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The map label for this gene is FrdB/GlpC [C]

Identifier: 20093572

GI number: 20093572

Start: 126133

End: 127611

Strand: Direct

Name: FrdB/GlpC [C]

Synonym: MK0132

Alternate gene names: 20093572

Gene position: 126133-127611 (Clockwise)

Preceding gene: 20093571

Following gene: 20093578

Centisome position: 7.44

GC content: 61.66

Gene sequence:

>1479_bases
GTGGTGAGGGACTTGAACGAAGCCGTCGTGATTCGCATCGAGACCCCCGAGCGATCGGAGCGCGTGAAAGTACCGTATCG
TGAGGGGATGACGCTACTCGACGCGCTACGATGGATCAAGGAGCACGAGATACCGGACCTCGAGTTCGAGTTCTCGTGCC
GGAACGCTCAATGTGGCACCTGCGCCGTGCTAGTGAACGGGAAAGCTCGACTCGCCTGCGAGTACCGGTTGGAACCCGGC
CAGGAAGTGACCGTGGGGCCGTTGAGACACCTGCCCGTGGTTAAGGACCTGGCGGTCGATTGGTCGGCGGTCACGTCGAG
GCTCCGGCCTCTTTCCCCTAAATCCCACCGAGAGTGGTTCCGTCGGATGGAACCCGAGAAGCAGCGGAAATTGTACGAGC
TCAGATCTTGCATCGAGTGCCTCTGCTGTGTCGCCGAGTGCCCCGTGATCAAGGCGGGATCGGCGCGGAACCCGGGTCCG
ATCGTGCTACGGAAGGTAGCGGAGGAGGCCGAAAAATGGGACGAGTCCCCCGAAATAGACGACTCCGTGTACGCCTGCAC
CACGTGCCATACCTGCGCCGAGGTGTGTCCTAAGGACATAGAGATCCCGGCGAAGGCCGTCGAGACGGTACGGGCGAGAC
TCTACGAGGAAGGTAAAGGCCCACTACCCGAGCACAAAGAGCTAGGAGAGAGGGCCGTACGCACGGGCAGGTCCGTCGAG
AAGAGGGACAGGTCGTTCTTAGAGGAGTACTCCGGCGAGTACGGGGAAGGAGACGTCAAGGCCATGTTTTTCACGGGATG
TCTCGTGGACTACCGACTACCCGATACCGGGAAGGCCCTAGTCAGGCTGGCCGAGGAGTTAGGGATCAGACTGATCGTCC
CTCGGGAGCAGGTCTGCTGCGGCTCACCGCTCCTGAGGACCGGGCAGCACGACCGCGCCGAGCGTCTAGCTTTCGAGAAC
CTGGAGACGTTCCGACGGGTCGACCCCGACGTTATCGTCACCGTCTGCGCCGGTTGTGGGGCCACGCTGAAGAACAATTA
CCCTGAGCTCCTCGGTGATAGGTTCGAGTGGGATGTACTCGACGTCACGGAGTTACTCGTAGAGATAAGGGCACACGAGC
GGGGGTTCCGGCTCCCGGAGCGTACAACGGTTACGTACCACGACCCGTGTCACCTGAAGCGGGGGCAAGGCGTCGAGGAC
GAGCCCAGGAAGCTCATCCGGTCGATCGAGAACGTCGAGTTCGTCGAGATGGAGGAACCGGACCGGTGTTGCGGGGCCGG
TGGGGGCGTTCGATCCGGTCTACCGGAGCTCGCGGAGCTGATGTCCGACGTGAAGGCTCACATGGTACGCGAGACCGGAG
CCGAAGTGCTGACCACGGTCTGCCCGTTCTGCGAATACAACCTCAGGGAAGGACTGGAGCGCAACGACGTCGAGGCACGA
GTGGAGAACTTAACGGTGCTACTCTCCAGGGGTCTTTAA

Upstream 100 bases:

>100_bases
ACCTCGGTTACCGTGGAGATCCACTCGACCTGGGTCGACGCGTTGCCGTCGAATTCGTCCGCGAGATCACGGATGTGGAG
TTGGACCTCACCAAGATCAG

Downstream 100 bases:

>100_bases
CCCCCAAGCCTTCGGGTACGTGCCCGGCTCCATCAGGACCCTCTTGGTGTCCACCATAATACCCCGATCCGCGTGTAGCA
TCTCCTTCCAAGTGGCCTTG

Product: succinate dehydrogenase/fumarate reductase iron-sulfur subunit

Products: fumarate; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MVRDLNEAVVIRIETPERSERVKVPYREGMTLLDALRWIKEHEIPDLEFEFSCRNAQCGTCAVLVNGKARLACEYRLEPG
QEVTVGPLRHLPVVKDLAVDWSAVTSRLRPLSPKSHREWFRRMEPEKQRKLYELRSCIECLCCVAECPVIKAGSARNPGP
IVLRKVAEEAEKWDESPEIDDSVYACTTCHTCAEVCPKDIEIPAKAVETVRARLYEEGKGPLPEHKELGERAVRTGRSVE
KRDRSFLEEYSGEYGEGDVKAMFFTGCLVDYRLPDTGKALVRLAEELGIRLIVPREQVCCGSPLLRTGQHDRAERLAFEN
LETFRRVDPDVIVTVCAGCGATLKNNYPELLGDRFEWDVLDVTELLVEIRAHERGFRLPERTTVTYHDPCHLKRGQGVED
EPRKLIRSIENVEFVEMEEPDRCCGAGGGVRSGLPELAELMSDVKAHMVRETGAEVLTTVCPFCEYNLREGLERNDVEAR
VENLTVLLSRGL

Sequences:

>Translated_492_residues
MVRDLNEAVVIRIETPERSERVKVPYREGMTLLDALRWIKEHEIPDLEFEFSCRNAQCGTCAVLVNGKARLACEYRLEPG
QEVTVGPLRHLPVVKDLAVDWSAVTSRLRPLSPKSHREWFRRMEPEKQRKLYELRSCIECLCCVAECPVIKAGSARNPGP
IVLRKVAEEAEKWDESPEIDDSVYACTTCHTCAEVCPKDIEIPAKAVETVRARLYEEGKGPLPEHKELGERAVRTGRSVE
KRDRSFLEEYSGEYGEGDVKAMFFTGCLVDYRLPDTGKALVRLAEELGIRLIVPREQVCCGSPLLRTGQHDRAERLAFEN
LETFRRVDPDVIVTVCAGCGATLKNNYPELLGDRFEWDVLDVTELLVEIRAHERGFRLPERTTVTYHDPCHLKRGQGVED
EPRKLIRSIENVEFVEMEEPDRCCGAGGGVRSGLPELAELMSDVKAHMVRETGAEVLTTVCPFCEYNLREGLERNDVEAR
VENLTVLLSRGL
>Mature_492_residues
MVRDLNEAVVIRIETPERSERVKVPYREGMTLLDALRWIKEHEIPDLEFEFSCRNAQCGTCAVLVNGKARLACEYRLEPG
QEVTVGPLRHLPVVKDLAVDWSAVTSRLRPLSPKSHREWFRRMEPEKQRKLYELRSCIECLCCVAECPVIKAGSARNPGP
IVLRKVAEEAEKWDESPEIDDSVYACTTCHTCAEVCPKDIEIPAKAVETVRARLYEEGKGPLPEHKELGERAVRTGRSVE
KRDRSFLEEYSGEYGEGDVKAMFFTGCLVDYRLPDTGKALVRLAEELGIRLIVPREQVCCGSPLLRTGQHDRAERLAFEN
LETFRRVDPDVIVTVCAGCGATLKNNYPELLGDRFEWDVLDVTELLVEIRAHERGFRLPERTTVTYHDPCHLKRGQGVED
EPRKLIRSIENVEFVEMEEPDRCCGAGGGVRSGLPELAELMSDVKAHMVRETGAEVLTTVCPFCEYNLREGLERNDVEAR
VENLTVLLSRGL

Specific function: Electron Transfer Protein; May Also Function As The Membrane Anchor For The Glpab Dimer. [C]

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Loosely Bound To The Cytoplasm Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=215, Percent_Identity=29.7674418604651, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788576, Length=406, Percent_Identity=24.384236453202, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790596, Length=210, Percent_Identity=30, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786497, Length=239, Percent_Identity=29.2887029288703, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786943, Length=207, Percent_Identity=29.951690821256, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI48994913, Length=377, Percent_Identity=23.8726790450928, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17533915, Length=222, Percent_Identity=30.6306306306306, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322987, Length=206, Percent_Identity=29.126213592233, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137106, Length=224, Percent_Identity=30.3571428571429, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24643156, Length=220, Percent_Identity=31.8181818181818, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR004017
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: PF02754 CCG; PF00111 Fer2 [H]

EC number: 1.3.99.1

Molecular weight: Translated: 55721; Mature: 55721

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRDLNEAVVIRIETPERSERVKVPYREGMTLLDALRWIKEHEIPDLEFEFSCRNAQCGT
CCCCCCCEEEEEEECCCCCCCCCCCHHHCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCE
CAVLVNGKARLACEYRLEPGQEVTVGPLRHLPVVKDLAVDWSAVTSRLRPLSPKSHREWF
EEEEECCCEEEEEEEECCCCCEEECCCHHHCCHHHHHHCCHHHHHHHHCCCCCHHHHHHH
RRMEPEKQRKLYELRSCIECLCCVAECPVIKAGSARNPGPIVLRKVAEEAEKWDESPEID
HHCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCC
DSVYACTTCHTCAEVCPKDIEIPAKAVETVRARLYEEGKGPLPEHKELGERAVRTGRSVE
CCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHH
KRDRSFLEEYSGEYGEGDVKAMFFTGCLVDYRLPDTGKALVRLAEELGIRLIVPREQVCC
HHHHHHHHHHCCCCCCCCEEEEEEEHEEEEECCCCCHHHHHHHHHHCCCEEEECCHHHHC
GSPLLRTGQHDRAERLAFENLETFRRVDPDVIVTVCAGCGATLKNNYPELLGDRFEWDVL
CCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHCCCHHHCCCCCCCHHH
DVTELLVEIRAHERGFRLPERTTVTYHDPCHLKRGQGVEDEPRKLIRSIENVEFVEMEEP
HHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCC
DRCCGAGGGVRSGLPELAELMSDVKAHMVRETGAEVLTTVCPFCEYNLREGLERNDVEAR
HHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VENLTVLLSRGL
HHHHHHHHHCCC
>Mature Secondary Structure
MVRDLNEAVVIRIETPERSERVKVPYREGMTLLDALRWIKEHEIPDLEFEFSCRNAQCGT
CCCCCCCEEEEEEECCCCCCCCCCCHHHCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCE
CAVLVNGKARLACEYRLEPGQEVTVGPLRHLPVVKDLAVDWSAVTSRLRPLSPKSHREWF
EEEEECCCEEEEEEEECCCCCEEECCCHHHCCHHHHHHCCHHHHHHHHCCCCCHHHHHHH
RRMEPEKQRKLYELRSCIECLCCVAECPVIKAGSARNPGPIVLRKVAEEAEKWDESPEID
HHCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCC
DSVYACTTCHTCAEVCPKDIEIPAKAVETVRARLYEEGKGPLPEHKELGERAVRTGRSVE
CCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHH
KRDRSFLEEYSGEYGEGDVKAMFFTGCLVDYRLPDTGKALVRLAEELGIRLIVPREQVCC
HHHHHHHHHHCCCCCCCCEEEEEEEHEEEEECCCCCHHHHHHHHHHCCCEEEECCHHHHC
GSPLLRTGQHDRAERLAFENLETFRRVDPDVIVTVCAGCGATLKNNYPELLGDRFEWDVL
CCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHCCCHHHCCCCCCCHHH
DVTELLVEIRAHERGFRLPERTTVTYHDPCHLKRGQGVEDEPRKLIRSIENVEFVEMEEP
HHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCC
DRCCGAGGGVRSGLPELAELMSDVKAHMVRETGAEVLTTVCPFCEYNLREGLERNDVEAR
HHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VENLTVLLSRGL
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: succinate; acceptor

Specific reaction: succinate + acceptor = fumarate + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA