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The map label for this gene is Dcd_1

Identifier: 20093731

GI number: 20093731

Start: 280561

End: 281142

Strand: Reverse

Name: Dcd_1

Synonym: MK0291

Alternate gene names: 20093731

Gene position: 281142-280561 (Counterclockwise)

Preceding gene: 20093733

Following gene: 20093729

Centisome position: 16.59

GC content: 59.79

Gene sequence:

>582_bases
TTGACGGTACTTTCGGACCGAGATATCAAACGGGCATTGGAAGAGGGCGATATCGTCGTGAAGCCCCTCGAGGAGGAGTA
CCTCGAGGAGGCCCTCGGACCGGCCAGTCTGGATCTGCGCTTAGGCAACGAGTTCGTGGTGTTCAAAACACTCCATAAGC
CCTGCATAGATCCAACGGTCGACGCCGGTGAGAACACGGAGCGGATAGTGATCGACGAAGATGAGGAGTTCGTGATCAAC
CCGGGCGAGCTCGTGCTGGCCGTCACGCACGAGTGGATCGAGATCAACGCACCGGACATAACTGGGGTCCTTCACGGACG
CTCGTCGTTGGGCAGGCTCGGAATACAGGCCCACGTGGAGGCCGGATACGTGGATCCGGGATGGCGTGGGCGGCTGACGC
TAGAACTGGTTAACTTCAACCCCATGCCCGTCAAGCTGCGGCCCGGCATGCGGGTGGTGCAGATAGTGTTCCACAGACTC
TCCAGCCCCGCGGAGCGTACCTACGCGGAGTCCAGTGGTAAATACCACGGGGACGAGAGACCGTCACCCTCTAAGATGCA
CCTGGACTTCTGTCGCGGATAA

Upstream 100 bases:

>100_bases
CACGCTCGATCGCCGCCTCCAGTACGGACTTGTCCCGGGATTCGTCGAGATGGAGGTCCGAAACGTGTGCGATCCGCAGG
TCCAACCTGGGGGTCTCCCC

Downstream 100 bases:

>100_bases
CAGTCGATCTTCGGGCCGTTAATACCCGAGGGCGCGGGCGGTGGACCGGGGATACCGTTGGCCTTTAGACAGTACCTCCT
TCCCGACTTCCTCGACGTTA

Product: deoxycytidine deaminase

Products: NA

Alternate protein names: dCTP deaminase

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTVLSDRDIKRALEEGDIVVKPLEEEYLEEALGPASLDLRLGNEFVVFKTLHKPCIDPTVDAGENTERIVIDEDEEFVIN
PGELVLAVTHEWIEINAPDITGVLHGRSSLGRLGIQAHVEAGYVDPGWRGRLTLELVNFNPMPVKLRPGMRVVQIVFHRL
SSPAERTYAESSGKYHGDERPSPSKMHLDFCRG

Sequences:

>Translated_193_residues
MTVLSDRDIKRALEEGDIVVKPLEEEYLEEALGPASLDLRLGNEFVVFKTLHKPCIDPTVDAGENTERIVIDEDEEFVIN
PGELVLAVTHEWIEINAPDITGVLHGRSSLGRLGIQAHVEAGYVDPGWRGRLTLELVNFNPMPVKLRPGMRVVQIVFHRL
SSPAERTYAESSGKYHGDERPSPSKMHLDFCRG
>Mature_192_residues
TVLSDRDIKRALEEGDIVVKPLEEEYLEEALGPASLDLRLGNEFVVFKTLHKPCIDPTVDAGENTERIVIDEDEEFVINP
GELVLAVTHEWIEINAPDITGVLHGRSSLGRLGIQAHVEAGYVDPGWRGRLTLELVNFNPMPVKLRPGMRVVQIVFHRLS
SPAERTYAESSGKYHGDERPSPSKMHLDFCRG

Specific function: De novo synthesis of thymidylate. [C]

COG id: COG0717

COG function: function code F; Deoxycytidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dCTP deaminase family

Homologues:

Organism=Escherichia coli, GI1788379, Length=195, Percent_Identity=39.4871794871795, Blast_Score=119, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCD_METKA (Q8TYK5)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613578.1
- ProteinModelPortal:   Q8TYK5
- SMR:   Q8TYK5
- GeneID:   1477594
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0291
- NMPDR:   fig|190192.1.peg.291
- HOGENOM:   HBG553199
- OMA:   FSGHVTL
- BioCyc:   MKAN190192:MK0291-MONOMER
- BRENDA:   3.5.4.13
- HAMAP:   MF_00146
- InterPro:   IPR011962
- InterPro:   IPR008180
- TIGRFAMs:   TIGR02274

Pfam domain/function: PF00692 dUTPase

EC number: =3.5.4.13

Molecular weight: Translated: 21593; Mature: 21462

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLSDRDIKRALEEGDIVVKPLEEEYLEEALGPASLDLRLGNEFVVFKTLHKPCIDPTV
CCCCCCHHHHHHHHCCCEEEECCHHHHHHHHCCCCEEEEEECCEEEEEEECCCCCCCCCC
DAGENTERIVIDEDEEFVINPGELVLAVTHEWIEINAPDITGVLHGRSSLGRLGIQAHVE
CCCCCCCEEEEECCCCEEECCCCEEEEEEEEEEEEECCCEEEEEECCCCCCCCCEEEEEE
AGYVDPGWRGRLTLELVNFNPMPVKLRPGMRVVQIVFHRLSSPAERTYAESSGKYHGDER
CCCCCCCCCCEEEEEEECCCCCCEEECCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCC
PSPSKMHLDFCRG
CCCCCEEEEECCC
>Mature Secondary Structure 
TVLSDRDIKRALEEGDIVVKPLEEEYLEEALGPASLDLRLGNEFVVFKTLHKPCIDPTV
CCCCCHHHHHHHHCCCEEEECCHHHHHHHHCCCCEEEEEECCEEEEEEECCCCCCCCCC
DAGENTERIVIDEDEEFVINPGELVLAVTHEWIEINAPDITGVLHGRSSLGRLGIQAHVE
CCCCCCCEEEEECCCCEEECCCCEEEEEEEEEEEEECCCEEEEEECCCCCCCCCEEEEEE
AGYVDPGWRGRLTLELVNFNPMPVKLRPGMRVVQIVFHRLSSPAERTYAESSGKYHGDER
CCCCCCCCCCEEEEEEECCCCCCEEECCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCC
PSPSKMHLDFCRG
CCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014