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The map label for this gene is gldA [H]

Identifier: 19746930

GI number: 19746930

Start: 1759101

End: 1760189

Strand: Reverse

Name: gldA [H]

Synonym: spyM18_2108

Alternate gene names: 19746930

Gene position: 1760189-1759101 (Counterclockwise)

Preceding gene: 19746931

Following gene: 19746928

Centisome position: 92.89

GC content: 45.09

Gene sequence:

>1089_bases
ATGAAAGTATTTGCAAGTCCATCTCGTTACATTCAAGGTAAAAATGCCTTGTTTACCAATGCTAAAACCCTAAAACAACT
AGGGGATAGCCCCATTTTACTGTGTGATGACGTGGTGTATGGCATCGTCGGAGAAAGATTTGAAAGCTATTTGATAGATA
ATGGCATGACTCCTGTTCACGTAGCCTTTAATGGCGAAGCCTCAGATAATGAAATCAGCCGCGTGGTTGCCATTGCCAAG
GAAAATAGCAATGATGTTATTATTGGACTTGGTGGTGGAAAAACCATTGACAGTGCTAAGGCTATCGCTGACTTACTTGC
TGTTCCAGTGATTATTGCCCCAACCATTGCTTCAACAGATGCCCCAACCTCAGCCTTATCGGTTATTTACACCGATGAAG
GAGCCTTTGAAAAATACATTTTCTATTCAAAAAATCCAGATCTTGTTTTGGTTGACACACAAGTGATCTGTCAGGCACCA
AAACGATTACTGGCCTCTGGGATTGCAGATGGGTTAGCAACATGGGTAGAGGCGCGTGCTGTTATGCAAAAAAATGGAGA
CACCATGGCAGGTGGCAATCAAACCTTGGCAGGAGTTGCCATTGCCAAAGCCTGTGAGCAGACCTTGTTTGCAGATGGCC
TAAAAGCGATGGCTAGTTGTGACAGACAAGTCGTGACCCCGGCCTTGGAAAATGTCATTGAAGCCAATACACTTCTTAGT
GGACTTGGTTTTGAAAGTGCGGGTCTGGCTGCTGCACATGCCATTCACAATGGCTTTACAGCGCTGACAGGTGCTATTCA
TCACCTTACCCATGGTGAAAAAGTCGCCTATGGCACGTTGACCCAACTCTTCTTGGAAAATCGTTCGCGTGAAGAAATTG
ACCGCTACATCGACTTTTACCAAGCCATTGGCATGCCAACAACCCTCAAAGAAATGCATTTAGACACGGCTACTCAAGAG
GATTTCTTAAAAATTGGCCGTCAAGCAACCATGGCAGGCGAAACCATCCATCAAATGCCGTTTGTTATCAGTCCAGAAGA
TGTAGCAGCGGCTTTGGTTGCTGTCGATGCTTATGTTACGAGTCGATAG

Upstream 100 bases:

>100_bases
TTGGCAAGGATTGGGAAGCCATTCATCACCGCAAGAGCATTTAAGAAATAGCATCAGTAGTAATCACATCATTAGGAATC
ACAGATAAAGGAGTTCAACG

Downstream 100 bases:

>100_bases
GCTAACCAAAAAGAGATTTCTTATTTGCCAGATAACCTCAAAAAAACAAGTCTAGGGAGTCATTTCCTAGACTTGTTTTG
CTTATTGCTGGTTGGTAATA

Product: glycerol dehydrogenase

Products: NA

Alternate protein names: GDH; GLDH; GlyDH [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKVFASPSRYIQGKNALFTNAKTLKQLGDSPILLCDDVVYGIVGERFESYLIDNGMTPVHVAFNGEASDNEISRVVAIAK
ENSNDVIIGLGGGKTIDSAKAIADLLAVPVIIAPTIASTDAPTSALSVIYTDEGAFEKYIFYSKNPDLVLVDTQVICQAP
KRLLASGIADGLATWVEARAVMQKNGDTMAGGNQTLAGVAIAKACEQTLFADGLKAMASCDRQVVTPALENVIEANTLLS
GLGFESAGLAAAHAIHNGFTALTGAIHHLTHGEKVAYGTLTQLFLENRSREEIDRYIDFYQAIGMPTTLKEMHLDTATQE
DFLKIGRQATMAGETIHQMPFVISPEDVAAALVAVDAYVTSR

Sequences:

>Translated_362_residues
MKVFASPSRYIQGKNALFTNAKTLKQLGDSPILLCDDVVYGIVGERFESYLIDNGMTPVHVAFNGEASDNEISRVVAIAK
ENSNDVIIGLGGGKTIDSAKAIADLLAVPVIIAPTIASTDAPTSALSVIYTDEGAFEKYIFYSKNPDLVLVDTQVICQAP
KRLLASGIADGLATWVEARAVMQKNGDTMAGGNQTLAGVAIAKACEQTLFADGLKAMASCDRQVVTPALENVIEANTLLS
GLGFESAGLAAAHAIHNGFTALTGAIHHLTHGEKVAYGTLTQLFLENRSREEIDRYIDFYQAIGMPTTLKEMHLDTATQE
DFLKIGRQATMAGETIHQMPFVISPEDVAAALVAVDAYVTSR
>Mature_362_residues
MKVFASPSRYIQGKNALFTNAKTLKQLGDSPILLCDDVVYGIVGERFESYLIDNGMTPVHVAFNGEASDNEISRVVAIAK
ENSNDVIIGLGGGKTIDSAKAIADLLAVPVIIAPTIASTDAPTSALSVIYTDEGAFEKYIFYSKNPDLVLVDTQVICQAP
KRLLASGIADGLATWVEARAVMQKNGDTMAGGNQTLAGVAIAKACEQTLFADGLKAMASCDRQVVTPALENVIEANTLLS
GLGFESAGLAAAHAIHNGFTALTGAIHHLTHGEKVAYGTLTQLFLENRSREEIDRYIDFYQAIGMPTTLKEMHLDTATQE
DFLKIGRQATMAGETIHQMPFVISPEDVAAALVAVDAYVTSR

Specific function: Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions. Is also able to use various diols as substrates, such as propan-1,2-diol, butan-

COG id: COG0371

COG function: function code C; Glycerol dehydrogenase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87082352, Length=357, Percent_Identity=49.2997198879552, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1786815, Length=303, Percent_Identity=32.6732673267327, Blast_Score=141, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016205 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.6 [H]

Molecular weight: Translated: 38569; Mature: 38569

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFASPSRYIQGKNALFTNAKTLKQLGDSPILLCDDVVYGIVGERFESYLIDNGMTPVH
CCCCCCCHHHHCCCCCEECCHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEE
VAFNGEASDNEISRVVAIAKENSNDVIIGLGGGKTIDSAKAIADLLAVPVIIAPTIASTD
EEECCCCCCCHHHHEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
APTSALSVIYTDEGAFEKYIFYSKNPDLVLVDTQVICQAPKRLLASGIADGLATWVEARA
CCCCEEEEEEECCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMQKNGDTMAGGNQTLAGVAIAKACEQTLFADGLKAMASCDRQVVTPALENVIEANTLLS
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GLGFESAGLAAAHAIHNGFTALTGAIHHLTHGEKVAYGTLTQLFLENRSREEIDRYIDFY
HCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHH
QAIGMPTTLKEMHLDTATQEDFLKIGRQATMAGETIHQMPFVISPEDVAAALVAVDAYVT
HHHCCCHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHC
SR
CC
>Mature Secondary Structure
MKVFASPSRYIQGKNALFTNAKTLKQLGDSPILLCDDVVYGIVGERFESYLIDNGMTPVH
CCCCCCCHHHHCCCCCEECCHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEE
VAFNGEASDNEISRVVAIAKENSNDVIIGLGGGKTIDSAKAIADLLAVPVIIAPTIASTD
EEECCCCCCCHHHHEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
APTSALSVIYTDEGAFEKYIFYSKNPDLVLVDTQVICQAPKRLLASGIADGLATWVEARA
CCCCEEEEEEECCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMQKNGDTMAGGNQTLAGVAIAKACEQTLFADGLKAMASCDRQVVTPALENVIEANTLLS
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GLGFESAGLAAAHAIHNGFTALTGAIHHLTHGEKVAYGTLTQLFLENRSREEIDRYIDFY
HCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHH
QAIGMPTTLKEMHLDTATQEDFLKIGRQATMAGETIHQMPFVISPEDVAAALVAVDAYVT
HHHCCCHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHC
SR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339360 [H]