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The map label for this gene is AtpA

Identifier: 20807128

GI number: 20807128

Start: 637888

End: 639408

Strand: Direct

Name: AtpA

Synonym: TTE0635

Alternate gene names: 20807128

Gene position: 637888-639408 (Clockwise)

Preceding gene: 20807127

Following gene: 20807129

Centisome position: 23.72

GC content: 45.43

Gene sequence:

>1521_bases
ATGGGAATAAGACCAGAGGAAATTAGTTCTGTTTTGGCGGAAAAAATTAAAAACTTTGATTTTAGCGTAGAAACTCAAGA
AATAGGCTATGTTATTCAGTCAGGGGACGGAATAGCGAGGATATACGGCCTTGACAATGCTGTGTACGGTGAAATGGTGG
AGTTTGAGAGCGGAGTCGTAGGCATGGTCCTGAACCTAGAAGAAGACACAGTAGGTGTTGTAGTGTTAGGAGACCCTGAG
AAAGTAAAAGAAGGGGACGTAGTGAAAAGAACAGGCCGCATAATGGAAGTGCCTGTAGGTAAAGGACTTTTAGGAAGGGT
TGTAAATCCACTGGGAGAGCCTATTGACGGAAAAGGCCCTATAGAGTATGAAGGGAAAAGGCCTATTGAAAGTCCTGCTC
CTCCTATAGTAAGGAGGCAGCCTGTTAATACGCCTCTTCAGACTGGTATTCTCGCCATTGACTCCATGATACCAATCGGT
AGAGGTCAGAGAGAGCTCATCATAGGCGACAGGCAGACGGGGAAAACCGCTATAGCAGTTGACACCATAATAAACCAAAA
AGACAAAGGGGTATACTGCATATATGTTGCAATAGGGCAGAAAGCTTCTACTGTGGCAAGTGTAGTGAATACGCTTGAAA
AATATGGAGCAATGGAATATACCACGGTAGTTGCAGCAACTGCCAGTGAGTCGGCGGCTTTGCAGTATATAGCTCCTTAT
GCGGGCTGTGCAATGGGAGAGCACTTCATGTATCAGGGAAAAGACGTGCTTGTGGTGTATGACGACCTTTCGAAGCATGC
GGTGGCATACAGAACTCTATCGCTCCTTCTAAGAAGGCCGCCTGGAAGAGAGGCTTATCCTGGAGACGTATTTTACCTGC
ATTCACGCTTGCTTGAGCGCTCTGCTCGACTTTCTGATGAGTATGGCGGCGGGTCTTTGACAGCTCTACCGATTGTTGAG
ACTCAAGCAGGAGATATATCAGCATATATTCCAACAAACGTCATATCCATAACAGATGGTCAGATATATCTGGAGTCAGA
GCTTTTCTACAGCGGCATAAGGCCTGCTATAAACGTGGGTCTTTCAGTATCCCGTGTTGGCGGTGCCGCTCAGATAAAAG
CGATGAAAAAGGTTGCAGGGCGCTTGAGACTTGAGCTTTCACAGTACAGAGAATTGCAGGTTTTTGCAAGATTTGGAACT
GACTTAGATAAAGCTACTCTTGAGGTTTTGAGGCAGGGCGAGAGAATTGTAGAGATTACGAAACAGCCTCAGTACCAGCC
TATGGCTGTTGAGGACCAGGTAATAGCGATTTACACTGTGATGAATAGATATGTGACAGACATTGAGGTAAGTGAAGTAA
GACCTTTTGTCATGGGGCTTCTCAAGTTCTTGGACGAAGCTTATCCAGAGATAAAGCAGTCCATAAGAGATACAAAAGAC
CTCACCAAAGAGACGGAGGAGAAACTTAAAGCTGCAATCCTCGAGTACAAGGAAAAGTACGCCGCAAAGGGTGAAAAATA
A

Upstream 100 bases:

>100_bases
GCAATACTGTAATTGACGGTTCAATTAAAGCAAGACTTGAAGCTCTTCTCAAAAACATGCGTCAGGCTGTCTAAAATGAA
TTTAAGAAGGTGAAAAGCGT

Downstream 100 bases:

>100_bases
TGGGAAAACGAGATATAGCCTTAAGGATTAAGAGTGTGAAAGAAGTGCGAAAAATCACCAGAGCGATGTATCTCATCTCT
GCTTCAAAATTCCAGAAAGC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MGIRPEEISSVLAEKIKNFDFSVETQEIGYVIQSGDGIARIYGLDNAVYGEMVEFESGVVGMVLNLEEDTVGVVVLGDPE
KVKEGDVVKRTGRIMEVPVGKGLLGRVVNPLGEPIDGKGPIEYEGKRPIESPAPPIVRRQPVNTPLQTGILAIDSMIPIG
RGQRELIIGDRQTGKTAIAVDTIINQKDKGVYCIYVAIGQKASTVASVVNTLEKYGAMEYTTVVAATASESAALQYIAPY
AGCAMGEHFMYQGKDVLVVYDDLSKHAVAYRTLSLLLRRPPGREAYPGDVFYLHSRLLERSARLSDEYGGGSLTALPIVE
TQAGDISAYIPTNVISITDGQIYLESELFYSGIRPAINVGLSVSRVGGAAQIKAMKKVAGRLRLELSQYRELQVFARFGT
DLDKATLEVLRQGERIVEITKQPQYQPMAVEDQVIAIYTVMNRYVTDIEVSEVRPFVMGLLKFLDEAYPEIKQSIRDTKD
LTKETEEKLKAAILEYKEKYAAKGEK

Sequences:

>Translated_506_residues
MGIRPEEISSVLAEKIKNFDFSVETQEIGYVIQSGDGIARIYGLDNAVYGEMVEFESGVVGMVLNLEEDTVGVVVLGDPE
KVKEGDVVKRTGRIMEVPVGKGLLGRVVNPLGEPIDGKGPIEYEGKRPIESPAPPIVRRQPVNTPLQTGILAIDSMIPIG
RGQRELIIGDRQTGKTAIAVDTIINQKDKGVYCIYVAIGQKASTVASVVNTLEKYGAMEYTTVVAATASESAALQYIAPY
AGCAMGEHFMYQGKDVLVVYDDLSKHAVAYRTLSLLLRRPPGREAYPGDVFYLHSRLLERSARLSDEYGGGSLTALPIVE
TQAGDISAYIPTNVISITDGQIYLESELFYSGIRPAINVGLSVSRVGGAAQIKAMKKVAGRLRLELSQYRELQVFARFGT
DLDKATLEVLRQGERIVEITKQPQYQPMAVEDQVIAIYTVMNRYVTDIEVSEVRPFVMGLLKFLDEAYPEIKQSIRDTKD
LTKETEEKLKAAILEYKEKYAAKGEK
>Mature_505_residues
GIRPEEISSVLAEKIKNFDFSVETQEIGYVIQSGDGIARIYGLDNAVYGEMVEFESGVVGMVLNLEEDTVGVVVLGDPEK
VKEGDVVKRTGRIMEVPVGKGLLGRVVNPLGEPIDGKGPIEYEGKRPIESPAPPIVRRQPVNTPLQTGILAIDSMIPIGR
GQRELIIGDRQTGKTAIAVDTIINQKDKGVYCIYVAIGQKASTVASVVNTLEKYGAMEYTTVVAATASESAALQYIAPYA
GCAMGEHFMYQGKDVLVVYDDLSKHAVAYRTLSLLLRRPPGREAYPGDVFYLHSRLLERSARLSDEYGGGSLTALPIVET
QAGDISAYIPTNVISITDGQIYLESELFYSGIRPAINVGLSVSRVGGAAQIKAMKKVAGRLRLELSQYRELQVFARFGTD
LDKATLEVLRQGERIVEITKQPQYQPMAVEDQVIAIYTVMNRYVTDIEVSEVRPFVMGLLKFLDEAYPEIKQSIRDTKDL
TKETEEKLKAAILEYKEKYAAKGEK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=504, Percent_Identity=59.5238095238095, Blast_Score=604, Evalue=1e-173,
Organism=Homo sapiens, GI4757810, Length=504, Percent_Identity=59.5238095238095, Blast_Score=604, Evalue=1e-173,
Organism=Homo sapiens, GI19913428, Length=303, Percent_Identity=31.023102310231, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI19913426, Length=307, Percent_Identity=30.9446254071661, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI32189394, Length=367, Percent_Identity=25.6130790190736, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI19913424, Length=246, Percent_Identity=27.2357723577236, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790172, Length=508, Percent_Identity=55.9055118110236, Blast_Score=583, Evalue=1e-168,
Organism=Escherichia coli, GI1790170, Length=402, Percent_Identity=25.8706467661692, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1788251, Length=271, Percent_Identity=29.1512915129151, Blast_Score=102, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=503, Percent_Identity=57.8528827037773, Blast_Score=600, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI71988080, Length=503, Percent_Identity=57.8528827037773, Blast_Score=598, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI71988074, Length=503, Percent_Identity=53.6779324055666, Blast_Score=539, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17570191, Length=303, Percent_Identity=31.023102310231, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=299, Percent_Identity=31.1036789297659, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25144756, Length=441, Percent_Identity=24.9433106575964, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71988068, Length=77, Percent_Identity=48.0519480519481, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=60, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565854, Length=252, Percent_Identity=27.3809523809524, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=497, Percent_Identity=59.1549295774648, Blast_Score=598, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319603, Length=306, Percent_Identity=30.0653594771242, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322581, Length=386, Percent_Identity=26.9430051813472, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=58.019801980198, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI281361666, Length=302, Percent_Identity=31.4569536423841, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646341, Length=302, Percent_Identity=31.4569536423841, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136796, Length=302, Percent_Identity=31.4569536423841, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24638766, Length=367, Percent_Identity=26.4305177111717, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28574560, Length=431, Percent_Identity=25.754060324826, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583988, Length=253, Percent_Identity=26.8774703557312, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583986, Length=253, Percent_Identity=26.8774703557312, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583984, Length=253, Percent_Identity=26.8774703557312, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583992, Length=253, Percent_Identity=28.0632411067194, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_THETN (Q8RC17)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622299.1
- ProteinModelPortal:   Q8RC17
- SMR:   Q8RC17
- GeneID:   996571
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0635
- NMPDR:   fig|273068.3.peg.310
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- ProtClustDB:   PRK09281
- BioCyc:   TTEN273068:TTE0635-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR018538
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF09378 HAS-barrel; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55617; Mature: 55486

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIRPEEISSVLAEKIKNFDFSVETQEIGYVIQSGDGIARIYGLDNAVYGEMVEFESGVV
CCCCHHHHHHHHHHHHHCCCCEEEHHHHCEEEECCCCEEEEEECCCHHHHHHHHHCCCEE
GMVLNLEEDTVGVVVLGDPEKVKEGDVVKRTGRIMEVPVGKGLLGRVVNPLGEPIDGKGP
EEEEEECCCCEEEEEECCCHHCCCCCHHHHCCCEEEECCCCCHHHHHHHHCCCCCCCCCC
IEYEGKRPIESPAPPIVRRQPVNTPLQTGILAIDSMIPIGRGQRELIIGDRQTGKTAIAV
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEE
DTIINQKDKGVYCIYVAIGQKASTVASVVNTLEKYGAMEYTTVVAATASESAALQYIAPY
EHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHH
AGCAMGEHFMYQGKDVLVVYDDLSKHAVAYRTLSLLLRRPPGREAYPGDVFYLHSRLLER
HHHHCCCHHEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
SARLSDEYGGGSLTALPIVETQAGDISAYIPTNVISITDGQIYLESELFYSGIRPAINVG
HHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEHHHHHHCCCHHHHCC
LSVSRVGGAAQIKAMKKVAGRLRLELSQYRELQVFARFGTDLDKATLEVLRQGERIVEIT
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEC
KQPQYQPMAVEDQVIAIYTVMNRYVTDIEVSEVRPFVMGLLKFLDEAYPEIKQSIRDTKD
CCCCCCCEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTKETEEKLKAAILEYKEKYAAKGEK
HHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GIRPEEISSVLAEKIKNFDFSVETQEIGYVIQSGDGIARIYGLDNAVYGEMVEFESGVV
CCCHHHHHHHHHHHHHCCCCEEEHHHHCEEEECCCCEEEEEECCCHHHHHHHHHCCCEE
GMVLNLEEDTVGVVVLGDPEKVKEGDVVKRTGRIMEVPVGKGLLGRVVNPLGEPIDGKGP
EEEEEECCCCEEEEEECCCHHCCCCCHHHHCCCEEEECCCCCHHHHHHHHCCCCCCCCCC
IEYEGKRPIESPAPPIVRRQPVNTPLQTGILAIDSMIPIGRGQRELIIGDRQTGKTAIAV
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEE
DTIINQKDKGVYCIYVAIGQKASTVASVVNTLEKYGAMEYTTVVAATASESAALQYIAPY
EHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHH
AGCAMGEHFMYQGKDVLVVYDDLSKHAVAYRTLSLLLRRPPGREAYPGDVFYLHSRLLER
HHHHCCCHHEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
SARLSDEYGGGSLTALPIVETQAGDISAYIPTNVISITDGQIYLESELFYSGIRPAINVG
HHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEHHHHHHCCCHHHHCC
LSVSRVGGAAQIKAMKKVAGRLRLELSQYRELQVFARFGTDLDKATLEVLRQGERIVEIT
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEC
KQPQYQPMAVEDQVIAIYTVMNRYVTDIEVSEVRPFVMGLLKFLDEAYPEIKQSIRDTKD
CCCCCCCEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTKETEEKLKAAILEYKEKYAAKGEK
HHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11997336