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The map label for this gene is HemN [H]

Identifier: 20807433

GI number: 20807433

Start: 956005

End: 957132

Strand: Direct

Name: HemN [H]

Synonym: TTE0952

Alternate gene names: 20807433

Gene position: 956005-957132 (Clockwise)

Preceding gene: 20807432

Following gene: 20807434

Centisome position: 35.55

GC content: 36.97

Gene sequence:

>1128_bases
ATGAGGGAAATAGGTATATACATTCACATTCCTTTTTGCAAGAAAAAATGCTATTACTGTGATTTTAATTCTTACGCCGG
CTATGAACACTTGATGGAGGACTATTTAAAGGCTTTGCTTGAAGAGGTTAAAACATATTCCGACAGAAGCTTTAGGGTTA
TTTCTGTGTATATAGGAGGAGGTACTCCCAATTTCCTCCCTCCTTCCCATGTAGAAAGAGTGCTAAGTGAAGTTCACAAA
GACTATAATGTATCGAGGGATGCTGAGATTACAATTGAAGTAAATCCCGGGCTTTTGACAGAGGATAAATTAAAAATTTA
CAAGATAAACGGCATAAACCGAATAAGCATGGGACTTCAGGCTTTTCAGAATCGCCTTCTTGAGTATATCGGTCGAATCC
ACACAGCAGAAGACTTTCTTGAAAACTACGCTCTTGTGAGAAAATATTTTGACAATGTGAATGTTGATTTAATTTACGCC
CTGCCAACGCAAAGTTTTGAAGAGTGGCAGGAAACTTTGACAAAAGTTGTAGAATTAAAACCTGAACACATCTCTACTTA
CAGCCTCATTTTGGAAGAAAATACCCTCTTTGGAAGACTTTATAAGGAAAATAGGCTTCCTGTGGTGGGAGAAGAAGAGG
AACTTAAGATGTACCACTGGGGAATAGAGTTTTTAAAAAGCAAGGGATACTGCCATTATGAGATTTCAAATTTTGCTCTT
TTAGGATACCAGTGCAGACACAACATTTTGTACTGGGAGTGCAGAGAATATTTAGGCTTTGGAGCAGGTGCTCACTCTTA
CTTTGAAGGTACAAGGTGGAACAATGTAGAAAGAATAGAGAAATATATTGAAGCCATTTTGAAAAGAAAAGATGCTAGAG
AAGAGATTATAAACTTAAGCTTTGAAGACAAAATGTCAGAATTTATGTTTTTGGGCTTAAGAATGAGAAAAGGGGTGTGC
GAAGAGGAATTCAGAAAAAGGTTTGGAATCAGTATGTTTGAAAGGTACGAGGAGATTTTCATTAAGTATGAGAAGATGGG
ACTTATCGAGAAAGATAAAGATTGTGTGAGGCTGACAGAGAAAGGGATAGATGTTTCAAATGTGATTTTTGAAGATTTCT
TGCCCTAA

Upstream 100 bases:

>100_bases
TGGAGAAGCAGAAGGAAGGTAAAAAGAGGATGAGACAAATAGGGACTGTGGAAATACCGCAGGAAGCTTTTATGTCAATT
TTAAAGTTGGATGACCAAAA

Downstream 100 bases:

>100_bases
GGCACCCTAAAATGAGTATTGACAAAAAATTATAAGAGTGGTATTTTAAAAACATGGATTAGCACTCAATGAGTGAGAGT
GCTAATAATACATGGGGTGG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MREIGIYIHIPFCKKKCYYCDFNSYAGYEHLMEDYLKALLEEVKTYSDRSFRVISVYIGGGTPNFLPPSHVERVLSEVHK
DYNVSRDAEITIEVNPGLLTEDKLKIYKINGINRISMGLQAFQNRLLEYIGRIHTAEDFLENYALVRKYFDNVNVDLIYA
LPTQSFEEWQETLTKVVELKPEHISTYSLILEENTLFGRLYKENRLPVVGEEEELKMYHWGIEFLKSKGYCHYEISNFAL
LGYQCRHNILYWECREYLGFGAGAHSYFEGTRWNNVERIEKYIEAILKRKDAREEIINLSFEDKMSEFMFLGLRMRKGVC
EEEFRKRFGISMFERYEEIFIKYEKMGLIEKDKDCVRLTEKGIDVSNVIFEDFLP

Sequences:

>Translated_375_residues
MREIGIYIHIPFCKKKCYYCDFNSYAGYEHLMEDYLKALLEEVKTYSDRSFRVISVYIGGGTPNFLPPSHVERVLSEVHK
DYNVSRDAEITIEVNPGLLTEDKLKIYKINGINRISMGLQAFQNRLLEYIGRIHTAEDFLENYALVRKYFDNVNVDLIYA
LPTQSFEEWQETLTKVVELKPEHISTYSLILEENTLFGRLYKENRLPVVGEEEELKMYHWGIEFLKSKGYCHYEISNFAL
LGYQCRHNILYWECREYLGFGAGAHSYFEGTRWNNVERIEKYIEAILKRKDAREEIINLSFEDKMSEFMFLGLRMRKGVC
EEEFRKRFGISMFERYEEIFIKYEKMGLIEKDKDCVRLTEKGIDVSNVIFEDFLP
>Mature_375_residues
MREIGIYIHIPFCKKKCYYCDFNSYAGYEHLMEDYLKALLEEVKTYSDRSFRVISVYIGGGTPNFLPPSHVERVLSEVHK
DYNVSRDAEITIEVNPGLLTEDKLKIYKINGINRISMGLQAFQNRLLEYIGRIHTAEDFLENYALVRKYFDNVNVDLIYA
LPTQSFEEWQETLTKVVELKPEHISTYSLILEENTLFGRLYKENRLPVVGEEEELKMYHWGIEFLKSKGYCHYEISNFAL
LGYQCRHNILYWECREYLGFGAGAHSYFEGTRWNNVERIEKYIEAILKRKDAREEIINLSFEDKMSEFMFLGLRMRKGVC
EEEFRKRFGISMFERYEEIFIKYEKMGLIEKDKDCVRLTEKGIDVSNVIFEDFLP

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=270, Percent_Identity=36.6666666666667, Blast_Score=184, Evalue=8e-47,
Organism=Escherichia coli, GI1789325, Length=391, Percent_Identity=32.4808184143223, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI87082341, Length=388, Percent_Identity=27.5773195876289, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 44548; Mature: 44548

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREIGIYIHIPFCKKKCYYCDFNSYAGYEHLMEDYLKALLEEVKTYSDRSFRVISVYIGG
CCEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
GTPNFLPPSHVERVLSEVHKDYNVSRDAEITIEVNPGLLTEDKLKIYKINGINRISMGLQ
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHH
AFQNRLLEYIGRIHTAEDFLENYALVRKYFDNVNVDLIYALPTQSFEEWQETLTKVVELK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
PEHISTYSLILEENTLFGRLYKENRLPVVGEEEELKMYHWGIEFLKSKGYCHYEISNFAL
CCCCCEEEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCEEE
LGYQCRHNILYWECREYLGFGAGAHSYFEGTRWNNVERIEKYIEAILKRKDAREEIINLS
EEHHHHCCCHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCC
FEDKMSEFMFLGLRMRKGVCEEEFRKRFGISMFERYEEIFIKYEKMGLIEKDKDCVRLTE
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
KGIDVSNVIFEDFLP
CCCCHHHHHHHHCCC
>Mature Secondary Structure
MREIGIYIHIPFCKKKCYYCDFNSYAGYEHLMEDYLKALLEEVKTYSDRSFRVISVYIGG
CCEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
GTPNFLPPSHVERVLSEVHKDYNVSRDAEITIEVNPGLLTEDKLKIYKINGINRISMGLQ
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHH
AFQNRLLEYIGRIHTAEDFLENYALVRKYFDNVNVDLIYALPTQSFEEWQETLTKVVELK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
PEHISTYSLILEENTLFGRLYKENRLPVVGEEEELKMYHWGIEFLKSKGYCHYEISNFAL
CCCCCEEEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCEEE
LGYQCRHNILYWECREYLGFGAGAHSYFEGTRWNNVERIEKYIEAILKRKDAREEIINLS
EEHHHHCCCHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCC
FEDKMSEFMFLGLRMRKGVCEEEFRKRFGISMFERYEEIFIKYEKMGLIEKDKDCVRLTE
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
KGIDVSNVIFEDFLP
CCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]