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The map label for this gene is AcrA [H]

Identifier: 20806777

GI number: 20806777

Start: 260191

End: 261750

Strand: Direct

Name: AcrA [H]

Synonym: TTE0256

Alternate gene names: 20806777

Gene position: 260191-261750 (Clockwise)

Preceding gene: 20806776

Following gene: 20806778

Centisome position: 9.67

GC content: 36.79

Gene sequence:

>1560_bases
ATGAAAAGGAAGTATGCATACGTAATTGTCGCTATCCTTCTAATTGCAGGTATTGCTACATTTTATTTTCTAAACAAAAC
CAAAACTTCTACTTCTTCACAGATTCCATACGTAACTGTTACTCGAGGAAACATTTCCATGACAATTACCGGTACAGGTA
ATTTAACAGGAGATGTGAGAGCGATTACTTTAAAAAACGGAGTTGTAAAAAAGGTGTATTTTAATGTAGGCGATTCAGTC
AAAAAAGGTGACCTTTTATATGAACTTGAGGACGATAATTTAAATAATCAGCTGGAACAGGCTAAATTAAATCTTGATTT
GGCGACTCAACAATTAAATCAGGACACAAAAAATTACAATAGCGCTGTTGCAAAACTTAGCATCACTTCTCCTGTTGACG
GAGTAGTAGAAATTTTGGTAAAAGAAGGCCAAGATGTCACTCCAGGTATGCCAGTTGCAGTAGTTAATGTTAATAAATCT
AATGGAAGCGAAGAAGGACAACCTTCTGGTAATAGCGGGACTAATGTCACAGCGCAAGTTTCAGGAACTGTGGAAAAAAT
ATATGTTTCATCAGGGCAGAATGTCAGAAAGGGAGAGGTTTTAATTAAGCTTTCTTCAAGCAATATAAGTGATGCTCAAA
TACAAAGCGACAAAATAAAAGTAATGCAGGCTCAAAATAACTATAATCAAATTTTAAAGCAGATTGAGAGTTTAAAGATT
TATTCTCCAATTGATGGGAAAATATTAAGTCAGAACATAAAAGAAGGAGATGTTCTGGGGAATTTTAGCAGTAACGCAGG
CAATAATAATCTCAATGCTTCTTACGTGCAGACAGGTTTTGTGCCTGTTTTGGACATTACACAGCTTTCATCTTATGAGA
GCCAGCCAGATACAGCAGTAATCGTAGGCAATTCGGGATATATTGTGAACCTTTCCGTTGATGAGACAGATATTAAGAAT
ATAAAAATAGGTCAAAAGGTCCAGCTTACAACTGATGACTTACCAGGAAAGGTATTTAGTGGAACGGTATCTCAAGTATC
ACAGTTGCCAACTATACAGAATGGCGTTGCATCGTACAATGTAACTATACAGGTAGACCCGAGTGAGGATCTAATGCTTG
GTATGTCAATGGATGTAGCTATTACAGTTGCAGAAAAAAACGATGTTTTACTCCTCCCTATACAGGCAGTACAGACGCTG
GGAAATAGACAGTATGTGATACTTTATACAGATGATATGAAAAATCAAAATCTTTCTGATGCCAATGCCAATAATATGAG
GAACTTGTTTAGAAATAATATAAGGTTTATAGAAACAGGAATTCACAACAACAATTTTGTAGAAATAGTAAGTGGACTGC
AGGAAGGCGACAGGGTGTTAATTCCTTTGAACTCCTCTTTGGCTAATAGTAACAATAGAAATCCTCAAGGCTTTAATTTT
ATGATGAGGCCGCAGGGAGGATTCAATAGAAATACTGAAAGGCCGAGTGGAAGCTTTCAAGGAGGAAGCTTTAACAGGTC
ATGGCAGAACAACTCTTCCTCAGGGGGCAATAATAGATGA

Upstream 100 bases:

>100_bases
GCGGACCTTTTTGCACACAAATTTCTCACATATTTGTAATTTTTGTATCATAATTTTCTGCTAGTATATTTACAAACCTT
TCGATTAAAGAGGTGGCAAT

Downstream 100 bases:

>100_bases
ATAGTGATAAAGTACTGATAAAAATGAGAAATTTAACAAAAATTTATAGAATCGGGCAGAATGAAGTAAGGGCATTAGAT
GGAATAGATTTGGATATCCG

Product: membrane-fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MKRKYAYVIVAILLIAGIATFYFLNKTKTSTSSQIPYVTVTRGNISMTITGTGNLTGDVRAITLKNGVVKKVYFNVGDSV
KKGDLLYELEDDNLNNQLEQAKLNLDLATQQLNQDTKNYNSAVAKLSITSPVDGVVEILVKEGQDVTPGMPVAVVNVNKS
NGSEEGQPSGNSGTNVTAQVSGTVEKIYVSSGQNVRKGEVLIKLSSSNISDAQIQSDKIKVMQAQNNYNQILKQIESLKI
YSPIDGKILSQNIKEGDVLGNFSSNAGNNNLNASYVQTGFVPVLDITQLSSYESQPDTAVIVGNSGYIVNLSVDETDIKN
IKIGQKVQLTTDDLPGKVFSGTVSQVSQLPTIQNGVASYNVTIQVDPSEDLMLGMSMDVAITVAEKNDVLLLPIQAVQTL
GNRQYVILYTDDMKNQNLSDANANNMRNLFRNNIRFIETGIHNNNFVEIVSGLQEGDRVLIPLNSSLANSNNRNPQGFNF
MMRPQGGFNRNTERPSGSFQGGSFNRSWQNNSSSGGNNR

Sequences:

>Translated_519_residues
MKRKYAYVIVAILLIAGIATFYFLNKTKTSTSSQIPYVTVTRGNISMTITGTGNLTGDVRAITLKNGVVKKVYFNVGDSV
KKGDLLYELEDDNLNNQLEQAKLNLDLATQQLNQDTKNYNSAVAKLSITSPVDGVVEILVKEGQDVTPGMPVAVVNVNKS
NGSEEGQPSGNSGTNVTAQVSGTVEKIYVSSGQNVRKGEVLIKLSSSNISDAQIQSDKIKVMQAQNNYNQILKQIESLKI
YSPIDGKILSQNIKEGDVLGNFSSNAGNNNLNASYVQTGFVPVLDITQLSSYESQPDTAVIVGNSGYIVNLSVDETDIKN
IKIGQKVQLTTDDLPGKVFSGTVSQVSQLPTIQNGVASYNVTIQVDPSEDLMLGMSMDVAITVAEKNDVLLLPIQAVQTL
GNRQYVILYTDDMKNQNLSDANANNMRNLFRNNIRFIETGIHNNNFVEIVSGLQEGDRVLIPLNSSLANSNNRNPQGFNF
MMRPQGGFNRNTERPSGSFQGGSFNRSWQNNSSSGGNNR
>Mature_519_residues
MKRKYAYVIVAILLIAGIATFYFLNKTKTSTSSQIPYVTVTRGNISMTITGTGNLTGDVRAITLKNGVVKKVYFNVGDSV
KKGDLLYELEDDNLNNQLEQAKLNLDLATQQLNQDTKNYNSAVAKLSITSPVDGVVEILVKEGQDVTPGMPVAVVNVNKS
NGSEEGQPSGNSGTNVTAQVSGTVEKIYVSSGQNVRKGEVLIKLSSSNISDAQIQSDKIKVMQAQNNYNQILKQIESLKI
YSPIDGKILSQNIKEGDVLGNFSSNAGNNNLNASYVQTGFVPVLDITQLSSYESQPDTAVIVGNSGYIVNLSVDETDIKN
IKIGQKVQLTTDDLPGKVFSGTVSQVSQLPTIQNGVASYNVTIQVDPSEDLMLGMSMDVAITVAEKNDVLLLPIQAVQTL
GNRQYVILYTDDMKNQNLSDANANNMRNLFRNNIRFIETGIHNNNFVEIVSGLQEGDRVLIPLNSSLANSNNRNPQGFNF
MMRPQGGFNRNTERPSGSFQGGSFNRSWQNNSSSGGNNR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 56391; Mature: 56391

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKYAYVIVAILLIAGIATFYFLNKTKTSTSSQIPYVTVTRGNISMTITGTGNLTGDVR
CCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEECCCEEEEEEECCCCCCCEE
AITLKNGVVKKVYFNVGDSVKKGDLLYELEDDNLNNQLEQAKLNLDLATQQLNQDTKNYN
EEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHC
SAVAKLSITSPVDGVVEILVKEGQDVTPGMPVAVVNVNKSNGSEEGQPSGNSGTNVTAQV
CEEEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEE
SGTVEKIYVSSGQNVRKGEVLIKLSSSNISDAQIQSDKIKVMQAQNNYNQILKQIESLKI
CCCEEEEEECCCCCEECCEEEEEECCCCCCCCEECCCEEEEEEECCHHHHHHHHHHHEEE
YSPIDGKILSQNIKEGDVLGNFSSNAGNNNLNASYVQTGFVPVLDITQLSSYESQPDTAV
ECCCCCHHHHCCCCCCCEEECCCCCCCCCCCCCEEEEECCEEEEEEHHHCCCCCCCCEEE
IVGNSGYIVNLSVDETDIKNIKIGQKVQLTTDDLPGKVFSGTVSQVSQLPTIQNGVASYN
EECCCCEEEEEEECCCCCCEEECCCEEEEECCCCCCHHHHCHHHHHHHCCCHHCCCEEEE
VTIQVDPSEDLMLGMSMDVAITVAEKNDVLLLPIQAVQTLGNRQYVILYTDDMKNQNLSD
EEEEECCCCCEEEEEEEEEEEEEECCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCCCCC
ANANNMRNLFRNNIRFIETGIHNNNFVEIVSGLQEGDRVLIPLNSSLANSNNRNPQGFNF
CCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHCCCCCCCCCCCEE
MMRPQGGFNRNTERPSGSFQGGSFNRSWQNNSSSGGNNR
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRKYAYVIVAILLIAGIATFYFLNKTKTSTSSQIPYVTVTRGNISMTITGTGNLTGDVR
CCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEECCCEEEEEEECCCCCCCEE
AITLKNGVVKKVYFNVGDSVKKGDLLYELEDDNLNNQLEQAKLNLDLATQQLNQDTKNYN
EEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHC
SAVAKLSITSPVDGVVEILVKEGQDVTPGMPVAVVNVNKSNGSEEGQPSGNSGTNVTAQV
CEEEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEE
SGTVEKIYVSSGQNVRKGEVLIKLSSSNISDAQIQSDKIKVMQAQNNYNQILKQIESLKI
CCCEEEEEECCCCCEECCEEEEEECCCCCCCCEECCCEEEEEEECCHHHHHHHHHHHEEE
YSPIDGKILSQNIKEGDVLGNFSSNAGNNNLNASYVQTGFVPVLDITQLSSYESQPDTAV
ECCCCCHHHHCCCCCCCEEECCCCCCCCCCCCCEEEEECCEEEEEEHHHCCCCCCCCEEE
IVGNSGYIVNLSVDETDIKNIKIGQKVQLTTDDLPGKVFSGTVSQVSQLPTIQNGVASYN
EECCCCEEEEEEECCCCCCEEECCCEEEEECCCCCCHHHHCHHHHHHHCCCHHCCCEEEE
VTIQVDPSEDLMLGMSMDVAITVAEKNDVLLLPIQAVQTLGNRQYVILYTDDMKNQNLSD
EEEEECCCCCEEEEEEEEEEEEEECCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCCCCC
ANANNMRNLFRNNIRFIETGIHNNNFVEIVSGLQEGDRVLIPLNSSLANSNNRNPQGFNF
CCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHCCCCCCCCCCCEE
MMRPQGGFNRNTERPSGSFQGGSFNRSWQNNSSSGGNNR
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]