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The map label for this gene is NtpD

Identifier: 20095110

GI number: 20095110

Start: 1676578

End: 1677276

Strand: Direct

Name: NtpD

Synonym: MK1674

Alternate gene names: 20095110

Gene position: 1676578-1677276 (Clockwise)

Preceding gene: 20095109

Following gene: 20095111

Centisome position: 98.91

GC content: 57.65

Gene sequence:

>699_bases
GTGACCCAGGAGATCCTAGAGGACGTCAACCCTACTAGGATGGAATTACTGAAACTCCAGGACAGAATCGAACTTGCGAA
GAAGGGTCACAAGCTGCTCAAGGAGAAGCGAGACGCCCTCATCATGGAGTTCTTCGAGATGGTGAAGCGCGCCTCCGAGA
TCAGGGAGCAGGCCGTCAAGAAGTTGATGGAGGCGTACAGCAAGCTGGCAGCGGCCAAGGTGACCGTCGGTGAGATCGGA
GTGGAGCGCGCCTCCATGGCCACCGGCGAGGAGATCAAGGTGGACGTGGGATCGAGGAACGTGATGGGTGTAGTCGTACC
GATCATCGAGCGCGTGAGCGAAGATGGCGGTTCAAAGGTCGTCTATGGCTTCGCCGACACGTCCGGCGCACTCGATGAGG
CGATGCGAGCCTTCACGGAGGCTATCGACGCCGTGCTGGAGCTGGCCGAGATCGAGGAAACCCTCCGTCTCATGGCCGAG
GAGATCGAACGTACTAAGCGCAGGGTGAACGCGTTGGAGCATATAGTCATCCCGCGCCTCGAGAACACCGAGAAGTACAT
TGAGATGAAACTCGACGAGCAGGAGAGGGAGAACTTCGTACGGCTGAAGCGCGTGAAGGATCTAATCGAACGGAAGAAGT
TGAAAGAAGAACTCGAGCGGGTCGTCGAAGAAGGGGCCGAACTCCCATCCTTCGAGTGA

Upstream 100 bases:

>100_bases
GAAGTACCACCCGAAGTACAGGCAGAAGAAGGAGGAACAGGAAGAGTAAGGCTCCCTCCGGCCCCATCTCCACTCAAACC
TATCTAGGTGGGGGATACCC

Downstream 100 bases:

>100_bases
GGCGCGGGTGAGTAGAGCATGGTCTTCGTTAGCGTCGCCAAGAGGAAGGTCACTGAGCGTGTCCGCCGGCGCCGCGAGCC
CTACGACTTCAAAACCGACA

Product: V-type ATP synthase subunit D

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit D

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MTQEILEDVNPTRMELLKLQDRIELAKKGHKLLKEKRDALIMEFFEMVKRASEIREQAVKKLMEAYSKLAAAKVTVGEIG
VERASMATGEEIKVDVGSRNVMGVVVPIIERVSEDGGSKVVYGFADTSGALDEAMRAFTEAIDAVLELAEIEETLRLMAE
EIERTKRRVNALEHIVIPRLENTEKYIEMKLDEQERENFVRLKRVKDLIERKKLKEELERVVEEGAELPSFE

Sequences:

>Translated_232_residues
MTQEILEDVNPTRMELLKLQDRIELAKKGHKLLKEKRDALIMEFFEMVKRASEIREQAVKKLMEAYSKLAAAKVTVGEIG
VERASMATGEEIKVDVGSRNVMGVVVPIIERVSEDGGSKVVYGFADTSGALDEAMRAFTEAIDAVLELAEIEETLRLMAE
EIERTKRRVNALEHIVIPRLENTEKYIEMKLDEQERENFVRLKRVKDLIERKKLKEELERVVEEGAELPSFE
>Mature_231_residues
TQEILEDVNPTRMELLKLQDRIELAKKGHKLLKEKRDALIMEFFEMVKRASEIREQAVKKLMEAYSKLAAAKVTVGEIGV
ERASMATGEEIKVDVGSRNVMGVVVPIIERVSEDGGSKVVYGFADTSGALDEAMRAFTEAIDAVLELAEIEETLRLMAEE
IERTKRRVNALEHIVIPRLENTEKYIEMKLDEQERENFVRLKRVKDLIERKKLKEELERVVEEGAELPSFE

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane

COG id: COG1394

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit D

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the V-ATPase D subunit family

Homologues:

Organism=Homo sapiens, GI7706757, Length=217, Percent_Identity=34.1013824884793, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17553636, Length=209, Percent_Identity=33.4928229665072, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320784, Length=203, Percent_Identity=32.512315270936, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21355551, Length=199, Percent_Identity=34.6733668341709, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20128937, Length=199, Percent_Identity=33.6683417085427, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20129907, Length=197, Percent_Identity=29.9492385786802, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): VATD_METKA (Q8TUS9)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614957.1
- GeneID:   1478269
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1674
- NMPDR:   fig|190192.1.peg.1670
- HOGENOM:   HBG732046
- OMA:   GEVMKEA
- ProtClustDB:   PRK00373
- BioCyc:   MKAN190192:MK1674-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_00271
- InterPro:   IPR002699
- PANTHER:   PTHR11671
- TIGRFAMs:   TIGR00309

Pfam domain/function: PF01813 ATP-synt_D

EC number: 3.6.3.14

Molecular weight: Translated: 26560; Mature: 26429

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQEILEDVNPTRMELLKLQDRIELAKKGHKLLKEKRDALIMEFFEMVKRASEIREQAVK
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLMEAYSKLAAAKVTVGEIGVERASMATGEEIKVDVGSRNVMGVVVPIIERVSEDGGSKV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEE
VYGFADTSGALDEAMRAFTEAIDAVLELAEIEETLRLMAEEIERTKRRVNALEHIVIPRL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ENTEKYIEMKLDEQERENFVRLKRVKDLIERKKLKEELERVVEEGAELPSFE
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TQEILEDVNPTRMELLKLQDRIELAKKGHKLLKEKRDALIMEFFEMVKRASEIREQAVK
CHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLMEAYSKLAAAKVTVGEIGVERASMATGEEIKVDVGSRNVMGVVVPIIERVSEDGGSKV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEE
VYGFADTSGALDEAMRAFTEAIDAVLELAEIEETLRLMAEEIERTKRRVNALEHIVIPRL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ENTEKYIEMKLDEQERENFVRLKRVKDLIERKKLKEELERVVEEGAELPSFE
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014