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The map label for this gene is ComC [H]

Identifier: 20093830

GI number: 20093830

Start: 375270

End: 376295

Strand: Reverse

Name: ComC [H]

Synonym: MK0392

Alternate gene names: 20093830

Gene position: 376295-375270 (Counterclockwise)

Preceding gene: 20093831

Following gene: 20093828

Centisome position: 22.2

GC content: 61.4

Gene sequence:

>1026_bases
TTGAAAATACGGCCTGAGGATTTGACGGACTTCGTCAGTGAAGCTCTCCACGCCGTCGGCGTGCCGCGTAAAGACGCTCG
GACCGCCGCCGAAGTCATCGTGGAGGGAGACCTTCGCGGATTCCACTCCCACGGCGTCCTGAGGTTGCCTGGTTATATCG
AAGGGATCAAGAGGGGCGCAATCCGTCCCGAGATGAGGATAGAGGAAATCTCCAGGAAGTCCTCGGTCGTACTCTACGAC
GCCGATCATTCGCTGGGACACGTCGTCGGGTATCGGGCAACACTGGAGGCCGTCGAACTCGCCCGGAAGCACGGATTAGG
TATGGTGGCTGTTCGTAACGCGTCTCACTACGGGATCGCCGGGTACTACACGACGCTGGTCGCCGAACGGGGGTTCATCG
GATTCACGACCTGCGGGACGGAACCCGCGGTCGCCCCTTACGGTGGCTCCCAACCTGTGCTAGGAACCAATCCGGTATCC
ATCGCGTTCCCTCGTAGGGACGGTCCACCTATCGTCGTCGATATGGCCACGAGCGTGGTCGCGAGGGGGAAGATCCTTCA
GGCGTTGCGAGAGAACAGGGAGATACCTCAGGACTGGGCCGTAGGGCCCGACGGAGAGCCCACCACGGATCCCGAGGAGG
CCCTCGAAGGGGCACTACTACCGTTCGGGGGACACAAGGGGTACGCCCTGTGCTTGGCACTCGAGGTGCTGGCGGGTCCC
GTCGTCGGGGCTGCCGCCGGGAAGGATGTTCAGGGGACTACTGATCCCACGGTTCCGTGCAACAAGGGTGATGTGTTCGT
GGCGCTCGACCTGTCGACCTTGGTCGATGAGCATGAATACTACGAGCGGCTTGAAAGGTTGATATCGCAAGTTAAATCCG
CCGGAGATGATGTTCTCCTTCCGGGAGAGCCGGAGTTCCGACGCCGAGAACGCGCACTTCGGGAGGGTATCGAGCTCCCG
GAAGGATCGGTGCGTGCCGTTCGAGAAGTGGCGGAAGAGTTAGGGTTGGAGGACCCGACGCGTTAG

Upstream 100 bases:

>100_bases
GCTAGAGGTCGAGCCTGGAAACGCTGACGTTCCCTTAATAGATTTGGATCCGGAGGAGATCAAGGTGCGGTTCGTTCGAG
CGCTGCGGGAGGGATGATCG

Downstream 100 bases:

>100_bases
TCCCTACGTCGACGTGCCAGCCGATTCACGCCCCGAACGAACGCCTTCACGCTGGCCATCACGATATCCTCGGCGGCACC
GCGGGCCGTGGTGACGTTCC

Product: L-sulfolactate dehydrogenase

Products: NA

Alternate protein names: (R)-2-hydroxyacid dehydrogenase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKIRPEDLTDFVSEALHAVGVPRKDARTAAEVIVEGDLRGFHSHGVLRLPGYIEGIKRGAIRPEMRIEEISRKSSVVLYD
ADHSLGHVVGYRATLEAVELARKHGLGMVAVRNASHYGIAGYYTTLVAERGFIGFTTCGTEPAVAPYGGSQPVLGTNPVS
IAFPRRDGPPIVVDMATSVVARGKILQALRENREIPQDWAVGPDGEPTTDPEEALEGALLPFGGHKGYALCLALEVLAGP
VVGAAAGKDVQGTTDPTVPCNKGDVFVALDLSTLVDEHEYYERLERLISQVKSAGDDVLLPGEPEFRRRERALREGIELP
EGSVRAVREVAEELGLEDPTR

Sequences:

>Translated_341_residues
MKIRPEDLTDFVSEALHAVGVPRKDARTAAEVIVEGDLRGFHSHGVLRLPGYIEGIKRGAIRPEMRIEEISRKSSVVLYD
ADHSLGHVVGYRATLEAVELARKHGLGMVAVRNASHYGIAGYYTTLVAERGFIGFTTCGTEPAVAPYGGSQPVLGTNPVS
IAFPRRDGPPIVVDMATSVVARGKILQALRENREIPQDWAVGPDGEPTTDPEEALEGALLPFGGHKGYALCLALEVLAGP
VVGAAAGKDVQGTTDPTVPCNKGDVFVALDLSTLVDEHEYYERLERLISQVKSAGDDVLLPGEPEFRRRERALREGIELP
EGSVRAVREVAEELGLEDPTR
>Mature_341_residues
MKIRPEDLTDFVSEALHAVGVPRKDARTAAEVIVEGDLRGFHSHGVLRLPGYIEGIKRGAIRPEMRIEEISRKSSVVLYD
ADHSLGHVVGYRATLEAVELARKHGLGMVAVRNASHYGIAGYYTTLVAERGFIGFTTCGTEPAVAPYGGSQPVLGTNPVS
IAFPRRDGPPIVVDMATSVVARGKILQALRENREIPQDWAVGPDGEPTTDPEEALEGALLPFGGHKGYALCLALEVLAGP
VVGAAAGKDVQGTTDPTVPCNKGDVFVALDLSTLVDEHEYYERLERLISQVKSAGDDVLLPGEPEFRRRERALREGIELP
EGSVRAVREVAEELGLEDPTR

Specific function: Acts on oxaloacetate, sulfopyruvate but not on pyruvate. Has a higher selectivity for the coenzyme NADH than for NADPH [H]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=327, Percent_Identity=33.3333333333333, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1787020, Length=354, Percent_Identity=29.9435028248588, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI1790000, Length=295, Percent_Identity=29.1525423728814, Blast_Score=138, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17507179, Length=349, Percent_Identity=30.945558739255, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17536633, Length=353, Percent_Identity=30.5949008498584, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24667904, Length=342, Percent_Identity=30.1169590643275, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24667908, Length=342, Percent_Identity=30.1169590643275, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI45553211, Length=342, Percent_Identity=30.1169590643275, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24667912, Length=342, Percent_Identity=30.1169590643275, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24658010, Length=335, Percent_Identity=28.6567164179104, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24648360, Length=341, Percent_Identity=27.8592375366569, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.272; =1.1.1.37; =1.1.1.82 [H]

Molecular weight: Translated: 36769; Mature: 36769

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRPEDLTDFVSEALHAVGVPRKDARTAAEVIVEGDLRGFHSHGVLRLPGYIEGIKRGA
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCEECCHHHHHHHHCC
IRPEMRIEEISRKSSVVLYDADHSLGHVVGYRATLEAVELARKHGLGMVAVRNASHYGIA
CCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
GYYTTLVAERGFIGFTTCGTEPAVAPYGGSQPVLGTNPVSIAFPRRDGPPIVVDMATSVV
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEHHHHHH
ARGKILQALRENREIPQDWAVGPDGEPTTDPEEALEGALLPFGGHKGYALCLALEVLAGP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
VVGAAAGKDVQGTTDPTVPCNKGDVFVALDLSTLVDEHEYYERLERLISQVKSAGDDVLL
HHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
PGEPEFRRRERALREGIELPEGSVRAVREVAEELGLEDPTR
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKIRPEDLTDFVSEALHAVGVPRKDARTAAEVIVEGDLRGFHSHGVLRLPGYIEGIKRGA
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCEECCHHHHHHHHCC
IRPEMRIEEISRKSSVVLYDADHSLGHVVGYRATLEAVELARKHGLGMVAVRNASHYGIA
CCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
GYYTTLVAERGFIGFTTCGTEPAVAPYGGSQPVLGTNPVSIAFPRRDGPPIVVDMATSVV
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEHHHHHH
ARGKILQALRENREIPQDWAVGPDGEPTTDPEEALEGALLPFGGHKGYALCLALEVLAGP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
VVGAAAGKDVQGTTDPTVPCNKGDVFVALDLSTLVDEHEYYERLERLISQVKSAGDDVLL
HHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
PGEPEFRRRERALREGIELPEGSVRAVREVAEELGLEDPTR
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2110059; 10850983 [H]