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The map label for this gene is 20094844

Identifier: 20094844

GI number: 20094844

Start: 1437721

End: 1438929

Strand: Reverse

Name: 20094844

Synonym: MK1408

Alternate gene names: NA

Gene position: 1438929-1437721 (Counterclockwise)

Preceding gene: 20094845

Following gene: 20094843

Centisome position: 84.89

GC content: 63.11

Gene sequence:

>1209_bases
ATGCGGCCCAAGCAGGTCTGGGTCTCGGTGGCGTTCGAGGGCGAGTGGAACGAGAAGAAGCCCTACGTCACGGAATCGAT
CGAAGCCGGTGTCGACGTGATAGTTTGCCTACCCGAGGACGTAGAGCGCGTGAAGGAGCTCGGGAACGTTAAGGTCGCGG
TGCCGCTGATGCCGGAGTCTCCGGGCTCTCCCGACCTAGCCCTTGAGGAGCTGGACGCCATCGACGCCGACGTGGTGATC
GTGGGCAAGGGTGGCGAGGGAGACGGTTCTATCGACCTGCCGGACGACATATCCGAGTCTATCGACGCCGCGCTCATCGA
GAAGGCGCGGGATCGCGGGTTCGAGGTCGCCGAGTACGTCGAGATCCTGGACAAGCCTTACGAGCGCTTCGCCGCGGAGA
TCGCGAAGAACGTGGGTCCCGACTACGTGATCGCGATCGGCCGTGACTGGAAGATCATCCCACTGGAGAACCTCATCGCG
GAACTTCAGGGTGAGAAGACGCAGCTCATCGCCGGAGCTCGGGACGCCGAGGAGGCACGTATAGCCTTCGAGACGCTCGA
GGTGGGTTCGGACGGCGTCCTGCTCGACGCGGAGCGTATCGATCCGTCCGAGATCAAGAAGACCGCGGAGATCGCGGAGC
GGGCCGCAGCCGAGCGATTCGAGCTCGTCGCGGTCGAGGTGAAGGAAGTCAAACCGATAGGTAAGGGCGACAGGGTCTGC
GTGGACACCTGCTCGCTCATGTCCGAGGGCGAGGGAATGCTCGTAGGATCGACCTCCCGCGGGATGTTCCTCATTCATAG
CGAGAGCCTCGAGAACCCGTACGTCGAGCCGCGACCCTTCCGGGTGAACGCCGGTCCGGTCCACGCCTACATCCGCGTGC
CCGGTGGGAAGACGAAGTACCTGGCCGAGCTGAGACCCGGCGATGAGGTCCTGATAGTCGACACGGAAGGACGTACGAGG
GCCGCGGTGGTGGGCCGACTGAAGATCGAACGGAGACCGCTGATGCTCATCCGCGCGGAGTACGAAGGTGTGGAGATTCA
GACCATAGTTCAGAACGCCGAGACCATTCACCTGGTACGCGAGGACGGTGAGCCGGTGTCCGTGGTCGACCTCAAGCCGG
GTGACAAGGTGCTCGCGTACGTGGAGACCGAGGAAGGTAAGGGCCGTCACTTCGGGATGGAGGTGGAGGAAACCATCGTG
GAGAAGTAG

Upstream 100 bases:

>100_bases
ACGCATGCGTGAGGCAATGACCCGTGCCATCGCGAGGATCATACATGAAGACGCGGAAGTGGAGGAAGCGATGAAGGAGC
TGGAGCGGGTGTAAGTCGAG

Downstream 100 bases:

>100_bases
CTTCCTCCTTCCCCGCTTTTCGCTATTGTTACAATTATCGTAACGAATTCCACACCGGCCCCCACCTTGTATGTACGCTT
CGGAACCACCGACTGTCGGG

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: DHQ synthase

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MRPKQVWVSVAFEGEWNEKKPYVTESIEAGVDVIVCLPEDVERVKELGNVKVAVPLMPESPGSPDLALEELDAIDADVVI
VGKGGEGDGSIDLPDDISESIDAALIEKARDRGFEVAEYVEILDKPYERFAAEIAKNVGPDYVIAIGRDWKIIPLENLIA
ELQGEKTQLIAGARDAEEARIAFETLEVGSDGVLLDAERIDPSEIKKTAEIAERAAAERFELVAVEVKEVKPIGKGDRVC
VDTCSLMSEGEGMLVGSTSRGMFLIHSESLENPYVEPRPFRVNAGPVHAYIRVPGGKTKYLAELRPGDEVLIVDTEGRTR
AAVVGRLKIERRPLMLIRAEYEGVEIQTIVQNAETIHLVREDGEPVSVVDLKPGDKVLAYVETEEGKGRHFGMEVEETIV
EK

Sequences:

>Translated_402_residues
MRPKQVWVSVAFEGEWNEKKPYVTESIEAGVDVIVCLPEDVERVKELGNVKVAVPLMPESPGSPDLALEELDAIDADVVI
VGKGGEGDGSIDLPDDISESIDAALIEKARDRGFEVAEYVEILDKPYERFAAEIAKNVGPDYVIAIGRDWKIIPLENLIA
ELQGEKTQLIAGARDAEEARIAFETLEVGSDGVLLDAERIDPSEIKKTAEIAERAAAERFELVAVEVKEVKPIGKGDRVC
VDTCSLMSEGEGMLVGSTSRGMFLIHSESLENPYVEPRPFRVNAGPVHAYIRVPGGKTKYLAELRPGDEVLIVDTEGRTR
AAVVGRLKIERRPLMLIRAEYEGVEIQTIVQNAETIHLVREDGEPVSVVDLKPGDKVLAYVETEEGKGRHFGMEVEETIV
EK
>Mature_402_residues
MRPKQVWVSVAFEGEWNEKKPYVTESIEAGVDVIVCLPEDVERVKELGNVKVAVPLMPESPGSPDLALEELDAIDADVVI
VGKGGEGDGSIDLPDDISESIDAALIEKARDRGFEVAEYVEILDKPYERFAAEIAKNVGPDYVIAIGRDWKIIPLENLIA
ELQGEKTQLIAGARDAEEARIAFETLEVGSDGVLLDAERIDPSEIKKTAEIAERAAAERFELVAVEVKEVKPIGKGDRVC
VDTCSLMSEGEGMLVGSTSRGMFLIHSESLENPYVEPRPFRVNAGPVHAYIRVPGGKTKYLAELRPGDEVLIVDTEGRTR
AAVVGRLKIERRPLMLIRAEYEGVEIQTIVQNAETIHLVREDGEPVSVVDLKPGDKVLAYVETEEGKGRHFGMEVEETIV
EK

Specific function: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis

COG id: COG1465

COG function: function code E; Predicted alternative 3-dehydroquinate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type DHQ synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHQS_METKA (Q8TVI1)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614691.1
- ProteinModelPortal:   Q8TVI1
- GeneID:   1478003
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1408
- NMPDR:   fig|190192.1.peg.1404
- HOGENOM:   HBG670179
- OMA:   MEVEETI
- ProtClustDB:   PRK02290
- BioCyc:   MKAN190192:MK1408-MONOMER
- HAMAP:   MF_01244
- InterPro:   IPR002812
- PIRSF:   PIRSF006655
- ProDom:   PD017907

Pfam domain/function: PF01959 DHQS

EC number: NA

Molecular weight: Translated: 44136; Mature: 44136

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPKQVWVSVAFEGEWNEKKPYVTESIEAGVDVIVCLPEDVERVKELGNVKVAVPLMPES
CCCCEEEEEEEEECCCCCCCCCCHHHHCCCCEEEEECCHHHHHHHHHCCEEEEEEECCCC
PGSPDLALEELDAIDADVVIVGKGGEGDGSIDLPDDISESIDAALIEKARDRGFEVAEYV
CCCCCCHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
EILDKPYERFAAEIAKNVGPDYVIAIGRDWKIIPLENLIAELQGEKTQLIAGARDAEEAR
HHHHCHHHHHHHHHHHHCCCCEEEEECCCEEEEEHHHHHHHHCCCCEEEEECCCCCHHHE
IAFETLEVGSDGVLLDAERIDPSEIKKTAEIAERAAAERFELVAVEVKEVKPIGKGDRVC
EEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCCCCCEEE
VDTCSLMSEGEGMLVGSTSRGMFLIHSESLENPYVEPRPFRVNAGPVHAYIRVPGGKTKY
EEEHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCEEECCCCEEEEEECCCCCEEE
LAELRPGDEVLIVDTEGRTRAAVVGRLKIERRPLMLIRAEYEGVEIQTIVQNAETIHLVR
EEEECCCCEEEEEECCCCCEEEEEEEEEECCCCEEEEEECCCCEEEEEECCCCEEEEEEE
EDGEPVSVVDLKPGDKVLAYVETEEGKGRHFGMEVEETIVEK
CCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MRPKQVWVSVAFEGEWNEKKPYVTESIEAGVDVIVCLPEDVERVKELGNVKVAVPLMPES
CCCCEEEEEEEEECCCCCCCCCCHHHHCCCCEEEEECCHHHHHHHHHCCEEEEEEECCCC
PGSPDLALEELDAIDADVVIVGKGGEGDGSIDLPDDISESIDAALIEKARDRGFEVAEYV
CCCCCCHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
EILDKPYERFAAEIAKNVGPDYVIAIGRDWKIIPLENLIAELQGEKTQLIAGARDAEEAR
HHHHCHHHHHHHHHHHHCCCCEEEEECCCEEEEEHHHHHHHHCCCCEEEEECCCCCHHHE
IAFETLEVGSDGVLLDAERIDPSEIKKTAEIAERAAAERFELVAVEVKEVKPIGKGDRVC
EEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCCCCCEEE
VDTCSLMSEGEGMLVGSTSRGMFLIHSESLENPYVEPRPFRVNAGPVHAYIRVPGGKTKY
EEEHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCEEECCCCEEEEEECCCCCEEE
LAELRPGDEVLIVDTEGRTRAAVVGRLKIERRPLMLIRAEYEGVEIQTIVQNAETIHLVR
EEEECCCCEEEEEECCCCCEEEEEEEEEECCCCEEEEEECCCCEEEEEECCCCEEEEEEE
EDGEPVSVVDLKPGDKVLAYVETEEGKGRHFGMEVEETIVEK
CCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014