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The map label for this gene is HrcA

Identifier: 20807434

GI number: 20807434

Start: 957238

End: 958269

Strand: Direct

Name: HrcA

Synonym: TTE0953

Alternate gene names: 20807434

Gene position: 957238-958269 (Clockwise)

Preceding gene: 20807433

Following gene: 20807435

Centisome position: 35.59

GC content: 37.5

Gene sequence:

>1032_bases
ATGCCGTTAGATGATAGGAAGAAAAGGATTCTCTTTGCTGTTGTTACTGATTACATCATGACGGCAGAACCAATAGGGTC
AAGGACTATTGCAAAAAAGTACAATATGGGCATAAGCTCTGCGACAATAAGAAATGAAATGGCTGATTTGGAGGAAATGG
GATATTTGGAGCAGCCTCACACTTCTGCTGGTAGAATACCTTCTGACAAAGGTTATAGATTTTACGTTGATACTATTTTG
CAGAATTTCATGAAGGAGGATTTAAGCCCTCCTCCGAGGGTGAGAGAAGAGGTCATAGCTGAGTTCGATGAGATTGTAAA
AAAGTATGCGAAAATTCTGGCGGATATAACTCACCACACCACTGTTGCAAAAATGCCAAAGCTAAACCCTGACAAGATCA
AAAGGTTGCAGCTTATCCCCGTGGCTTCAAATAAGATGATAATGGTAGTGATTACTGATACAGGAATTGTGAAAAATTAT
TTGCTGAATTTGTGCCAGAGTGTAGATAGAAATGTGTTCGAGTTTTTAAACAACCTCTTGAATGACAAAATTGCAGGAAA
AAGCGAAAAGGCGATTTTTAACTTCCTTGAAAAGGAGCTAAAAGACACTCTAGGAGATATGGCTTTTATGGCGGATGAGC
TTATAAAGACCATACTTTTGAGTTTAAAGCAGTTGCAGGAGACAGATGTTTACACTGATGGCACTTTACACATTCTTGAT
TTTCCAGAATATAAGGACTTGAACAAAGCAAAGAATTTTTTAAGCCTTCTGGACAATAAGTCCTTACTAAATGAAGTTTT
AGAACCAGTAGATGACTTTGTAGATGTTAAAATTGGGAGAGAAAACAGATTTGAAGAGATGAGAGAACTCAGTGTTATAA
AGACCACCTATAAAATAAATGATAGGGTAGTTGGAACTATAGGAATAATAGGACCTACCCGAATGGACTACAGAAGGCTT
ATAAGCGAGCTTACGCTTATGACGAGAGAACTTTCAAATCTCTTGTCTTCGATATACAATGATGAAGTATGA

Upstream 100 bases:

>100_bases
CCTAAAATGAGTATTGACAAAAAATTATAAGAGTGGTATTTTAAAAACATGGATTAGCACTCAATGAGTGAGAGTGCTAA
TAATACATGGGGTGGTGAAA

Downstream 100 bases:

>100_bases
CGGGGTGATATAAGTGGAAGAATTGGAAAAAGACAAAATTGAAAGAAATGAAGAGATGAGCGAGGAGGTAAAAGGAGAGG
GTCCTCCTTCTGAATTGGAG

Product: heat shock gene transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MPLDDRKKRILFAVVTDYIMTAEPIGSRTIAKKYNMGISSATIRNEMADLEEMGYLEQPHTSAGRIPSDKGYRFYVDTIL
QNFMKEDLSPPPRVREEVIAEFDEIVKKYAKILADITHHTTVAKMPKLNPDKIKRLQLIPVASNKMIMVVITDTGIVKNY
LLNLCQSVDRNVFEFLNNLLNDKIAGKSEKAIFNFLEKELKDTLGDMAFMADELIKTILLSLKQLQETDVYTDGTLHILD
FPEYKDLNKAKNFLSLLDNKSLLNEVLEPVDDFVDVKIGRENRFEEMRELSVIKTTYKINDRVVGTIGIIGPTRMDYRRL
ISELTLMTRELSNLLSSIYNDEV

Sequences:

>Translated_343_residues
MPLDDRKKRILFAVVTDYIMTAEPIGSRTIAKKYNMGISSATIRNEMADLEEMGYLEQPHTSAGRIPSDKGYRFYVDTIL
QNFMKEDLSPPPRVREEVIAEFDEIVKKYAKILADITHHTTVAKMPKLNPDKIKRLQLIPVASNKMIMVVITDTGIVKNY
LLNLCQSVDRNVFEFLNNLLNDKIAGKSEKAIFNFLEKELKDTLGDMAFMADELIKTILLSLKQLQETDVYTDGTLHILD
FPEYKDLNKAKNFLSLLDNKSLLNEVLEPVDDFVDVKIGRENRFEEMRELSVIKTTYKINDRVVGTIGIIGPTRMDYRRL
ISELTLMTRELSNLLSSIYNDEV
>Mature_342_residues
PLDDRKKRILFAVVTDYIMTAEPIGSRTIAKKYNMGISSATIRNEMADLEEMGYLEQPHTSAGRIPSDKGYRFYVDTILQ
NFMKEDLSPPPRVREEVIAEFDEIVKKYAKILADITHHTTVAKMPKLNPDKIKRLQLIPVASNKMIMVVITDTGIVKNYL
LNLCQSVDRNVFEFLNNLLNDKIAGKSEKAIFNFLEKELKDTLGDMAFMADELIKTILLSLKQLQETDVYTDGTLHILDF
PEYKDLNKAKNFLSLLDNKSLLNEVLEPVDDFVDVKIGRENRFEEMRELSVIKTTYKINDRVVGTIGIIGPTRMDYRRLI
SELTLMTRELSNLLSSIYNDEV

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_THETN (Q8RB70)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622605.1
- GeneID:   995850
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0953
- NMPDR:   fig|273068.3.peg.377
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   CLSK901016
- BioCyc:   TTEN273068:TTE0953-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR023120
- InterPro:   IPR011991
- Gene3D:   G3DSA:3.30.390.60
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 39370; Mature: 39239

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDDRKKRILFAVVTDYIMTAEPIGSRTIAKKYNMGISSATIRNEMADLEEMGYLEQPH
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
TSAGRIPSDKGYRFYVDTILQNFMKEDLSPPPRVREEVIAEFDEIVKKYAKILADITHHT
CCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVAKMPKLNPDKIKRLQLIPVASNKMIMVVITDTGIVKNYLLNLCQSVDRNVFEFLNNLL
HHHHCCCCCHHHHHHEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
NDKIAGKSEKAIFNFLEKELKDTLGDMAFMADELIKTILLSLKQLQETDVYTDGTLHILD
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
FPEYKDLNKAKNFLSLLDNKSLLNEVLEPVDDFVDVKIGRENRFEEMRELSVIKTTYKIN
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHEEC
DRVVGTIGIIGPTRMDYRRLISELTLMTRELSNLLSSIYNDEV
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLDDRKKRILFAVVTDYIMTAEPIGSRTIAKKYNMGISSATIRNEMADLEEMGYLEQPH
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
TSAGRIPSDKGYRFYVDTILQNFMKEDLSPPPRVREEVIAEFDEIVKKYAKILADITHHT
CCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVAKMPKLNPDKIKRLQLIPVASNKMIMVVITDTGIVKNYLLNLCQSVDRNVFEFLNNLL
HHHHCCCCCHHHHHHEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
NDKIAGKSEKAIFNFLEKELKDTLGDMAFMADELIKTILLSLKQLQETDVYTDGTLHILD
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
FPEYKDLNKAKNFLSLLDNKSLLNEVLEPVDDFVDVKIGRENRFEEMRELSVIKTTYKIN
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHEEC
DRVVGTIGIIGPTRMDYRRLISELTLMTRELSNLLSSIYNDEV
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336