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The map label for this gene is IlvD

Identifier: 20806562

GI number: 20806562

Start: 23171

End: 24841

Strand: Direct

Name: IlvD

Synonym: TTE0020

Alternate gene names: 20806562

Gene position: 23171-24841 (Clockwise)

Preceding gene: 20806561

Following gene: 20806563

Centisome position: 0.86

GC content: 44.7

Gene sequence:

>1671_bases
TTGAGAAGCGATGCTGTAAAAAAAGGGGTGGAGAGGGCACCTCATAGGTCCTTGCTTTATGCCTTAGGGCTTACTGATGA
AGAGCTAAAAAGGCCTATAATAGGAGTGGCCAATTCAAAAAATGAAATAATCCCAGGGCACATTCACCTTGATAAAATAG
CAGAAGCGGTGAAAGCAGGTATAAGGATGGCGGGAGGAACGCCTGTTGAATTTTCTACCATTGGAGTGTGTGATGGCATT
GCCATGGGTCATGGAGGGATGAAGTATTCTTTAGGGAGCAGAGAAGTGATTGCTGACAGCATAGAGATAATGGCAATGGC
TCATGGCTTTGATGGAATTGTACTCATACCCAATTGTGACAAGATAGTACCAGGCATGCTTATGGCGGCGGCAAGGCTTG
ATATTCCAGCGATTGTAGTAAGCGGCGGCCCCATGCTGGCAGGTATTTGTGATGGCACGACTTGTGACTTGAGCACAGTT
TTTGAGGCGGTAGGAGCATTAAAGGCTGGCAAAATAACAGAAGAGGAATTTTACAGTATAGAAAGAAATGCCTGTCCTAC
TTGCGGGTCCTGTTCAGGAATGTTTACAGCAAATACAATGAACTGCCTTACAGAAGCTTTAGGTTTGGGACTTCCTGGAA
ATGGAACGATACCGGCGGTTTACTCTGAAAGGATAAGGCTTGCAAAGGAAGCCGGGATGAAAATAGTAGAGCTTGTTGAA
AGAAACATAACTCCTTCACAGATACTCACAAAAGAAGCATTTGTGAATGCTTTTAGCTTGGACATGGCATTAGGAGGGTC
TACTAATACGGTCCTTCACCTAAAAGCCATAGCTCATGAAGCAGGAGTAGATATACCTTTAGAAGAGATAAATGACATAA
GCGATAGGGTTCCAAACCTTTGCAAGTTAAGTCCTGCAGGGAAATACCACATAGAAGACCTTCACTTTGCAGGGGGAGTT
TCTGCTGTGCTAAAAGAGCTTTCAAAAGCAGGCCTTTTACACCTTGATGCTTTGACAGTGACAGGTCGGACTCTTGGAGA
AAACATAAAAGATGCAAAAGTGCGAAATAGGGATGTGATAAGGACCATAGAAGATCCTTACAGCAAGACAGGAGGAATAG
CAATATTATTTGGAAATATAGCTAGGGAAGGGGCTGTTGTGAAAGCTTCTGCTGTCTCACCAGAGATGTTAAGACATGAG
GGACCGGCTAGAGTATTTGATTCAGAAGAAGAGGCTATTGAGGCGATATACGGTGGAAAGATACAAAAAGGAGACGTTGT
GGTTATAAGGTACGAAGGGCCTAAAGGTGGTCCAGGCATGAGAGAAATGCTAAGCCCTACATCCGCCCTTGCAGGTATGG
GTCTTGATAAGGACGTCGCCCTAATAACGGATGGAAGGTTTTCGGGAGCGACAAGGGGGGCTTCTATAGGGCATGTCTCT
CCTGAGGCGATGGAGGGAGGAGAGATTGCCATAATTGAGGATGGAGACATTATTGAAATTGACATTCCAGCGAGGAAGAT
AAATGTCAAATTGAGTGATGAGGAAATAAAGAAAAGGATGGCAAATTGGAAGAGGCCAGAACCCAAGATAAAGAAGGGTT
ATATGGCGAGGTATACAAGAGAGGTGACTTCGGGGAGTAAAGGAGCGGTATTTAGGGAGGGAGGAGTATGA

Upstream 100 bases:

>100_bases
TTGGAGGAAGGCTTTAGAACAGCAGATTTGGGCAAAGGAATTGTGCTTTCTACAGAAGAGATGGGAGATAAAGTTGTTGA
GTATATAAAGGGGTGATATT

Downstream 100 bases:

>100_bases
AGCTAAAAGGGGCTCAAGTTGTGATAGAAGTTTTAAAGGAGATGGGGGTTGATAATGTATTTGGAATCCCTGGAGGAGCA
GTTATTCCGATTTACGATGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MRSDAVKKGVERAPHRSLLYALGLTDEELKRPIIGVANSKNEIIPGHIHLDKIAEAVKAGIRMAGGTPVEFSTIGVCDGI
AMGHGGMKYSLGSREVIADSIEIMAMAHGFDGIVLIPNCDKIVPGMLMAAARLDIPAIVVSGGPMLAGICDGTTCDLSTV
FEAVGALKAGKITEEEFYSIERNACPTCGSCSGMFTANTMNCLTEALGLGLPGNGTIPAVYSERIRLAKEAGMKIVELVE
RNITPSQILTKEAFVNAFSLDMALGGSTNTVLHLKAIAHEAGVDIPLEEINDISDRVPNLCKLSPAGKYHIEDLHFAGGV
SAVLKELSKAGLLHLDALTVTGRTLGENIKDAKVRNRDVIRTIEDPYSKTGGIAILFGNIAREGAVVKASAVSPEMLRHE
GPARVFDSEEEAIEAIYGGKIQKGDVVVIRYEGPKGGPGMREMLSPTSALAGMGLDKDVALITDGRFSGATRGASIGHVS
PEAMEGGEIAIIEDGDIIEIDIPARKINVKLSDEEIKKRMANWKRPEPKIKKGYMARYTREVTSGSKGAVFREGGV

Sequences:

>Translated_556_residues
MRSDAVKKGVERAPHRSLLYALGLTDEELKRPIIGVANSKNEIIPGHIHLDKIAEAVKAGIRMAGGTPVEFSTIGVCDGI
AMGHGGMKYSLGSREVIADSIEIMAMAHGFDGIVLIPNCDKIVPGMLMAAARLDIPAIVVSGGPMLAGICDGTTCDLSTV
FEAVGALKAGKITEEEFYSIERNACPTCGSCSGMFTANTMNCLTEALGLGLPGNGTIPAVYSERIRLAKEAGMKIVELVE
RNITPSQILTKEAFVNAFSLDMALGGSTNTVLHLKAIAHEAGVDIPLEEINDISDRVPNLCKLSPAGKYHIEDLHFAGGV
SAVLKELSKAGLLHLDALTVTGRTLGENIKDAKVRNRDVIRTIEDPYSKTGGIAILFGNIAREGAVVKASAVSPEMLRHE
GPARVFDSEEEAIEAIYGGKIQKGDVVVIRYEGPKGGPGMREMLSPTSALAGMGLDKDVALITDGRFSGATRGASIGHVS
PEAMEGGEIAIIEDGDIIEIDIPARKINVKLSDEEIKKRMANWKRPEPKIKKGYMARYTREVTSGSKGAVFREGGV
>Mature_556_residues
MRSDAVKKGVERAPHRSLLYALGLTDEELKRPIIGVANSKNEIIPGHIHLDKIAEAVKAGIRMAGGTPVEFSTIGVCDGI
AMGHGGMKYSLGSREVIADSIEIMAMAHGFDGIVLIPNCDKIVPGMLMAAARLDIPAIVVSGGPMLAGICDGTTCDLSTV
FEAVGALKAGKITEEEFYSIERNACPTCGSCSGMFTANTMNCLTEALGLGLPGNGTIPAVYSERIRLAKEAGMKIVELVE
RNITPSQILTKEAFVNAFSLDMALGGSTNTVLHLKAIAHEAGVDIPLEEINDISDRVPNLCKLSPAGKYHIEDLHFAGGV
SAVLKELSKAGLLHLDALTVTGRTLGENIKDAKVRNRDVIRTIEDPYSKTGGIAILFGNIAREGAVVKASAVSPEMLRHE
GPARVFDSEEEAIEAIYGGKIQKGDVVVIRYEGPKGGPGMREMLSPTSALAGMGLDKDVALITDGRFSGATRGASIGHVS
PEAMEGGEIAIIEDGDIIEIDIPARKINVKLSDEEIKKRMANWKRPEPKIKKGYMARYTREVTSGSKGAVFREGGV

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=48.3498349834984, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1788157, Length=523, Percent_Identity=32.1223709369025, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1786464, Length=489, Percent_Identity=36.8098159509202, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI2367371, Length=517, Percent_Identity=35.0096711798839, Blast_Score=226, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322476, Length=546, Percent_Identity=43.2234432234432, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_THETN (Q8RDJ9)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_621733.1
- ProteinModelPortal:   Q8RDJ9
- SMR:   Q8RDJ9
- GeneID:   996486
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0020
- NMPDR:   fig|273068.3.peg.32
- HOGENOM:   HBG671001
- OMA:   SIERNAC
- ProtClustDB:   PRK00911
- BioCyc:   TTEN273068:TTE0020-MONOMER
- BRENDA:   4.2.1.9
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58995; Mature: 58995

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDAVKKGVERAPHRSLLYALGLTDEELKRPIIGVANSKNEIIPGHIHLDKIAEAVKAG
CCCHHHHHHHHHCCCHHEEEEECCCHHHHCCCEEEECCCCCCCCCCEEEHHHHHHHHHHH
IRMAGGTPVEFSTIGVCDGIAMGHGGMKYSLGSREVIADSIEIMAMAHGFDGIVLIPNCD
HEECCCCCEEEEEEECCCCEEECCCCEEECCCCCHHHHHHHEEEEEECCCCCEEECCCCC
KIVPGMLMAAARLDIPAIVVSGGPMLAGICDGTTCDLSTVFEAVGALKAGKITEEEFYSI
HHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHCHHCCCCCHHHHHHH
ERNACPTCGSCSGMFTANTMNCLTEALGLGLPGNGTIPAVYSERIRLAKEAGMKIVELVE
HCCCCCCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHH
RNITPSQILTKEAFVNAFSLDMALGGSTNTVLHLKAIAHEAGVDIPLEEINDISDRVPNL
CCCCHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEEHHHHCCCCCCHHHHHHHHHHCCCE
CKLSPAGKYHIEDLHFAGGVSAVLKELSKAGLLHLDALTVTGRTLGENIKDAKVRNRDVI
EECCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCHHHCCCCHHHHHCCCHHH
RTIEDPYSKTGGIAILFGNIAREGAVVKASAVSPEMLRHEGPARVFDSEEEAIEAIYGGK
HHHHCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHCCC
IQKGDVVVIRYEGPKGGPGMREMLSPTSALAGMGLDKDVALITDGRFSGATRGASIGHVS
CCCCCEEEEEECCCCCCCCHHHHHCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCC
PEAMEGGEIAIIEDGDIIEIDIPARKINVKLSDEEIKKRMANWKRPEPKIKKGYMARYTR
HHHCCCCCEEEEECCCEEEEECCCEEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EVTSGSKGAVFREGGV
HHCCCCCCCEEECCCC
>Mature Secondary Structure
MRSDAVKKGVERAPHRSLLYALGLTDEELKRPIIGVANSKNEIIPGHIHLDKIAEAVKAG
CCCHHHHHHHHHCCCHHEEEEECCCHHHHCCCEEEECCCCCCCCCCEEEHHHHHHHHHHH
IRMAGGTPVEFSTIGVCDGIAMGHGGMKYSLGSREVIADSIEIMAMAHGFDGIVLIPNCD
HEECCCCCEEEEEEECCCCEEECCCCEEECCCCCHHHHHHHEEEEEECCCCCEEECCCCC
KIVPGMLMAAARLDIPAIVVSGGPMLAGICDGTTCDLSTVFEAVGALKAGKITEEEFYSI
HHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHCHHCCCCCHHHHHHH
ERNACPTCGSCSGMFTANTMNCLTEALGLGLPGNGTIPAVYSERIRLAKEAGMKIVELVE
HCCCCCCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHH
RNITPSQILTKEAFVNAFSLDMALGGSTNTVLHLKAIAHEAGVDIPLEEINDISDRVPNL
CCCCHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEEHHHHCCCCCCHHHHHHHHHHCCCE
CKLSPAGKYHIEDLHFAGGVSAVLKELSKAGLLHLDALTVTGRTLGENIKDAKVRNRDVI
EECCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCHHHCCCCHHHHHCCCHHH
RTIEDPYSKTGGIAILFGNIAREGAVVKASAVSPEMLRHEGPARVFDSEEEAIEAIYGGK
HHHHCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHCCC
IQKGDVVVIRYEGPKGGPGMREMLSPTSALAGMGLDKDVALITDGRFSGATRGASIGHVS
CCCCCEEEEEECCCCCCCCHHHHHCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCC
PEAMEGGEIAIIEDGDIIEIDIPARKINVKLSDEEIKKRMANWKRPEPKIKKGYMARYTR
HHHCCCCCEEEEECCCEEEEECCCEEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EVTSGSKGAVFREGGV
HHCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336