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The map label for this gene is Icd [H]

Identifier: 20806899

GI number: 20806899

Start: 410034

End: 411245

Strand: Reverse

Name: Icd [H]

Synonym: TTE0387

Alternate gene names: 20806899

Gene position: 411245-410034 (Counterclockwise)

Preceding gene: 20806901

Following gene: 20806897

Centisome position: 15.29

GC content: 36.55

Gene sequence:

>1212_bases
ATGGCACAAAAAATTGAGATGAAGGTTCCTATTGTGGAAATGGACGGAGATGAAATGACAAGAATTATATGGAAATTGAT
AAAAGAAATGCTTATAAAGCCCTATGTAGATTTAAAGACAGAGTACTATGATTTGGGCATTAAAAACAGAGATGAAACAG
AAGACCAGGTCACAGTTGATGCAGCATACGCAATAAAAAAATACGGAGTCGGGGTAAAATGCGCAACAATCACCCCAAAT
GCTGAAAGAGTAAAAGAATACAATTTGAAAAATATGTGGAAAAGCCCTAACGCTACTATACGATCCATACTCGATGGGAC
AGTATTTCGCACACCTATTCTGGTTGAAGGAATAAAGCCGCTTGTAAGGACATGGAAAAAACCTATTACAATTGCAAGGC
ATGCTTATGGGGATATTTATAAAGGGGTAGAATACAGAATCCCTGAAAAAGGTAAGGCTGAGCTTGTCTTTACTTCTGAA
AAAGGAGAAGAGATAAGGTATGCAATACACGAGTTTGAAACTCCTGGTGTCATATTAGGTATGCACAACACTGATGAGTC
AATAAAAAGTTTTGCGAGAGCATGTTTTAATTATGCTTTAGATACGAAGCAGGATTTGTGGTTTGCGACTAAAGACACCA
TTTCAAAAATATACGACCACAGATTTAAAGACATATTCCAGGAAATATATGAAAATGAATATAAAGAAAAATTTGAAGAA
GCAGGTATTGAATATTTTTACACCCTTATTGACGATGCCGTAGCTCGAATTGTAAGGTCTGAAGGCGGAATGATTTGGGC
ATGCAAAAATTATGACGGCGATGTAATGTCAGATATGGTAGCAACAGCATTTGGCAGCCTTGCCATGATGACTTCTGTAC
TGGTATCTCCTGATGGTAAATACGAATTTGAAGCGGCTCATGGGACAGTTACAAGGCATTATTATAAATACCTTAAAGGT
GAAGAAACTTCTACTAATCCTATTGCTACAATTTTCGCGTGGACAGGTGCTTTGAAAAAGAGAGGAGAACTTGACGGAAT
AAAAGACCTTGTTGATTTTGCAGATAAGCTTGAAAAAGCCTCACTTAAAACGGTTGAAAAAGGAATAATGACAAAAGACT
TAGCCGCTTTATCTGAATTGCCAAATAAAACTGTTGTAAACACGGAAACTTTCCTCATTGAAATTAAAAAAACTTTAGAA
GAGATGCTGTAA

Upstream 100 bases:

>100_bases
CCCCTTATATTCTATATAATAGAATCAAGCTGTGATAAAAAATCGCAATAAAGCATTTTAAAAATTTTATTGTTACATTT
TAAACAAAGGGGAGAAGAAA

Downstream 100 bases:

>100_bases
TGAAAAGGGACGGTCCTCAGATAAAAGGAACCGTCCCCTTTGTTTGATTTTTAGTCCAGCAGTTTATAATAATCAATATT
CACAAACACTGTCACAAGAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAQKIEMKVPIVEMDGDEMTRIIWKLIKEMLIKPYVDLKTEYYDLGIKNRDETEDQVTVDAAYAIKKYGVGVKCATITPN
AERVKEYNLKNMWKSPNATIRSILDGTVFRTPILVEGIKPLVRTWKKPITIARHAYGDIYKGVEYRIPEKGKAELVFTSE
KGEEIRYAIHEFETPGVILGMHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKFEE
AGIEYFYTLIDDAVARIVRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPDGKYEFEAAHGTVTRHYYKYLKG
EETSTNPIATIFAWTGALKKRGELDGIKDLVDFADKLEKASLKTVEKGIMTKDLAALSELPNKTVVNTETFLIEIKKTLE
EML

Sequences:

>Translated_403_residues
MAQKIEMKVPIVEMDGDEMTRIIWKLIKEMLIKPYVDLKTEYYDLGIKNRDETEDQVTVDAAYAIKKYGVGVKCATITPN
AERVKEYNLKNMWKSPNATIRSILDGTVFRTPILVEGIKPLVRTWKKPITIARHAYGDIYKGVEYRIPEKGKAELVFTSE
KGEEIRYAIHEFETPGVILGMHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKFEE
AGIEYFYTLIDDAVARIVRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPDGKYEFEAAHGTVTRHYYKYLKG
EETSTNPIATIFAWTGALKKRGELDGIKDLVDFADKLEKASLKTVEKGIMTKDLAALSELPNKTVVNTETFLIEIKKTLE
EML
>Mature_402_residues
AQKIEMKVPIVEMDGDEMTRIIWKLIKEMLIKPYVDLKTEYYDLGIKNRDETEDQVTVDAAYAIKKYGVGVKCATITPNA
ERVKEYNLKNMWKSPNATIRSILDGTVFRTPILVEGIKPLVRTWKKPITIARHAYGDIYKGVEYRIPEKGKAELVFTSEK
GEEIRYAIHEFETPGVILGMHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKFEEA
GIEYFYTLIDDAVARIVRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPDGKYEFEAAHGTVTRHYYKYLKGE
ETSTNPIATIFAWTGALKKRGELDGIKDLVDFADKLEKASLKTVEKGIMTKDLAALSELPNKTVVNTETFLIEIKKTLEE
ML

Specific function: Catalyzes The Oxidation Of 3-Carboxy-2-Hydroxy-4- Methylpentanoate (3-Isopropylmalate) To 3-Carboxy-4-Methyl-2- Oxopentanoate. The Product Decarboxylates To 4-Methyl-2 Oxopentanoate. [C]

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=56.1274509803922, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI28178825, Length=397, Percent_Identity=58.1863979848867, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17540874, Length=406, Percent_Identity=56.4039408866995, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17550822, Length=408, Percent_Identity=54.4117647058823, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6320137, Length=406, Percent_Identity=57.1428571428571, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6324319, Length=405, Percent_Identity=55.8024691358025, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6323203, Length=403, Percent_Identity=53.5980148883375, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=55.2567237163814, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=55.2567237163814, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=55.2567237163814, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=55.2567237163814, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=55.2567237163814, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=55.2567237163814, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=55.2567237163814, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=55.2567237163814, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=55.2567237163814, Blast_Score=447, Evalue=1e-126,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46062; Mature: 45930

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKIEMKVPIVEMDGDEMTRIIWKLIKEMLIKPYVDLKTEYYDLGIKNRDETEDQVTVD
CCCCEEEECCEEECCCHHHHHHHHHHHHHHHHCCCHHCCCHHEECCCCCCCCCCCCEEHH
AAYAIKKYGVGVKCATITPNAERVKEYNLKNMWKSPNATIRSILDGTVFRTPILVEGIKP
HHHHHHHHCCCEEEEEECCCHHHHHHHCHHHHCCCCCHHHHHHHCCHHHHCHHHHHHHHH
LVRTWKKPITIARHAYGDIYKGVEYRIPEKGKAELVFTSEKGEEIRYAIHEFETPGVILG
HHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEE
MHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKFEE
ECCCHHHHHHHHHHHHHHHCCCCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGIEYFYTLIDDAVARIVRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPDGK
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
YEFEAAHGTVTRHYYKYLKGEETSTNPIATIFAWTGALKKRGELDGIKDLVDFADKLEKA
EEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SLKTVEKGIMTKDLAALSELPNKTVVNTETFLIEIKKTLEEML
HHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHC
>Mature Secondary Structure 
AQKIEMKVPIVEMDGDEMTRIIWKLIKEMLIKPYVDLKTEYYDLGIKNRDETEDQVTVD
CCCEEEECCEEECCCHHHHHHHHHHHHHHHHCCCHHCCCHHEECCCCCCCCCCCCEEHH
AAYAIKKYGVGVKCATITPNAERVKEYNLKNMWKSPNATIRSILDGTVFRTPILVEGIKP
HHHHHHHHCCCEEEEEECCCHHHHHHHCHHHHCCCCCHHHHHHHCCHHHHCHHHHHHHHH
LVRTWKKPITIARHAYGDIYKGVEYRIPEKGKAELVFTSEKGEEIRYAIHEFETPGVILG
HHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEE
MHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKFEE
ECCCHHHHHHHHHHHHHHHCCCCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGIEYFYTLIDDAVARIVRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPDGK
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
YEFEAAHGTVTRHYYKYLKGEETSTNPIATIFAWTGALKKRGELDGIKDLVDFADKLEKA
EEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SLKTVEKGIMTKDLAALSELPNKTVVNTETFLIEIKKTLEEML
HHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]