Click here to switch to the map view.

The map label for this gene is hisG

Identifier: 20093803

GI number: 20093803

Start: 352763

End: 353614

Strand: Reverse

Name: hisG

Synonym: MK0365

Alternate gene names: 20093803

Gene position: 353614-352763 (Counterclockwise)

Preceding gene: 20093805

Following gene: 20093800

Centisome position: 20.86

GC content: 60.8

Gene sequence:

>852_bases
GTGATAACCGTAGCGGTACCCAACAAAGGACGCCTACACGAGCCGGCGCTCAAGCTCCTCGAGCGCGCGGGAATCGGCGT
AGAGGAGCCTCTGGGACGCCGTCTCAAGGCCAGAACCACGGACCCCGATATCGAGGTCATGTTCGTCAGGGCCGCGGATA
TCCCTCGGCTAGTGGAAGAGGGAGTGGCGCAACTCGGGATCACTGGATACGACCTTATCGTGGAGGCCGGGGCGGAGGTG
AAGGAGCTACTCGATCTACGGTTCGGTCGGGCGCGGCTGGTGCTCGCGGTACCCGAAGAGTCGGATGTGAAGTCCCCGGA
AGACCTCGACGGTGGTACCGTCGCCACGGAGTTCCCCAACATCGCCCGGCAGTACTTCGAGGACGTCGGTGTGGACGTGG
AGATCATCCAGGTGTCAGGAGCCACCGAGATCATGCCGAGGATAGGAGTCGCGGACGCGATCGTGGACCTGTGCAGCACG
GGGACTACGCTCAAGGTCAACAGGCTTCGTGTTGTTGACGAACTGCTGGAGACCTCCGCACGGTTGATCGCCAATCCCGA
CGCGACGGACGGTGAGGTGATCCGGCGAGTTTACCTGTCGTTGAAGGGTGTTCTCAACGCCGATGGAAAGTGCCTCGTCA
TGATGAACGTACCTCGAGAGCGGTTGGAGGAGTTCCACGAGCTGTTGCCGGGTGTGACAGGTCCCACGGTGTCGGAAATA
TACGGGGACGAGGACATGGTCGAGGTCTACGCGGTAGTGAACGAGGAGGACGTGTCGGAGGTCGTACTCAGGGCCAAAGA
GTTGGGTGCAGAAGGTATCATCGTCCTCCCCATCGAGAGGATGATACCCTAA

Upstream 100 bases:

>100_bases
CTCCGGAGTTACCGCGATGCCTCCTAGTATCGCGAGCCTCAAGTCCGAGGTCCCCGGGTACCGTTATATCCTGCGGCTGG
GACGTCGACGGAGGGCGCAA

Downstream 100 bases:

>100_bases
TCCTCCTCCATGAGATCAAGTAGTGCCACGGGATCGATGTCCCCGTGGTACAGGGCGGTCCCGATCACTACCCCGTACGC
TCCGGCCTCCTTGGCCCGCT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MITVAVPNKGRLHEPALKLLERAGIGVEEPLGRRLKARTTDPDIEVMFVRAADIPRLVEEGVAQLGITGYDLIVEAGAEV
KELLDLRFGRARLVLAVPEESDVKSPEDLDGGTVATEFPNIARQYFEDVGVDVEIIQVSGATEIMPRIGVADAIVDLCST
GTTLKVNRLRVVDELLETSARLIANPDATDGEVIRRVYLSLKGVLNADGKCLVMMNVPRERLEEFHELLPGVTGPTVSEI
YGDEDMVEVYAVVNEEDVSEVVLRAKELGAEGIIVLPIERMIP

Sequences:

>Translated_283_residues
MITVAVPNKGRLHEPALKLLERAGIGVEEPLGRRLKARTTDPDIEVMFVRAADIPRLVEEGVAQLGITGYDLIVEAGAEV
KELLDLRFGRARLVLAVPEESDVKSPEDLDGGTVATEFPNIARQYFEDVGVDVEIIQVSGATEIMPRIGVADAIVDLCST
GTTLKVNRLRVVDELLETSARLIANPDATDGEVIRRVYLSLKGVLNADGKCLVMMNVPRERLEEFHELLPGVTGPTVSEI
YGDEDMVEVYAVVNEEDVSEVVLRAKELGAEGIIVLPIERMIP
>Mature_283_residues
MITVAVPNKGRLHEPALKLLERAGIGVEEPLGRRLKARTTDPDIEVMFVRAADIPRLVEEGVAQLGITGYDLIVEAGAEV
KELLDLRFGRARLVLAVPEESDVKSPEDLDGGTVATEFPNIARQYFEDVGVDVEIIQVSGATEIMPRIGVADAIVDLCST
GTTLKVNRLRVVDELLETSARLIANPDATDGEVIRRVYLSLKGVLNADGKCLVMMNVPRERLEEFHELLPGVTGPTVSEI
YGDEDMVEVYAVVNEEDVSEVVLRAKELGAEGIIVLPIERMIP

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=293, Percent_Identity=35.1535836177474, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320896, Length=284, Percent_Identity=35.9154929577465, Blast_Score=145, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_METKA (Q8TYD5)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613650.1
- ProteinModelPortal:   Q8TYD5
- SMR:   Q8TYD5
- GeneID:   1477668
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0365
- NMPDR:   fig|190192.1.peg.363
- HOGENOM:   HBG391868
- OMA:   LLMFRAE
- ProtClustDB:   PRK00489
- BioCyc:   MKAN190192:MK0365-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 30875; Mature: 30875

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVAVPNKGRLHEPALKLLERAGIGVEEPLGRRLKARTTDPDIEVMFVRAADIPRLVEE
CEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCEEEEEEECCCCHHHHHH
GVAQLGITGYDLIVEAGAEVKELLDLRFGRARLVLAVPEESDVKSPEDLDGGTVATEFPN
HHHHHCCCHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEHHCHH
IARQYFEDVGVDVEIIQVSGATEIMPRIGVADAIVDLCSTGTTLKVNRLRVVDELLETSA
HHHHHHHHHCCCEEEEEECCCHHHHHHCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHH
RLIANPDATDGEVIRRVYLSLKGVLNADGKCLVMMNVPRERLEEFHELLPGVTGPTVSEI
HEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCHHHH
YGDEDMVEVYAVVNEEDVSEVVLRAKELGAEGIIVLPIERMIP
CCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure
MITVAVPNKGRLHEPALKLLERAGIGVEEPLGRRLKARTTDPDIEVMFVRAADIPRLVEE
CEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCEEEEEEECCCCHHHHHH
GVAQLGITGYDLIVEAGAEVKELLDLRFGRARLVLAVPEESDVKSPEDLDGGTVATEFPN
HHHHHCCCHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEHHCHH
IARQYFEDVGVDVEIIQVSGATEIMPRIGVADAIVDLCSTGTTLKVNRLRVVDELLETSA
HHHHHHHHHCCCEEEEEECCCHHHHHHCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHH
RLIANPDATDGEVIRRVYLSLKGVLNADGKCLVMMNVPRERLEEFHELLPGVTGPTVSEI
HEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCHHHH
YGDEDMVEVYAVVNEEDVSEVVLRAKELGAEGIIVLPIERMIP
CCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014