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The map label for this gene is trpS [H]

Identifier: 19747039

GI number: 19747039

Start: 1883526

End: 1884548

Strand: Reverse

Name: trpS [H]

Synonym: spyM18_2245

Alternate gene names: 19747039

Gene position: 1884548-1883526 (Counterclockwise)

Preceding gene: 19747043

Following gene: 19747038

Centisome position: 99.45

GC content: 36.27

Gene sequence:

>1023_bases
ATGACAAAACCTATTATTTTAACTGGAGATAGACCAACTGGAAAATTACATTTAGGTCATTATGTCGGAAGTCTTAAAAA
TCGTGTCTTTTTACAAAATGAAAACAAGTATAAGATGTTTGTTTTCTTGGCCGATCAACAGGCACTGACGGATCATGCTA
AAGAATCCGAATTAATTCAAGAATCTATTGGAAATGTTGCCTTGGATTACCTCTCTGTCGGTTTGGATCCGAAGCAATCA
ACGATTTTTATTCAAAGTCAGATTCCAGAGCTAGCTGAATTGAGCATGTATTATATGAATCTGGTATCATTAGCACGTTT
GGAAAGAAATCCCACTGTTAAAACCGAAATTGCTCAGAAAGGTTTTGGCGAAAGTATTCCATCTGGTTTTTTGGTTTATC
CAGTATCACAGGCCGCTGATATTACAGCATTTAAAGCGAATTTAGTACCTGTAGGTAACGACCAGAAACCGATGATTGAA
CAAACACGTGAAATTGTGAGAAGTTTTAATCATACTTACCATACAGACTGTTTAGTAGAACCTGAAGGTATTTATCCAGA
AAATGAAAAAGCTGGACGCTTACCTGGTCTTGATGGCAATGCCAAAATGTCTAAATCATTGGGAAATGGAATCTATCTTT
CAGATGATGCAGATACCGTTCGCAAAAAAGTGATGAGCATGTATACTGATCCAAATCATATTAAAATAGAAGATCCTGGT
CAAATTGAAGGGAATATGGTCTTTCATTATTTGGATATTTTTGCTAGAAAAGAAGATCAAGCTGATATCGAAGCAATGAA
AGAGCATTATCAAAGAGGTGGTTTAGGAGATGTGAAAACGAAACGCTACCTTCTAGATATTTTAGAACGTGAATTAGCAC
CTATTCGTGAAAGACGTTTGGAGTACGCTAAAGATATGGGAGAGGTGTTCCGTATGTTACAAGAAGGTAGTCAAAAAGCA
AGAACTGTGGCAGCCAAGACTTTATCAGAAGTGAAGTCAGCAATGGGTATTAATTATTTTTAA

Upstream 100 bases:

>100_bases
GCTAATTGAGGTGGTACCGCGTATTACTTGTAATAACGCCCTCACGTTTTAATAGCGTGGGGACTTTTTGCTATATCAAG
AGATAGTTAGGGAGAAAATG

Downstream 100 bases:

>100_bases
TGTTTTAGAGAAAAAGCTAAGTTAGTAATGATAAGATAATTACTATTGTCAAAGCAGGACCTATTTTGTCATTTCTTTAC
AGGATAGTAGAGATTATGTT

Product: tryptophanyl-tRNA synthetase II

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTKPIILTGDRPTGKLHLGHYVGSLKNRVFLQNENKYKMFVFLADQQALTDHAKESELIQESIGNVALDYLSVGLDPKQS
TIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQKGFGESIPSGFLVYPVSQAADITAFKANLVPVGNDQKPMIE
QTREIVRSFNHTYHTDCLVEPEGIYPENEKAGRLPGLDGNAKMSKSLGNGIYLSDDADTVRKKVMSMYTDPNHIKIEDPG
QIEGNMVFHYLDIFARKEDQADIEAMKEHYQRGGLGDVKTKRYLLDILERELAPIRERRLEYAKDMGEVFRMLQEGSQKA
RTVAAKTLSEVKSAMGINYF

Sequences:

>Translated_340_residues
MTKPIILTGDRPTGKLHLGHYVGSLKNRVFLQNENKYKMFVFLADQQALTDHAKESELIQESIGNVALDYLSVGLDPKQS
TIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQKGFGESIPSGFLVYPVSQAADITAFKANLVPVGNDQKPMIE
QTREIVRSFNHTYHTDCLVEPEGIYPENEKAGRLPGLDGNAKMSKSLGNGIYLSDDADTVRKKVMSMYTDPNHIKIEDPG
QIEGNMVFHYLDIFARKEDQADIEAMKEHYQRGGLGDVKTKRYLLDILERELAPIRERRLEYAKDMGEVFRMLQEGSQKA
RTVAAKTLSEVKSAMGINYF
>Mature_339_residues
TKPIILTGDRPTGKLHLGHYVGSLKNRVFLQNENKYKMFVFLADQQALTDHAKESELIQESIGNVALDYLSVGLDPKQST
IFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQKGFGESIPSGFLVYPVSQAADITAFKANLVPVGNDQKPMIEQ
TREIVRSFNHTYHTDCLVEPEGIYPENEKAGRLPGLDGNAKMSKSLGNGIYLSDDADTVRKKVMSMYTDPNHIKIEDPGQ
IEGNMVFHYLDIFARKEDQADIEAMKEHYQRGGLGDVKTKRYLLDILERELAPIRERRLEYAKDMGEVFRMLQEGSQKAR
TVAAKTLSEVKSAMGINYF

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=339, Percent_Identity=29.2035398230088, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI41352700, Length=172, Percent_Identity=32.5581395348837, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1789786, Length=340, Percent_Identity=31.7647058823529, Blast_Score=150, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71982800, Length=348, Percent_Identity=28.735632183908, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71982793, Length=348, Percent_Identity=28.735632183908, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320474, Length=351, Percent_Identity=27.9202279202279, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24666151, Length=336, Percent_Identity=31.8452380952381, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 38373; Mature: 38242

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPIILTGDRPTGKLHLGHYVGSLKNRVFLQNENKYKMFVFLADQQALTDHAKESELIQ
CCCCEEEECCCCCCEEEHHHHHHHHHCEEEEECCCCEEEEEEEECCHHHHHHHHHHHHHH
ESIGNVALDYLSVGLDPKQSTIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQK
HHHHHHHHHHHHCCCCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GFGESIPSGFLVYPVSQAADITAFKANLVPVGNDQKPMIEQTREIVRSFNHTYHTDCLVE
CCCCCCCCCEEEEECCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEC
PEGIYPENEKAGRLPGLDGNAKMSKSLGNGIYLSDDADTVRKKVMSMYTDPNHIKIEDPG
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCEEEECCCC
QIEGNMVFHYLDIFARKEDQADIEAMKEHYQRGGLGDVKTKRYLLDILERELAPIRERRL
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EYAKDMGEVFRMLQEGSQKARTVAAKTLSEVKSAMGINYF
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKPIILTGDRPTGKLHLGHYVGSLKNRVFLQNENKYKMFVFLADQQALTDHAKESELIQ
CCCEEEECCCCCCEEEHHHHHHHHHCEEEEECCCCEEEEEEEECCHHHHHHHHHHHHHH
ESIGNVALDYLSVGLDPKQSTIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQK
HHHHHHHHHHHHCCCCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GFGESIPSGFLVYPVSQAADITAFKANLVPVGNDQKPMIEQTREIVRSFNHTYHTDCLVE
CCCCCCCCCEEEEECCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEC
PEGIYPENEKAGRLPGLDGNAKMSKSLGNGIYLSDDADTVRKKVMSMYTDPNHIKIEDPG
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCEEEECCCC
QIEGNMVFHYLDIFARKEDQADIEAMKEHYQRGGLGDVKTKRYLLDILERELAPIRERRL
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EYAKDMGEVFRMLQEGSQKARTVAAKTLSEVKSAMGINYF
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]