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The map label for this gene is Tmk

Identifier: 20806623

GI number: 20806623

Start: 97419

End: 98045

Strand: Direct

Name: Tmk

Synonym: TTE0094

Alternate gene names: 20806623

Gene position: 97419-98045 (Clockwise)

Preceding gene: 20806622

Following gene: 20806624

Centisome position: 3.62

GC content: 41.79

Gene sequence:

>627_bases
ATGAGAGGGAAATTTATAAGTTTCGAAGGCATAGACGGATGTGGGAAGACCACACAGGTTAAGCTTTTGGAAGAACATCT
TAAAAAAGAGGGTTATGACCTACTTGTCTTAAGGGAGCCGGGTGGGACGAGAGTAGGAGAGAAAGTCCGCGAAATTTTGC
TTGACAGAGAAAATCTCATCTTCCCGGTGACAGAAATGCTCCTTTACGCTTCCTCTAGGGCGCAACTGGTGGAAGAGAAG
ATTTTACCCGCTCTTTCTAAAGGTCAAATGGTAATAGTTGATAGGTTTATAGATAGTTCTTATGTATATCAGGGATATGC
TAGGGGATTGGGACTGGAAAAAGTTAAAATTGTAAATGAAATAGCAACTAAAGGTTTGTTTCCGGATATTACAGTATATA
TAGACATTACACCGGAGGAAGCCATAAAAAGGCGACAGGGTAAAAAAGCCGACAGGCTCGAAGGGGAGGACTATGAATTT
CACAAAAAAGTGAGGGAAGGTTATCTTAGACTGGTGAAGGATTTTCCGGAGAGGTTCATTTTGATAGACGGTATGCAGGA
GGTACTGGCGGTTCATAAAATGGTGGTAAAGGCAGTAGAAGAATATTTGAAGGGGGCGAAAGTATGA

Upstream 100 bases:

>100_bases
AGAGGATTGAAAAAGATATGGTAAAATATATAGAAGTATTGTATAATAAAGGTATTAAGGTTTTGGGTATACAGGATAAT
TTACTGTCGGTGTGTGAGAT

Downstream 100 bases:

>100_bases
AGTTAGTTCTTGCGATCGTACAGGATGAAGATGTCAGAAGGTTGATGGATGGGCTAACAGAAGGAGGATTCAGCTTTACA
AGGATTGCTTCTACAGGTGG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MRGKFISFEGIDGCGKTTQVKLLEEHLKKEGYDLLVLREPGGTRVGEKVREILLDRENLIFPVTEMLLYASSRAQLVEEK
ILPALSKGQMVIVDRFIDSSYVYQGYARGLGLEKVKIVNEIATKGLFPDITVYIDITPEEAIKRRQGKKADRLEGEDYEF
HKKVREGYLRLVKDFPERFILIDGMQEVLAVHKMVVKAVEEYLKGAKV

Sequences:

>Translated_208_residues
MRGKFISFEGIDGCGKTTQVKLLEEHLKKEGYDLLVLREPGGTRVGEKVREILLDRENLIFPVTEMLLYASSRAQLVEEK
ILPALSKGQMVIVDRFIDSSYVYQGYARGLGLEKVKIVNEIATKGLFPDITVYIDITPEEAIKRRQGKKADRLEGEDYEF
HKKVREGYLRLVKDFPERFILIDGMQEVLAVHKMVVKAVEEYLKGAKV
>Mature_208_residues
MRGKFISFEGIDGCGKTTQVKLLEEHLKKEGYDLLVLREPGGTRVGEKVREILLDRENLIFPVTEMLLYASSRAQLVEEK
ILPALSKGQMVIVDRFIDSSYVYQGYARGLGLEKVKIVNEIATKGLFPDITVYIDITPEEAIKRRQGKKADRLEGEDYEF
HKKVREGYLRLVKDFPERFILIDGMQEVLAVHKMVVKAVEEYLKGAKV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=210, Percent_Identity=35.7142857142857, Blast_Score=125, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322517, Length=207, Percent_Identity=27.0531400966184, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28573735, Length=207, Percent_Identity=29.951690821256, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_THETN (Q8RDE6)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_621794.1
- ProteinModelPortal:   Q8RDE6
- SMR:   Q8RDE6
- GeneID:   996421
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0094
- NMPDR:   fig|273068.3.peg.267
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   CLSK900620
- BioCyc:   TTEN273068:TTE0094-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23779; Mature: 23779

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKFISFEGIDGCGKTTQVKLLEEHLKKEGYDLLVLREPGGTRVGEKVREILLDRENLI
CCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCH
FPVTEMLLYASSRAQLVEEKILPALSKGQMVIVDRFIDSSYVYQGYARGLGLEKVKIVNE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHCCCHHHHHHHHH
IATKGLFPDITVYIDITPEEAIKRRQGKKADRLEGEDYEFHKKVREGYLRLVKDFPERFI
HHHCCCCCCEEEEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEE
LIDGMQEVLAVHKMVVKAVEEYLKGAKV
EHHCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRGKFISFEGIDGCGKTTQVKLLEEHLKKEGYDLLVLREPGGTRVGEKVREILLDRENLI
CCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCH
FPVTEMLLYASSRAQLVEEKILPALSKGQMVIVDRFIDSSYVYQGYARGLGLEKVKIVNE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHCCCHHHHHHHHH
IATKGLFPDITVYIDITPEEAIKRRQGKKADRLEGEDYEFHKKVREGYLRLVKDFPERFI
HHHCCCCCCEEEEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEE
LIDGMQEVLAVHKMVVKAVEEYLKGAKV
EHHCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336