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The map label for this gene is hutH

Identifier: 20807326

GI number: 20807326

Start: 852056

End: 853582

Strand: Direct

Name: hutH

Synonym: TTE0844

Alternate gene names: 20807326

Gene position: 852056-853582 (Clockwise)

Preceding gene: 20807325

Following gene: 20807327

Centisome position: 31.68

GC content: 42.17

Gene sequence:

>1527_bases
ATGAAAAAAGTTGTGATTGATGGCAATAATTTGACAATAGAGGATGTGGTAAAAGTTGCAAGAGATAAATGGGAAGTTGT
GTTAAGTGAAGTGGCGAAAGAGAGAATTGTCCACTCAAGGGAGATAGTTGATAGATATGTTAAAGAGGGGAAAGTGGTGT
ACGGCATTACTACGGGTTTCGGGAAATTTAGTGACGTGGTAATCTCTAAAGAGGATACAGAAGCGCTCCAAAAGAACCTG
ATAATGAGCCATTCTTGCGCAGTGGGAGATCCATTGCCTGAAGAAGTAGTGAGAGCCATCATGCTTTTGAGGGCAAATGC
TTTGGCTAAAGGTTTTTCAGGAGTGAGGCTAGAAACAGTTGAGACGCTAATTGAAATGATAAACAAAAATGTGGTGCCTG
TAATTCCAGAAAAGGGTTCGCTGGGGGCTAGTGGAGACCTTGCGCCTTTGGCTCATATGGTATTAGTTATGATAGGTAGG
GGAGAGGCTTTTTATGCTGGAGAGAGAGTATCTGGAGAAGAGGCCATGAGGAGGGCAGGAATACCTACCATTACTTTAAG
CTCAAAGGAAGGTTTGGCACTTATAAATGGGACTCAGGTGATGTCAGCATTAGGATGCCTCAATGTATATGACGCAAAAA
GGATAATTGCCGTTGCTGATGCTGTGGCTTCTATAACTTTGGAAGCTTTGAGGGGAATAATAGATGCCTTTGATGACAGG
GTTCAGATGGTTAGGCCTCATAAAGGGCAGATTGTATCTGCCAAAAATGTGAGGAAAATGGTGGAAGGAAGTGAACTTAT
AACGAGGCAGGGAGAAATTAGGGTGCAGGATGCCTATACATTAAGGTGTATTCCTCAGGTACACGGCGCTGTGAGAGATG
CCATATCCTACATTGAACGGGTTTTAGGTGTAGAGATAAATTCTGCTACTGACAATCCGCTGATTTTCCCCGATGATGGT
GAAGTAATTTCAGGAGGAAATTTTCACGGCGAACCTGTAGCCCTTGCAATGGATTTTCTTTCCATTGCCCTTTCAGAAAT
TGCAAATATTTCTGAAAGGCGAATTGAAAGGCTGGTCAATTATCAGCTGAATGATTTACCGCCTTTTTTGACGGAAAAAG
GGGGACTTAATTCAGGGATGATGATTGCACAGTACACAGCAGCCTCTCTGGTTTCTGAAAATAAGGTGCTTTCTCATCCA
GCTTCGGTGGATTCAATTCCTTCTTCTGCTAACCAGGAGGACCATGTCAGCATGGGCACAATCGCAGCTAGAAAAGCAAG
AGAGGTTCTTAAAAATGTGACTACAGTTCTAGCTATAGAGCTTCTGACAGCCTCACAGGCATTGGAATTTAGAAAAGGGT
TTAAAAGAGGTAAAGGGACAGATAGAATATATAGGTTGGTGAGAGAAAAAGTAAATCCTCTTGTTGAGGATAGGGAACTT
TATATTGACATAAATGCTTGCTTTGATATCATAAGGTCAGGGAGGATTGAAGAAGTTTTGAAAGAGGAAGGAATAATGCT
TGAGTAG

Upstream 100 bases:

>100_bases
TACAGTATCTTACAATTTAATAATGAAAAAGAAGGCGGGGTTTTACCTCGCCTTTTTGATTTTATTGTGATAAAGGATTA
ACGTGAAAAGGAGGGGGATT

Downstream 100 bases:

>100_bases
GTGAATTTAGTGAGGAGAATAAAACAGTATTTGAAGGCAATAAGAGCGTGCGTTTCAGAAGAGGACTATAAGTTTTTGCT
TAGAGTGCTCAGCAAAAAAG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MKKVVIDGNNLTIEDVVKVARDKWEVVLSEVAKERIVHSREIVDRYVKEGKVVYGITTGFGKFSDVVISKEDTEALQKNL
IMSHSCAVGDPLPEEVVRAIMLLRANALAKGFSGVRLETVETLIEMINKNVVPVIPEKGSLGASGDLAPLAHMVLVMIGR
GEAFYAGERVSGEEAMRRAGIPTITLSSKEGLALINGTQVMSALGCLNVYDAKRIIAVADAVASITLEALRGIIDAFDDR
VQMVRPHKGQIVSAKNVRKMVEGSELITRQGEIRVQDAYTLRCIPQVHGAVRDAISYIERVLGVEINSATDNPLIFPDDG
EVISGGNFHGEPVALAMDFLSIALSEIANISERRIERLVNYQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSENKVLSHP
ASVDSIPSSANQEDHVSMGTIAARKAREVLKNVTTVLAIELLTASQALEFRKGFKRGKGTDRIYRLVREKVNPLVEDREL
YIDINACFDIIRSGRIEEVLKEEGIMLE

Sequences:

>Translated_508_residues
MKKVVIDGNNLTIEDVVKVARDKWEVVLSEVAKERIVHSREIVDRYVKEGKVVYGITTGFGKFSDVVISKEDTEALQKNL
IMSHSCAVGDPLPEEVVRAIMLLRANALAKGFSGVRLETVETLIEMINKNVVPVIPEKGSLGASGDLAPLAHMVLVMIGR
GEAFYAGERVSGEEAMRRAGIPTITLSSKEGLALINGTQVMSALGCLNVYDAKRIIAVADAVASITLEALRGIIDAFDDR
VQMVRPHKGQIVSAKNVRKMVEGSELITRQGEIRVQDAYTLRCIPQVHGAVRDAISYIERVLGVEINSATDNPLIFPDDG
EVISGGNFHGEPVALAMDFLSIALSEIANISERRIERLVNYQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSENKVLSHP
ASVDSIPSSANQEDHVSMGTIAARKAREVLKNVTTVLAIELLTASQALEFRKGFKRGKGTDRIYRLVREKVNPLVEDREL
YIDINACFDIIRSGRIEEVLKEEGIMLE
>Mature_508_residues
MKKVVIDGNNLTIEDVVKVARDKWEVVLSEVAKERIVHSREIVDRYVKEGKVVYGITTGFGKFSDVVISKEDTEALQKNL
IMSHSCAVGDPLPEEVVRAIMLLRANALAKGFSGVRLETVETLIEMINKNVVPVIPEKGSLGASGDLAPLAHMVLVMIGR
GEAFYAGERVSGEEAMRRAGIPTITLSSKEGLALINGTQVMSALGCLNVYDAKRIIAVADAVASITLEALRGIIDAFDDR
VQMVRPHKGQIVSAKNVRKMVEGSELITRQGEIRVQDAYTLRCIPQVHGAVRDAISYIERVLGVEINSATDNPLIFPDDG
EVISGGNFHGEPVALAMDFLSIALSEIANISERRIERLVNYQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSENKVLSHP
ASVDSIPSSANQEDHVSMGTIAARKAREVLKNVTTVLAIELLTASQALEFRKGFKRGKGTDRIYRLVREKVNPLVEDREL
YIDINACFDIIRSGRIEEVLKEEGIMLE

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=504, Percent_Identity=48.4126984126984, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17567831, Length=510, Percent_Identity=45.6862745098039, Blast_Score=436, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_THETN (Q8RBH4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622497.1
- ProteinModelPortal:   Q8RBH4
- SMR:   Q8RBH4
- GeneID:   995586
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0844
- NMPDR:   fig|273068.3.peg.1157
- HOGENOM:   HBG510887
- OMA:   CKPDDTI
- ProtClustDB:   PRK09367
- BioCyc:   TTEN273068:TTE0844-MONOMER
- BRENDA:   4.3.1.3
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 55571; Mature: 55571

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00488 PAL_HISTIDASE; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVVIDGNNLTIEDVVKVARDKWEVVLSEVAKERIVHSREIVDRYVKEGKVVYGITTGF
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
GKFSDVVISKEDTEALQKNLIMSHSCAVGDPLPEEVVRAIMLLRANALAKGFSGVRLETV
CCHHHEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
ETLIEMINKNVVPVIPEKGSLGASGDLAPLAHMVLVMIGRGEAFYAGERVSGEEAMRRAG
HHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHCC
IPTITLSSKEGLALINGTQVMSALGCLNVYDAKRIIAVADAVASITLEALRGIIDAFDDR
CCEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQMVRPHKGQIVSAKNVRKMVEGSELITRQGEIRVQDAYTLRCIPQVHGAVRDAISYIER
HHHCCCCCCCEECHHHHHHHHCCHHHHHCCCCEEEECCEEEEEHHHHHHHHHHHHHHHHH
VLGVEINSATDNPLIFPDDGEVISGGNFHGEPVALAMDFLSIALSEIANISERRIERLVN
HHCCEEECCCCCCEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
YQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSENKVLSHPASVDSIPSSANQEDHVSMGT
CCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCHHHH
IAARKAREVLKNVTTVLAIELLTASQALEFRKGFKRGKGTDRIYRLVREKVNPLVEDREL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEE
YIDINACFDIIRSGRIEEVLKEEGIMLE
EEEHHHHHHHHHCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MKKVVIDGNNLTIEDVVKVARDKWEVVLSEVAKERIVHSREIVDRYVKEGKVVYGITTGF
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
GKFSDVVISKEDTEALQKNLIMSHSCAVGDPLPEEVVRAIMLLRANALAKGFSGVRLETV
CCHHHEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
ETLIEMINKNVVPVIPEKGSLGASGDLAPLAHMVLVMIGRGEAFYAGERVSGEEAMRRAG
HHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHCC
IPTITLSSKEGLALINGTQVMSALGCLNVYDAKRIIAVADAVASITLEALRGIIDAFDDR
CCEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQMVRPHKGQIVSAKNVRKMVEGSELITRQGEIRVQDAYTLRCIPQVHGAVRDAISYIER
HHHCCCCCCCEECHHHHHHHHCCHHHHHCCCCEEEECCEEEEEHHHHHHHHHHHHHHHHH
VLGVEINSATDNPLIFPDDGEVISGGNFHGEPVALAMDFLSIALSEIANISERRIERLVN
HHCCEEECCCCCCEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
YQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSENKVLSHPASVDSIPSSANQEDHVSMGT
CCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCHHHH
IAARKAREVLKNVTTVLAIELLTASQALEFRKGFKRGKGTDRIYRLVREKVNPLVEDREL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEE
YIDINACFDIIRSGRIEEVLKEEGIMLE
EEEHHHHHHHHHCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336