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The map label for this gene is Zwf [H]

Identifier: 20807485

GI number: 20807485

Start: 1007603

End: 1009060

Strand: Direct

Name: Zwf [H]

Synonym: TTE1005

Alternate gene names: 20807485

Gene position: 1007603-1009060 (Clockwise)

Preceding gene: 20807484

Following gene: 20807486

Centisome position: 37.47

GC content: 37.52

Gene sequence:

>1458_bases
ATGAAAGATAAAGACCTTTCAAACGTGATGGTCATATTCGGTGGAACAGGAGATTTAACCCATAAAAAATTGATGCCGGC
CCTTTACAACTTAAGATATCAAAATATCCTGCCTGAAAATTTTGCTGTAGTTGCTATAGGGAGAAGAGACAAGACTGAAG
AGGAATATAGAAATGAGATGCTGGAGTCTGTTAAAACTTATTCTAGATTTGACATTGACGAAAAAATCTGGCAAGATTTA
AGTAGCAGGATATTCTACAAAAGATTTGATTTTAACTATGACAACGGATATATGGAACTTAGTTACTTTTTAGATGAACT
GGATAGGAAATACAATACACAGGGCAACAGGGTATATTATCTTGCAGTTGCACCGGAATATTTTGGCATCATTGTGGAAA
AGTTATACAGACACGGAATGGTAAGTAATGAAACTTCATGGCAGAGAGTAGTTATAGAAAAGCCTTTTGGAGAAAATTTA
GAATCTGCCCGGAAACTAAATAAAATGATAACAGATGTCTTTACAGAAAGAAATACTTATAGAATTGATCACTATTTAGG
AAAAGAGATGCTACAGAATATAATGGTCATCAGATTTGCCAATGTGTTTTTTGAGCCAGTTTGGAACAGAAGATATATAG
ACAATGTGCAAATTTCTTCTAATGAGACGGTAGGGATAGAAAATAGAGGAGGATACTACGAGAAAGCAGGAGCTTTGAGG
GACATGGTTCAAAACCACATGATGCAGCTTCTGACCTTGACGGCGATGGAACCACCTGTAAATTTGGATACAGAATCTAT
AAGGGATGAGAAGGTGAAGGTTTTAAAATCCTTAGAGATTATGACTCCTGAGCTTGTAGAGAAAAATGTGGTGAGAGGGC
AGTATGTGGGATATAGGCAGGAGGAAAAAGTATCTCCAACTTCCAATACAGAGACTTTTGTGGCATTAAAAGTGCACATA
GAAAATTTCAGATGGGCAGGAGTTCCTTTTTACATCAGGACTGGAAAAAGGATGCCGGAAAAATCCACACAGATTGTCAT
CCAATTTAAGCCTCTGCCAGGTATTTTGTATTTCAAAGAGTATAAAAATTTGCTTCCCAATTTGCTTGTAATAAAAATTC
AGCCGGAGGAAGGAGTAAAACTTCAGTTTAATGCCAAAGTGCCGGGAGCAGGAGATATAACTATAGAGCCTGTAAATATG
GATTTTTGTCAGAACTGCCAGATATCCAATAATTCTCCAGAGGCATATGAAAGACTTCTTTTTGATGTGATGAGAGGAGA
TTCTACTTTATTTACTCGCTGGGATGAGGTAGAATATTCTTGGAGGTTTGTAGATGCTATTGCTAAAGCATGGGCAGAAA
AAACACCCGATTTTCCTAATTACTATCCAGGGACCTGGGGTCCTAGTGAGGCAGAAGAGCTTTTGAGAAGAGATGGAAGA
ATGTGGTGGAATGTATAG

Upstream 100 bases:

>100_bases
ATATGTGGTATAATAATATAACTACTCAAGATAAAAAGTATTAATTGACAATAAATAGTTGCACGGAATCGTTTAACAAC
ATTTTCGTGAGGTGATCAAC

Downstream 100 bases:

>100_bases
GATAGGGGGATGGAAAGTGAAGATATACGATATTTCTATGGAAATTCATGAAAATATGACTGTCTACAAAAACAAGGAGG
AAAAAAGGCCTCAGCATACT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKDKDLSNVMVIFGGTGDLTHKKLMPALYNLRYQNILPENFAVVAIGRRDKTEEEYRNEMLESVKTYSRFDIDEKIWQDL
SSRIFYKRFDFNYDNGYMELSYFLDELDRKYNTQGNRVYYLAVAPEYFGIIVEKLYRHGMVSNETSWQRVVIEKPFGENL
ESARKLNKMITDVFTERNTYRIDHYLGKEMLQNIMVIRFANVFFEPVWNRRYIDNVQISSNETVGIENRGGYYEKAGALR
DMVQNHMMQLLTLTAMEPPVNLDTESIRDEKVKVLKSLEIMTPELVEKNVVRGQYVGYRQEEKVSPTSNTETFVALKVHI
ENFRWAGVPFYIRTGKRMPEKSTQIVIQFKPLPGILYFKEYKNLLPNLLVIKIQPEEGVKLQFNAKVPGAGDITIEPVNM
DFCQNCQISNNSPEAYERLLFDVMRGDSTLFTRWDEVEYSWRFVDAIAKAWAEKTPDFPNYYPGTWGPSEAEELLRRDGR
MWWNV

Sequences:

>Translated_485_residues
MKDKDLSNVMVIFGGTGDLTHKKLMPALYNLRYQNILPENFAVVAIGRRDKTEEEYRNEMLESVKTYSRFDIDEKIWQDL
SSRIFYKRFDFNYDNGYMELSYFLDELDRKYNTQGNRVYYLAVAPEYFGIIVEKLYRHGMVSNETSWQRVVIEKPFGENL
ESARKLNKMITDVFTERNTYRIDHYLGKEMLQNIMVIRFANVFFEPVWNRRYIDNVQISSNETVGIENRGGYYEKAGALR
DMVQNHMMQLLTLTAMEPPVNLDTESIRDEKVKVLKSLEIMTPELVEKNVVRGQYVGYRQEEKVSPTSNTETFVALKVHI
ENFRWAGVPFYIRTGKRMPEKSTQIVIQFKPLPGILYFKEYKNLLPNLLVIKIQPEEGVKLQFNAKVPGAGDITIEPVNM
DFCQNCQISNNSPEAYERLLFDVMRGDSTLFTRWDEVEYSWRFVDAIAKAWAEKTPDFPNYYPGTWGPSEAEELLRRDGR
MWWNV
>Mature_485_residues
MKDKDLSNVMVIFGGTGDLTHKKLMPALYNLRYQNILPENFAVVAIGRRDKTEEEYRNEMLESVKTYSRFDIDEKIWQDL
SSRIFYKRFDFNYDNGYMELSYFLDELDRKYNTQGNRVYYLAVAPEYFGIIVEKLYRHGMVSNETSWQRVVIEKPFGENL
ESARKLNKMITDVFTERNTYRIDHYLGKEMLQNIMVIRFANVFFEPVWNRRYIDNVQISSNETVGIENRGGYYEKAGALR
DMVQNHMMQLLTLTAMEPPVNLDTESIRDEKVKVLKSLEIMTPELVEKNVVRGQYVGYRQEEKVSPTSNTETFVALKVHI
ENFRWAGVPFYIRTGKRMPEKSTQIVIQFKPLPGILYFKEYKNLLPNLLVIKIQPEEGVKLQFNAKVPGAGDITIEPVNM
DFCQNCQISNNSPEAYERLLFDVMRGDSTLFTRWDEVEYSWRFVDAIAKAWAEKTPDFPNYYPGTWGPSEAEELLRRDGR
MWWNV

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=487, Percent_Identity=36.1396303901437, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI109389365, Length=487, Percent_Identity=36.1396303901437, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI52145310, Length=494, Percent_Identity=27.9352226720648, Blast_Score=156, Evalue=5e-38,
Organism=Escherichia coli, GI1788158, Length=487, Percent_Identity=41.6837782340862, Blast_Score=384, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17538218, Length=486, Percent_Identity=39.0946502057613, Blast_Score=335, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6324088, Length=483, Percent_Identity=35.8178053830228, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24643350, Length=483, Percent_Identity=34.5755693581781, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24643352, Length=483, Percent_Identity=34.5755693581781, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI221513548, Length=488, Percent_Identity=28.2786885245902, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57063; Mature: 57063

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKDLSNVMVIFGGTGDLTHKKLMPALYNLRYQNILPENFAVVAIGRRDKTEEEYRNEM
CCCCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHCCCCCEEEEEECCCCCCHHHHHHHH
LESVKTYSRFDIDEKIWQDLSSRIFYKRFDFNYDNGYMELSYFLDELDRKYNTQGNRVYY
HHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCEEEE
LAVAPEYFGIIVEKLYRHGMVSNETSWQRVVIEKPFGENLESARKLNKMITDVFTERNTY
EEECHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCE
RIDHYLGKEMLQNIMVIRFANVFFEPVWNRRYIDNVQISSNETVGIENRGGYYEKAGALR
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEECCCCEEEECCCCCCHHHHHHHH
DMVQNHMMQLLTLTAMEPPVNLDTESIRDEKVKVLKSLEIMTPELVEKNVVRGQYVGYRQ
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHCCCCC
EEKVSPTSNTETFVALKVHIENFRWAGVPFYIRTGKRMPEKSTQIVIQFKPLPGILYFKE
CCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCCCCCCCCEEEEEEECCCCEEHHHH
YKNLLPNLLVIKIQPEEGVKLQFNAKVPGAGDITIEPVNMDFCQNCQISNNSPEAYERLL
HHHCCCCEEEEEEECCCCCEEEEECCCCCCCCEEEEECCHHHHCCCCCCCCCHHHHHHHH
FDVMRGDSTLFTRWDEVEYSWRFVDAIAKAWAEKTPDFPNYYPGTWGPSEAEELLRRDGR
HHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC
MWWNV
EECCC
>Mature Secondary Structure
MKDKDLSNVMVIFGGTGDLTHKKLMPALYNLRYQNILPENFAVVAIGRRDKTEEEYRNEM
CCCCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHCCCCCEEEEEECCCCCCHHHHHHHH
LESVKTYSRFDIDEKIWQDLSSRIFYKRFDFNYDNGYMELSYFLDELDRKYNTQGNRVYY
HHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCEEEE
LAVAPEYFGIIVEKLYRHGMVSNETSWQRVVIEKPFGENLESARKLNKMITDVFTERNTY
EEECHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCE
RIDHYLGKEMLQNIMVIRFANVFFEPVWNRRYIDNVQISSNETVGIENRGGYYEKAGALR
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEECCCCEEEECCCCCCHHHHHHHH
DMVQNHMMQLLTLTAMEPPVNLDTESIRDEKVKVLKSLEIMTPELVEKNVVRGQYVGYRQ
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHCCCCC
EEKVSPTSNTETFVALKVHIENFRWAGVPFYIRTGKRMPEKSTQIVIQFKPLPGILYFKE
CCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCCCCCCCCEEEEEEECCCCEEHHHH
YKNLLPNLLVIKIQPEEGVKLQFNAKVPGAGDITIEPVNMDFCQNCQISNNSPEAYERLL
HHHCCCCEEEEEEECCCCCEEEEECCCCCCCCEEEEECCHHHHCCCCCCCCCHHHHHHHH
FDVMRGDSTLFTRWDEVEYSWRFVDAIAKAWAEKTPDFPNYYPGTWGPSEAEELLRRDGR
HHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC
MWWNV
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]