Click here to switch to the map view.

The map label for this gene is GlmS [H]

Identifier: 20093567

GI number: 20093567

Start: 120262

End: 122115

Strand: Reverse

Name: GlmS [H]

Synonym: MK0127

Alternate gene names: 20093567

Gene position: 122115-120262 (Counterclockwise)

Preceding gene: 20093568

Following gene: 20093562

Centisome position: 7.2

GC content: 60.68

Gene sequence:

>1854_bases
GTGAACGGTTTGTGCGGGATCGTGGGATACACAGGGGAGCGTGACGCGGCCCCCATTATAGTCGACTCGTTGGTTAGGCT
CGAGTACCGCGGCTACGACTCCGCCGGAGTCGCCACGATCCACGAGGGTCGATTGTACCTCGAGAAGGATGCCGGGAAGC
TTACCGAAGGCGGCGAGCCGACGAAGCTGCAGCGTAGCCTCAGAAAGCTTCCCGGTAAGATTGGAATCGGACACACCCGA
TGGGCGACTCATGGAGACCCTAACCGCCGTAACGCGCATCCGCACACGGACTGCCGTGACGAGATCGCGGTCGTACACAA
CGGAATCATCGAGAACTTCATGCAACTTAGGGAGGAGCTGGAGGATAAGGGACACCGGTTCGACTCCGAGACGGACACCG
AGGTCGTACCTCATCTCATCGAGCAGGGGATGAAGGAAGGGAAGTCGTTCTTCGAGGCGTTCGTCGAAGCCGTGCGCCGG
CTGGAGGGGTCGTACGCCATCGCCGCCATTTGTACCCGCGAGCCCGACGTAATCCTGGCCGCTAGAAAGGAGAGCCCGTT
GGTAGTAGGGTTGGGAGACGACGGTAACTTCTTGGCGTCCGATATACCGGCGATACTACCCGAGACGAACCGCGTGATCC
CTATCGACGACGGCGAGATCGTCGTGGTGAAGCGTGATGAGGTCAGAATACTGGACGCGGAGACCCTTGAGGATGTCACG
GAAGAGAAGGAAGTGCAGATAGTTGAAGAGGATCCGCACACGCTGGAACGCCGCGGTTATCCACACTTCATGCTCAAGGA
GATCCACGAGCAACCCGAAGCCGTCAGGAACACGCTACGGATCGAACGGGAGAACCTCATGGAGATGGCGGAAGAGCTCG
TCGGCGGCGATTACACCAAGTTGTACATCGTCGCGTGCGGTACCTCGTATCACGCTGGACTCGGCGCGAAGTATGCCACC
GAGTTGCTCGCGAAGTTCCCCGTGGACGTGGTGATAGCCTCCGAGTTCCGGTACGTGACAAAGGAACTCGTCGACGAGAA
TACCCTCGTTCTAGCCATCTCCCAGTCGGGTGAGACCGCCGATACGCTGGCGGCTGTACGAGAAGCGAACGCTCGGGGAG
CTACGACGATCGCGCTGACCAACGTCGTCGGGAGCACGATCACCCGCGAGGTCGATCACGTCATGTACACCCACGCCGGC
TTCGAGAAAGCCGTCGCCGCCACGAAGACCTACACGGCGCAGCTCGCGGCGATGTACACACTGGCCGTGGAGCTAGCCCG
CCACTTCGGGGAGATCACGAACAAGGAGGCGGAGGAGTACCACGCGGAGCTGAACAAGGTTCCGGAGATGTTGGAGGAGG
TACTCAGCTGGGAGCGGGAGCGTGAGATAGCGGTGATGGGTGGTCGATACAAGGAACGTCCCAACTGGTTCTTCATCGGC
CGTGGTCCGGGATACCCGACCGCCATGGAGGGCGCACTGAAGCTCAAGGAGATCACCTACCAGCACGCGGAGGCGTACCC
GGCGGGTGAGCTCAAGCACGGTCCGCTGGCGTTGATCGAGGAAGGCGTGCCGGTGGTCGCCGTAGCTCAGCCAGGCGGCG
TCTACGAGAAGATGCTCGCGAACATCGAGGAGGTGAAAGCTCGGGGTGCCACTGTGATCACCGTGGCCGATGAGAAGGAC
GAGGCCGTGGAGGAGCACTCCGATCACGTCATCCGAGTGCCGAGTATCAGCGAGGTGTTCTCCCCGATCGTTTACACGGT
ACCGCTTCAGTTGCTGGCGTACTACATGAGCGTGGCCAGAGGCATCGATCCGGACTATCCACGGAACCTGGCCAAGAGCG
TAACCGTGGAGTGA

Upstream 100 bases:

>100_bases
ACTACGCACACTCCCCTTCGGAGCACGTCCCGATCGAGGAGCTCGTGGATGCCGTTCGCGTGCTTTATGACGTTGTGGAA
TACCTCTCGTCGTAAAGGGT

Downstream 100 bases:

>100_bases
GTTCAGTCCTCCTCCTCTTCGATACCTATCACCTTGAAGATCCGCTTACGTACCGCCTGCTCGACGAGGTCGAGCACCAT
GTCGCTCTCGACGTCCTGGA

Product: glucosamine 6-phosphate synthetase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MNGLCGIVGYTGERDAAPIIVDSLVRLEYRGYDSAGVATIHEGRLYLEKDAGKLTEGGEPTKLQRSLRKLPGKIGIGHTR
WATHGDPNRRNAHPHTDCRDEIAVVHNGIIENFMQLREELEDKGHRFDSETDTEVVPHLIEQGMKEGKSFFEAFVEAVRR
LEGSYAIAAICTREPDVILAARKESPLVVGLGDDGNFLASDIPAILPETNRVIPIDDGEIVVVKRDEVRILDAETLEDVT
EEKEVQIVEEDPHTLERRGYPHFMLKEIHEQPEAVRNTLRIERENLMEMAEELVGGDYTKLYIVACGTSYHAGLGAKYAT
ELLAKFPVDVVIASEFRYVTKELVDENTLVLAISQSGETADTLAAVREANARGATTIALTNVVGSTITREVDHVMYTHAG
FEKAVAATKTYTAQLAAMYTLAVELARHFGEITNKEAEEYHAELNKVPEMLEEVLSWEREREIAVMGGRYKERPNWFFIG
RGPGYPTAMEGALKLKEITYQHAEAYPAGELKHGPLALIEEGVPVVAVAQPGGVYEKMLANIEEVKARGATVITVADEKD
EAVEEHSDHVIRVPSISEVFSPIVYTVPLQLLAYYMSVARGIDPDYPRNLAKSVTVE

Sequences:

>Translated_617_residues
MNGLCGIVGYTGERDAAPIIVDSLVRLEYRGYDSAGVATIHEGRLYLEKDAGKLTEGGEPTKLQRSLRKLPGKIGIGHTR
WATHGDPNRRNAHPHTDCRDEIAVVHNGIIENFMQLREELEDKGHRFDSETDTEVVPHLIEQGMKEGKSFFEAFVEAVRR
LEGSYAIAAICTREPDVILAARKESPLVVGLGDDGNFLASDIPAILPETNRVIPIDDGEIVVVKRDEVRILDAETLEDVT
EEKEVQIVEEDPHTLERRGYPHFMLKEIHEQPEAVRNTLRIERENLMEMAEELVGGDYTKLYIVACGTSYHAGLGAKYAT
ELLAKFPVDVVIASEFRYVTKELVDENTLVLAISQSGETADTLAAVREANARGATTIALTNVVGSTITREVDHVMYTHAG
FEKAVAATKTYTAQLAAMYTLAVELARHFGEITNKEAEEYHAELNKVPEMLEEVLSWEREREIAVMGGRYKERPNWFFIG
RGPGYPTAMEGALKLKEITYQHAEAYPAGELKHGPLALIEEGVPVVAVAQPGGVYEKMLANIEEVKARGATVITVADEKD
EAVEEHSDHVIRVPSISEVFSPIVYTVPLQLLAYYMSVARGIDPDYPRNLAKSVTVE
>Mature_617_residues
MNGLCGIVGYTGERDAAPIIVDSLVRLEYRGYDSAGVATIHEGRLYLEKDAGKLTEGGEPTKLQRSLRKLPGKIGIGHTR
WATHGDPNRRNAHPHTDCRDEIAVVHNGIIENFMQLREELEDKGHRFDSETDTEVVPHLIEQGMKEGKSFFEAFVEAVRR
LEGSYAIAAICTREPDVILAARKESPLVVGLGDDGNFLASDIPAILPETNRVIPIDDGEIVVVKRDEVRILDAETLEDVT
EEKEVQIVEEDPHTLERRGYPHFMLKEIHEQPEAVRNTLRIERENLMEMAEELVGGDYTKLYIVACGTSYHAGLGAKYAT
ELLAKFPVDVVIASEFRYVTKELVDENTLVLAISQSGETADTLAAVREANARGATTIALTNVVGSTITREVDHVMYTHAG
FEKAVAATKTYTAQLAAMYTLAVELARHFGEITNKEAEEYHAELNKVPEMLEEVLSWEREREIAVMGGRYKERPNWFFIG
RGPGYPTAMEGALKLKEITYQHAEAYPAGELKHGPLALIEEGVPVVAVAQPGGVYEKMLANIEEVKARGATVITVADEKD
EAVEEHSDHVIRVPSISEVFSPIVYTVPLQLLAYYMSVARGIDPDYPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=695, Percent_Identity=35.6834532374101, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI205277386, Length=693, Percent_Identity=34.3434343434343, Blast_Score=367, Evalue=1e-101,
Organism=Escherichia coli, GI1790167, Length=626, Percent_Identity=45.0479233226837, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI87082251, Length=320, Percent_Identity=25.3125, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788651, Length=207, Percent_Identity=29.951690821256, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539970, Length=720, Percent_Identity=34.1666666666667, Blast_Score=349, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17532897, Length=436, Percent_Identity=37.6146788990826, Blast_Score=258, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI17532899, Length=436, Percent_Identity=37.6146788990826, Blast_Score=257, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6322745, Length=448, Percent_Identity=34.375, Blast_Score=253, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=27.3781902552204, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=38.6473429951691, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323958, Length=206, Percent_Identity=26.2135922330097, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357745, Length=695, Percent_Identity=33.5251798561151, Blast_Score=355, Evalue=6e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 68397; Mature: 68397

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLCGIVGYTGERDAAPIIVDSLVRLEYRGYDSAGVATIHEGRLYLEKDAGKLTEGGEP
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCEEEEECCCCCCCCCCCC
TKLQRSLRKLPGKIGIGHTRWATHGDPNRRNAHPHTDCRDEIAVVHNGIIENFMQLREEL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EDKGHRFDSETDTEVVPHLIEQGMKEGKSFFEAFVEAVRRLEGSYAIAAICTREPDVILA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEE
ARKESPLVVGLGDDGNFLASDIPAILPETNRVIPIDDGEIVVVKRDEVRILDAETLEDVT
ECCCCCEEEEECCCCCCHHHCCCHHCCCCCCEEEECCCCEEEEECCCEEEECHHHHHHHC
EEKEVQIVEEDPHTLERRGYPHFMLKEIHEQPEAVRNTLRIERENLMEMAEELVGGDYTK
CCCCEEEECCCCCHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LYIVACGTSYHAGLGAKYATELLAKFPVDVVIASEFRYVTKELVDENTLVLAISQSGETA
EEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCEEEEEEECCCCHH
DTLAAVREANARGATTIALTNVVGSTITREVDHVMYTHAGFEKAVAATKTYTAQLAAMYT
HHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LAVELARHFGEITNKEAEEYHAELNKVPEMLEEVLSWEREREIAVMGGRYKERPNWFFIG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEE
RGPGYPTAMEGALKLKEITYQHAEAYPAGELKHGPLALIEEGVPVVAVAQPGGVYEKMLA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEECCCCHHHHHHH
NIEEVKARGATVITVADEKDEAVEEHSDHVIRVPSISEVFSPIVYTVPLQLLAYYMSVAR
HHHHHHHCCCEEEEEECCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIDPDYPRNLAKSVTVE
CCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MNGLCGIVGYTGERDAAPIIVDSLVRLEYRGYDSAGVATIHEGRLYLEKDAGKLTEGGEP
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCEEEEECCCCCCCCCCCC
TKLQRSLRKLPGKIGIGHTRWATHGDPNRRNAHPHTDCRDEIAVVHNGIIENFMQLREEL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EDKGHRFDSETDTEVVPHLIEQGMKEGKSFFEAFVEAVRRLEGSYAIAAICTREPDVILA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEE
ARKESPLVVGLGDDGNFLASDIPAILPETNRVIPIDDGEIVVVKRDEVRILDAETLEDVT
ECCCCCEEEEECCCCCCHHHCCCHHCCCCCCEEEECCCCEEEEECCCEEEECHHHHHHHC
EEKEVQIVEEDPHTLERRGYPHFMLKEIHEQPEAVRNTLRIERENLMEMAEELVGGDYTK
CCCCEEEECCCCCHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LYIVACGTSYHAGLGAKYATELLAKFPVDVVIASEFRYVTKELVDENTLVLAISQSGETA
EEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCEEEEEEECCCCHH
DTLAAVREANARGATTIALTNVVGSTITREVDHVMYTHAGFEKAVAATKTYTAQLAAMYT
HHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LAVELARHFGEITNKEAEEYHAELNKVPEMLEEVLSWEREREIAVMGGRYKERPNWFFIG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEE
RGPGYPTAMEGALKLKEITYQHAEAYPAGELKHGPLALIEEGVPVVAVAQPGGVYEKMLA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEECCCCHHHHHHH
NIEEVKARGATVITVADEKDEAVEEHSDHVIRVPSISEVFSPIVYTVPLQLLAYYMSVAR
HHHHHHHCCCEEEEEECCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIDPDYPRNLAKSVTVE
CCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]