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The map label for this gene is QRI7

Identifier: 20094894

GI number: 20094894

Start: 1484461

End: 1485501

Strand: Direct

Name: QRI7

Synonym: MK1458

Alternate gene names: 20094894

Gene position: 1484461-1485501 (Clockwise)

Preceding gene: 20094892

Following gene: 20094895

Centisome position: 87.58

GC content: 63.4

Gene sequence:

>1041_bases
ATGATCTGTGTGGGTATAGAGTCTACGGCCGAGAAACTCGGCGTGGGTGTCGTGACGGACGACGGGGAGATACTGGTCAA
CGTGAAGGCTCAGTACATCCCCCCTCCGGGCTCGGGGATACTACCCAGAGAGGCGGCTGAACATCACTCCAGAGAACTGC
CGGAGCTCCTCGAACGCGCGTTGAAGAACGCGGGAGTGGAGCCCGAAGACATCGACTTAGTGGCTTACTCGCAAGGGCCT
GGACTGGGACCCTGCCTACGTGTCGGCGCCACCGCGGCCCGAACCCTGGCACTGACGCTCGAGGTCCCCCTGGCACCGGT
CAACCACTGCGTGGCCCACGTGGAGATAGGGAAGTTAGCGGCACGCCAGGACGGGTTCGATTTCGACGAGCCGGTAACAC
TCTACGTGTCCGGAGGGAACACCCAGGTGCTGGCCCTCAAAGCCGGACGATACCGGGTGTTCGGGGAAACCCTGGATCTC
CCCGTGGGTAACATGCTGGACACTTTCGCCCGTAAGGTCGGACTCCCACATCCCGGTGGGCCCGAGATAGAACGCCTCGC
CGAGGAAGGTGAGCCCGTGGAACTCCCTTACACTGTACGTGGCACCGACGTGTCGTTCTCAGGCCTTCTGACGGCGGCAC
TGCGGAGATACGAGCAGGGAGACAGGCTCGAGGACGTGTGTGCAGGACTTCAGGAGACAGCCTTCGCAATGCTGGTGGAG
ATAACGGAGCGTGCCGCGGCCCAGCTGGGCCGGGATGAGATCCTGCTCACGGGAGGGGTGGCCGCGAACCGTCGTCTCTC
CGAGATGATGCACGAAATGGCGGAGGACCGCGGTGCGGAGGCGTACACGGTGCCCCCGGAACTGGCCGGAGACAACGGGG
CCATGATCGCTTGGACGGGGATCCTCGTCCACGAACACGGCCTCTCGATACCGCCCGATGAGATCCCGGAGAAGGCTATC
GTCAAGCAACGATACCGTGTAGACGAGGCGCCCGTCCCGTGGGCCGCTCGTCCTTCCAGATCGGCCGATTCTCAAGGATA
G

Upstream 100 bases:

>100_bases
CCAGCTCCTCCAGTACGAACCTACAGTCCCGGCGGAACAGGGACAAGTTAAGATCCGTCATCGCGCCTTTCCCCGCAGGC
GGGGTGCCGTAATGTCGACG

Downstream 100 bases:

>100_bases
AGTAGGCAGCTCGTCGAGCCCACGCTATGGGGGTTGGAACTGGCCCGTAGACGACGGTGGGTTACCATCTTCAGGATACC
CACGGAAATCCGGGCTCACG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MICVGIESTAEKLGVGVVTDDGEILVNVKAQYIPPPGSGILPREAAEHHSRELPELLERALKNAGVEPEDIDLVAYSQGP
GLGPCLRVGATAARTLALTLEVPLAPVNHCVAHVEIGKLAARQDGFDFDEPVTLYVSGGNTQVLALKAGRYRVFGETLDL
PVGNMLDTFARKVGLPHPGGPEIERLAEEGEPVELPYTVRGTDVSFSGLLTAALRRYEQGDRLEDVCAGLQETAFAMLVE
ITERAAAQLGRDEILLTGGVAANRRLSEMMHEMAEDRGAEAYTVPPELAGDNGAMIAWTGILVHEHGLSIPPDEIPEKAI
VKQRYRVDEAPVPWAARPSRSADSQG

Sequences:

>Translated_346_residues
MICVGIESTAEKLGVGVVTDDGEILVNVKAQYIPPPGSGILPREAAEHHSRELPELLERALKNAGVEPEDIDLVAYSQGP
GLGPCLRVGATAARTLALTLEVPLAPVNHCVAHVEIGKLAARQDGFDFDEPVTLYVSGGNTQVLALKAGRYRVFGETLDL
PVGNMLDTFARKVGLPHPGGPEIERLAEEGEPVELPYTVRGTDVSFSGLLTAALRRYEQGDRLEDVCAGLQETAFAMLVE
ITERAAAQLGRDEILLTGGVAANRRLSEMMHEMAEDRGAEAYTVPPELAGDNGAMIAWTGILVHEHGLSIPPDEIPEKAI
VKQRYRVDEAPVPWAARPSRSADSQG
>Mature_346_residues
MICVGIESTAEKLGVGVVTDDGEILVNVKAQYIPPPGSGILPREAAEHHSRELPELLERALKNAGVEPEDIDLVAYSQGP
GLGPCLRVGATAARTLALTLEVPLAPVNHCVAHVEIGKLAARQDGFDFDEPVTLYVSGGNTQVLALKAGRYRVFGETLDL
PVGNMLDTFARKVGLPHPGGPEIERLAEEGEPVELPYTVRGTDVSFSGLLTAALRRYEQGDRLEDVCAGLQETAFAMLVE
ITERAAAQLGRDEILLTGGVAANRRLSEMMHEMAEDRGAEAYTVPPELAGDNGAMIAWTGILVHEHGLSIPPDEIPEKAI
VKQRYRVDEAPVPWAARPSRSADSQG

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI8923380, Length=340, Percent_Identity=47.0588235294118, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI116812636, Length=349, Percent_Identity=28.6532951289398, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1789445, Length=324, Percent_Identity=34.8765432098765, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71995670, Length=345, Percent_Identity=47.2463768115942, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17557464, Length=344, Percent_Identity=26.7441860465116, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322891, Length=376, Percent_Identity=39.8936170212766, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320099, Length=320, Percent_Identity=25.625, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357207, Length=355, Percent_Identity=45.0704225352113, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI20129063, Length=337, Percent_Identity=29.080118694362, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_METKA (Q8TVD4)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614741.1
- ProteinModelPortal:   Q8TVD4
- SMR:   Q8TVD4
- MEROPS:   M22.003
- GeneID:   1478053
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1458
- NMPDR:   fig|190192.1.peg.1454
- HOGENOM:   HBG304663
- OMA:   TQRFRTD
- ProtClustDB:   PRK14878
- BioCyc:   MKAN190192:MK1458-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01446
- InterPro:   IPR022449
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03722
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37058; Mature: 37058

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICVGIESTAEKLGVGVVTDDGEILVNVKAQYIPPPGSGILPREAAEHHSRELPELLERA
CEEECCCHHHHHHCCEEEECCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
LKNAGVEPEDIDLVAYSQGPGLGPCLRVGATAARTLALTLEVPLAPVNHCVAHVEIGKLA
HHHCCCCCCCEEEEEECCCCCCCHHHHHCCHHHEEEEEEEECCCCCHHHHHHHHHHHHHH
ARQDGFDFDEPVTLYVSGGNTQVLALKAGRYRVFGETLDLPVGNMLDTFARKVGLPHPGG
HHCCCCCCCCCEEEEEECCCEEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCC
PEIERLAEEGEPVELPYTVRGTDVSFSGLLTAALRRYEQGDRLEDVCAGLQETAFAMLVE
HHHHHHHHCCCCEECCEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHH
ITERAAAQLGRDEILLTGGVAANRRLSEMMHEMAEDRGAEAYTVPPELAGDNGAMIAWTG
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEECCHHHCCCCCCEEEEEE
ILVHEHGLSIPPDEIPEKAIVKQRYRVDEAPVPWAARPSRSADSQG
EEEEECCCCCCHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MICVGIESTAEKLGVGVVTDDGEILVNVKAQYIPPPGSGILPREAAEHHSRELPELLERA
CEEECCCHHHHHHCCEEEECCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
LKNAGVEPEDIDLVAYSQGPGLGPCLRVGATAARTLALTLEVPLAPVNHCVAHVEIGKLA
HHHCCCCCCCEEEEEECCCCCCCHHHHHCCHHHEEEEEEEECCCCCHHHHHHHHHHHHHH
ARQDGFDFDEPVTLYVSGGNTQVLALKAGRYRVFGETLDLPVGNMLDTFARKVGLPHPGG
HHCCCCCCCCCEEEEEECCCEEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCC
PEIERLAEEGEPVELPYTVRGTDVSFSGLLTAALRRYEQGDRLEDVCAGLQETAFAMLVE
HHHHHHHHCCCCEECCEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHH
ITERAAAQLGRDEILLTGGVAANRRLSEMMHEMAEDRGAEAYTVPPELAGDNGAMIAWTG
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEECCHHHCCCCCCEEEEEE
ILVHEHGLSIPPDEIPEKAIVKQRYRVDEAPVPWAARPSRSADSQG
EEEEECCCCCCHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014