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The map label for this gene is DinP

Identifier: 20806775

GI number: 20806775

Start: 257528

End: 258682

Strand: Direct

Name: DinP

Synonym: TTE0254

Alternate gene names: 20806775

Gene position: 257528-258682 (Clockwise)

Preceding gene: 20806774

Following gene: 20806776

Centisome position: 9.58

GC content: 36.28

Gene sequence:

>1155_bases
ATGAAAAGAAAGATTATCCATGTTGATATGGACGCTTTCTTTGCGTCCATTGAACAACAGGATAATCCTGAATACAGAGG
GAAGCCTGTCATTGTTGGAGGATTATCAGGAAGAGGTGTTGTTTCCACATGTTCTTATGAGGCGCGAAAGTACGGGATTC
ACTCTGCTATGCCAATGTACATGGCAAAAAAACTGTGCCCTCAGGGCATTTTTTTGCCTGTCAGGAGAAAACGATATGAA
GAAGTATCAGAACAGATTTTTAGAATCTTATACGACATAACTCCCTTTGTAGAGCCTGTATCTATAGACGAGGCTTATTT
AGATGTTACACATGTTGACAAAAATCCTGAGGATATTGCCCTGGAAATAAAGAAGAGAGTAAAAGATGCGACAGGCCTTA
CTGTTTCTGTAGGCATTTCTTACAACAAATTTCTTGCAAAGCTTGCCTCTGACTGGAATAAACCAGATGGTTTGATGGTG
ATAACAGAAGACATGGTACCAGAAATATTAAAGCCCCTTCCTGTTACGAAAGTCCATGGAATAGGCGAAAAATCTGCGGA
AAAACTAAGAAGTATAGGGATAGAGACTGTGGAAGATTTATTAAAACTTCCTCAAGAAAATCTTATAGAACTTTTTGGGA
AAACAGGGGTAGAGATATACAATCGAATTAGAGGTATTGATGAGAGGCCTGTCGAGACGATGAGGGAGATTAAGTCTATA
GGGAAAGAAAAGACTTTGGAAAAAGATACAAAGAATAAAGAACTGCTAATTCAACATCTAAAAGAATTTTCTGAAATTGT
ATCGGAAGAGCTTATCAAAGAAAGGCTTTACTGCAGGACAGTTACTGTGAAAATAAAAACTGCAGATTTTGCTGTTCACA
CAAAGAGCAAAACAGTAGATAAATACATAAGATTTAGTGAAGACATTTATGAGGTGGCAAAAGGGATATTAGAAGAGTGG
AAATTAGAGCAATATGTTAGACTGATAGGACTCTCTGTGTCTAATTTAAGCCCTGTGAAATATGAGCAATTGTCCTTCTT
AGATAAAAGATTGGTTAAAGTAATAAAAGCTGGGAATTTGGCAGAAGAGATAAATAAAAGAATAGGGAAAAAAATAATCA
AAAAAGGAAGCGAACTTCTAAAAGATAATAAATAG

Upstream 100 bases:

>100_bases
TCTGGAGATCTCTTAATTTGTCTAATTCCGTTGCCATAATAGTATATGAAGCCTTAAAGCAGTTGGGTTTTCCCAATATG
AGATGAAATGAGGGAAATTT

Downstream 100 bases:

>100_bases
GCTAAAATGGGGGGATTGAATTGGAAGCAAAAGAAGAGGAAAGGCGAAATGTAGCAAAAGAAGTCATGGAGATTGCCTGG
CCTTCTATAGCTGAGCAAAT

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKRKIIHVDMDAFFASIEQQDNPEYRGKPVIVGGLSGRGVVSTCSYEARKYGIHSAMPMYMAKKLCPQGIFLPVRRKRYE
EVSEQIFRILYDITPFVEPVSIDEAYLDVTHVDKNPEDIALEIKKRVKDATGLTVSVGISYNKFLAKLASDWNKPDGLMV
ITEDMVPEILKPLPVTKVHGIGEKSAEKLRSIGIETVEDLLKLPQENLIELFGKTGVEIYNRIRGIDERPVETMREIKSI
GKEKTLEKDTKNKELLIQHLKEFSEIVSEELIKERLYCRTVTVKIKTADFAVHTKSKTVDKYIRFSEDIYEVAKGILEEW
KLEQYVRLIGLSVSNLSPVKYEQLSFLDKRLVKVIKAGNLAEEINKRIGKKIIKKGSELLKDNK

Sequences:

>Translated_384_residues
MKRKIIHVDMDAFFASIEQQDNPEYRGKPVIVGGLSGRGVVSTCSYEARKYGIHSAMPMYMAKKLCPQGIFLPVRRKRYE
EVSEQIFRILYDITPFVEPVSIDEAYLDVTHVDKNPEDIALEIKKRVKDATGLTVSVGISYNKFLAKLASDWNKPDGLMV
ITEDMVPEILKPLPVTKVHGIGEKSAEKLRSIGIETVEDLLKLPQENLIELFGKTGVEIYNRIRGIDERPVETMREIKSI
GKEKTLEKDTKNKELLIQHLKEFSEIVSEELIKERLYCRTVTVKIKTADFAVHTKSKTVDKYIRFSEDIYEVAKGILEEW
KLEQYVRLIGLSVSNLSPVKYEQLSFLDKRLVKVIKAGNLAEEINKRIGKKIIKKGSELLKDNK
>Mature_384_residues
MKRKIIHVDMDAFFASIEQQDNPEYRGKPVIVGGLSGRGVVSTCSYEARKYGIHSAMPMYMAKKLCPQGIFLPVRRKRYE
EVSEQIFRILYDITPFVEPVSIDEAYLDVTHVDKNPEDIALEIKKRVKDATGLTVSVGISYNKFLAKLASDWNKPDGLMV
ITEDMVPEILKPLPVTKVHGIGEKSAEKLRSIGIETVEDLLKLPQENLIELFGKTGVEIYNRIRGIDERPVETMREIKSI
GKEKTLEKDTKNKELLIQHLKEFSEIVSEELIKERLYCRTVTVKIKTADFAVHTKSKTVDKYIRFSEDIYEVAKGILEEW
KLEQYVRLIGLSVSNLSPVKYEQLSFLDKRLVKVIKAGNLAEEINKRIGKKIIKKGSELLKDNK

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI84043967, Length=410, Percent_Identity=28.5365853658537, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI7706681, Length=411, Percent_Identity=28.4671532846715, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI5729982, Length=351, Percent_Identity=27.9202279202279, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI7705344, Length=122, Percent_Identity=43.4426229508197, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI154350220, Length=289, Percent_Identity=29.4117647058824, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1786425, Length=355, Percent_Identity=41.1267605633803, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI1787432, Length=363, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193205700, Length=401, Percent_Identity=30.6733167082294, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI193205702, Length=345, Percent_Identity=29.5652173913043, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17537959, Length=401, Percent_Identity=26.4339152119701, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115534089, Length=350, Percent_Identity=28, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324921, Length=269, Percent_Identity=25.2788104089219, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19923006, Length=350, Percent_Identity=25.7142857142857, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21355641, Length=316, Percent_Identity=29.4303797468354, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24644984, Length=316, Percent_Identity=29.4303797468354, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24668444, Length=120, Percent_Identity=34.1666666666667, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO4_THETN (P58965)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_621946.1
- ProteinModelPortal:   P58965
- SMR:   P58965
- GeneID:   996547
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0254
- NMPDR:   fig|273068.3.peg.1047
- HOGENOM:   HBG734504
- OMA:   GDEHIIR
- ProtClustDB:   PRK14133
- BioCyc:   TTEN273068:TTE0254-MONOMER
- BRENDA:   2.7.7.7
- GO:   GO:0005737
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 43917; Mature: 43917

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 104-104

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKIIHVDMDAFFASIEQQDNPEYRGKPVIVGGLSGRGVVSTCSYEARKYGIHSAMPMY
CCCEEEEECHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCHHHHHHH
MAKKLCPQGIFLPVRRKRYEEVSEQIFRILYDITPFVEPVSIDEAYLDVTHVDKNPEDIA
HHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEHEECCCCHHHHH
LEIKKRVKDATGLTVSVGISYNKFLAKLASDWNKPDGLMVITEDMVPEILKPLPVTKVHG
HHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCCHHHCC
IGEKSAEKLRSIGIETVEDLLKLPQENLIELFGKTGVEIYNRIRGIDERPVETMREIKSI
CCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHH
GKEKTLEKDTKNKELLIQHLKEFSEIVSEELIKERLYCRTVTVKIKTADFAVHTKSKTVD
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCEEEECCHHHHH
KYIRFSEDIYEVAKGILEEWKLEQYVRLIGLSVSNLSPVKYEQLSFLDKRLVKVIKAGNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCH
AEEINKRIGKKIIKKGSELLKDNK
HHHHHHHHHHHHHHCCHHHHCCCC
>Mature Secondary Structure
MKRKIIHVDMDAFFASIEQQDNPEYRGKPVIVGGLSGRGVVSTCSYEARKYGIHSAMPMY
CCCEEEEECHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCHHHHHHH
MAKKLCPQGIFLPVRRKRYEEVSEQIFRILYDITPFVEPVSIDEAYLDVTHVDKNPEDIA
HHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEHEECCCCHHHHH
LEIKKRVKDATGLTVSVGISYNKFLAKLASDWNKPDGLMVITEDMVPEILKPLPVTKVHG
HHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCCHHHCC
IGEKSAEKLRSIGIETVEDLLKLPQENLIELFGKTGVEIYNRIRGIDERPVETMREIKSI
CCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHH
GKEKTLEKDTKNKELLIQHLKEFSEIVSEELIKERLYCRTVTVKIKTADFAVHTKSKTVD
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCEEEECCHHHHH
KYIRFSEDIYEVAKGILEEWKLEQYVRLIGLSVSNLSPVKYEQLSFLDKRLVKVIKAGNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCH
AEEINKRIGKKIIKKGSELLKDNK
HHHHHHHHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336