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The map label for this gene is ComEB [H]

Identifier: 20806677

GI number: 20806677

Start: 146268

End: 146774

Strand: Direct

Name: ComEB [H]

Synonym: TTE0148

Alternate gene names: 20806677

Gene position: 146268-146774 (Clockwise)

Preceding gene: 20806676

Following gene: 20806678

Centisome position: 5.44

GC content: 45.17

Gene sequence:

>507_bases
TTGTTCCAGGGTTGGGGGATGCTGGAGATAGATTGTTTGGAACTAAGTGAGGAGAGGATAAAAATGAGGCCCTCGTGGGA
TGAATATTTTATGCAGATTGTGGACGTGGTGAAGACCAGGTCTACTTGCATAAGAAGACAGGTAGGAGCTATTTTAGTGG
TGGACAAACACATAATTTCTACCGGCTACAACGGGCCTCCGACCGGATTACCCCATTGTGAGGAGACAGGTTGCCTAAGA
GACCAACTGGGCATACCTCCAGGAGAAAGGCCTGAGCTTTGCAGAGGGGTTCATGCAGAACAGAATGCCATAATACAGGC
GGCTTTGCATGGAGTGAGTACAAAAGGGGCTACTCTTTATGTGAGCGCAAGCCCCTGCGTCATATGCGCTAAAATGCTTA
TAAACGCTGGGGTAAAGAGAATTGTGTACGAAGAAGAATATCCAGATGAATTGGCTTTTCAACTTTTAAAGGAAGCAGGT
ATTGAATTAGTAAAGTTTAAAAGGTAA

Upstream 100 bases:

>100_bases
ATAGCTGCCCCTGAAGGGATAAAGGCTGTTCACAAAGACCATCCAGAGGTGCCTATTTATGTGGCTAGCATAGACCAGGG
GCTTAATGAGCACGGCTACA

Downstream 100 bases:

>100_bases
AATAATTATTGGTAATAGCAAAAGAGGGGTACCCTCCAAAGACAAACGGTAAAATGTCAAGGGGGTAATTAAAAAATTTT
TGAGGCATTTAAAGGGCAAA

Product: deoxycytidylate deaminase

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MFQGWGMLEIDCLELSEERIKMRPSWDEYFMQIVDVVKTRSTCIRRQVGAILVVDKHIISTGYNGPPTGLPHCEETGCLR
DQLGIPPGERPELCRGVHAEQNAIIQAALHGVSTKGATLYVSASPCVICAKMLINAGVKRIVYEEEYPDELAFQLLKEAG
IELVKFKR

Sequences:

>Translated_168_residues
MFQGWGMLEIDCLELSEERIKMRPSWDEYFMQIVDVVKTRSTCIRRQVGAILVVDKHIISTGYNGPPTGLPHCEETGCLR
DQLGIPPGERPELCRGVHAEQNAIIQAALHGVSTKGATLYVSASPCVICAKMLINAGVKRIVYEEEYPDELAFQLLKEAG
IELVKFKR
>Mature_168_residues
MFQGWGMLEIDCLELSEERIKMRPSWDEYFMQIVDVVKTRSTCIRRQVGAILVVDKHIISTGYNGPPTGLPHCEETGCLR
DQLGIPPGERPELCRGVHAEQNAIIQAALHGVSTKGATLYVSASPCVICAKMLINAGVKRIVYEEEYPDELAFQLLKEAG
IELVKFKR

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742821, Length=172, Percent_Identity=33.1395348837209, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI61742819, Length=171, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321938, Length=146, Percent_Identity=39.7260273972603, Blast_Score=118, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 18775; Mature: 18775

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQGWGMLEIDCLELSEERIKMRPSWDEYFMQIVDVVKTRSTCIRRQVGAILVVDKHIIS
CCCCCCCEEEHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHH
TGYNGPPTGLPHCEETGCLRDQLGIPPGERPELCRGVHAEQNAIIQAALHGVSTKGATLY
CCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCEEE
VSASPCVICAKMLINAGVKRIVYEEEYPDELAFQLLKEAGIELVKFKR
EECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEECCC
>Mature Secondary Structure
MFQGWGMLEIDCLELSEERIKMRPSWDEYFMQIVDVVKTRSTCIRRQVGAILVVDKHIIS
CCCCCCCEEEHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHH
TGYNGPPTGLPHCEETGCLRDQLGIPPGERPELCRGVHAEQNAIIQAALHGVSTKGATLY
CCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCEEE
VSASPCVICAKMLINAGVKRIVYEEEYPDELAFQLLKEAGIELVKFKR
EECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]