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The map label for this gene is NuoD [H]

Identifier: 20806656

GI number: 20806656

Start: 128502

End: 129584

Strand: Direct

Name: NuoD [H]

Synonym: TTE0127

Alternate gene names: 20806656

Gene position: 128502-129584 (Clockwise)

Preceding gene: 20806655

Following gene: 20806657

Centisome position: 4.78

GC content: 43.03

Gene sequence:

>1083_bases
ATGAGTGAGAAGAGCACAATACCTTTTGGGCCACAGCATCCTGTTTTGCCTGAGCCTATACATCTTAAACTGATAGTAGA
AGACGAAAAGGTAGTAGAAGCGTATCCTGCTTTTGGCTATGTTCACAGAGGTTTAGAACTTCTTGTGAAAAAAAGGGACT
TTAATCAGATGGTTTATGTAGTTGACCACATATGCGGCATTTGCAGTGCTATACATGGAGAGACTTATTGCCAGGCAGTG
GAGAAATTGATTGGGATTGACGTTCCGGAAAGGGCAAAGTTTTTGAGAGTCATCTGGGCTGAAATTCACAGGATTCACAG
CCATCTTTTGTGGTTTGGCCTTTTAGCAGATGCTTTTGGGTTTGAAAACCTGTTTATGCTTTCTTGGAGAATAAGGGAGA
AGGTAATGGACATATTGGAGGCTACGGCTGGCAATAGAGTTGTGATTTCTGTCAATATTGTAGGCGGTGTGAGAAGAGAT
ATTGACAGTGAGCAGGCCAAATGGGTGCTTGCCCAGCTTAAAGAGGTAGAGGAAGGGCTAAAAGAGATTGAAAAGATAGT
AAGAGATAACTACACTTTGAAAAAGAGAACTGTAGGGATAGGAGTCCTTTCAAAAGAAGAGGCTTATATGCTGGGAGCAG
TAGGGCCTACTTTGAGAGGAAGTGGAGTTCCAATAGATACTAGAACCTTGGGATATGCTGCTTACAAATATTTAGACTTT
GAACCAGTTGTTGAAAAAGATGGGGATACCTATGCAAGAACTCTCGTCAGACTAAGGGAGATGTTCCAGTCTATTGACCT
TGTGAGGCAAGCTATAAGCAAGATGCCAGAAGGTGAAATAAATGTCAAAGTAAAACCCAATTTGCCAGCAGGAGAGGTCA
TAGAAAGGGCTGAGCAGCCCAGAGGAGAAGTATTTTACTATATCAAGTCAAATGGAGGCAAATACTTGGATAGATTGAGG
ATAAGGACTCCCACTTTTGCGAATCTGGCTGCTCTTCTGCACATGCTACCGGGCTGTACTTTGGCAGACGTGCCTGTTCT
GGTTCTGACGATTGACCCATGTATCAGCTGTACGGAAAGGTAG

Upstream 100 bases:

>100_bases
TTAGCTTTAGATTTTCAGGGGCTTTTGTTTTTGGGAGAATTTGCTCCAATATCTCCACAAGCTAGCATAGAAATTATGAG
AAGGGACAAAGGTGATAAGA

Downstream 100 bases:

>100_bases
GGGAGAAAAATGCTTTCAATGCTCAAAAATGTGGTTTATAACCTTACCCATAAGCCTGCTACGAGGAGATACCCTTTTGA
GAAGAGGGAACCTTTCGAGG

Product: NADH:ubiquinone oxidoreductase 49 kD subunit 7

Products: NAD+; ubiquinol

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSEKSTIPFGPQHPVLPEPIHLKLIVEDEKVVEAYPAFGYVHRGLELLVKKRDFNQMVYVVDHICGICSAIHGETYCQAV
EKLIGIDVPERAKFLRVIWAEIHRIHSHLLWFGLLADAFGFENLFMLSWRIREKVMDILEATAGNRVVISVNIVGGVRRD
IDSEQAKWVLAQLKEVEEGLKEIEKIVRDNYTLKKRTVGIGVLSKEEAYMLGAVGPTLRGSGVPIDTRTLGYAAYKYLDF
EPVVEKDGDTYARTLVRLREMFQSIDLVRQAISKMPEGEINVKVKPNLPAGEVIERAEQPRGEVFYYIKSNGGKYLDRLR
IRTPTFANLAALLHMLPGCTLADVPVLVLTIDPCISCTER

Sequences:

>Translated_360_residues
MSEKSTIPFGPQHPVLPEPIHLKLIVEDEKVVEAYPAFGYVHRGLELLVKKRDFNQMVYVVDHICGICSAIHGETYCQAV
EKLIGIDVPERAKFLRVIWAEIHRIHSHLLWFGLLADAFGFENLFMLSWRIREKVMDILEATAGNRVVISVNIVGGVRRD
IDSEQAKWVLAQLKEVEEGLKEIEKIVRDNYTLKKRTVGIGVLSKEEAYMLGAVGPTLRGSGVPIDTRTLGYAAYKYLDF
EPVVEKDGDTYARTLVRLREMFQSIDLVRQAISKMPEGEINVKVKPNLPAGEVIERAEQPRGEVFYYIKSNGGKYLDRLR
IRTPTFANLAALLHMLPGCTLADVPVLVLTIDPCISCTER
>Mature_359_residues
SEKSTIPFGPQHPVLPEPIHLKLIVEDEKVVEAYPAFGYVHRGLELLVKKRDFNQMVYVVDHICGICSAIHGETYCQAVE
KLIGIDVPERAKFLRVIWAEIHRIHSHLLWFGLLADAFGFENLFMLSWRIREKVMDILEATAGNRVVISVNIVGGVRRDI
DSEQAKWVLAQLKEVEEGLKEIEKIVRDNYTLKKRTVGIGVLSKEEAYMLGAVGPTLRGSGVPIDTRTLGYAAYKYLDFE
PVVEKDGDTYARTLVRLREMFQSIDLVRQAISKMPEGEINVKVKPNLPAGEVIERAEQPRGEVFYYIKSNGGKYLDRLRI
RTPTFANLAALLHMLPGCTLADVPVLVLTIDPCISCTER

Specific function: The carbon monoxide dehydrogenase (CODH) oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (probably CooH) [H]

COG id: COG3261

COG function: function code C; Ni,Fe-hydrogenase III large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli formate hydrogenlyase hydrogenase isozyme 3 and to bovine mitochondrial NADH-ubiquinone oxidoreductase [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=375, Percent_Identity=32.2666666666667, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI260898743, Length=373, Percent_Identity=32.171581769437, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1789076, Length=360, Percent_Identity=33.8888888888889, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1788832, Length=360, Percent_Identity=34.4444444444444, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI145693162, Length=381, Percent_Identity=28.8713910761155, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789368, Length=117, Percent_Identity=35.042735042735, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17568379, Length=378, Percent_Identity=30.952380952381, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17555284, Length=386, Percent_Identity=30.0518134715026, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI221459469, Length=375, Percent_Identity=33.0666666666667, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24638644, Length=375, Percent_Identity=33.0666666666667, Blast_Score=184, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR001501 [H]

Pfam domain/function: PF00346 Complex1_49kDa; PF00374 NiFeSe_Hases [H]

EC number: 1.6.5.3

Molecular weight: Translated: 40643; Mature: 40512

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKSTIPFGPQHPVLPEPIHLKLIVEDEKVVEAYPAFGYVHRGLELLVKKRDFNQMVYV
CCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VDHICGICSAIHGETYCQAVEKLIGIDVPERAKFLRVIWAEIHRIHSHLLWFGLLADAFG
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FENLFMLSWRIREKVMDILEATAGNRVVISVNIVGGVRRDIDSEQAKWVLAQLKEVEEGL
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHH
KEIEKIVRDNYTLKKRTVGIGVLSKEEAYMLGAVGPTLRGSGVPIDTRTLGYAAYKYLDF
HHHHHHHHCCCEEEEHEEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCC
EPVVEKDGDTYARTLVRLREMFQSIDLVRQAISKMPEGEINVKVKPNLPAGEVIERAEQP
CHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCC
RGEVFYYIKSNGGKYLDRLRIRTPTFANLAALLHMLPGCTLADVPVLVLTIDPCISCTER
CCCEEEEEECCCCHHHHHHEECCCCHHHHHHHHHHCCCCCHHCCCEEEEEECHHHCCCCC
>Mature Secondary Structure 
SEKSTIPFGPQHPVLPEPIHLKLIVEDEKVVEAYPAFGYVHRGLELLVKKRDFNQMVYV
CCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VDHICGICSAIHGETYCQAVEKLIGIDVPERAKFLRVIWAEIHRIHSHLLWFGLLADAFG
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FENLFMLSWRIREKVMDILEATAGNRVVISVNIVGGVRRDIDSEQAKWVLAQLKEVEEGL
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHH
KEIEKIVRDNYTLKKRTVGIGVLSKEEAYMLGAVGPTLRGSGVPIDTRTLGYAAYKYLDF
HHHHHHHHCCCEEEEHEEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCC
EPVVEKDGDTYARTLVRLREMFQSIDLVRQAISKMPEGEINVKVKPNLPAGEVIERAEQP
CHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCC
RGEVFYYIKSNGGKYLDRLRIRTPTFANLAALLHMLPGCTLADVPVLVLTIDPCISCTER
CCCEEEEEECCCCHHHHHHEECCCCHHHHHHHHHHCCCCCHHCCCEEEEEECHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626276; 1644755 [H]