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The map label for this gene is 20095082

Identifier: 20095082

GI number: 20095082

Start: 1646079

End: 1647389

Strand: Reverse

Name: 20095082

Synonym: MK1646

Alternate gene names: NA

Gene position: 1647389-1646079 (Counterclockwise)

Preceding gene: 20095084

Following gene: 20095081

Centisome position: 97.19

GC content: 59.8

Gene sequence:

>1311_bases
GTGATCGATCGGCTACGAGAGGCGCTGAAACGGTTCAATCCGTGCGATTCCTGCCTGGGCCGGGCCTTCGGTTACGGGTT
GACAGGGCTCGAGAACAGGGAGCGGGGTCGAGCCATTAAGCTGTACCTAGGAATGCGAGCACACTTGGAAGGGGAGGAGG
AGACACTCGAGCTGCTCGCCCGATCCGGGCTGGAGGAGGCCGCAGCGGTACTCGACGACCCTCCCGAGCCCGAACCCTGT
GGTGTATGCCGTGGAGTGCTGGACAAAGTGGACGAGTTCGCCGAGGTAGTCGCGTGTGAGTTGAAGGACCTTGAGTTTCG
GGGGTTCGTGGTGGGATCCAGATGGCCGGAGGAGATACGGAAAGCCGAGAAGGAGCTCTGGGAGACGCTCGGCGTCGAGG
GTGAACCCATCAAACGCGAGTTCAACAGGGAGGTCGGTAAGAGGGTGGAACACCTGCTGGACGTGCGCGCGGATCCGAGG
AACCCGGATATCGAGGTGGTGTTCGATTTCCGGCCCTCCTTGGAGGATCCGAAGTTCGAAGTCCACGTACGCCCCATCTA
CGTGCGAGGGCGCTACCTTAAGTTGAGGAGGGGGATCCCGCAGACGAAGTGGCCCTGCCCGCGGTGCCGGGGGGCGGGAT
GTCCGAACTGCGATTTCACCGGTAAGCTGTACACGGAGTCCGTGGAGGAACTCATTGGGATGGTGCTGAAGGACGCCTTC
CTGGCGGAGTCGCACAAGTTCCACGCCGCGGGTCGCGAGGACATCGACGTGAGAATGCTCGGAAACGGTAGACCTTTCGT
GATGGAACTCCTGTACCCTAAGCGCCGGAATGTCGACCTTAAGGAGATCGAAGGAGAGATCAACCGGAAGGTGGGCGACG
ACGTACAGGTGGTGGGACTGGAGTACGGGGATCCCGAAGACGTCGGGAAGGTAAAAGACCTCTCCGAGCGATCCCGGAAG
AGGTACCGAGCGTGGGTGAAGTTCGGAAAACCAGTTCCGGAGGACAAGCTGAGAGAAGTCCTGAAGGGGCTGGAGAGGAG
TGTGATAGAGCAGAGGACACCGAGGCGCGTGCTCCACAGGAGGGCGGACAAAGTTAGGAGGAAAAGAGTTCACGAGGCCA
AGCTGATCGAGTACGACGGAGATCGAGCCGTCATCGAGTTCCTCTGCGACCCGGGACTGTACGTGAAAGAATTAATATCT
GGAGATGCTGGACGGACTCGCCCCAGTCTCGCCGAGCTTGTTGAGGTTGAAGCGGAATGTGAGCGTCTCGATGTGATCGA
GTTTCTGGATGAGGGAGGTGATCGGAGTTGA

Upstream 100 bases:

>100_bases
CGCTTTACGCTGCCGTTGTACTCGGGTGCAAGTCTTAGCCGTCGTCACCGATCCGTCGATGTCAACGTCTCTCGGAGCGA
CTCACGGGTGGTGATCCGCC

Downstream 100 bases:

>100_bases
AAGTCATGGTCGAACGCTGTCTCGGGTGCGCCGCGTGCGCTGCGGTCTGCCCCAAGGACGCGCTGACGATTTCCGGTGGA
AAGCCCGAGTTCGGTCCTGA

Product: pseudouridylate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MIDRLREALKRFNPCDSCLGRAFGYGLTGLENRERGRAIKLYLGMRAHLEGEEETLELLARSGLEEAAAVLDDPPEPEPC
GVCRGVLDKVDEFAEVVACELKDLEFRGFVVGSRWPEEIRKAEKELWETLGVEGEPIKREFNREVGKRVEHLLDVRADPR
NPDIEVVFDFRPSLEDPKFEVHVRPIYVRGRYLKLRRGIPQTKWPCPRCRGAGCPNCDFTGKLYTESVEELIGMVLKDAF
LAESHKFHAAGREDIDVRMLGNGRPFVMELLYPKRRNVDLKEIEGEINRKVGDDVQVVGLEYGDPEDVGKVKDLSERSRK
RYRAWVKFGKPVPEDKLREVLKGLERSVIEQRTPRRVLHRRADKVRRKRVHEAKLIEYDGDRAVIEFLCDPGLYVKELIS
GDAGRTRPSLAELVEVEAECERLDVIEFLDEGGDRS

Sequences:

>Translated_436_residues
MIDRLREALKRFNPCDSCLGRAFGYGLTGLENRERGRAIKLYLGMRAHLEGEEETLELLARSGLEEAAAVLDDPPEPEPC
GVCRGVLDKVDEFAEVVACELKDLEFRGFVVGSRWPEEIRKAEKELWETLGVEGEPIKREFNREVGKRVEHLLDVRADPR
NPDIEVVFDFRPSLEDPKFEVHVRPIYVRGRYLKLRRGIPQTKWPCPRCRGAGCPNCDFTGKLYTESVEELIGMVLKDAF
LAESHKFHAAGREDIDVRMLGNGRPFVMELLYPKRRNVDLKEIEGEINRKVGDDVQVVGLEYGDPEDVGKVKDLSERSRK
RYRAWVKFGKPVPEDKLREVLKGLERSVIEQRTPRRVLHRRADKVRRKRVHEAKLIEYDGDRAVIEFLCDPGLYVKELIS
GDAGRTRPSLAELVEVEAECERLDVIEFLDEGGDRS
>Mature_436_residues
MIDRLREALKRFNPCDSCLGRAFGYGLTGLENRERGRAIKLYLGMRAHLEGEEETLELLARSGLEEAAAVLDDPPEPEPC
GVCRGVLDKVDEFAEVVACELKDLEFRGFVVGSRWPEEIRKAEKELWETLGVEGEPIKREFNREVGKRVEHLLDVRADPR
NPDIEVVFDFRPSLEDPKFEVHVRPIYVRGRYLKLRRGIPQTKWPCPRCRGAGCPNCDFTGKLYTESVEELIGMVLKDAF
LAESHKFHAAGREDIDVRMLGNGRPFVMELLYPKRRNVDLKEIEGEINRKVGDDVQVVGLEYGDPEDVGKVKDLSERSRK
RYRAWVKFGKPVPEDKLREVLKGLERSVIEQRTPRRVLHRRADKVRRKRVHEAKLIEYDGDRAVIEFLCDPGLYVKELIS
GDAGRTRPSLAELVEVEAECERLDVIEFLDEGGDRS

Specific function: Unknown

COG id: COG1258

COG function: function code J; Predicted pseudouridylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 THUMP domain [H]

Homologues:

Organism=Homo sapiens, GI207113130, Length=243, Percent_Identity=37.037037037037, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17537241, Length=335, Percent_Identity=29.2537313432836, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19920442, Length=247, Percent_Identity=33.1983805668016, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005912
- InterPro:   IPR020103
- InterPro:   IPR004114 [H]

Pfam domain/function: PF02926 THUMP [H]

EC number: NA

Molecular weight: Translated: 50020; Mature: 50020

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRLREALKRFNPCDSCLGRAFGYGLTGLENRERGRAIKLYLGMRAHLEGEEETLELLA
CHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECHHHHCCCHHHHHHHHH
RSGLEEAAAVLDDPPEPEPCGVCRGVLDKVDEFAEVVACELKDLEFRGFVVGSRWPEEIR
HCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
KAEKELWETLGVEGEPIKREFNREVGKRVEHLLDVRADPRNPDIEVVFDFRPSLEDPKFE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEE
VHVRPIYVRGRYLKLRRGIPQTKWPCPRCRGAGCPNCDFTGKLYTESVEELIGMVLKDAF
EEEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LAESHKFHAAGREDIDVRMLGNGRPFVMELLYPKRRNVDLKEIEGEINRKVGDDVQVVGL
HHHCCHHCCCCCCCCEEEEECCCCCEEHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEE
EYGDPEDVGKVKDLSERSRKRYRAWVKFGKPVPEDKLREVLKGLERSVIEQRTPRRVLHR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
RADKVRRKRVHEAKLIEYDGDRAVIEFLCDPGLYVKELISGDAGRTRPSLAELVEVEAEC
HHHHHHHHHHHHHHHEEECCCHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
ERLDVIEFLDEGGDRS
HHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIDRLREALKRFNPCDSCLGRAFGYGLTGLENRERGRAIKLYLGMRAHLEGEEETLELLA
CHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECHHHHCCCHHHHHHHHH
RSGLEEAAAVLDDPPEPEPCGVCRGVLDKVDEFAEVVACELKDLEFRGFVVGSRWPEEIR
HCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
KAEKELWETLGVEGEPIKREFNREVGKRVEHLLDVRADPRNPDIEVVFDFRPSLEDPKFE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEE
VHVRPIYVRGRYLKLRRGIPQTKWPCPRCRGAGCPNCDFTGKLYTESVEELIGMVLKDAF
EEEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LAESHKFHAAGREDIDVRMLGNGRPFVMELLYPKRRNVDLKEIEGEINRKVGDDVQVVGL
HHHCCHHCCCCCCCCEEEEECCCCCEEHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEE
EYGDPEDVGKVKDLSERSRKRYRAWVKFGKPVPEDKLREVLKGLERSVIEQRTPRRVLHR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
RADKVRRKRVHEAKLIEYDGDRAVIEFLCDPGLYVKELISGDAGRTRPSLAELVEVEAEC
HHHHHHHHHHHHHHHEEECCCHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
ERLDVIEFLDEGGDRS
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]