Click here to switch to the map view.

The map label for this gene is LysA [H]

Identifier: 20093921

GI number: 20093921

Start: 442817

End: 444034

Strand: Reverse

Name: LysA [H]

Synonym: MK0483

Alternate gene names: 20093921

Gene position: 444034-442817 (Counterclockwise)

Preceding gene: 20093922

Following gene: 20093920

Centisome position: 26.2

GC content: 59.36

Gene sequence:

>1218_bases
GTGGTCGAGAGCTCGACGACATCCTGGAGGAGGCCGGTACGAGGACACCGGTGTACGTCTACGACGCGGATGCTGCCCGT
AAAGGCCGCCCGCGAATATCAGGAGGCGTTTTCTTGGTTCCCGGATCGCGTGTACGTATGCTACGCGATGAAAGCGAACT
TCAACCCATACCTCGTCGAACACATCGTAGACGAGACTCGAGCCGCAGACGTGGTGTCGCTGTGGGAGATGAAGGTCGCG
GTCAACGCGGGAGCGGAGACAGTGGTGGTCAACGGCAACGCGAAGTCCTCGGATGAGATCCGCGCGGCCGTGGAACGCTC
GTGGGTGATCAACGTCGACTCCTTCGAGGAGTTCCAACGTATCGAAAAAATCGCGCGGCATGAAGGTGAGAGGGCCTTAG
TGGCGCTCAGGGTCAACCCGAAGGTGAGTCCCGATACCCACTCTCACATCGCCACCGCGGTCGAAGGGTCGAAGTTCGGT
GTTGAGCTGGAAATCGCCGAACGAGTCTGCAGGCGGATGATCGAATCGGAGTGGGTCGAGTTCCTGGGGCTTCACTACCA
TATAGGCTCCCAAATCACCGATTTGAGGCCGTTTTCAGAGGCGTTGAGATCCGTCCGAACGTTTCTCGAGGACACCGGAC
TGATCGAGGAAATCTCGTACCTAAACATCGGCGGTGGGCTCGGGATTCGGTACCGCCGAGGTGAGGAGGTACCGTCTCCT
CACGATCTGGCGGAGGAACTCCAGGAGGACCTGAAAGAGCTTCACTCCGAGTCGTCGGGGTTCGACCTGTACCTCGAGCC
CGGTCGGAGCATAGTGGGTGAAGCCGGGATCCTGGTCACAAGCGTCAGACAGGTCAAACGGGGACGTCGGAGGTGGGTTT
TCGTTGACACCGGTATGAACGCCCTGATACGACCAGCTCTTTACGATGCTTACCACGAGGTCGTCGTTCACGGTGGCGAT
TACTCGGCCACCGAGAAGGCCTCCGTGGCTGGCCCGCTGTGCGAGAGTGGGGATGTACTCGCCGAAGACCGGGAGCTTCC
CATCGATATTTCGGAGGGCGACCTCGTGGTGTTCCTGTCCGCCGGTGCCTACTGCGAATCTATGGCCAGCAACTATAACT
GCTACCCGATTCCGGGCTCGGTGGTCGTACGGAACGGGGAAATCACCGGAGTCCGAAGGGTCCAGGACTATGAGGCGTTC
TCGAAAACATGGTGGTGA

Upstream 100 bases:

>100_bases
GGAGTGGCATCGGACCTAAGTCGGTGGAGCTACTGGTCGCCAACTTGAAGGGGTAGTCCCGCAATGATAGAAACGGAACA
CGTAGCGGTGGTTAAAGTCA

Downstream 100 bases:

>100_bases
CCTTCGGGAGCGCGTACTCCGCACACTCGCGGAGAAGGGTCCGCTCTCCCGCCGTGAACTCATGGACGAGGTGAGCGGTA
ACCGGGGTCTCATCAGCAAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MVESSTTSWRRPVRGHRCTSTTRMLPVKAAREYQEAFSWFPDRVYVCYAMKANFNPYLVEHIVDETRAADVVSLWEMKVA
VNAGAETVVVNGNAKSSDEIRAAVERSWVINVDSFEEFQRIEKIARHEGERALVALRVNPKVSPDTHSHIATAVEGSKFG
VELEIAERVCRRMIESEWVEFLGLHYHIGSQITDLRPFSEALRSVRTFLEDTGLIEEISYLNIGGGLGIRYRRGEEVPSP
HDLAEELQEDLKELHSESSGFDLYLEPGRSIVGEAGILVTSVRQVKRGRRRWVFVDTGMNALIRPALYDAYHEVVVHGGD
YSATEKASVAGPLCESGDVLAEDRELPIDISEGDLVVFLSAGAYCESMASNYNCYPIPGSVVVRNGEITGVRRVQDYEAF
SKTWW

Sequences:

>Translated_405_residues
MVESSTTSWRRPVRGHRCTSTTRMLPVKAAREYQEAFSWFPDRVYVCYAMKANFNPYLVEHIVDETRAADVVSLWEMKVA
VNAGAETVVVNGNAKSSDEIRAAVERSWVINVDSFEEFQRIEKIARHEGERALVALRVNPKVSPDTHSHIATAVEGSKFG
VELEIAERVCRRMIESEWVEFLGLHYHIGSQITDLRPFSEALRSVRTFLEDTGLIEEISYLNIGGGLGIRYRRGEEVPSP
HDLAEELQEDLKELHSESSGFDLYLEPGRSIVGEAGILVTSVRQVKRGRRRWVFVDTGMNALIRPALYDAYHEVVVHGGD
YSATEKASVAGPLCESGDVLAEDRELPIDISEGDLVVFLSAGAYCESMASNYNCYPIPGSVVVRNGEITGVRRVQDYEAF
SKTWW
>Mature_405_residues
MVESSTTSWRRPVRGHRCTSTTRMLPVKAAREYQEAFSWFPDRVYVCYAMKANFNPYLVEHIVDETRAADVVSLWEMKVA
VNAGAETVVVNGNAKSSDEIRAAVERSWVINVDSFEEFQRIEKIARHEGERALVALRVNPKVSPDTHSHIATAVEGSKFG
VELEIAERVCRRMIESEWVEFLGLHYHIGSQITDLRPFSEALRSVRTFLEDTGLIEEISYLNIGGGLGIRYRRGEEVPSP
HDLAEELQEDLKELHSESSGFDLYLEPGRSIVGEAGILVTSVRQVKRGRRRWVFVDTGMNALIRPALYDAYHEVVVHGGD
YSATEKASVAGPLCESGDVLAEDRELPIDISEGDLVVFLSAGAYCESMASNYNCYPIPGSVVVRNGEITGVRRVQDYEAF
SKTWW

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=385, Percent_Identity=31.6883116883117, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562780, Length=361, Percent_Identity=23.2686980609418, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322664, Length=376, Percent_Identity=22.3404255319149, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24586472, Length=354, Percent_Identity=24.0112994350282, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24586474, Length=351, Percent_Identity=23.3618233618234, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45468; Mature: 45468

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVESSTTSWRRPVRGHRCTSTTRMLPVKAAREYQEAFSWFPDRVYVCYAMKANFNPYLVE
CCCCCCCHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHH
HIVDETRAADVVSLWEMKVAVNAGAETVVVNGNAKSSDEIRAAVERSWVINVDSFEEFQR
HHHHHHHHHHHHHHHHEEEEEECCCCEEEEECCCCCHHHHHHHHHCCEEEECCCHHHHHH
IEKIARHEGERALVALRVNPKVSPDTHSHIATAVEGSKFGVELEIAERVCRRMIESEWVE
HHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHH
FLGLHYHIGSQITDLRPFSEALRSVRTFLEDTGLIEEISYLNIGGGLGIRYRRGEEVPSP
HHHHHEECCCCHHCCCHHHHHHHHHHHHHHHCCHHHHHHEEECCCCCCEEEECCCCCCCH
HDLAEELQEDLKELHSESSGFDLYLEPGRSIVGEAGILVTSVRQVKRGRRRWVFVDTGMN
HHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHCCCHHHHHHHHHHHCCCCEEEEEECCCH
ALIRPALYDAYHEVVVHGGDYSATEKASVAGPLCESGDVLAEDRELPIDISEGDLVVFLS
HHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCEECCCCCCEEECCCCEEEEEE
AGAYCESMASNYNCYPIPGSVVVRNGEITGVRRVQDYEAFSKTWW
CCHHHHHHHCCCCEEECCCCEEEECCCCCEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MVESSTTSWRRPVRGHRCTSTTRMLPVKAAREYQEAFSWFPDRVYVCYAMKANFNPYLVE
CCCCCCCHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHH
HIVDETRAADVVSLWEMKVAVNAGAETVVVNGNAKSSDEIRAAVERSWVINVDSFEEFQR
HHHHHHHHHHHHHHHHEEEEEECCCCEEEEECCCCCHHHHHHHHHCCEEEECCCHHHHHH
IEKIARHEGERALVALRVNPKVSPDTHSHIATAVEGSKFGVELEIAERVCRRMIESEWVE
HHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHH
FLGLHYHIGSQITDLRPFSEALRSVRTFLEDTGLIEEISYLNIGGGLGIRYRRGEEVPSP
HHHHHEECCCCHHCCCHHHHHHHHHHHHHHHCCHHHHHHEEECCCCCCEEEECCCCCCCH
HDLAEELQEDLKELHSESSGFDLYLEPGRSIVGEAGILVTSVRQVKRGRRRWVFVDTGMN
HHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHCCCHHHHHHHHHHHCCCCEEEEEECCCH
ALIRPALYDAYHEVVVHGGDYSATEKASVAGPLCESGDVLAEDRELPIDISEGDLVVFLS
HHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCEECCCCCCEEECCCCEEEEEE
AGAYCESMASNYNCYPIPGSVVVRNGEITGVRRVQDYEAFSKTWW
CCHHHHHHHCCCCEEECCCCEEEECCCCCEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]