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The map label for this gene is DYS1

Identifier: 20094174

GI number: 20094174

Start: 701479

End: 702372

Strand: Reverse

Name: DYS1

Synonym: MK0737

Alternate gene names: 20094174

Gene position: 702372-701479 (Counterclockwise)

Preceding gene: 20094175

Following gene: 20094173

Centisome position: 41.44

GC content: 61.19

Gene sequence:

>894_bases
GTGAAGCGTGAAACGTTCAGGTATCGAGGCGACATGGACCTCGACGGGTTCCTGCGAGAGATGGAACGCGTCGGCGCGTT
AGGCGCCGGAAGATTGGGTAGAGCGGCACGGATCTTGGAGAAGATGTGGTCTTCGGACGACGTCACGGTCCTCCTCACCG
TAGCCGGCCCTGCGGTAGCGGGTGGACTCGGCGAGCTCTTCGAGCGGCTCATCCGTGAAGGCCTCGTCGACGCCGTGATC
ACGTCCGGCGCTAACGTAGTTCACGACGCCCTGGACGCCCTCGGCGGTATCCACGTGTGCTTGGGAGAGCGCAACGTCGA
TGGGTACGGTCGGGTTCATGATACGCACATACCGACGGAAGCGTTCGAGAAGTTCGAGCACTTCATGCGGGAAGTCCTCT
CCGATCTCTCGGGGCGCGTATCCTGCCGAGAGCTGCTGTGGGAAATGGGGAAGAGGCTCGAGAGCGGCTTCCTCAGGGCC
GCAGCCGACGAAGGAGTGCCGATATACTCGCCGGGAATACTGGACTCGATGGTCGGCCTGCACGTGTGGATACACTCACA
GGATCACGACTTTCACCTGGACCTTGTGGACGATATGCACCATCTCGCGGACCTCGTTTTCGAAGCCGAGGAGTTAGGAG
CCATCATCTTAGGCGGGAGCGTGCCGAAGCACTTCGCGATGGGGGCCGCGATGCTTCGAGGTGGTCTGGACTACGCCGTT
CAGATCACGATGGATAGGCCCGAAACGGGAAGCCTCAGTGGTGCGCCTCTGGAGGAAGGTAAATCGTGGGAGAAGGTGCG
AGAAGACGCCGAGGTGGCCACCATCGTGGGGGACTACCTGATAATCTTCCCACTGCTCGCATCCGGCGTCATGCAGCGGC
TGGGGATCGTATGA

Upstream 100 bases:

>100_bases
ACCTAGATGTAGTCGAGCTCTGTCCCACGGTCGAAAGCCACGTGTCGCCGGTGACGGCCGCCCGCTTGGTGGGCGAATAC
CTCAAGGGAGTGGCTGAAAG

Downstream 100 bases:

>100_bases
TTGGGGCCTGAGCTGGCGGCGGTGTCCGGGTTCGCGCTGAAGATCGCGGACGACTTGGTAGATGAGTTGAGCCGGCCGCA
GTGGGCGTTACCGTGCGGGC

Product: deoxyhypusine synthase

Products: NA

Alternate protein names: DHS

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKRETFRYRGDMDLDGFLREMERVGALGAGRLGRAARILEKMWSSDDVTVLLTVAGPAVAGGLGELFERLIREGLVDAVI
TSGANVVHDALDALGGIHVCLGERNVDGYGRVHDTHIPTEAFEKFEHFMREVLSDLSGRVSCRELLWEMGKRLESGFLRA
AADEGVPIYSPGILDSMVGLHVWIHSQDHDFHLDLVDDMHHLADLVFEAEELGAIILGGSVPKHFAMGAAMLRGGLDYAV
QITMDRPETGSLSGAPLEEGKSWEKVREDAEVATIVGDYLIIFPLLASGVMQRLGIV

Sequences:

>Translated_297_residues
MKRETFRYRGDMDLDGFLREMERVGALGAGRLGRAARILEKMWSSDDVTVLLTVAGPAVAGGLGELFERLIREGLVDAVI
TSGANVVHDALDALGGIHVCLGERNVDGYGRVHDTHIPTEAFEKFEHFMREVLSDLSGRVSCRELLWEMGKRLESGFLRA
AADEGVPIYSPGILDSMVGLHVWIHSQDHDFHLDLVDDMHHLADLVFEAEELGAIILGGSVPKHFAMGAAMLRGGLDYAV
QITMDRPETGSLSGAPLEEGKSWEKVREDAEVATIVGDYLIIFPLLASGVMQRLGIV
>Mature_297_residues
MKRETFRYRGDMDLDGFLREMERVGALGAGRLGRAARILEKMWSSDDVTVLLTVAGPAVAGGLGELFERLIREGLVDAVI
TSGANVVHDALDALGGIHVCLGERNVDGYGRVHDTHIPTEAFEKFEHFMREVLSDLSGRVSCRELLWEMGKRLESGFLRA
AADEGVPIYSPGILDSMVGLHVWIHSQDHDFHLDLVDDMHHLADLVFEAEELGAIILGGSVPKHFAMGAAMLRGGLDYAV
QITMDRPETGSLSGAPLEEGKSWEKVREDAEVATIVGDYLIIFPLLASGVMQRLGIV

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family

Homologues:

Organism=Homo sapiens, GI4503325, Length=259, Percent_Identity=28.1853281853282, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17536927, Length=264, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6321859, Length=279, Percent_Identity=24.3727598566308, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45550569, Length=254, Percent_Identity=26.3779527559055, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHYS_METKA (Q8TXD7)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614021.1
- ProteinModelPortal:   Q8TXD7
- SMR:   Q8TXD7
- GeneID:   1476838
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0737
- NMPDR:   fig|190192.1.peg.734
- HOGENOM:   HBG716221
- OMA:   NAAVNER
- BioCyc:   MKAN190192:MK0737-MONOMER
- BRENDA:   2.5.1.46
- HAMAP:   MF_00153
- InterPro:   IPR002773
- InterPro:   IPR022899
- Gene3D:   G3DSA:3.40.910.10
- PANTHER:   PTHR11703

Pfam domain/function: PF01916 DS

EC number: =2.5.1.46

Molecular weight: Translated: 32476; Mature: 32476

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: ACT_SITE 265-265

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRETFRYRGDMDLDGFLREMERVGALGAGRLGRAARILEKMWSSDDVTVLLTVAGPAVA
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHH
GGLGELFERLIREGLVDAVITSGANVVHDALDALGGIHVCLGERNVDGYGRVHDTHIPTE
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCCCCCCCCCEECCCCCHH
AFEKFEHFMREVLSDLSGRVSCRELLWEMGKRLESGFLRAAADEGVPIYSPGILDSMVGL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
HVWIHSQDHDFHLDLVDDMHHLADLVFEAEELGAIILGGSVPKHFAMGAAMLRGGLDYAV
EEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHCCCCEEE
QITMDRPETGSLSGAPLEEGKSWEKVREDAEVATIVGDYLIIFPLLASGVMQRLGIV
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRETFRYRGDMDLDGFLREMERVGALGAGRLGRAARILEKMWSSDDVTVLLTVAGPAVA
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHH
GGLGELFERLIREGLVDAVITSGANVVHDALDALGGIHVCLGERNVDGYGRVHDTHIPTE
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCCCCCCCCCEECCCCCHH
AFEKFEHFMREVLSDLSGRVSCRELLWEMGKRLESGFLRAAADEGVPIYSPGILDSMVGL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
HVWIHSQDHDFHLDLVDDMHHLADLVFEAEELGAIILGGSVPKHFAMGAAMLRGGLDYAV
EEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHCCCCEEE
QITMDRPETGSLSGAPLEEGKSWEKVREDAEVATIVGDYLIIFPLLASGVMQRLGIV
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014