Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 19746946

GI number: 19746946

Start: 1778092

End: 1779723

Strand: Reverse

Name: groEL [H]

Synonym: spyM18_2129

Alternate gene names: 19746946

Gene position: 1779723-1778092 (Counterclockwise)

Preceding gene: 19746947

Following gene: 19746944

Centisome position: 93.92

GC content: 43.08

Gene sequence:

>1632_bases
ATGGCAAAAGATATTAAATTTTCAGCAGATGCGCGTGCTGCCATGGTGCGCGGAGTTGATATGTTAGCAGATACCGTCAA
AGTAACGCTTGGTCCTAAAGGGCGCAATGTTGTTCTTGAAAAAGCTTTTGGTTCTCCCTTAATTACTAATGACGGGGTAA
CCATTGCTAAAGAGATCGAATTAGAAGATCATTTTGAAAACATGGGAGCAAAATTGGTGTCTGAAGTGGCTTCTAAAACC
AATGATATTGCTGGTGATGGGACGACTACTGCAACAGTTTTGACACAAGCCATTGTTCATGAAGGACTAAAAAATGTGAC
AGCAGGTGCTAATCCAATTGGTATTCGTCGAGGCATTGAAACAGCAACAGCAACAGCCGTTGAAGCCTTGAAAGCCATTG
CTCAACCTGTATCTGGCAAGGAAGCTATTGCTCAGGTCGCTGCAGTATCATCACGCTCTGAAAAAGTTGGAGAGTATATC
TCAGAAGCTATGGAGCGTGTGGGCAACGATGGTGTGATTACCATCGAAGAATCTCGAGGTATGGAAACAGAACTTGAAGT
GGTTGAAGGCATGCAATTTGACCGTGGTTACCTGTCTCAATACATGGTCACAGACAATGAAAAAATGGTTGCAGACCTTG
AAAACCCATTTATCTTAATCACGGATAAAAAAGTGTCAAACATCCAAGACATTTTGCCACTACTTGAGGAAGTTCTTAAA
ACCAACCGTCCATTACTCATTATTGCAGATGATGTGGATGGTGAAGCCCTTCCAACCCTTGTCTTGAACAAGATTCGTGG
TACTTTCAATGTGGTTGCTGTCAAAGCGCCAGGATTTGGTGATCGCCGTAAAGCTATGCTTGAAGACATTGCTATCTTGA
CAGGTGGTACAGTGATTACAGAGGATCTAGGACTTGAATTAAAAGATGCTACAATGACAGCCCTTGGACAGGCTGCTAAG
ATTACAGTTGATAAAGATAGCACAGTAATTGTTGAAGGTTCAGGAAGTTCAGAAGCTATTGCTAACCGTATTGCACTGAT
TAAATCGCAATTAGAAACAACAACTTCTGACTTTGACCGTGAAAAACTACAAGAACGTTTGGCGAAATTAGCTGGTGGTG
TAGCTGTTATCAAAGTAGGAGCTCCAACAGAGACAGCTTTAAAAGAAATGAAACTCCGCATTGAGGACGCTCTAAATGCT
ACACGTGCAGCCGTTGAAGAAGGTATCGTTGCTGGTGGTGGAACAGCACTTATTACGGTTATTGAAAAAGTAGCAGCTCT
TGAACTTGAGGGCGATGATGCTACTGGACGTAACATTGTGCTTCGTGCTCTAGAAGAGCCTGTACGTCAAATTGCTTTAA
ATGCTGGGTACGAAGGCTCCGTAATTATTGACAAGTTGAAAAACAGCCCTGCAGGAACAGGATTTAATGCTGCAACAGGT
GAGTGGGTTGATATGATTAAAACAGGAATCATTGACCCTGTCAAAGTAACACGATCAGCGCTTCAAAATGCAGCTTCTGT
AGCTAGTCTTATTTTGACAACAGAAGCAGTTGTCGCTAATAAACCTGAACCAGCAGCGCCAGCGCCAGCAATGCCAGCAG
GTATGGATCCAGGAATGATGGGCGGCTTCTAA

Upstream 100 bases:

>100_bases
CCGTAGATGATGAGAAAGTTTCTATCATCCGTGAATCTGACATCATTGCTATTGTTACAAAATAAAACGACAAATCTCTA
AATAGAAAGAAGGATTGAAT

Downstream 100 bases:

>100_bases
GCTCTCTATAGCATTAAGGATTATGAAAAAGAAGTTGAGACTAAAGGTCTGCTTCTTACTATGAAAAAAGAACAAAGATT
GGATTTCGACTCATGATATC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MAKDIKFSADARAAMVRGVDMLADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKT
NDIAGDGTTTATVLTQAIVHEGLKNVTAGANPIGIRRGIETATATAVEALKAIAQPVSGKEAIAQVAAVSSRSEKVGEYI
SEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKVSNIQDILPLLEEVLK
TNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATMTALGQAAK
ITVDKDSTVIVEGSGSSEAIANRIALIKSQLETTTSDFDREKLQERLAKLAGGVAVIKVGAPTETALKEMKLRIEDALNA
TRAAVEEGIVAGGGTALITVIEKVAALELEGDDATGRNIVLRALEEPVRQIALNAGYEGSVIIDKLKNSPAGTGFNAATG
EWVDMIKTGIIDPVKVTRSALQNAASVASLILTTEAVVANKPEPAAPAPAMPAGMDPGMMGGF

Sequences:

>Translated_543_residues
MAKDIKFSADARAAMVRGVDMLADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKT
NDIAGDGTTTATVLTQAIVHEGLKNVTAGANPIGIRRGIETATATAVEALKAIAQPVSGKEAIAQVAAVSSRSEKVGEYI
SEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKVSNIQDILPLLEEVLK
TNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATMTALGQAAK
ITVDKDSTVIVEGSGSSEAIANRIALIKSQLETTTSDFDREKLQERLAKLAGGVAVIKVGAPTETALKEMKLRIEDALNA
TRAAVEEGIVAGGGTALITVIEKVAALELEGDDATGRNIVLRALEEPVRQIALNAGYEGSVIIDKLKNSPAGTGFNAATG
EWVDMIKTGIIDPVKVTRSALQNAASVASLILTTEAVVANKPEPAAPAPAMPAGMDPGMMGGF
>Mature_542_residues
AKDIKFSADARAAMVRGVDMLADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTN
DIAGDGTTTATVLTQAIVHEGLKNVTAGANPIGIRRGIETATATAVEALKAIAQPVSGKEAIAQVAAVSSRSEKVGEYIS
EAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKVSNIQDILPLLEEVLKT
NRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATMTALGQAAKI
TVDKDSTVIVEGSGSSEAIANRIALIKSQLETTTSDFDREKLQERLAKLAGGVAVIKVGAPTETALKEMKLRIEDALNAT
RAAVEEGIVAGGGTALITVIEKVAALELEGDDATGRNIVLRALEEPVRQIALNAGYEGSVIIDKLKNSPAGTGFNAATGE
WVDMIKTGIIDPVKVTRSALQNAASVASLILTTEAVVANKPEPAAPAPAMPAGMDPGMMGGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=49.8098859315589, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=49.8098859315589, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI5453607, Length=554, Percent_Identity=24.0072202166065, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI302058290, Length=517, Percent_Identity=21.8568665377176, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI38455427, Length=565, Percent_Identity=22.8318584070796, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI24307939, Length=356, Percent_Identity=25.561797752809, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=61.4503816793893, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=49.2452830188679, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=47.8672985781991, Blast_Score=179, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI25144674, Length=173, Percent_Identity=31.7919075144509, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564182, Length=554, Percent_Identity=23.2851985559567, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.2319391634981, Blast_Score=523, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6322446, Length=532, Percent_Identity=23.1203007518797, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322524, Length=129, Percent_Identity=31.0077519379845, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320058, Length=178, Percent_Identity=26.9662921348315, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=49.8098859315589, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=49.8098859315589, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=46.3740458015267, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=46.3740458015267, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=46.3740458015267, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=41.5607985480944, Blast_Score=424, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24584129, Length=540, Percent_Identity=35.7407407407407, Blast_Score=298, Evalue=7e-81,
Organism=Drosophila melanogaster, GI19921262, Length=540, Percent_Identity=35.7407407407407, Blast_Score=298, Evalue=7e-81,
Organism=Drosophila melanogaster, GI17647245, Length=448, Percent_Identity=24.1071428571429, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24652903, Length=436, Percent_Identity=24.3119266055046, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI18858175, Length=558, Percent_Identity=23.8351254480287, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28571140, Length=558, Percent_Identity=23.8351254480287, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24645179, Length=511, Percent_Identity=23.679060665362, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583944, Length=187, Percent_Identity=26.7379679144385, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57080; Mature: 56949

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDIKFSADARAAMVRGVDMLADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIE
CCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCCEEEEECC
LEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVHEGLKNVTAGANPIGIRRGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCH
TATATAVEALKAIAQPVSGKEAIAQVAAVSSRSEKVGEYISEAMERVGNDGVITIEESRG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
METELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKVSNIQDILPLLEEVLK
CCHHHHHHHCCCCCHHHHHHHEECCCCHHEEECCCCEEEEECCHHHHHHHHHHHHHHHHH
TNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVIT
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEE
EDLGLELKDATMTALGQAAKITVDKDSTVIVEGSGSSEAIANRIALIKSQLETTTSDFDR
CCCCCEECHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAPTETALKEMKLRIEDALNATRAAVEEGIVAGGGTALITV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IEKVAALELEGDDATGRNIVLRALEEPVRQIALNAGYEGSVIIDKLKNSPAGTGFNAATG
HHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCH
EWVDMIKTGIIDPVKVTRSALQNAASVASLILTTEAVVANKPEPAAPAPAMPAGMDPGMM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GGF
CCC
>Mature Secondary Structure 
AKDIKFSADARAAMVRGVDMLADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCCEEEEECC
LEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVHEGLKNVTAGANPIGIRRGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCH
TATATAVEALKAIAQPVSGKEAIAQVAAVSSRSEKVGEYISEAMERVGNDGVITIEESRG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
METELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKVSNIQDILPLLEEVLK
CCHHHHHHHCCCCCHHHHHHHEECCCCHHEEECCCCEEEEECCHHHHHHHHHHHHHHHHH
TNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVIT
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEE
EDLGLELKDATMTALGQAAKITVDKDSTVIVEGSGSSEAIANRIALIKSQLETTTSDFDR
CCCCCEECHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAPTETALKEMKLRIEDALNATRAAVEEGIVAGGGTALITV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IEKVAALELEGDDATGRNIVLRALEEPVRQIALNAGYEGSVIIDKLKNSPAGTGFNAATG
HHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCH
EWVDMIKTGIIDPVKVTRSALQNAASVASLILTTEAVVANKPEPAAPAPAMPAGMDPGMM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GGF
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA