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The map label for this gene is Ald [H]

Identifier: 20806687

GI number: 20806687

Start: 157822

End: 158946

Strand: Direct

Name: Ald [H]

Synonym: TTE0161

Alternate gene names: 20806687

Gene position: 157822-158946 (Clockwise)

Preceding gene: 20806686

Following gene: 20806688

Centisome position: 5.87

GC content: 44.0

Gene sequence:

>1125_bases
ATGAGAATTGGTGTTCCCAAAGAAATAAAAACTGCAGAGTCCCGTGTAGCCATAACGCCTGCAGGAGTAGAGGCTTTTGT
CAAGAATGGACATGAAGTGTACATTGAAAAGGACGCAGGATTAGGTAGCGGTATCACAAATGAGGAATATGAAAAGGCAG
GGGCAAAAATACTTCCAACTGCCAAAGAAGTGTACGACATAGCTGACATGATAATGAAGGTAAAAGAGCCACAGCCAAGC
GAATACGACTACTTAAAAGAGGGACAAGTTTTATTTACTTATCTACATTTAGCACCCGATAAACAGCAGACAGAAGCTTT
ATTAAGACAGAAAGTAGTAGGAATCGCCTATGAGACGGTACAGCTTGACAACGGTTCTTTGCCTTTGTTAACACCCATGA
GCGAAGTTGCTGGTAGAATGGCTGTCACCATAGGAGCTTACCTTTTGACTAGCATAAATCAAGGCAGAGGTATTGTGATG
GGCGGGGTTCCTGGAGTAGAGCCAGCAGAAGTAGTCATAATAGGCGGCGGAACAGTGGGCACCAATGCGGCAAAGGTAGC
AGTTGGCATGGGAGCAAGAGTTACTATACTGGATGTAAATCCTGCAAGGCTTGCCTACCTTGACGACATATTTGGAGGAA
GAGTGACAACTCTAATGTCAAATAGCTTTAATATTGCAGAAAGCGTAAAGAAGGCAGACTTATTGATAGGTGCTGTTCTT
ATACCAGGGGCTCGAGCGCCTAAGCTTGTAACTGAAGAAATGGTCAAGACAATGAAGAAGGGCGCTGTAATTGTGGATGT
AGCAATAGACCAGGGTGGATGCGTAGAAACATGTGACAGAACTACTTCCCACACAGATCCATATTTCATCAAGCACGGAG
TTGTTCACTACTCAGTTCCTAATATACCAGGAGCTGTACCAAGGACTTCAACCTTTGCTCTCACGAATGTCACACTTCCT
TACGCATTAGAAATTGCTAACAAGGGCTACAAGAGGGCGTTGCTTGAAAATAGAGCACTTCTAAAAGGGCTCAATGTCTA
CAAAGGCATGGTGACATACAAACCTGTGGCAGAAGCGCAAGGATTAGAGTATGTGGATCCCGTTGAAGCTTTGAATAAAG
CGTAA

Upstream 100 bases:

>100_bases
TTTACTATTTCTATTTTTTGTAGAAGGATTTTTGGCAGCATGTGTAGAATTTATATACTGAAAAGCTTTTGATAAAAAAT
TGATAAAGGGGAGAGTATTT

Downstream 100 bases:

>100_bases
ATGTCTGACCTCCCACAATAAATGTGGGAGGTTTATTTAGTCTGTTGACAGAGTTTAAAAAGTGGCATTTTGTGTGTAAA
TGCGACTTGTTGTCAAAGCG

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MRIGVPKEIKTAESRVAITPAGVEAFVKNGHEVYIEKDAGLGSGITNEEYEKAGAKILPTAKEVYDIADMIMKVKEPQPS
EYDYLKEGQVLFTYLHLAPDKQQTEALLRQKVVGIAYETVQLDNGSLPLLTPMSEVAGRMAVTIGAYLLTSINQGRGIVM
GGVPGVEPAEVVIIGGGTVGTNAAKVAVGMGARVTILDVNPARLAYLDDIFGGRVTTLMSNSFNIAESVKKADLLIGAVL
IPGARAPKLVTEEMVKTMKKGAVIVDVAIDQGGCVETCDRTTSHTDPYFIKHGVVHYSVPNIPGAVPRTSTFALTNVTLP
YALEIANKGYKRALLENRALLKGLNVYKGMVTYKPVAEAQGLEYVDPVEALNKA

Sequences:

>Translated_374_residues
MRIGVPKEIKTAESRVAITPAGVEAFVKNGHEVYIEKDAGLGSGITNEEYEKAGAKILPTAKEVYDIADMIMKVKEPQPS
EYDYLKEGQVLFTYLHLAPDKQQTEALLRQKVVGIAYETVQLDNGSLPLLTPMSEVAGRMAVTIGAYLLTSINQGRGIVM
GGVPGVEPAEVVIIGGGTVGTNAAKVAVGMGARVTILDVNPARLAYLDDIFGGRVTTLMSNSFNIAESVKKADLLIGAVL
IPGARAPKLVTEEMVKTMKKGAVIVDVAIDQGGCVETCDRTTSHTDPYFIKHGVVHYSVPNIPGAVPRTSTFALTNVTLP
YALEIANKGYKRALLENRALLKGLNVYKGMVTYKPVAEAQGLEYVDPVEALNKA
>Mature_374_residues
MRIGVPKEIKTAESRVAITPAGVEAFVKNGHEVYIEKDAGLGSGITNEEYEKAGAKILPTAKEVYDIADMIMKVKEPQPS
EYDYLKEGQVLFTYLHLAPDKQQTEALLRQKVVGIAYETVQLDNGSLPLLTPMSEVAGRMAVTIGAYLLTSINQGRGIVM
GGVPGVEPAEVVIIGGGTVGTNAAKVAVGMGARVTILDVNPARLAYLDDIFGGRVTTLMSNSFNIAESVKKADLLIGAVL
IPGARAPKLVTEEMVKTMKKGAVIVDVAIDQGGCVETCDRTTSHTDPYFIKHGVVHYSVPNIPGAVPRTSTFALTNVTLP
YALEIANKGYKRALLENRALLKGLNVYKGMVTYKPVAEAQGLEYVDPVEALNKA

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=350, Percent_Identity=32.2857142857143, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI122939153, Length=350, Percent_Identity=32.2857142857143, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1787887, Length=335, Percent_Identity=31.9402985074627, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17550456, Length=347, Percent_Identity=31.4121037463977, Blast_Score=157, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39987; Mature: 39987

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGVPKEIKTAESRVAITPAGVEAFVKNGHEVYIEKDAGLGSGITNEEYEKAGAKILPT
CCCCCCCHHHHCCCEEEEECCCHHHHHCCCCEEEEEECCCCCCCCCCHHHHHCCCEECCC
AKEVYDIADMIMKVKEPQPSEYDYLKEGQVLFTYLHLAPDKQQTEALLRQKVVGIAYETV
HHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHEEEEEE
QLDNGSLPLLTPMSEVAGRMAVTIGAYLLTSINQGRGIVMGGVPGVEPAEVVIIGGGTVG
EECCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCCCC
TNAAKVAVGMGARVTILDVNPARLAYLDDIFGGRVTTLMSNSFNIAESVKKADLLIGAVL
CCCEEEEECCCCEEEEEECCCHHHHHHHHHCCCEEEEHHCCCCCHHHHHHHHHHHEEHEE
IPGARAPKLVTEEMVKTMKKGAVIVDVAIDQGGCVETCDRTTSHTDPYFIKHGVVHYSVP
CCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCCCCCCCEEEECCEEEEECC
NIPGAVPRTSTFALTNVTLPYALEIANKGYKRALLENRALLKGLNVYKGMVTYKPVAEAQ
CCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEECCHHHHC
GLEYVDPVEALNKA
CCCCCCHHHHHHCC
>Mature Secondary Structure
MRIGVPKEIKTAESRVAITPAGVEAFVKNGHEVYIEKDAGLGSGITNEEYEKAGAKILPT
CCCCCCCHHHHCCCEEEEECCCHHHHHCCCCEEEEEECCCCCCCCCCHHHHHCCCEECCC
AKEVYDIADMIMKVKEPQPSEYDYLKEGQVLFTYLHLAPDKQQTEALLRQKVVGIAYETV
HHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHEEEEEE
QLDNGSLPLLTPMSEVAGRMAVTIGAYLLTSINQGRGIVMGGVPGVEPAEVVIIGGGTVG
EECCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCCCC
TNAAKVAVGMGARVTILDVNPARLAYLDDIFGGRVTTLMSNSFNIAESVKKADLLIGAVL
CCCEEEEECCCCEEEEEECCCHHHHHHHHHCCCEEEEHHCCCCCHHHHHHHHHHHEEHEE
IPGARAPKLVTEEMVKTMKKGAVIVDVAIDQGGCVETCDRTTSHTDPYFIKHGVVHYSVP
CCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCCCCCCCEEEECCEEEEECC
NIPGAVPRTSTFALTNVTLPYALEIANKGYKRALLENRALLKGLNVYKGMVTYKPVAEAQ
CCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEECCHHHHC
GLEYVDPVEALNKA
CCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA