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The map label for this gene is upp [H]

Identifier: 20806676

GI number: 20806676

Start: 145685

End: 146317

Strand: Direct

Name: upp [H]

Synonym: TTE0147

Alternate gene names: 20806676

Gene position: 145685-146317 (Clockwise)

Preceding gene: 20806675

Following gene: 20806677

Centisome position: 5.42

GC content: 42.34

Gene sequence:

>633_bases
ATGTATGAGAATGTCTTTGTTATAGATCATCCTCTTATACAACATAAAATAAGTCTCATAAGAGATGAAAACACGGGTTC
CAAGGAATTTAGAGAGCTGGTTGGAGAAATAGCCATGCTAATGGCCTATGAGGTGACAAGAGACCTGCCTCTGGAAGAGA
TAGAAGTAAAAACTCCCATTGCTGTTGCGAAAACAAAAGTCATTGCAGGCAAAAAGTTGGGCATCATTCCTATTTTAAGG
GCCGGGCTGGTGATGGCAGATGGGATGCTTAAACTAATTCCCACTGCAAAAGTAGGGCATATAGGTATATACAGAGATCC
TGAAACTTTAAAACCTGTTGAATATTACTGCAAGCTTCCTTCTGACATTGCAGAAAGAGACCTCATAGTAGTAGATCCAA
TGCTGGCTACAGGAGGTTCTGCATCGGCTGCAATCCATTTCTTAAAAGAAAGAGGAGCTCAAAGCATAAAGCTTGTGAAT
TTAATAGCTGCCCCTGAAGGGATAAAGGCTGTTCACAAAGACCATCCAGAGGTGCCTATTTATGTGGCTAGCATAGACCA
GGGGCTTAATGAGCACGGCTACATTGTTCCAGGGTTGGGGGATGCTGGAGATAGATTGTTTGGAACTAAGTGA

Upstream 100 bases:

>100_bases
AATGCCACTTTCCAAGGAGGAAGGCATCAGAAGAGGATTGACAAAATAACAGAAATCGAAAAAAAGTACATGAAATGATA
AACAGGAGGGTTTTTATTTT

Downstream 100 bases:

>100_bases
GGAGAGGATAAAAATGAGGCCCTCGTGGGATGAATATTTTATGCAGATTGTGGACGTGGTGAAGACCAGGTCTACTTGCA
TAAGAAGACAGGTAGGAGCT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MYENVFVIDHPLIQHKISLIRDENTGSKEFRELVGEIAMLMAYEVTRDLPLEEIEVKTPIAVAKTKVIAGKKLGIIPILR
AGLVMADGMLKLIPTAKVGHIGIYRDPETLKPVEYYCKLPSDIAERDLIVVDPMLATGGSASAAIHFLKERGAQSIKLVN
LIAAPEGIKAVHKDHPEVPIYVASIDQGLNEHGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_210_residues
MYENVFVIDHPLIQHKISLIRDENTGSKEFRELVGEIAMLMAYEVTRDLPLEEIEVKTPIAVAKTKVIAGKKLGIIPILR
AGLVMADGMLKLIPTAKVGHIGIYRDPETLKPVEYYCKLPSDIAERDLIVVDPMLATGGSASAAIHFLKERGAQSIKLVN
LIAAPEGIKAVHKDHPEVPIYVASIDQGLNEHGYIVPGLGDAGDRLFGTK
>Mature_210_residues
MYENVFVIDHPLIQHKISLIRDENTGSKEFRELVGEIAMLMAYEVTRDLPLEEIEVKTPIAVAKTKVIAGKKLGIIPILR
AGLVMADGMLKLIPTAKVGHIGIYRDPETLKPVEYYCKLPSDIAERDLIVVDPMLATGGSASAAIHFLKERGAQSIKLVN
LIAAPEGIKAVHKDHPEVPIYVASIDQGLNEHGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=30.1980198019802, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=30.1980198019802, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=53.2019704433498, Blast_Score=229, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17539892, Length=215, Percent_Identity=25.1162790697674, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539894, Length=215, Percent_Identity=25.1162790697674, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=39.5833333333333, Blast_Score=129, Evalue=4e-31,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=30.5418719211823, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=30.5418719211823, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=30.5418719211823, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=30.5418719211823, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358379, Length=195, Percent_Identity=23.5897435897436, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22910; Mature: 22910

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYENVFVIDHPLIQHKISLIRDENTGSKEFRELVGEIAMLMAYEVTRDLPLEEIEVKTPI
CCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCH
AVAKTKVIAGKKLGIIPILRAGLVMADGMLKLIPTAKVGHIGIYRDPETLKPVEYYCKLP
HHHHEEEECCCCCCHHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCCCHHHHHHCCC
SDIAERDLIVVDPMLATGGSASAAIHFLKERGAQSIKLVNLIAAPEGIKAVHKDHPEVPI
HHHHHCCEEEECCHHCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCCE
YVASIDQGLNEHGYIVPGLGDAGDRLFGTK
EEEECCCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MYENVFVIDHPLIQHKISLIRDENTGSKEFRELVGEIAMLMAYEVTRDLPLEEIEVKTPI
CCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCH
AVAKTKVIAGKKLGIIPILRAGLVMADGMLKLIPTAKVGHIGIYRDPETLKPVEYYCKLP
HHHHEEEECCCCCCHHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCCCHHHHHHCCC
SDIAERDLIVVDPMLATGGSASAAIHFLKERGAQSIKLVNLIAAPEGIKAVHKDHPEVPI
HHHHHCCEEEECCHHCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCCE
YVASIDQGLNEHGYIVPGLGDAGDRLFGTK
EEEECCCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA