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The map label for this gene is CobB_2 [H]

Identifier: 20095079

GI number: 20095079

Start: 1642891

End: 1644282

Strand: Reverse

Name: CobB_2 [H]

Synonym: MK1643

Alternate gene names: 20095079

Gene position: 1644282-1642891 (Counterclockwise)

Preceding gene: 20095081

Following gene: 20095078

Centisome position: 97.01

GC content: 62.57

Gene sequence:

>1392_bases
ATGATACACGGAAACAGGGGTGCCCTGTTGCCGATACCCCGGATAGTACTCGCGGGCTCGTCCAGCGCCTGCGGTAAGAC
TATGATCACCGCCGGCATAATTCAGGCGCTACGAGCCGACGGCTACGAGGTACAACCGTTCAAGGTGGGCCCCGACTACA
TCGATCCGTCGTACCACTGGTTGGCTTCCGGGCGACCGTGCGGTAACCTCGACACGTTCCTCTTCCGCGAGAAGCACGTC
AGATGGCTCTTCGAGCACCGATGTGAGGGCGCCGATCTCGCCGTCGTGGAGGGAGTTCGAGGGCTTTACGAGGGTATCGG
CGCCGTCGGTGTGAGGGGGAGCACGTATCACGTCTCCGAGGTCCTCAACGCACCCGTAGTGTTGATCGTCGACGCCCGGA
GTCTCACCAAGAGTGTGGCGGCGTTGGTGAAGGGCTACGCGGAACTGGAAGGAGCGAACATAGCCGGTGTGATACTGAAC
CGCATCAGGTCCGAGGTTCACTACCACAAGGTGCGACGCGCCCTGGTTAAGTACACCGACGTCAAGGTCCTGGGTTACGT
CCCTAGGGACCGCAGGCTCAAGGTGGAATACCGGCATTTGGGTCTGGTGCCGACCCCCGAACGCCTCGAGGAGATGAGGG
AACGTCTCCGCACAGTGGCCGAGGTGATCTCCGAGCATGTGGACCTGGACGCGCTCATCGACGTGGCGGAGGCCGCCGGT
CCGCTGGGGCCCGGGGAGCGTCCCTGGGAAGTGAACCCGACCAAATGCCGCATCGCCGTGGCTAAGGATGAGGCTTTCAA
CTTCTACTACCCGGAGAACCTGGAGGCACTCGAGGAGAACGGCGCGAAGCTCCTGGAGTTCAGCCCCGTGCGCGACGAGG
ACGTTCCACCCGACGCGGATGCGCTTTACATCGGGGGCGGCTACCCGGAGCTGTTCGCACGTCAGCTGGAAGATGCCGAG
AGTACGCGTAACTCCATCCGAGAGTTGGCGGAGTCGGGCGCCCCGATATATGCGGAATGCGGCGGCTTCATGTACCTGTG
TAGGGAGCTCAGGTGGAACGAGGACAGGTACAGGTGGGTGGGTGTCTTCGACGTAGCGGTCGAAATGACGGATAGGGTTC
AAGGCCTCAGCTACACGGTCGCCCGCGCCGTGGACGACACCCCGGTAACGCGTAAGGGGGAGACGTTCAAGGGCCACGAG
TTTCATTACTCACGCCTCGTGAGGCCCGAGGGTCTCGAGAGCGCGTACCGGATAATCCGGGGTCAAGGTTGGCGCGGACG
GGAGGGGTTTCGGCCCAAAGACCTCCCGAACGTGTTGGGAACGTACGTCCACGTGCACGCGGCCTCCCATCCGACGTTCG
CCACTAACTTCACGGGGAGTACCGGGTCTTGA

Upstream 100 bases:

>100_bases
TCACGCTCCTCCAAGTTGGAGGAACCGCATCTCCTGCATCGCATGGCCGTGAAGCTTTTCCCCCGAGCGGTCGGCGTGGA
AGTCCTGTATATCAAATTTT

Downstream 100 bases:

>100_bases
AACGCAGTCCGCGCGACTCCGTGCCCTACGTGACCCTTGACGGCTCGCTGATCTACGAGGTCGTGCGCCCGGAGTTCTCC
CGCGTTAACACCGTGAGCCT

Product: cobyrinic acid a,c-diamide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MIHGNRGALLPIPRIVLAGSSSACGKTMITAGIIQALRADGYEVQPFKVGPDYIDPSYHWLASGRPCGNLDTFLFREKHV
RWLFEHRCEGADLAVVEGVRGLYEGIGAVGVRGSTYHVSEVLNAPVVLIVDARSLTKSVAALVKGYAELEGANIAGVILN
RIRSEVHYHKVRRALVKYTDVKVLGYVPRDRRLKVEYRHLGLVPTPERLEEMRERLRTVAEVISEHVDLDALIDVAEAAG
PLGPGERPWEVNPTKCRIAVAKDEAFNFYYPENLEALEENGAKLLEFSPVRDEDVPPDADALYIGGGYPELFARQLEDAE
STRNSIRELAESGAPIYAECGGFMYLCRELRWNEDRYRWVGVFDVAVEMTDRVQGLSYTVARAVDDTPVTRKGETFKGHE
FHYSRLVRPEGLESAYRIIRGQGWRGREGFRPKDLPNVLGTYVHVHAASHPTFATNFTGSTGS

Sequences:

>Translated_463_residues
MIHGNRGALLPIPRIVLAGSSSACGKTMITAGIIQALRADGYEVQPFKVGPDYIDPSYHWLASGRPCGNLDTFLFREKHV
RWLFEHRCEGADLAVVEGVRGLYEGIGAVGVRGSTYHVSEVLNAPVVLIVDARSLTKSVAALVKGYAELEGANIAGVILN
RIRSEVHYHKVRRALVKYTDVKVLGYVPRDRRLKVEYRHLGLVPTPERLEEMRERLRTVAEVISEHVDLDALIDVAEAAG
PLGPGERPWEVNPTKCRIAVAKDEAFNFYYPENLEALEENGAKLLEFSPVRDEDVPPDADALYIGGGYPELFARQLEDAE
STRNSIRELAESGAPIYAECGGFMYLCRELRWNEDRYRWVGVFDVAVEMTDRVQGLSYTVARAVDDTPVTRKGETFKGHE
FHYSRLVRPEGLESAYRIIRGQGWRGREGFRPKDLPNVLGTYVHVHAASHPTFATNFTGSTGS
>Mature_463_residues
MIHGNRGALLPIPRIVLAGSSSACGKTMITAGIIQALRADGYEVQPFKVGPDYIDPSYHWLASGRPCGNLDTFLFREKHV
RWLFEHRCEGADLAVVEGVRGLYEGIGAVGVRGSTYHVSEVLNAPVVLIVDARSLTKSVAALVKGYAELEGANIAGVILN
RIRSEVHYHKVRRALVKYTDVKVLGYVPRDRRLKVEYRHLGLVPTPERLEEMRERLRTVAEVISEHVDLDALIDVAEAAG
PLGPGERPWEVNPTKCRIAVAKDEAFNFYYPENLEALEENGAKLLEFSPVRDEDVPPDADALYIGGGYPELFARQLEDAE
STRNSIRELAESGAPIYAECGGFMYLCRELRWNEDRYRWVGVFDVAVEMTDRVQGLSYTVARAVDDTPVTRKGETFKGHE
FHYSRLVRPEGLESAYRIIRGQGWRGREGFRPKDLPNVLGTYVHVHAASHPTFATNFTGSTGS

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: NA

Molecular weight: Translated: 51593; Mature: 51593

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHGNRGALLPIPRIVLAGSSSACGKTMITAGIIQALRADGYEVQPFKVGPDYIDPSYHW
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCE
LASGRPCGNLDTFLFREKHVRWLFEHRCEGADLAVVEGVRGLYEGIGAVGVRGSTYHVSE
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEHHH
VLNAPVVLIVDARSLTKSVAALVKGYAELEGANIAGVILNRIRSEVHYHKVRRALVKYTD
HHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
VKVLGYVPRDRRLKVEYRHLGLVPTPERLEEMRERLRTVAEVISEHVDLDALIDVAEAAG
EEEEEECCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
PLGPGERPWEVNPTKCRIAVAKDEAFNFYYPENLEALEENGAKLLEFSPVRDEDVPPDAD
CCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCHHHHHCCCCEEEEECCCCCCCCCCCCC
ALYIGGGYPELFARQLEDAESTRNSIRELAESGAPIYAECGGFMYLCRELRWNEDRYRWV
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCCEEEE
GVFDVAVEMTDRVQGLSYTVARAVDDTPVTRKGETFKGHEFHYSRLVRPEGLESAYRIIR
EEHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHH
GQGWRGREGFRPKDLPNVLGTYVHVHAASHPTFATNFTGSTGS
CCCCCCCCCCCCCCHHHHHHHEEEEEECCCCCEEEECCCCCCC
>Mature Secondary Structure
MIHGNRGALLPIPRIVLAGSSSACGKTMITAGIIQALRADGYEVQPFKVGPDYIDPSYHW
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCE
LASGRPCGNLDTFLFREKHVRWLFEHRCEGADLAVVEGVRGLYEGIGAVGVRGSTYHVSE
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEHHH
VLNAPVVLIVDARSLTKSVAALVKGYAELEGANIAGVILNRIRSEVHYHKVRRALVKYTD
HHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
VKVLGYVPRDRRLKVEYRHLGLVPTPERLEEMRERLRTVAEVISEHVDLDALIDVAEAAG
EEEEEECCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
PLGPGERPWEVNPTKCRIAVAKDEAFNFYYPENLEALEENGAKLLEFSPVRDEDVPPDAD
CCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCHHHHHCCCCEEEEECCCCCCCCCCCCC
ALYIGGGYPELFARQLEDAESTRNSIRELAESGAPIYAECGGFMYLCRELRWNEDRYRWV
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCCEEEE
GVFDVAVEMTDRVQGLSYTVARAVDDTPVTRKGETFKGHEFHYSRLVRPEGLESAYRIIR
EEHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHH
GQGWRGREGFRPKDLPNVLGTYVHVHAASHPTFATNFTGSTGS
CCCCCCCCCCCCCCHHHHHHHEEEEEECCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]