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The map label for this gene is NorM [H]

Identifier: 20806776

GI number: 20806776

Start: 258703

End: 260073

Strand: Direct

Name: NorM [H]

Synonym: TTE0255

Alternate gene names: 20806776

Gene position: 258703-260073 (Clockwise)

Preceding gene: 20806775

Following gene: 20806777

Centisome position: 9.62

GC content: 39.75

Gene sequence:

>1371_bases
TTGGAAGCAAAAGAAGAGGAAAGGCGAAATGTAGCAAAAGAAGTCATGGAGATTGCCTGGCCTTCTATAGCTGAGCAAAT
GCTTGTGATGGCAGTAGGAATGATTTCCACCATATTTGTTGGACGTATAAGTGCGGCTGCCCTTGCCGCTGTAGGGCTTA
TAAACATGGTTATATTTTTTCTACAAGCAGTCTTTGCAGGATTGTCTACAGGTGTTACAGTGGTTGTGGCTAGACTTGTT
GGTGAGGAAGATATTGAAGGGGTTAAGACTGCTACTTCGCAGTCTTTTATAATGGCAGTTTTTTTGACACTTTTATTTAC
ACTTTTAGGATATGCCTTTGACATTCCTATCATAAAAACTCTCTTTGGCAAGATCGAGCCTGAGGTTTTTGAATTTGCTA
TTTTGTACTACAGAATTGCTCTCATAGGGTTTCCTTTTATGGTCATTGCCTTAATATTGGGAGGTGCATTAAGAGGGGCG
GGGGATACAAAAACTCCCATGTATGTGACTGCAGTTGTAAACATAATAAACCTCATTTTAAATGCGCTTTTGGTTTTTGG
TGTACCTTATAAAGGTAGGTACCTGATACCTCCTTTTGGTGTTAAAGGTGCGGCTTTTTCTGTGACAGCTGCGCGCATAG
TAGGTGGGATACTTCTACCTTATTTAATTTATTCTGGGAAAAACCAGGCGGGAATAGCCATCAGAGGGCCCTTTAAATTA
GATTTTGATATGATGAAAAGGATTATAAAAATAGGAGTTCCTGCCTCTTTAGAGCAGCTGGTGATGCAGGGAGGATTTTT
AGTAGTTCAGATAATAGTGTCCACAATGGGCACAACAGCTATAGCCGTCTATCAAATAGGAATGAATGCAAACAGCCTTG
CGTTTATGCCAATATTTGGTTTTTCAATAGCAGCTACAGCCTTAGTAGGAAGGAGCCTTGGGGCAGAAGAATTTGATATG
GCGGAGACTTACGCCAAAGTTTCCAGGAATATTTCTGTTGTAGTAATTTCTGTTATAGGCGTTTTTATGTTTGTGTTTTC
CAAACAGCTTGCAGCGCTTTATACTACCGATCCGGAAGTTATAAGAGTGTCTGCTAGCATTTTAAAAATATTTGCAGTAG
TAGAGCCCTTTCTTGCAATTATGGTGGTGATGGCGGGAGTATTAAGGGCTGCAGGCGATATATCGTATGTTGTAATTACT
ACTGTGGTAGGCCTTTGGCTTTTCAGGATAGTATTGGGTTCTTTTTTAGCTAAAAATTTTGGGATGGACATCTACGGGAT
ATGGATTGGGGTTTTTACCGATTTTATAGTTCGTTCGATAATGTACATTTTTAGGTTTAGAGCAGGAAAGTGGAAGTACA
TAAAAGTATAA

Upstream 100 bases:

>100_bases
ATTTGGCAGAAGAGATAAATAAAAGAATAGGGAAAAAAATAATCAAAAAAGGAAGCGAACTTCTAAAAGATAATAAATAG
GCTAAAATGGGGGGATTGAA

Downstream 100 bases:

>100_bases
GGGTCCGCTAAAAGTCAGCGGACCTTTTTGCACACAAATTTCTCACATATTTGTAATTTTTGTATCATAATTTTCTGCTA
GTATATTTACAAACCTTTCG

Product: Na+-driven multidrug efflux pump

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MEAKEEERRNVAKEVMEIAWPSIAEQMLVMAVGMISTIFVGRISAAALAAVGLINMVIFFLQAVFAGLSTGVTVVVARLV
GEEDIEGVKTATSQSFIMAVFLTLLFTLLGYAFDIPIIKTLFGKIEPEVFEFAILYYRIALIGFPFMVIALILGGALRGA
GDTKTPMYVTAVVNIINLILNALLVFGVPYKGRYLIPPFGVKGAAFSVTAARIVGGILLPYLIYSGKNQAGIAIRGPFKL
DFDMMKRIIKIGVPASLEQLVMQGGFLVVQIIVSTMGTTAIAVYQIGMNANSLAFMPIFGFSIAATALVGRSLGAEEFDM
AETYAKVSRNISVVVISVIGVFMFVFSKQLAALYTTDPEVIRVSASILKIFAVVEPFLAIMVVMAGVLRAAGDISYVVIT
TVVGLWLFRIVLGSFLAKNFGMDIYGIWIGVFTDFIVRSIMYIFRFRAGKWKYIKV

Sequences:

>Translated_456_residues
MEAKEEERRNVAKEVMEIAWPSIAEQMLVMAVGMISTIFVGRISAAALAAVGLINMVIFFLQAVFAGLSTGVTVVVARLV
GEEDIEGVKTATSQSFIMAVFLTLLFTLLGYAFDIPIIKTLFGKIEPEVFEFAILYYRIALIGFPFMVIALILGGALRGA
GDTKTPMYVTAVVNIINLILNALLVFGVPYKGRYLIPPFGVKGAAFSVTAARIVGGILLPYLIYSGKNQAGIAIRGPFKL
DFDMMKRIIKIGVPASLEQLVMQGGFLVVQIIVSTMGTTAIAVYQIGMNANSLAFMPIFGFSIAATALVGRSLGAEEFDM
AETYAKVSRNISVVVISVIGVFMFVFSKQLAALYTTDPEVIRVSASILKIFAVVEPFLAIMVVMAGVLRAAGDISYVVIT
TVVGLWLFRIVLGSFLAKNFGMDIYGIWIGVFTDFIVRSIMYIFRFRAGKWKYIKV
>Mature_456_residues
MEAKEEERRNVAKEVMEIAWPSIAEQMLVMAVGMISTIFVGRISAAALAAVGLINMVIFFLQAVFAGLSTGVTVVVARLV
GEEDIEGVKTATSQSFIMAVFLTLLFTLLGYAFDIPIIKTLFGKIEPEVFEFAILYYRIALIGFPFMVIALILGGALRGA
GDTKTPMYVTAVVNIINLILNALLVFGVPYKGRYLIPPFGVKGAAFSVTAARIVGGILLPYLIYSGKNQAGIAIRGPFKL
DFDMMKRIIKIGVPASLEQLVMQGGFLVVQIIVSTMGTTAIAVYQIGMNANSLAFMPIFGFSIAATALVGRSLGAEEFDM
AETYAKVSRNISVVVISVIGVFMFVFSKQLAALYTTDPEVIRVSASILKIFAVVEPFLAIMVVMAGVLRAAGDISYVVIT
TVVGLWLFRIVLGSFLAKNFGMDIYGIWIGVFTDFIVRSIMYIFRFRAGKWKYIKV

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=453, Percent_Identity=23.3995584988962, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI153792564, Length=445, Percent_Identity=24.2696629213483, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI226510954, Length=444, Percent_Identity=30.8558558558559, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI48994890, Length=448, Percent_Identity=27.4553571428571, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320545, Length=426, Percent_Identity=22.3004694835681, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49588; Mature: 49588

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAKEEERRNVAKEVMEIAWPSIAEQMLVMAVGMISTIFVGRISAAALAAVGLINMVIFF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQAVFAGLSTGVTVVVARLVGEEDIEGVKTATSQSFIMAVFLTLLFTLLGYAFDIPIIKT
HHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFGKIEPEVFEFAILYYRIALIGFPFMVIALILGGALRGAGDTKTPMYVTAVVNIINLIL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHH
NALLVFGVPYKGRYLIPPFGVKGAAFSVTAARIVGGILLPYLIYSGKNQAGIAIRGPFKL
HHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
DFDMMKRIIKIGVPASLEQLVMQGGFLVVQIIVSTMGTTAIAVYQIGMNANSLAFMPIFG
CHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCHHHEEEEEECCCCCCEEEHHHHH
FSIAATALVGRSLGAEEFDMAETYAKVSRNISVVVISVIGVFMFVFSKQLAALYTTDPEV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
IRVSASILKIFAVVEPFLAIMVVMAGVLRAAGDISYVVITTVVGLWLFRIVLGSFLAKNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GMDIYGIWIGVFTDFIVRSIMYIFRFRAGKWKYIKV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MEAKEEERRNVAKEVMEIAWPSIAEQMLVMAVGMISTIFVGRISAAALAAVGLINMVIFF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQAVFAGLSTGVTVVVARLVGEEDIEGVKTATSQSFIMAVFLTLLFTLLGYAFDIPIIKT
HHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFGKIEPEVFEFAILYYRIALIGFPFMVIALILGGALRGAGDTKTPMYVTAVVNIINLIL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHH
NALLVFGVPYKGRYLIPPFGVKGAAFSVTAARIVGGILLPYLIYSGKNQAGIAIRGPFKL
HHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
DFDMMKRIIKIGVPASLEQLVMQGGFLVVQIIVSTMGTTAIAVYQIGMNANSLAFMPIFG
CHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCHHHEEEEEECCCCCCEEEHHHHH
FSIAATALVGRSLGAEEFDMAETYAKVSRNISVVVISVIGVFMFVFSKQLAALYTTDPEV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
IRVSASILKIFAVVEPFLAIMVVMAGVLRAAGDISYVVITTVVGLWLFRIVLGSFLAKNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GMDIYGIWIGVFTDFIVRSIMYIFRFRAGKWKYIKV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]