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The map label for this gene is fixC [C]

Identifier: 20095081

GI number: 20095081

Start: 1644717

End: 1645973

Strand: Reverse

Name: fixC [C]

Synonym: MK1645

Alternate gene names: 20095081

Gene position: 1645973-1644717 (Counterclockwise)

Preceding gene: 20095082

Following gene: 20095079

Centisome position: 97.11

GC content: 61.26

Gene sequence:

>1257_bases
ATGACTGTGGTATTTGCGCCAAGGTTTGCCCGACGGGCGCCATCGAGAACGAGGGGGAGTGAGGCTATGGAGTTCGATGT
GGTGGTGGTCGGTGCGGGTCCGGCGGGTTCGGTGGCGGCGTGGGCCGCGGCGGAGGCCGGTTGTGATGTCCTGATACTCG
AGCGTAAGGCCGAGATCGGCGTCCCCAAACAGTGCGCCGAAGGAATAAGTGCACACGGGCTCGAACACGCTGGCATCGAG
CCCCAGGATGAGTGGATCGCTACCGAGATCTCGCGCGCCCTCATCTACGCTCCCAACGGGAAGGAGTTCGAGGTCCCCGG
TGACGGGTACGTGTTGGAGCGTCGTGTGTTTGATAAGTGGTTGGTTGTTCGGGCGGTGGAGGCTGGTGCGGAGGTCGAGT
TGTTGGCGCATGCTCGACGGGCGTTGTTAGATGAGGGTCGGGTGGTCGGGGTCGAGTACGAGGGCGAGGATGGAGTGCAC
GAGGTCCGAGCCCGCATCGTCATCGCCGCAGACGGAATCGAATCACGCATAGGAAGAACCGCCGGACTGGTTCCATCGCT
CAAACCCGTAGAGATGTGTACCTGCGCGCAATATGAGATGGTGGGCGTTGATGTGGAGGAGGACGCCACGCACTTCTTCG
TCGACGCCGAGTTCTTCCCGGGAGGGTACTTCTGGATCTTCCCGAAGGGCGAAGGTCGGGCGAACGTGGGATTAGGTATC
CGAGGGTCCGAATCCGAACCCGGGGATGCGCTGAAGGTACTGAACCGTGCCTTGGAGGATCACGAGCTGATCTCGGAAGC
GGTGGCGGACGCCGTCCCCGTGGAAGTGAACGTGGGTGGTGTGCCGGTGTGCGGGCCCGTCGAGCGGACGTACGGTGACG
GGATCCTCCTCGTGGGTGATGCGGCCCGCCAGGTCAACCCGTTAACCGGCGGTGGTCTTCATACTTCCCTGGTTTGCGGT
CGGATCGCGGGCGAGGTGGCGGCCGAGGCGATCGAAGAGGACGACACGTCCGCCTCCTTCCTGAAACGGTACCAAGACCG
GTGGGAGGAAGAGTTCGGTAAGACGTTCAAATACGCCCTGAAGGCGTCTAAGATATTCTCCGAAATGAGTAACGAGGAGC
TCAACGCATTGGCGGAGGCGCTGGACCGTGAGGATATCCTCAGGTTAGTGAAGGGAGAGGAAGTCGTGAAGGTGGCCAAG
AAGGTGATCAGCAGGAAACCGTCGCTCCTGAAGTACGCCAAGCACCTCATGAAATAA

Upstream 100 bases:

>100_bases
ATGGTCGAACGCTGTCTCGGGTGCGCCGCGTGCGCTGCGGTCTGCCCCAAGGACGCGCTGACGATTTCCGGTGGAAAGCC
CGAGTTCGGTCCTGAGTGCG

Downstream 100 bases:

>100_bases
ATACGGAGTCGGGGCGTTGGTATCGGATTTCCCCGCCCCGGCCACACAACTTCCCAGTGGCGGCGCGACTTGGGAGGTGT
CCCCTCCCGGGATGGGCGCC

Product: dehydrogenase (flavoprotein)

Products: NA

Alternate protein names: DGGGPL reductase 2; 2,3-di-O-geranylgeranylglyceryl phosphate reductase 2; Geranylgeranyl reductase 2; GGR 2 [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTVVFAPRFARRAPSRTRGSEAMEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIGVPKQCAEGISAHGLEHAGIE
PQDEWIATEISRALIYAPNGKEFEVPGDGYVLERRVFDKWLVVRAVEAGAEVELLAHARRALLDEGRVVGVEYEGEDGVH
EVRARIVIAADGIESRIGRTAGLVPSLKPVEMCTCAQYEMVGVDVEEDATHFFVDAEFFPGGYFWIFPKGEGRANVGLGI
RGSESEPGDALKVLNRALEDHELISEAVADAVPVEVNVGGVPVCGPVERTYGDGILLVGDAARQVNPLTGGGLHTSLVCG
RIAGEVAAEAIEEDDTSASFLKRYQDRWEEEFGKTFKYALKASKIFSEMSNEELNALAEALDREDILRLVKGEEVVKVAK
KVISRKPSLLKYAKHLMK

Sequences:

>Translated_418_residues
MTVVFAPRFARRAPSRTRGSEAMEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIGVPKQCAEGISAHGLEHAGIE
PQDEWIATEISRALIYAPNGKEFEVPGDGYVLERRVFDKWLVVRAVEAGAEVELLAHARRALLDEGRVVGVEYEGEDGVH
EVRARIVIAADGIESRIGRTAGLVPSLKPVEMCTCAQYEMVGVDVEEDATHFFVDAEFFPGGYFWIFPKGEGRANVGLGI
RGSESEPGDALKVLNRALEDHELISEAVADAVPVEVNVGGVPVCGPVERTYGDGILLVGDAARQVNPLTGGGLHTSLVCG
RIAGEVAAEAIEEDDTSASFLKRYQDRWEEEFGKTFKYALKASKIFSEMSNEELNALAEALDREDILRLVKGEEVVKVAK
KVISRKPSLLKYAKHLMK
>Mature_417_residues
TVVFAPRFARRAPSRTRGSEAMEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIGVPKQCAEGISAHGLEHAGIEP
QDEWIATEISRALIYAPNGKEFEVPGDGYVLERRVFDKWLVVRAVEAGAEVELLAHARRALLDEGRVVGVEYEGEDGVHE
VRARIVIAADGIESRIGRTAGLVPSLKPVEMCTCAQYEMVGVDVEEDATHFFVDAEFFPGGYFWIFPKGEGRANVGLGIR
GSESEPGDALKVLNRALEDHELISEAVADAVPVEVNVGGVPVCGPVERTYGDGILLVGDAARQVNPLTGGGLHTSLVCGR
IAGEVAAEAIEEDDTSASFLKRYQDRWEEEFGKTFKYALKASKIFSEMSNEELNALAEALDREDILRLVKGEEVVKVAKK
VISRKPSLLKYAKHLMK

Specific function: Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786227, Length=360, Percent_Identity=28.0555555555556, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787991, Length=361, Percent_Identity=29.6398891966759, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011777
- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: NA

Molecular weight: Translated: 45215; Mature: 45084

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVVFAPRFARRAPSRTRGSEAMEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIG
CEEEECCHHHHCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCC
VPKQCAEGISAHGLEHAGIEPQDEWIATEISRALIYAPNGKEFEVPGDGYVLERRVFDKW
CCHHHHCCHHHCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEECCCCCEEEHHHHHHHH
LVVRAVEAGAEVELLAHARRALLDEGRVVGVEYEGEDGVHEVRARIVIAADGIESRIGRT
HHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHEEEEEEECCHHHHHCCH
AGLVPSLKPVEMCTCAQYEMVGVDVEEDATHFFVDAEFFPGGYFWIFPKGEGRANVGLGI
HCCCCCCCHHHHHHHCCEEEEECCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCEEE
RGSESEPGDALKVLNRALEDHELISEAVADAVPVEVNVGGVPVCGPVERTYGDGILLVGD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHCCCCEEEEEC
AARQVNPLTGGGLHTSLVCGRIAGEVAAEAIEEDDTSASFLKRYQDRWEEEFGKTFKYAL
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KASKIFSEMSNEELNALAEALDREDILRLVKGEEVVKVAKKVISRKPSLLKYAKHLMK
HHHHHHHHHCCHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
TVVFAPRFARRAPSRTRGSEAMEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIG
EEEECCHHHHCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCC
VPKQCAEGISAHGLEHAGIEPQDEWIATEISRALIYAPNGKEFEVPGDGYVLERRVFDKW
CCHHHHCCHHHCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEECCCCCEEEHHHHHHHH
LVVRAVEAGAEVELLAHARRALLDEGRVVGVEYEGEDGVHEVRARIVIAADGIESRIGRT
HHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHEEEEEEECCHHHHHCCH
AGLVPSLKPVEMCTCAQYEMVGVDVEEDATHFFVDAEFFPGGYFWIFPKGEGRANVGLGI
HCCCCCCCHHHHHHHCCEEEEECCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCEEE
RGSESEPGDALKVLNRALEDHELISEAVADAVPVEVNVGGVPVCGPVERTYGDGILLVGD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHCCCCEEEEEC
AARQVNPLTGGGLHTSLVCGRIAGEVAAEAIEEDDTSASFLKRYQDRWEEEFGKTFKYAL
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KASKIFSEMSNEELNALAEALDREDILRLVKGEEVVKVAKKVISRKPSLLKYAKHLMK
HHHHHHHHHCCHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a quinone or similar compound as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]