Click here to switch to the map view.

The map label for this gene is PurL

Identifier: 20807292

GI number: 20807292

Start: 808199

End: 808873

Strand: Direct

Name: PurL

Synonym: TTE0810

Alternate gene names: 20807292

Gene position: 808199-808873 (Clockwise)

Preceding gene: 20807291

Following gene: 20807293

Centisome position: 30.05

GC content: 37.04

Gene sequence:

>675_bases
ATGAAATTTGCTGTTATAGTTTTTCCAGGGTCCAATTGCGATGTGGACTGCTATTATGCTGTTAAAGATGGGCTTGGGGA
AGGAGTAGAATATGTGTGGCATCAAGAAAAAAATTTGAGTAAGTACGATGTTATAATGTTACCAGGAGGATTTTCTTATG
GTGATTATTTGAGGGCAGGAGCTATTGCTAGGTTTTCGCCTGTTATGGAGGCTGTCAGAGAAGAAGCAGAAAAAGGAAAA
TTTATTATAGGCATATGCAACGGATTTCAGATACTTACAGAAGCTGGGCTTTTGCCGGGAGCTTTGAGAAAAAATGAAGG
GCTGAAATTTATCTGCAAGACTGTCAGTATAATAGTTGAAAATGACAAAACTCCTTTTACTACAAGGCTTAAAAAAGGGC
AGGAGATTTTACTTCCAATTGCTCATGGGGAAGGCAATTATTATGTAGATGACAAAACTTTAAAAGAACTAAAAGGAAAC
AATCAAATTGTTTTTAGGTACAAAGAAAATATCAACGGTTCTGTCGAGAGAATAGCCGGAGTTATAAATAAAAAAGGAAA
TGTTTTAGGAATGATGCCTCATCCAGAGAGAGCTTATGACTCCTTGCTGGGTAATACTGACGGGCTTTATATCTTAGGGT
CAATAGTGGATAATTTTGTAAAAGGCGGGGTTTAA

Upstream 100 bases:

>100_bases
ATTTATCCCTCCTAAAGGACAAAGTAGATGAGATGTGCAAAAGGATACTGACAAACCCAATTATTGAAGATTACACCTTT
GAAATTGTGGAGGGATAAAG

Downstream 100 bases:

>100_bases
GGATGAATAAAATATGGAGAGAGTTAGGACTTACTGATGAGGAGTATGAGAAAATTATTTCGATATTAGGAAGAGAACCT
AATATAACTGAATTAGGTAT

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKFAVIVFPGSNCDVDCYYAVKDGLGEGVEYVWHQEKNLSKYDVIMLPGGFSYGDYLRAGAIARFSPVMEAVREEAEKGK
FIIGICNGFQILTEAGLLPGALRKNEGLKFICKTVSIIVENDKTPFTTRLKKGQEILLPIAHGEGNYYVDDKTLKELKGN
NQIVFRYKENINGSVERIAGVINKKGNVLGMMPHPERAYDSLLGNTDGLYILGSIVDNFVKGGV

Sequences:

>Translated_224_residues
MKFAVIVFPGSNCDVDCYYAVKDGLGEGVEYVWHQEKNLSKYDVIMLPGGFSYGDYLRAGAIARFSPVMEAVREEAEKGK
FIIGICNGFQILTEAGLLPGALRKNEGLKFICKTVSIIVENDKTPFTTRLKKGQEILLPIAHGEGNYYVDDKTLKELKGN
NQIVFRYKENINGSVERIAGVINKKGNVLGMMPHPERAYDSLLGNTDGLYILGSIVDNFVKGGV
>Mature_224_residues
MKFAVIVFPGSNCDVDCYYAVKDGLGEGVEYVWHQEKNLSKYDVIMLPGGFSYGDYLRAGAIARFSPVMEAVREEAEKGK
FIIGICNGFQILTEAGLLPGALRKNEGLKFICKTVSIIVENDKTPFTTRLKKGQEILLPIAHGEGNYYVDDKTLKELKGN
NQIVFRYKENINGSVERIAGVINKKGNVLGMMPHPERAYDSLLGNTDGLYILGSIVDNFVKGGV

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=189, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321498, Length=180, Percent_Identity=29.4444444444444, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24582111, Length=193, Percent_Identity=29.5336787564767, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24582109, Length=193, Percent_Identity=29.5336787564767, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17137292, Length=193, Percent_Identity=29.5336787564767, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_THETN (Q8RBK6)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622463.1
- ProteinModelPortal:   Q8RBK6
- SMR:   Q8RBK6
- GeneID:   996939
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0810
- NMPDR:   fig|273068.3.peg.991
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   TTEN273068:TTE0810-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 24723; Mature: 24723

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 194-194 ACT_SITE 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAVIVFPGSNCDVDCYYAVKDGLGEGVEYVWHQEKNLSKYDVIMLPGGFSYGDYLRAG
CEEEEEEECCCCCCEEEEEEECCCCCCCHHHEECCCCCCCCEEEEEECCCCCHHHHHHHC
AIARFSPVMEAVREEAEKGKFIIGICNGFQILTEAGLLPGALRKNEGLKFICKTVSIIVE
CHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHCCCCCCCCCCCCCHHEEEEEEEEEEE
NDKTPFTTRLKKGQEILLPIAHGEGNYYVDDKTLKELKGNNQIVFRYKENINGSVERIAG
CCCCCHHHHHCCCCEEEEEEEECCCCEEECHHHHHHHCCCCEEEEEEECCCCCHHHHHHH
VINKKGNVLGMMPHPERAYDSLLGNTDGLYILGSIVDNFVKGGV
HHCCCCCEEEECCCCHHHHHHHHCCCCCEEEEHHHHHHHHHCCC
>Mature Secondary Structure
MKFAVIVFPGSNCDVDCYYAVKDGLGEGVEYVWHQEKNLSKYDVIMLPGGFSYGDYLRAG
CEEEEEEECCCCCCEEEEEEECCCCCCCHHHEECCCCCCCCEEEEEECCCCCHHHHHHHC
AIARFSPVMEAVREEAEKGKFIIGICNGFQILTEAGLLPGALRKNEGLKFICKTVSIIVE
CHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHCCCCCCCCCCCCCHHEEEEEEEEEEE
NDKTPFTTRLKKGQEILLPIAHGEGNYYVDDKTLKELKGNNQIVFRYKENINGSVERIAG
CCCCCHHHHHCCCCEEEEEEEECCCCEEECHHHHHHHCCCCEEEEEEECCCCCHHHHHHH
VINKKGNVLGMMPHPERAYDSLLGNTDGLYILGSIVDNFVKGGV
HHCCCCCEEEECCCCHHHHHHHHCCCCCEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336