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The map label for this gene is PurL2 [H]

Identifier: 20807293

GI number: 20807293

Start: 808876

End: 811077

Strand: Direct

Name: PurL2 [H]

Synonym: TTE0811

Alternate gene names: 20807293

Gene position: 808876-811077 (Clockwise)

Preceding gene: 20807292

Following gene: 20807294

Centisome position: 30.08

GC content: 37.78

Gene sequence:

>2202_bases
ATGAATAAAATATGGAGAGAGTTAGGACTTACTGATGAGGAGTATGAGAAAATTATTTCGATATTAGGAAGAGAACCTAA
TATAACTGAATTAGGTATGTATAGTGTTATGTGGTCTGAACATTGTTCCTATAAAAACTCTAAACCTCTTTTAAAATATC
TACCTACAAAAGGCGAAAGAGTAATACAAGGGCCGGGAGAAAATGCAGGAGTATTGGATATTGGAGATAATCTGGCAGTT
GTGATGAAGATAGAAAGCCATAACCATCCTTCTGCGATTGAACCCTATCAAGGAGCAGCTACAGGTGTTGGAGGAATAAT
AAGAGATATATTTACAATGGGGGCAAGGCCGATTGCTCTTTTGGATTCTTTGAGATTTGGAATTCCTGATGATAAAAGGA
CTAAATATCTCATTGAAAACGTGGTAGCCGGTATAGCGGATTATGGAAATTGCATAGGAATTCCTACAGTGGGTGGGGAT
ACCTATTTTGAAGAAAGTTACAAAGGGAATCCTTTAGTAAATGCGATGTGTGTAGGAATAGTGGAAAAAGACAAAATAAA
AAAAGGGATAGCAAAAGGTATAGGTAATCCTGTTATGGTAGTAGGTGCTACCACGGGGAGAGACGGTATCGGAGGTGCAA
GCTTTGCTTCTCAGGAGTTAAGCGAGGAATCAGAAGAAAAAAGGCCTTCTGTTCAAGTTGGTGACCCATTTATGGAAAAA
CTGCTTTTAGAGGCTTGTTTAGAACTTTTTGAAACAGATGCCGTAGTTGCTATACAAGATATGGGAGCGGCAGGTCTTAC
CTCTTCTTCTTGCGAGATGGCTTCCCGCGGTGGAGTTGGAATGGAGATTGACCTTGATAAAGTGCCTTTGAGAGAAGAGG
GAATGACACCTTATGAAATAATGCTTTCTGAATCTCAAGAGAGGATGTTGGTTGTAGTAAAGAAAGGCAAGGAAGAAGAT
GTGCAAAAGATATTTAAAAAATGGGGACTGAATGCCGCCACAATAGGGAAAATCACTGATGATGGAATGATAAGAGTGAT
TAAAGATGGAAAAATAGTTGCGGAAGTTCCAGCCAAGTCTTTAACGGAAGATGCTCCACAATATGTGAGAGAAGAAGAAG
TGCCTAAATGGCAAGAAGAGGTCAAGAAATTGGATATAAATGAAGTAAAACCTCCAGAGGATATGAATAAAGTTCTAAAA
GATGTAATTTCTTCTTTAAATATTGCAAGTAAAGAATGGATATACAGTCAATATGATTACATGGTGAGGACAGACACAGT
AATAACTCCAGGAATGGATGCGGCTGTTGTGAGGATAAAAGGTACAAGAAAAGCTATTGCATTAACAACGGATTGCAATG
GTAGGTATTGTTATTTAGATCCCTATATAGGTTCTCAAATTGCTGTAGCGGAGGCAGCTCGAAATCTTTGTATGGTTGGT
GCTAAGCCTATAGGGGTTACGGATTGTTTGAATTTTGGCAATCCAGAAAAGAAAGAAATATATTGGCAGTTAAAAAATTC
TATATTTGGAATAGCTAAAGCCTGCGAAACTTTTCAAATCCCTGTGGTAAGCGGAAATGTCAGTCTTTACAATGAAAATG
AGGGAGAGGCCATTTATCCTACTCCTGTAATAGGAATGGCAGGCCTTATAGAGGATGTATCAAAAATCTGTACAATGGAC
TTTAAAAAAGAAAGAGATGTAATTATAATTTTAGGTGAGAATAAAGGAGAGATTGGAGGAAGTGAGTATCTTAAAGTTTG
CTTTGGAATGGTAAAAGGGCAACCACCTCAAATAGACTTGGAAAAGGAAAAAAGATTGCAAGAATTGGTGCTAAAACTTA
TTGATGAAGGCTTAATTAACTCTTCTCATGACATATCAGAGGGCGGTTTTGCGGCTGCCTTGGTTGAAAGTGCAATTGCA
GGCAAAAAAGGTGCAAAAATTTCGCTACAAACTTCTCTGAGAGCAGATATAGAGTTGTTCTCTGAATCTCAATCGAGAGC
ATTAATTACTGTAAGTCCTGAAAAAGTAGATGAAGTGTTAAAAATAGCTTATGAACACCAAGTTCCAGCGCAAAAAGTAG
GAGTTGTAGAGGGTAAAGATATTGTAATTGATGTAAATGGCAAAAGAATAATAGACCTTCCTTTAGAAGTCTTAGAGGAA
AGCTGGAGAGGGAGAATAAAATGGGAAATGGAGAGAAATTAA

Upstream 100 bases:

>100_bases
CTCATCCAGAGAGAGCTTATGACTCCTTGCTGGGTAATACTGACGGGCTTTATATCTTAGGGTCAATAGTGGATAATTTT
GTAAAAGGCGGGGTTTAAGG

Downstream 100 bases:

>100_bases
AAGAGGAATGTGGTGTTTTTGGTGCCTTTAGTTTGTCCACTTCAGTTACTTCTTATATCTATTATGGCTTACAAGCCTTG
CAGCACAGAGGGCAGGAAAG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 733; Mature: 733

Protein sequence:

>733_residues
MNKIWRELGLTDEEYEKIISILGREPNITELGMYSVMWSEHCSYKNSKPLLKYLPTKGERVIQGPGENAGVLDIGDNLAV
VMKIESHNHPSAIEPYQGAATGVGGIIRDIFTMGARPIALLDSLRFGIPDDKRTKYLIENVVAGIADYGNCIGIPTVGGD
TYFEESYKGNPLVNAMCVGIVEKDKIKKGIAKGIGNPVMVVGATTGRDGIGGASFASQELSEESEEKRPSVQVGDPFMEK
LLLEACLELFETDAVVAIQDMGAAGLTSSSCEMASRGGVGMEIDLDKVPLREEGMTPYEIMLSESQERMLVVVKKGKEED
VQKIFKKWGLNAATIGKITDDGMIRVIKDGKIVAEVPAKSLTEDAPQYVREEEVPKWQEEVKKLDINEVKPPEDMNKVLK
DVISSLNIASKEWIYSQYDYMVRTDTVITPGMDAAVVRIKGTRKAIALTTDCNGRYCYLDPYIGSQIAVAEAARNLCMVG
AKPIGVTDCLNFGNPEKKEIYWQLKNSIFGIAKACETFQIPVVSGNVSLYNENEGEAIYPTPVIGMAGLIEDVSKICTMD
FKKERDVIIILGENKGEIGGSEYLKVCFGMVKGQPPQIDLEKEKRLQELVLKLIDEGLINSSHDISEGGFAAALVESAIA
GKKGAKISLQTSLRADIELFSESQSRALITVSPEKVDEVLKIAYEHQVPAQKVGVVEGKDIVIDVNGKRIIDLPLEVLEE
SWRGRIKWEMERN

Sequences:

>Translated_733_residues
MNKIWRELGLTDEEYEKIISILGREPNITELGMYSVMWSEHCSYKNSKPLLKYLPTKGERVIQGPGENAGVLDIGDNLAV
VMKIESHNHPSAIEPYQGAATGVGGIIRDIFTMGARPIALLDSLRFGIPDDKRTKYLIENVVAGIADYGNCIGIPTVGGD
TYFEESYKGNPLVNAMCVGIVEKDKIKKGIAKGIGNPVMVVGATTGRDGIGGASFASQELSEESEEKRPSVQVGDPFMEK
LLLEACLELFETDAVVAIQDMGAAGLTSSSCEMASRGGVGMEIDLDKVPLREEGMTPYEIMLSESQERMLVVVKKGKEED
VQKIFKKWGLNAATIGKITDDGMIRVIKDGKIVAEVPAKSLTEDAPQYVREEEVPKWQEEVKKLDINEVKPPEDMNKVLK
DVISSLNIASKEWIYSQYDYMVRTDTVITPGMDAAVVRIKGTRKAIALTTDCNGRYCYLDPYIGSQIAVAEAARNLCMVG
AKPIGVTDCLNFGNPEKKEIYWQLKNSIFGIAKACETFQIPVVSGNVSLYNENEGEAIYPTPVIGMAGLIEDVSKICTMD
FKKERDVIIILGENKGEIGGSEYLKVCFGMVKGQPPQIDLEKEKRLQELVLKLIDEGLINSSHDISEGGFAAALVESAIA
GKKGAKISLQTSLRADIELFSESQSRALITVSPEKVDEVLKIAYEHQVPAQKVGVVEGKDIVIDVNGKRIIDLPLEVLEE
SWRGRIKWEMERN
>Mature_733_residues
MNKIWRELGLTDEEYEKIISILGREPNITELGMYSVMWSEHCSYKNSKPLLKYLPTKGERVIQGPGENAGVLDIGDNLAV
VMKIESHNHPSAIEPYQGAATGVGGIIRDIFTMGARPIALLDSLRFGIPDDKRTKYLIENVVAGIADYGNCIGIPTVGGD
TYFEESYKGNPLVNAMCVGIVEKDKIKKGIAKGIGNPVMVVGATTGRDGIGGASFASQELSEESEEKRPSVQVGDPFMEK
LLLEACLELFETDAVVAIQDMGAAGLTSSSCEMASRGGVGMEIDLDKVPLREEGMTPYEIMLSESQERMLVVVKKGKEED
VQKIFKKWGLNAATIGKITDDGMIRVIKDGKIVAEVPAKSLTEDAPQYVREEEVPKWQEEVKKLDINEVKPPEDMNKVLK
DVISSLNIASKEWIYSQYDYMVRTDTVITPGMDAAVVRIKGTRKAIALTTDCNGRYCYLDPYIGSQIAVAEAARNLCMVG
AKPIGVTDCLNFGNPEKKEIYWQLKNSIFGIAKACETFQIPVVSGNVSLYNENEGEAIYPTPVIGMAGLIEDVSKICTMD
FKKERDVIIILGENKGEIGGSEYLKVCFGMVKGQPPQIDLEKEKRLQELVLKLIDEGLINSSHDISEGGFAAALVESAIA
GKKGAKISLQTSLRADIELFSESQSRALITVSPEKVDEVLKIAYEHQVPAQKVGVVEGKDIVIDVNGKRIIDLPLEVLEE
SWRGRIKWEMERN

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=728, Percent_Identity=24.7252747252747, Blast_Score=120, Evalue=6e-27,
Organism=Escherichia coli, GI48994899, Length=832, Percent_Identity=24.8798076923077, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17553022, Length=746, Percent_Identity=24.798927613941, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321498, Length=856, Percent_Identity=22.5467289719626, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24582111, Length=757, Percent_Identity=24.7027741083223, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24582109, Length=757, Percent_Identity=24.7027741083223, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17137292, Length=757, Percent_Identity=24.7027741083223, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 80477; Mature: 80477

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIWRELGLTDEEYEKIISILGREPNITELGMYSVMWSEHCSYKNSKPLLKYLPTKGER
CCHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCE
VIQGPGENAGVLDIGDNLAVVMKIESHNHPSAIEPYQGAATGVGGIIRDIFTMGARPIAL
EEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
LDSLRFGIPDDKRTKYLIENVVAGIADYGNCIGIPTVGGDTYFEESYKGNPLVNAMCVGI
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHCCCCCCCCHHHHHHHH
VEKDKIKKGIAKGIGNPVMVVGATTGRDGIGGASFASQELSEESEEKRPSVQVGDPFMEK
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCHHHHH
LLLEACLELFETDAVVAIQDMGAAGLTSSSCEMASRGGVGMEIDLDKVPLREEGMTPYEI
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHCCCCCEEEECCCCCCHHCCCCCCEE
MLSESQERMLVVVKKGKEEDVQKIFKKWGLNAATIGKITDDGMIRVIKDGKIVAEVPAKS
EECCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEECEECCCCEEEEEECCEEEEECCCHH
LTEDAPQYVREEEVPKWQEEVKKLDINEVKPPEDMNKVLKDVISSLNIASKEWIYSQYDY
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCE
MVRTDTVITPGMDAAVVRIKGTRKAIALTTDCNGRYCYLDPYIGSQIAVAEAARNLCMVG
EEEECEEECCCCCEEEEEEECCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHEEEC
AKPIGVTDCLNFGNPEKKEIYWQLKNSIFGIAKACETFQIPVVSGNVSLYNENEGEAIYP
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEECCCCCEECC
TPVIGMAGLIEDVSKICTMDFKKERDVIIILGENKGEIGGSEYLKVCFGMVKGQPPQIDL
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCC
EKEKRLQELVLKLIDEGLINSSHDISEGGFAAALVESAIAGKKGAKISLQTSLRADIELF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECHHHHHHHHH
SESQSRALITVSPEKVDEVLKIAYEHQVPAQKVGVVEGKDIVIDVNGKRIIDLPLEVLEE
CCCCCCEEEEECHHHHHHHHHHHHHCCCCHHHCCEECCCEEEEEECCCEEEECCHHHHHH
SWRGRIKWEMERN
HCCCCEEEEECCC
>Mature Secondary Structure
MNKIWRELGLTDEEYEKIISILGREPNITELGMYSVMWSEHCSYKNSKPLLKYLPTKGER
CCHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCE
VIQGPGENAGVLDIGDNLAVVMKIESHNHPSAIEPYQGAATGVGGIIRDIFTMGARPIAL
EEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
LDSLRFGIPDDKRTKYLIENVVAGIADYGNCIGIPTVGGDTYFEESYKGNPLVNAMCVGI
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHCCCCCCCCHHHHHHHH
VEKDKIKKGIAKGIGNPVMVVGATTGRDGIGGASFASQELSEESEEKRPSVQVGDPFMEK
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCHHHHH
LLLEACLELFETDAVVAIQDMGAAGLTSSSCEMASRGGVGMEIDLDKVPLREEGMTPYEI
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHCCCCCEEEECCCCCCHHCCCCCCEE
MLSESQERMLVVVKKGKEEDVQKIFKKWGLNAATIGKITDDGMIRVIKDGKIVAEVPAKS
EECCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEECEECCCCEEEEEECCEEEEECCCHH
LTEDAPQYVREEEVPKWQEEVKKLDINEVKPPEDMNKVLKDVISSLNIASKEWIYSQYDY
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCE
MVRTDTVITPGMDAAVVRIKGTRKAIALTTDCNGRYCYLDPYIGSQIAVAEAARNLCMVG
EEEECEEECCCCCEEEEEEECCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHEEEC
AKPIGVTDCLNFGNPEKKEIYWQLKNSIFGIAKACETFQIPVVSGNVSLYNENEGEAIYP
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEECCCCCEECC
TPVIGMAGLIEDVSKICTMDFKKERDVIIILGENKGEIGGSEYLKVCFGMVKGQPPQIDL
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCC
EKEKRLQELVLKLIDEGLINSSHDISEGGFAAALVESAIAGKKGAKISLQTSLRADIELF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECHHHHHHHHH
SESQSRALITVSPEKVDEVLKIAYEHQVPAQKVGVVEGKDIVIDVNGKRIIDLPLEVLEE
CCCCCCEEEEECHHHHHHHHHHHHHCCCCHHHCCEECCCEEEEEECCCEEEECCHHHHHH
SWRGRIKWEMERN
HCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA