Click here to switch to the map view.

The map label for this gene is CysK [H]

Identifier: 20807594

GI number: 20807594

Start: 1135653

End: 1136573

Strand: Direct

Name: CysK [H]

Synonym: TTE1134

Alternate gene names: 20807594

Gene position: 1135653-1136573 (Clockwise)

Preceding gene: 20807591

Following gene: 20807595

Centisome position: 42.23

GC content: 42.13

Gene sequence:

>921_bases
ATGGTGGCGAACAATATTCTTGATTTGATAGGGAAAACCCCTGTGGTAAAGTTAAATAAGGTGCCTGATAAAAATAGCGC
TGAAGTGTACTTGAAACTTGAGTTTTTTAACCCTGCCGGCAGCGTCAAAGACAGAATTGCACTTGCTATGATAGAAAAGG
CAGAAAAAGAAGGGATATTAAAAAAAGGCAGTGTGATTGTGGAACCCACCAGTGGAAATACAGGAATAGGGCTGGCAATG
GTGGGGGCTGCAAAAGGATATAAAGTTATAATAGTCATGCCTGACACCATGAGCATGGAAAGGCGGATGCTTTTGGCTGC
TTACGGGGCAGAGGTGATTTTGACTCCTGGAAAACTGGGCATGGAGGGAGCTATTAGAAAAGCGGAAGAGTTAGTTAAGC
AGAACAAGAACTATTTCATGCCCCAGCAGTTTGAGAATTTAGCAAATCCTCTCATTCATGAAGAGACTACTGCAAAGGAA
ATAATAGAGGATTTTAAGGAAGGTTTAGATGCTTTTGTAGCCGGTATAGGTACAGGAGGGACTATTACGGGAGTTGGTAG
GGTCCTTAAAAAAGTTTTTCCAGATATAAAGATTGTGGGGGTAGAACCTTACTCTGCCGCAGTTTTATCTGGAAGAGAAC
CGGGTCCCCACAAGATTCAGGGAATTGGAGCAGGCTTTATACCCAAAGTCTTGGATAGAGAAGTGCTAAATGAAGTGATA
CCAGTGAAAGATGAAGATGCCTTTGAAATGACTAGAATTTTGGCCAAAAAAGAAGGTATTTTGGCAGGGATTTCTACTGG
TGCTTCTTTGTGGGCAGCGCTTAATGTAGCTAAGAAATTAGGAAAAGGGAAGAAAGTCCTTGCGATAGCGCCAGACAGTG
GAGAAAGGTATTTAAGCACTCAGATTTTCAGAGAACATTGA

Upstream 100 bases:

>100_bases
GTTTTCCTCTAAAAATTTTAACTATTCGAATTTCCATTTGACAGATTAAGTTTTGTCAGTTTAAAATGGGTATAGCAATG
TATGTATGGAGGTCTTTAAA

Downstream 100 bases:

>100_bases
GGAGGGATGTTTATGGCTGGACATTCCAAATGGGCTAATATAAAGCACAAAAAAGAAAAAATGGACGCTAAAAAAGGGAG
AATCTTTACTAAACTTACAA

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MVANNILDLIGKTPVVKLNKVPDKNSAEVYLKLEFFNPAGSVKDRIALAMIEKAEKEGILKKGSVIVEPTSGNTGIGLAM
VGAAKGYKVIIVMPDTMSMERRMLLAAYGAEVILTPGKLGMEGAIRKAEELVKQNKNYFMPQQFENLANPLIHEETTAKE
IIEDFKEGLDAFVAGIGTGGTITGVGRVLKKVFPDIKIVGVEPYSAAVLSGREPGPHKIQGIGAGFIPKVLDREVLNEVI
PVKDEDAFEMTRILAKKEGILAGISTGASLWAALNVAKKLGKGKKVLAIAPDSGERYLSTQIFREH

Sequences:

>Translated_306_residues
MVANNILDLIGKTPVVKLNKVPDKNSAEVYLKLEFFNPAGSVKDRIALAMIEKAEKEGILKKGSVIVEPTSGNTGIGLAM
VGAAKGYKVIIVMPDTMSMERRMLLAAYGAEVILTPGKLGMEGAIRKAEELVKQNKNYFMPQQFENLANPLIHEETTAKE
IIEDFKEGLDAFVAGIGTGGTITGVGRVLKKVFPDIKIVGVEPYSAAVLSGREPGPHKIQGIGAGFIPKVLDREVLNEVI
PVKDEDAFEMTRILAKKEGILAGISTGASLWAALNVAKKLGKGKKVLAIAPDSGERYLSTQIFREH
>Mature_306_residues
MVANNILDLIGKTPVVKLNKVPDKNSAEVYLKLEFFNPAGSVKDRIALAMIEKAEKEGILKKGSVIVEPTSGNTGIGLAM
VGAAKGYKVIIVMPDTMSMERRMLLAAYGAEVILTPGKLGMEGAIRKAEELVKQNKNYFMPQQFENLANPLIHEETTAKE
IIEDFKEGLDAFVAGIGTGGTITGVGRVLKKVFPDIKIVGVEPYSAAVLSGREPGPHKIQGIGAGFIPKVLDREVLNEVI
PVKDEDAFEMTRILAKKEGILAGISTGASLWAALNVAKKLGKGKKVLAIAPDSGERYLSTQIFREH

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=305, Percent_Identity=43.6065573770492, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI295821200, Length=305, Percent_Identity=43.6065573770492, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI4557415, Length=305, Percent_Identity=43.6065573770492, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI11345492, Length=206, Percent_Identity=27.1844660194175, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788754, Length=304, Percent_Identity=52.3026315789474, Blast_Score=254, Evalue=3e-69,
Organism=Escherichia coli, GI2367138, Length=296, Percent_Identity=43.5810810810811, Blast_Score=227, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=47.6666666666667, Blast_Score=273, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=47, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=48.122866894198, Blast_Score=260, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=48.0392156862745, Blast_Score=252, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=45.6375838926174, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=45.7943925233645, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI25147552, Length=313, Percent_Identity=38.6581469648562, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=38.7301587301587, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=44.0677966101695, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=335, Percent_Identity=27.1641791044776, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17539800, Length=339, Percent_Identity=26.8436578171091, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539640, Length=336, Percent_Identity=26.7857142857143, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=39.3650793650794, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=36.4197530864198, Blast_Score=145, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=43.8311688311688, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=43.8311688311688, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32922; Mature: 32922

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVANNILDLIGKTPVVKLNKVPDKNSAEVYLKLEFFNPAGSVKDRIALAMIEKAEKEGIL
CCCHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCE
KKGSVIVEPTSGNTGIGLAMVGAAKGYKVIIVMPDTMSMERRMLLAAYGAEVILTPGKLG
ECCCEEEEECCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCC
MEGAIRKAEELVKQNKNYFMPQQFENLANPLIHEETTAKEIIEDFKEGLDAFVAGIGTGG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
TITGVGRVLKKVFPDIKIVGVEPYSAAVLSGREPGPHKIQGIGAGFIPKVLDREVLNEVI
HHHHHHHHHHHHCCCEEEEEECCHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHC
PVKDEDAFEMTRILAKKEGILAGISTGASLWAALNVAKKLGKGKKVLAIAPDSGERYLST
CCCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
QIFREH
HHHHCC
>Mature Secondary Structure
MVANNILDLIGKTPVVKLNKVPDKNSAEVYLKLEFFNPAGSVKDRIALAMIEKAEKEGIL
CCCHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCE
KKGSVIVEPTSGNTGIGLAMVGAAKGYKVIIVMPDTMSMERRMLLAAYGAEVILTPGKLG
ECCCEEEEECCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCC
MEGAIRKAEELVKQNKNYFMPQQFENLANPLIHEETTAKEIIEDFKEGLDAFVAGIGTGG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
TITGVGRVLKKVFPDIKIVGVEPYSAAVLSGREPGPHKIQGIGAGFIPKVLDREVLNEVI
HHHHHHHHHHHHCCCEEEEEECCHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHC
PVKDEDAFEMTRILAKKEGILAGISTGASLWAALNVAKKLGKGKKVLAIAPDSGERYLST
CCCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
QIFREH
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA