGTACAAGAACAACAAATTTTCTCC
CATAGTTTATGGAGCCATCACTACAGATGCGGGAGTTGACAAGGCGTTTCGTCTTTACACCCTATATAAGGGACTTGAAG
ATATTATAAAGCTTTATCGTCCAGAGATTGTAGCGATTGAAGAGCTTTTCTATAATAAAAATTCTAAGACGGTAATTACA
ATTGGAGAAGTTAGAGGGATTTCAATACTGGCTGCTGTAAATTCTGGGGTAAAAGTGTATGAGTATACCCCCCTACAGGT
GAAACAGGCAGTAGTTGGGTATGGGAGAGCGGAAAAACAGCAGGTTCAGCAGATGGTAAAGGTGCTTTTAAATCTTGATG
AGATACCAAAGCCAGATGATGTGGCTGATGCGCTGGCCGTTGCCATTTGCCACTGCCACAGCAATAATATGTTGGAAAGA
CTGGGGTATGGGCGATGA

Upstream 100 bases:

>100_bases
ACTTAATTTTATCTTTGAAAGGTCGATTTCTCCTTCGGGAGAACTTTTTCTTGTTTACAAGCTCTGTTGATGTTAAAATA
AATAAAAGGAGAGGAGAAGA

Downstream 100 bases:

>100_bases
TTGAGTACATAAGGGGAATTATTGAAGACATAGGACCAGATCATGTGATAATCGACCTTATGGGCATAGGTATAAAAATT
TTTGTGCCCTTTTCTACTAT

Product: Holliday junction resolvase

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MRVLGIDPGIATLGYGVVEYKNNKFSPIVYGAITTDAGVDKAFRLYTLYKGLEDIIKLYRPEIVAIEELFYNKNSKTVIT
IGEVRGISILAAVNSGVKVYEYTPLQVKQAVVGYGRAEKQQVQQMVKVLLNLDEIPKPDDVADALAVAICHCHSNNMLER
LGYGR

Sequences:

>Translated_165_residues
MRVLGIDPGIATLGYGVVEYKNNKFSPIVYGAITTDAGVDKAFRLYTLYKGLEDIIKLYRPEIVAIEELFYNKNSKTVIT
IGEVRGISILAAVNSGVKVYEYTPLQVKQAVVGYGRAEKQQVQQMVKVLLNLDEIPKPDDVADALAVAICHCHSNNMLER
LGYGR
>Mature_165_residues
MRVLGIDPGIATLGYGVVEYKNNKFSPIVYGAITTDAGVDKAFRLYTLYKGLEDIIKLYRPEIVAIEELFYNKNSKTVIT
IGEVRGISILAAVNSGVKVYEYTPLQVKQAVVGYGRAEKQQVQQMVKVLLNLDEIPKPDDVADALAVAICHCHSNNMLER
LGYGR

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=158, Percent_Identity=45.5696202531646, Blast_Score=115, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_THETN (Q8RAN4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622805.1
- ProteinModelPortal:   Q8RAN4
- SMR:   Q8RAN4
- GeneID:   995528
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1178
- NMPDR:   fig|273068.3.peg.875
- HOGENOM:   HBG437552
- OMA:   RTGWGVI
- ProtClustDB:   PRK00039
- BioCyc:   TTEN273068:TTE1178-MONOMER
- BRENDA:   3.1.22.4
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR020563
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 18267; Mature: 18267

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLGIDPGIATLGYGVVEYKNNKFSPIVYGAITTDAGVDKAFRLYTLYKGLEDIIKLYR
CEEEECCCCHHHHCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
PEIVAIEELFYNKNSKTVITIGEVRGISILAAVNSGVKVYEYTPLQVKQAVVGYGRAEKQ
CCCEEHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCEEEEECCHHHHHHHHCCCCCHHH
QVQQMVKVLLNLDEIPKPDDVADALAVAICHCHSNNMLERLGYGR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCC
>Mature Secondary Structure
MRVLGIDPGIATLGYGVVEYKNNKFSPIVYGAITTDAGVDKAFRLYTLYKGLEDIIKLYR
CEEEECCCCHHHHCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
PEIVAIEELFYNKNSKTVITIGEVRGISILAAVNSGVKVYEYTPLQVKQAVVGYGRAEKQ
CCCEEHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCEEEEECCHHHHHHHHCCCCCHHH
QVQQMVKVLLNLDEIPKPDDVADALAVAICHCHSNNMLERLGYGR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336