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The map label for this gene is pgsA [H]

Identifier: 19747028

GI number: 19747028

Start: 1870634

End: 1871176

Strand: Reverse

Name: pgsA [H]

Synonym: spyM18_2231

Alternate gene names: 19747028

Gene position: 1871176-1870634 (Counterclockwise)

Preceding gene: 19747029

Following gene: 19747027

Centisome position: 98.74

GC content: 36.28

Gene sequence:

>543_bases
ATGATAAAAAAAGAAAATATTCCTAATCTATTAACTCTTGTTCGAATCGCAATGATTCCTTTCTTTCTTTTTATTACTTC
CTCATCTAATAAGGTGGGGTGGCATATTTTTGCAGCTGTGATTTTTGCAATTGCCAGTTTTACCGATTATCTAGATGGGT
ATCTTGCGCGTAAGTGGCATGTAGTCAGTAATTTTGGAAAGTTTGCCGATCCTCTAGCAGATAAGATGCTTGTCATGAGT
GCCTTTATCATGTTAGTTGGACTTGGCTTAGTTCCTGCGTGGGTATCAGCTGTTATTATTTGCCGAGAATTGGCAGTAAC
TGGTCTTCGATTACTACTTGTTGAAACCGGAGGAAAGGTCCTTGCAGCTGCTATGCTGGGAAAAATCAAAACAGCGACAC
AAATGTTGTCTATTATTTTATTACTTTGCCATTGGATATTCCTAGGAAACGTCTTACTCTGTATTGCTCTTTTTTTCACT
ATTTATTCTGGATATGATTATTTTAAAGGAGCAAGCTTTCTTTTTAAGGATACGTTTAAATAA

Upstream 100 bases:

>100_bases
GTATCTGTAACAATTGATGGACAACCTGTTGATCTATCACCTTTAACAAGTACTGACTTAAGTTATATCACGTTTAAGAT
CCAATAATTAAGGTAGACTA

Downstream 100 bases:

>100_bases
CATGTCAGCTATTATTGAACTTAAAAAAGTTACATTTAATTACCATAAAGACCAAGAAAAACCAACATTAGATGGCGTAT
CGTTTCATGTGAAACAAGGT

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MIKKENIPNLLTLVRIAMIPFFLFITSSSNKVGWHIFAAVIFAIASFTDYLDGYLARKWHVVSNFGKFADPLADKMLVMS
AFIMLVGLGLVPAWVSAVIICRELAVTGLRLLLVETGGKVLAAAMLGKIKTATQMLSIILLLCHWIFLGNVLLCIALFFT
IYSGYDYFKGASFLFKDTFK

Sequences:

>Translated_180_residues
MIKKENIPNLLTLVRIAMIPFFLFITSSSNKVGWHIFAAVIFAIASFTDYLDGYLARKWHVVSNFGKFADPLADKMLVMS
AFIMLVGLGLVPAWVSAVIICRELAVTGLRLLLVETGGKVLAAAMLGKIKTATQMLSIILLLCHWIFLGNVLLCIALFFT
IYSGYDYFKGASFLFKDTFK
>Mature_180_residues
MIKKENIPNLLTLVRIAMIPFFLFITSSSNKVGWHIFAAVIFAIASFTDYLDGYLARKWHVVSNFGKFADPLADKMLVMS
AFIMLVGLGLVPAWVSAVIICRELAVTGLRLLLVETGGKVLAAAMLGKIKTATQMLSIILLLCHWIFLGNVLLCIALFFT
IYSGYDYFKGASFLFKDTFK

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=196, Percent_Identity=29.5918367346939, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI10092647, Length=188, Percent_Identity=29.2553191489362, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1788220, Length=175, Percent_Identity=38.8571428571429, Blast_Score=105, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71984838, Length=195, Percent_Identity=29.7435897435897, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71984834, Length=197, Percent_Identity=29.4416243654822, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320059, Length=110, Percent_Identity=39.0909090909091, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650130, Length=110, Percent_Identity=34.5454545454545, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24650126, Length=110, Percent_Identity=34.5454545454545, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24650128, Length=110, Percent_Identity=34.5454545454545, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 20012; Mature: 20012

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKENIPNLLTLVRIAMIPFFLFITSSSNKVGWHIFAAVIFAIASFTDYLDGYLARKWH
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSNFGKFADPLADKMLVMSAFIMLVGLGLVPAWVSAVIICRELAVTGLRLLLVETGGKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LAAAMLGKIKTATQMLSIILLLCHWIFLGNVLLCIALFFTIYSGYDYFKGASFLFKDTFK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCC
>Mature Secondary Structure
MIKKENIPNLLTLVRIAMIPFFLFITSSSNKVGWHIFAAVIFAIASFTDYLDGYLARKWH
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSNFGKFADPLADKMLVMSAFIMLVGLGLVPAWVSAVIICRELAVTGLRLLLVETGGKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LAAAMLGKIKTATQMLSIILLLCHWIFLGNVLLCIALFFTIYSGYDYFKGASFLFKDTFK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377 [H]